Amino acid dipepetide frequency for Pelagicola litorisediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.166AlaAla: 14.166 ± 0.144	1.131AlaCys: 1.131 ± 0.038	6.631AlaAsp: 6.631 ± 0.087	7.235AlaGlu: 7.235 ± 0.099	4.156AlaPhe: 4.156 ± 0.062	9.643AlaGly: 9.643 ± 0.113	2.284AlaHis: 2.284 ± 0.048	5.808AlaIle: 5.808 ± 0.075	4.169AlaLys: 4.169 ± 0.066	12.599AlaLeu: 12.599 ± 0.128	3.673AlaMet: 3.673 ± 0.056	2.94AlaAsn: 2.94 ± 0.055	4.987AlaPro: 4.987 ± 0.067	4.221AlaGln: 4.221 ± 0.063	7.774AlaArg: 7.774 ± 0.095	5.444AlaSer: 5.444 ± 0.069	5.601AlaThr: 5.601 ± 0.068	7.668AlaVal: 7.668 ± 0.078	1.314AlaTrp: 1.314 ± 0.036	2.583AlaTyr: 2.583 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.113CysAla: 1.113 ± 0.027	0.14CysCys: 0.14 ± 0.012	0.667CysAsp: 0.667 ± 0.025	0.471CysGlu: 0.471 ± 0.022	0.381CysPhe: 0.381 ± 0.018	1.054CysGly: 1.054 ± 0.034	0.308CysHis: 0.308 ± 0.02	0.478CysIle: 0.478 ± 0.019	0.273CysLys: 0.273 ± 0.013	0.945CysLeu: 0.945 ± 0.029	0.196CysMet: 0.196 ± 0.014	0.285CysAsn: 0.285 ± 0.016	0.545CysPro: 0.545 ± 0.023	0.276CysGln: 0.276 ± 0.014	0.609CysArg: 0.609 ± 0.024	0.523CysSer: 0.523 ± 0.021	0.509CysThr: 0.509 ± 0.024	0.672CysVal: 0.672 ± 0.026	0.135CysTrp: 0.135 ± 0.01	0.267CysTyr: 0.267 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.606AspAla: 6.606 ± 0.078	0.574AspCys: 0.574 ± 0.023	3.453AspAsp: 3.453 ± 0.064	3.528AspGlu: 3.528 ± 0.06	2.316AspPhe: 2.316 ± 0.044	5.143AspGly: 5.143 ± 0.081	1.413AspHis: 1.413 ± 0.033	3.441AspIle: 3.441 ± 0.06	2.028AspLys: 2.028 ± 0.038	6.278AspLeu: 6.278 ± 0.081	1.791AspMet: 1.791 ± 0.036	1.487AspAsn: 1.487 ± 0.04	3.435AspPro: 3.435 ± 0.066	2.167AspGln: 2.167 ± 0.043	3.942AspArg: 3.942 ± 0.067	2.313AspSer: 2.313 ± 0.042	3.132AspThr: 3.132 ± 0.055	4.327AspVal: 4.327 ± 0.067	1.159AspTrp: 1.159 ± 0.032	1.571AspTyr: 1.571 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.925GluAla: 6.925 ± 0.105	0.447GluCys: 0.447 ± 0.018	3.092GluAsp: 3.092 ± 0.056	3.25GluGlu: 3.25 ± 0.07	2.084GluPhe: 2.084 ± 0.043	4.489GluGly: 4.489 ± 0.073	1.183GluHis: 1.183 ± 0.035	3.813GluIle: 3.813 ± 0.057	2.673GluLys: 2.673 ± 0.053	5.219GluLeu: 5.219 ± 0.063	1.927GluMet: 1.927 ± 0.047	2.14GluAsn: 2.14 ± 0.039	2.436GluPro: 2.436 ± 0.052	1.981GluGln: 1.981 ± 0.043	3.894GluArg: 3.894 ± 0.062	2.31GluSer: 2.31 ± 0.048	3.831GluThr: 3.831 ± 0.063	4.207GluVal: 4.207 ± 0.062	0.735GluTrp: 0.735 ± 0.023	1.163GluTyr: 1.163 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.152PheAla: 4.152 ± 0.064	0.496PheCys: 0.496 ± 0.02	2.925PheAsp: 2.925 ± 0.049	2.336PheGlu: 2.336 ± 0.046	1.553PhePhe: 1.553 ± 0.038	3.818PheGly: 3.818 ± 0.06	0.805PheHis: 0.805 ± 0.029	1.848PheIle: 1.848 ± 0.042	1.104PheLys: 1.104 ± 0.027	3.626PheLeu: 3.626 ± 0.073	0.954PheMet: 0.954 ± 0.028	1.204PheAsn: 1.204 ± 0.033	1.572PhePro: 1.572 ± 0.037	1.138PheGln: 1.138 ± 0.032	2.143PheArg: 2.143 ± 0.039	2.364PheSer: 2.364 ± 0.047	2.154PheThr: 2.154 ± 0.05	2.723PheVal: 2.723 ± 0.052	0.622PheTrp: 0.622 ± 0.025	1.015PheTyr: 1.015 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.069GlyAla: 9.069 ± 0.107	0.936GlyCys: 0.936 ± 0.028	4.609GlyAsp: 4.609 ± 0.067	4.461GlyGlu: 4.461 ± 0.066	3.806GlyPhe: 3.806 ± 0.065	7.037GlyGly: 7.037 ± 0.099	2.005GlyHis: 2.005 ± 0.043	4.603GlyIle: 4.603 ± 0.07	3.567GlyLys: 3.567 ± 0.055	9.02GlyLeu: 9.02 ± 0.099	2.687GlyMet: 2.687 ± 0.052	2.41GlyAsn: 2.41 ± 0.047	3.567GlyPro: 3.567 ± 0.061	3.313GlyGln: 3.313 ± 0.057	5.336GlyArg: 5.336 ± 0.068	4.238GlySer: 4.238 ± 0.064	4.431GlyThr: 4.431 ± 0.075	6.248GlyVal: 6.248 ± 0.079	1.471GlyTrp: 1.471 ± 0.036	2.4GlyTyr: 2.4 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.352HisAla: 2.352 ± 0.047	0.283HisCys: 0.283 ± 0.015	1.354HisAsp: 1.354 ± 0.034	1.164HisGlu: 1.164 ± 0.032	0.89HisPhe: 0.89 ± 0.027	1.908HisGly: 1.908 ± 0.042	0.637HisHis: 0.637 ± 0.028	1.144HisIle: 1.144 ± 0.031	0.654HisLys: 0.654 ± 0.025	2.187HisLeu: 2.187 ± 0.041	0.583HisMet: 0.583 ± 0.023	0.55HisAsn: 0.55 ± 0.019	1.421HisPro: 1.421 ± 0.036	0.669HisGln: 0.669 ± 0.025	1.298HisArg: 1.298 ± 0.029	1.033HisSer: 1.033 ± 0.033	0.904HisThr: 0.904 ± 0.03	1.516HisVal: 1.516 ± 0.037	0.366HisTrp: 0.366 ± 0.017	0.591HisTyr: 0.591 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.759IleAla: 6.759 ± 0.081	0.717IleCys: 0.717 ± 0.024	3.588IleAsp: 3.588 ± 0.063	3.706IleGlu: 3.706 ± 0.059	1.949IlePhe: 1.949 ± 0.049	4.955IleGly: 4.955 ± 0.074	0.963IleHis: 0.963 ± 0.032	2.59IleIle: 2.59 ± 0.054	1.813IleLys: 1.813 ± 0.041	5.065IleLeu: 5.065 ± 0.073	1.282IleMet: 1.282 ± 0.036	1.661IleAsn: 1.661 ± 0.039	2.503IlePro: 2.503 ± 0.046	1.35IleGln: 1.35 ± 0.039	3.339IleArg: 3.339 ± 0.057	3.452IleSer: 3.452 ± 0.064	3.169IleThr: 3.169 ± 0.054	3.838IleVal: 3.838 ± 0.067	0.786IleTrp: 0.786 ± 0.026	1.29IleTyr: 1.29 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.288LysAla: 4.288 ± 0.066	0.244LysCys: 0.244 ± 0.013	1.963LysAsp: 1.963 ± 0.042	1.828LysGlu: 1.828 ± 0.049	1.161LysPhe: 1.161 ± 0.031	3.033LysGly: 3.033 ± 0.052	0.782LysHis: 0.782 ± 0.024	2.108LysIle: 2.108 ± 0.044	1.5LysLys: 1.5 ± 0.041	3.517LysLeu: 3.517 ± 0.058	1.031LysMet: 1.031 ± 0.031	1.045LysAsn: 1.045 ± 0.032	2.101LysPro: 2.101 ± 0.048	1.153LysGln: 1.153 ± 0.035	2.534LysArg: 2.534 ± 0.046	2.174LysSer: 2.174 ± 0.045	2.281LysThr: 2.281 ± 0.045	2.578LysVal: 2.578 ± 0.051	0.511LysTrp: 0.511 ± 0.019	0.785LysTyr: 0.785 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.821LeuAla: 11.821 ± 0.122	1.001LeuCys: 1.001 ± 0.031	5.829LeuAsp: 5.829 ± 0.073	5.626LeuGlu: 5.626 ± 0.075	3.616LeuPhe: 3.616 ± 0.064	8.28LeuGly: 8.28 ± 0.091	1.986LeuHis: 1.986 ± 0.047	5.607LeuIle: 5.607 ± 0.077	3.768LeuLys: 3.768 ± 0.064	8.9LeuLeu: 8.9 ± 0.12	2.74LeuMet: 2.74 ± 0.05	3.077LeuAsn: 3.077 ± 0.054	5.304LeuPro: 5.304 ± 0.069	2.991LeuGln: 2.991 ± 0.054	6.575LeuArg: 6.575 ± 0.081	6.628LeuSer: 6.628 ± 0.088	6.032LeuThr: 6.032 ± 0.08	6.699LeuVal: 6.699 ± 0.104	1.34LeuTrp: 1.34 ± 0.036	2.001LeuTyr: 2.001 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.548MetAla: 3.548 ± 0.055	0.223MetCys: 0.223 ± 0.013	1.424MetAsp: 1.424 ± 0.035	1.302MetGlu: 1.302 ± 0.034	0.885MetPhe: 0.885 ± 0.03	2.33MetGly: 2.33 ± 0.049	0.509MetHis: 0.509 ± 0.023	1.675MetIle: 1.675 ± 0.036	1.251MetLys: 1.251 ± 0.035	2.68MetLeu: 2.68 ± 0.045	0.824MetMet: 0.824 ± 0.027	0.965MetAsn: 0.965 ± 0.03	1.56MetPro: 1.56 ± 0.036	1.102MetGln: 1.102 ± 0.029	1.899MetArg: 1.899 ± 0.037	1.78MetSer: 1.78 ± 0.034	2.086MetThr: 2.086 ± 0.04	1.944MetVal: 1.944 ± 0.038	0.261MetTrp: 0.261 ± 0.015	0.395MetTyr: 0.395 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.346AsnAla: 3.346 ± 0.055	0.331AsnCys: 0.331 ± 0.017	1.655AsnAsp: 1.655 ± 0.04	1.414AsnGlu: 1.414 ± 0.031	1.132AsnPhe: 1.132 ± 0.035	2.665AsnGly: 2.665 ± 0.054	0.589AsnHis: 0.589 ± 0.021	1.631AsnIle: 1.631 ± 0.036	0.894AsnLys: 0.894 ± 0.032	2.943AsnLeu: 2.943 ± 0.051	0.796AsnMet: 0.796 ± 0.028	0.872AsnAsn: 0.872 ± 0.03	2.073AsnPro: 2.073 ± 0.042	0.868AsnGln: 0.868 ± 0.031	1.928AsnArg: 1.928 ± 0.042	1.442AsnSer: 1.442 ± 0.033	1.53AsnThr: 1.53 ± 0.035	2.004AsnVal: 2.004 ± 0.044	0.54AsnTrp: 0.54 ± 0.024	0.757AsnTyr: 0.757 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.946ProAla: 4.946 ± 0.071	0.383ProCys: 0.383 ± 0.019	3.97ProAsp: 3.97 ± 0.063	3.994ProGlu: 3.994 ± 0.069	1.965ProPhe: 1.965 ± 0.045	4.446ProGly: 4.446 ± 0.065	1.034ProHis: 1.034 ± 0.033	2.31ProIle: 2.31 ± 0.045	1.906ProLys: 1.906 ± 0.046	4.563ProLeu: 4.563 ± 0.06	1.276ProMet: 1.276 ± 0.032	1.464ProAsn: 1.464 ± 0.039	2.054ProPro: 2.054 ± 0.043	1.534ProGln: 1.534 ± 0.035	2.618ProArg: 2.618 ± 0.052	2.467ProSer: 2.467 ± 0.046	2.347ProThr: 2.347 ± 0.044	4.169ProVal: 4.169 ± 0.065	0.629ProTrp: 0.629 ± 0.023	1.17ProTyr: 1.17 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.173GlnAla: 4.173 ± 0.068	0.249GlnCys: 0.249 ± 0.017	1.682GlnAsp: 1.682 ± 0.041	1.634GlnGlu: 1.634 ± 0.037	1.183GlnPhe: 1.183 ± 0.029	2.672GlnGly: 2.672 ± 0.049	0.673GlnHis: 0.673 ± 0.023	2.182GlnIle: 2.182 ± 0.038	1.318GlnLys: 1.318 ± 0.03	3.101GlnLeu: 3.101 ± 0.064	1.151GlnMet: 1.151 ± 0.033	1.093GlnAsn: 1.093 ± 0.031	1.671GlnPro: 1.671 ± 0.038	1.175GlnGln: 1.175 ± 0.034	2.085GlnArg: 2.085 ± 0.043	1.928GlnSer: 1.928 ± 0.04	1.899GlnThr: 1.899 ± 0.039	2.516GlnVal: 2.516 ± 0.046	0.428GlnTrp: 0.428 ± 0.021	0.662GlnTyr: 0.662 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.105ArgAla: 7.105 ± 0.086	0.536ArgCys: 0.536 ± 0.021	4.134ArgAsp: 4.134 ± 0.069	3.593ArgGlu: 3.593 ± 0.064	2.63ArgPhe: 2.63 ± 0.052	4.209ArgGly: 4.209 ± 0.066	1.564ArgHis: 1.564 ± 0.037	3.798ArgIle: 3.798 ± 0.058	2.611ArgLys: 2.611 ± 0.052	6.801ArgLeu: 6.801 ± 0.092	1.871ArgMet: 1.871 ± 0.038	1.945ArgAsn: 1.945 ± 0.033	2.972ArgPro: 2.972 ± 0.057	2.437ArgGln: 2.437 ± 0.052	4.553ArgArg: 4.553 ± 0.07	3.171ArgSer: 3.171 ± 0.055	2.871ArgThr: 2.871 ± 0.046	4.482ArgVal: 4.482 ± 0.069	0.927ArgTrp: 0.927 ± 0.025	1.575ArgTyr: 1.575 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.653SerAla: 5.653 ± 0.073	0.478SerCys: 0.478 ± 0.019	3.577SerAsp: 3.577 ± 0.06	3.013SerGlu: 3.013 ± 0.057	2.315SerPhe: 2.315 ± 0.049	5.529SerGly: 5.529 ± 0.082	1.174SerHis: 1.174 ± 0.038	2.711SerIle: 2.711 ± 0.047	1.83SerLys: 1.83 ± 0.038	5.084SerLeu: 5.084 ± 0.067	1.407SerMet: 1.407 ± 0.036	1.565SerAsn: 1.565 ± 0.038	2.531SerPro: 2.531 ± 0.053	1.744SerGln: 1.744 ± 0.036	3.179SerArg: 3.179 ± 0.057	2.652SerSer: 2.652 ± 0.052	2.624SerThr: 2.624 ± 0.054	3.974SerVal: 3.974 ± 0.058	0.705SerTrp: 0.705 ± 0.027	1.376SerTyr: 1.376 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.938ThrAla: 5.938 ± 0.07	0.589ThrCys: 0.589 ± 0.021	3.136ThrAsp: 3.136 ± 0.052	2.958ThrGlu: 2.958 ± 0.053	2.037ThrPhe: 2.037 ± 0.039	5.535ThrGly: 5.535 ± 0.065	1.162ThrHis: 1.162 ± 0.035	2.835ThrIle: 2.835 ± 0.048	1.708ThrLys: 1.708 ± 0.037	5.902ThrLeu: 5.902 ± 0.075	1.31ThrMet: 1.31 ± 0.033	1.497ThrAsn: 1.497 ± 0.034	3.263ThrPro: 3.263 ± 0.061	1.751ThrGln: 1.751 ± 0.039	3.464ThrArg: 3.464 ± 0.051	2.831ThrSer: 2.831 ± 0.045	2.934ThrThr: 2.934 ± 0.053	4.012ThrVal: 4.012 ± 0.057	0.701ThrTrp: 0.701 ± 0.022	1.276ThrTyr: 1.276 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.158ValAla: 8.158 ± 0.089	0.706ValCys: 0.706 ± 0.023	4.041ValAsp: 4.041 ± 0.059	4.311ValGlu: 4.311 ± 0.065	2.94ValPhe: 2.94 ± 0.054	5.318ValGly: 5.318 ± 0.08	1.441ValHis: 1.441 ± 0.04	4.381ValIle: 4.381 ± 0.068	2.357ValLys: 2.357 ± 0.049	7.284ValLeu: 7.284 ± 0.089	2.213ValMet: 2.213 ± 0.041	2.077ValAsn: 2.077 ± 0.045	3.442ValPro: 3.442 ± 0.054	2.141ValGln: 2.141 ± 0.038	3.988ValArg: 3.988 ± 0.065	4.262ValSer: 4.262 ± 0.069	4.592ValThr: 4.592 ± 0.067	5.607ValVal: 5.607 ± 0.08	0.96ValTrp: 0.96 ± 0.031	1.496ValTyr: 1.496 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.408TrpAla: 1.408 ± 0.039	0.142TrpCys: 0.142 ± 0.011	0.749TrpAsp: 0.749 ± 0.026	0.682TrpGlu: 0.682 ± 0.029	0.598TrpPhe: 0.598 ± 0.024	1.045TrpGly: 1.045 ± 0.037	0.393TrpHis: 0.393 ± 0.019	0.77TrpIle: 0.77 ± 0.025	0.496TrpLys: 0.496 ± 0.022	1.638TrpLeu: 1.638 ± 0.043	0.405TrpMet: 0.405 ± 0.019	0.464TrpAsn: 0.464 ± 0.02	0.699TrpPro: 0.699 ± 0.026	0.669TrpGln: 0.669 ± 0.024	1.024TrpArg: 1.024 ± 0.033	0.804TrpSer: 0.804 ± 0.025	0.726TrpThr: 0.726 ± 0.029	0.963TrpVal: 0.963 ± 0.027	0.233TrpTrp: 0.233 ± 0.014	0.301TrpTyr: 0.301 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.047	0.24TyrCys: 0.24 ± 0.012	1.626TyrAsp: 1.626 ± 0.036	1.291TyrGlu: 1.291 ± 0.037	0.956TyrPhe: 0.956 ± 0.033	2.107TyrGly: 2.107 ± 0.041	0.602TyrHis: 0.602 ± 0.023	1.042TyrIle: 1.042 ± 0.03	0.697TyrLys: 0.697 ± 0.025	2.47TyrLeu: 2.47 ± 0.052	0.525TyrMet: 0.525 ± 0.021	0.669TyrAsn: 0.669 ± 0.025	1.109TyrPro: 1.109 ± 0.033	0.795TyrGln: 0.795 ± 0.027	1.604TyrArg: 1.604 ± 0.037	1.305TyrSer: 1.305 ± 0.035	1.186TyrThr: 1.186 ± 0.035	1.566TyrVal: 1.566 ± 0.041	0.383TyrTrp: 0.383 ± 0.02	0.627TyrTyr: 0.627 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3904 proteins (1190632 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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