Amino acid dipepetide frequency for Microbacterium rhizomatis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.636AlaAla: 20.636 ± 0.188	0.709AlaCys: 0.709 ± 0.027	8.417AlaAsp: 8.417 ± 0.112	7.495AlaGlu: 7.495 ± 0.112	3.97AlaPhe: 3.97 ± 0.06	12.265AlaGly: 12.265 ± 0.106	2.633AlaHis: 2.633 ± 0.052	6.258AlaIle: 6.258 ± 0.084	2.508AlaLys: 2.508 ± 0.05	13.822AlaLeu: 13.822 ± 0.137	2.701AlaMet: 2.701 ± 0.046	2.274AlaAsn: 2.274 ± 0.053	6.692AlaPro: 6.692 ± 0.08	3.912AlaGln: 3.912 ± 0.061	9.385AlaArg: 9.385 ± 0.121	7.88AlaSer: 7.88 ± 0.084	7.653AlaThr: 7.653 ± 0.082	11.47AlaVal: 11.47 ± 0.104	1.976AlaTrp: 1.976 ± 0.043	2.578AlaTyr: 2.578 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.724CysAla: 0.724 ± 0.023	0.042CysCys: 0.042 ± 0.006	0.324CysAsp: 0.324 ± 0.016	0.251CysGlu: 0.251 ± 0.014	0.176CysPhe: 0.176 ± 0.012	0.574CysGly: 0.574 ± 0.025	0.103CysHis: 0.103 ± 0.009	0.19CysIle: 0.19 ± 0.013	0.061CysLys: 0.061 ± 0.008	0.439CysLeu: 0.439 ± 0.019	0.09CysMet: 0.09 ± 0.01	0.111CysAsn: 0.111 ± 0.011	0.299CysPro: 0.299 ± 0.017	0.119CysGln: 0.119 ± 0.011	0.338CysArg: 0.338 ± 0.018	0.333CysSer: 0.333 ± 0.017	0.353CysThr: 0.353 ± 0.019	0.43CysVal: 0.43 ± 0.02	0.072CysTrp: 0.072 ± 0.008	0.103CysTyr: 0.103 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.415AspAla: 9.415 ± 0.105	0.255AspCys: 0.255 ± 0.014	4.274AspAsp: 4.274 ± 0.077	4.104AspGlu: 4.104 ± 0.062	1.712AspPhe: 1.712 ± 0.041	6.176AspGly: 6.176 ± 0.082	1.257AspHis: 1.257 ± 0.038	2.648AspIle: 2.648 ± 0.046	0.973AspLys: 0.973 ± 0.03	6.101AspLeu: 6.101 ± 0.073	0.856AspMet: 0.856 ± 0.031	0.963AspAsn: 0.963 ± 0.03	4.459AspPro: 4.459 ± 0.068	1.58AspGln: 1.58 ± 0.032	4.577AspArg: 4.577 ± 0.078	2.766AspSer: 2.766 ± 0.052	2.935AspThr: 2.935 ± 0.06	5.54AspVal: 5.54 ± 0.075	0.945AspTrp: 0.945 ± 0.026	1.277AspTyr: 1.277 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.491GluAla: 6.491 ± 0.083	0.242GluCys: 0.242 ± 0.014	2.541GluAsp: 2.541 ± 0.045	2.535GluGlu: 2.535 ± 0.058	1.742GluPhe: 1.742 ± 0.037	4.001GluGly: 4.001 ± 0.059	1.388GluHis: 1.388 ± 0.035	2.701GluIle: 2.701 ± 0.047	1.225GluLys: 1.225 ± 0.038	6.141GluLeu: 6.141 ± 0.088	0.872GluMet: 0.872 ± 0.028	1.123GluAsn: 1.123 ± 0.034	2.9GluPro: 2.9 ± 0.05	1.929GluGln: 1.929 ± 0.045	4.955GluArg: 4.955 ± 0.081	2.913GluSer: 2.913 ± 0.051	2.949GluThr: 2.949 ± 0.054	4.313GluVal: 4.313 ± 0.062	0.958GluTrp: 0.958 ± 0.028	1.235GluTyr: 1.235 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.417PheAla: 4.417 ± 0.06	0.175PheCys: 0.175 ± 0.014	2.481PheAsp: 2.481 ± 0.048	1.686PheGlu: 1.686 ± 0.039	1.069PhePhe: 1.069 ± 0.037	3.361PheGly: 3.361 ± 0.059	0.59PheHis: 0.59 ± 0.022	1.247PheIle: 1.247 ± 0.034	0.401PheLys: 0.401 ± 0.02	2.779PheLeu: 2.779 ± 0.052	0.433PheMet: 0.433 ± 0.02	0.663PheAsn: 0.663 ± 0.023	1.4PhePro: 1.4 ± 0.034	0.753PheGln: 0.753 ± 0.027	1.82PheArg: 1.82 ± 0.04	1.732PheSer: 1.732 ± 0.037	2.185PheThr: 2.185 ± 0.048	2.878PheVal: 2.878 ± 0.052	0.487PheTrp: 0.487 ± 0.022	0.693PheTyr: 0.693 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.054GlyAla: 11.054 ± 0.114	0.541GlyCys: 0.541 ± 0.023	5.173GlyAsp: 5.173 ± 0.066	4.74GlyGlu: 4.74 ± 0.064	3.324GlyPhe: 3.324 ± 0.063	7.77GlyGly: 7.77 ± 0.101	1.781GlyHis: 1.781 ± 0.044	4.96GlyIle: 4.96 ± 0.07	1.92GlyLys: 1.92 ± 0.042	8.564GlyLeu: 8.564 ± 0.102	2.019GlyMet: 2.019 ± 0.039	1.74GlyAsn: 1.74 ± 0.047	4.036GlyPro: 4.036 ± 0.048	2.46GlyGln: 2.46 ± 0.051	6.476GlyArg: 6.476 ± 0.074	5.596GlySer: 5.596 ± 0.074	5.686GlyThr: 5.686 ± 0.079	8.087GlyVal: 8.087 ± 0.089	1.745GlyTrp: 1.745 ± 0.04	2.262GlyTyr: 2.262 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.471HisAla: 2.471 ± 0.052	0.126HisCys: 0.126 ± 0.01	1.373HisAsp: 1.373 ± 0.034	1.134HisGlu: 1.134 ± 0.032	0.547HisPhe: 0.547 ± 0.023	2.008HisGly: 2.008 ± 0.038	0.54HisHis: 0.54 ± 0.024	0.817HisIle: 0.817 ± 0.022	0.268HisLys: 0.268 ± 0.016	1.986HisLeu: 1.986 ± 0.036	0.317HisMet: 0.317 ± 0.018	0.361HisAsn: 0.361 ± 0.017	1.584HisPro: 1.584 ± 0.039	0.481HisGln: 0.481 ± 0.024	1.576HisArg: 1.576 ± 0.039	0.989HisSer: 0.989 ± 0.028	1.041HisThr: 1.041 ± 0.024	1.719HisVal: 1.719 ± 0.04	0.28HisTrp: 0.28 ± 0.016	0.449HisTyr: 0.449 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.71IleAla: 7.71 ± 0.089	0.272IleCys: 0.272 ± 0.014	3.735IleAsp: 3.735 ± 0.062	2.815IleGlu: 2.815 ± 0.044	1.213IlePhe: 1.213 ± 0.032	4.808IleGly: 4.808 ± 0.072	0.801IleHis: 0.801 ± 0.024	1.927IleIle: 1.927 ± 0.044	0.762IleLys: 0.762 ± 0.026	3.9IleLeu: 3.9 ± 0.07	0.635IleMet: 0.635 ± 0.025	0.929IleAsn: 0.929 ± 0.025	2.655IlePro: 2.655 ± 0.048	1.085IleGln: 1.085 ± 0.03	2.842IleArg: 2.842 ± 0.048	2.498IleSer: 2.498 ± 0.045	2.993IleThr: 2.993 ± 0.052	4.904IleVal: 4.904 ± 0.079	0.575IleTrp: 0.575 ± 0.022	0.812IleTyr: 0.812 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.26LysAla: 2.26 ± 0.051	0.056LysCys: 0.056 ± 0.006	1.053LysAsp: 1.053 ± 0.034	0.822LysGlu: 0.822 ± 0.027	0.437LysPhe: 0.437 ± 0.02	1.422LysGly: 1.422 ± 0.041	0.413LysHis: 0.413 ± 0.019	0.921LysIle: 0.921 ± 0.028	0.64LysLys: 0.64 ± 0.027	1.674LysLeu: 1.674 ± 0.045	0.338LysMet: 0.338 ± 0.015	0.491LysAsn: 0.491 ± 0.023	1.058LysPro: 1.058 ± 0.029	0.57LysGln: 0.57 ± 0.026	1.372LysArg: 1.372 ± 0.031	1.093LysSer: 1.093 ± 0.031	1.305LysThr: 1.305 ± 0.037	1.557LysVal: 1.557 ± 0.043	0.255LysTrp: 0.255 ± 0.015	0.44LysTyr: 0.44 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.02LeuAla: 14.02 ± 0.132	0.519LeuCys: 0.519 ± 0.017	6.47LeuAsp: 6.47 ± 0.092	4.982LeuGlu: 4.982 ± 0.078	2.827LeuPhe: 2.827 ± 0.062	8.821LeuGly: 8.821 ± 0.114	1.815LeuHis: 1.815 ± 0.042	4.712LeuIle: 4.712 ± 0.082	1.552LeuLys: 1.552 ± 0.037	9.385LeuLeu: 9.385 ± 0.127	1.591LeuMet: 1.591 ± 0.039	1.831LeuAsn: 1.831 ± 0.037	5.324LeuPro: 5.324 ± 0.069	2.472LeuGln: 2.472 ± 0.047	7.407LeuArg: 7.407 ± 0.087	5.948LeuSer: 5.948 ± 0.075	6.412LeuThr: 6.412 ± 0.07	8.7LeuVal: 8.7 ± 0.091	1.312LeuTrp: 1.312 ± 0.04	1.66LeuTyr: 1.66 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.035MetAla: 2.035 ± 0.04	0.097MetCys: 0.097 ± 0.009	0.84MetAsp: 0.84 ± 0.027	0.602MetGlu: 0.602 ± 0.022	0.479MetPhe: 0.479 ± 0.02	1.335MetGly: 1.335 ± 0.032	0.325MetHis: 0.325 ± 0.017	0.906MetIle: 0.906 ± 0.03	0.417MetLys: 0.417 ± 0.019	1.867MetLeu: 1.867 ± 0.039	0.336MetMet: 0.336 ± 0.018	0.494MetAsn: 0.494 ± 0.02	1.211MetPro: 1.211 ± 0.03	0.515MetGln: 0.515 ± 0.018	1.448MetArg: 1.448 ± 0.035	1.547MetSer: 1.547 ± 0.033	1.757MetThr: 1.757 ± 0.033	1.299MetVal: 1.299 ± 0.032	0.224MetTrp: 0.224 ± 0.013	0.3MetTyr: 0.3 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.482AsnAla: 2.482 ± 0.043	0.124AsnCys: 0.124 ± 0.01	1.157AsnAsp: 1.157 ± 0.036	0.868AsnGlu: 0.868 ± 0.032	0.616AsnPhe: 0.616 ± 0.024	1.949AsnGly: 1.949 ± 0.051	0.372AsnHis: 0.372 ± 0.018	0.829AsnIle: 0.829 ± 0.032	0.376AsnLys: 0.376 ± 0.019	1.887AsnLeu: 1.887 ± 0.047	0.331AsnMet: 0.331 ± 0.018	0.463AsnAsn: 0.463 ± 0.02	1.651AsnPro: 1.651 ± 0.039	0.53AsnGln: 0.53 ± 0.021	1.266AsnArg: 1.266 ± 0.036	1.002AsnSer: 1.002 ± 0.031	1.162AsnThr: 1.162 ± 0.039	1.65AsnVal: 1.65 ± 0.042	0.304AsnTrp: 0.304 ± 0.016	0.477AsnTyr: 0.477 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.44ProAla: 7.44 ± 0.089	0.191ProCys: 0.191 ± 0.012	4.136ProAsp: 4.136 ± 0.062	3.589ProGlu: 3.589 ± 0.049	1.787ProPhe: 1.787 ± 0.037	5.243ProGly: 5.243 ± 0.08	1.169ProHis: 1.169 ± 0.035	2.337ProIle: 2.337 ± 0.04	0.929ProLys: 0.929 ± 0.036	4.836ProLeu: 4.836 ± 0.058	0.9ProMet: 0.9 ± 0.026	1.049ProAsn: 1.049 ± 0.031	2.668ProPro: 2.668 ± 0.068	1.509ProGln: 1.509 ± 0.036	3.632ProArg: 3.632 ± 0.053	3.354ProSer: 3.354 ± 0.057	3.58ProThr: 3.58 ± 0.07	4.858ProVal: 4.858 ± 0.065	0.904ProTrp: 0.904 ± 0.028	1.03ProTyr: 1.03 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.353GlnAla: 3.353 ± 0.058	0.111GlnCys: 0.111 ± 0.009	1.306GlnAsp: 1.306 ± 0.035	1.204GlnGlu: 1.204 ± 0.037	0.88GlnPhe: 0.88 ± 0.027	2.089GlnGly: 2.089 ± 0.047	0.629GlnHis: 0.629 ± 0.023	1.462GlnIle: 1.462 ± 0.034	0.621GlnLys: 0.621 ± 0.023	3.096GlnLeu: 3.096 ± 0.058	0.515GlnMet: 0.515 ± 0.024	0.665GlnAsn: 0.665 ± 0.024	1.531GlnPro: 1.531 ± 0.033	1.1GlnGln: 1.1 ± 0.036	2.374GlnArg: 2.374 ± 0.052	1.56GlnSer: 1.56 ± 0.037	1.686GlnThr: 1.686 ± 0.043	2.248GlnVal: 2.248 ± 0.047	0.484GlnTrp: 0.484 ± 0.02	0.641GlnTyr: 0.641 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.235ArgAla: 9.235 ± 0.104	0.321ArgCys: 0.321 ± 0.017	4.345ArgAsp: 4.345 ± 0.071	4.293ArgGlu: 4.293 ± 0.072	2.41ArgPhe: 2.41 ± 0.043	5.601ArgGly: 5.601 ± 0.08	1.61ArgHis: 1.61 ± 0.032	3.757ArgIle: 3.757 ± 0.059	1.278ArgLys: 1.278 ± 0.036	7.112ArgLeu: 7.112 ± 0.092	1.759ArgMet: 1.759 ± 0.034	1.293ArgAsn: 1.293 ± 0.033	3.736ArgPro: 3.736 ± 0.063	2.025ArgGln: 2.025 ± 0.047	6.535ArgArg: 6.535 ± 0.099	4.344ArgSer: 4.344 ± 0.064	4.43ArgThr: 4.43 ± 0.063	6.245ArgVal: 6.245 ± 0.074	1.239ArgTrp: 1.239 ± 0.031	1.586ArgTyr: 1.586 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.576SerAla: 7.576 ± 0.074	0.291SerCys: 0.291 ± 0.016	3.396SerAsp: 3.396 ± 0.052	2.695SerGlu: 2.695 ± 0.049	1.966SerPhe: 1.966 ± 0.039	6.081SerGly: 6.081 ± 0.076	1.07SerHis: 1.07 ± 0.029	2.903SerIle: 2.903 ± 0.047	0.995SerLys: 0.995 ± 0.033	5.485SerLeu: 5.485 ± 0.073	1.178SerMet: 1.178 ± 0.029	1.135SerAsn: 1.135 ± 0.032	3.349SerPro: 3.349 ± 0.052	1.44SerGln: 1.44 ± 0.032	3.967SerArg: 3.967 ± 0.053	3.712SerSer: 3.712 ± 0.064	3.883SerThr: 3.883 ± 0.066	4.897SerVal: 4.897 ± 0.063	1.012SerTrp: 1.012 ± 0.032	1.277SerTyr: 1.277 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	8.047ThrAla: 8.047 ± 0.099	0.301ThrCys: 0.301 ± 0.016	3.846ThrAsp: 3.846 ± 0.06	2.889ThrGlu: 2.889 ± 0.05	1.921ThrPhe: 1.921 ± 0.044	6.018ThrGly: 6.018 ± 0.087	1.217ThrHis: 1.217 ± 0.028	3.127ThrIle: 3.127 ± 0.058	1.144ThrLys: 1.144 ± 0.032	5.959ThrLeu: 5.959 ± 0.075	0.996ThrMet: 0.996 ± 0.028	1.185ThrAsn: 1.185 ± 0.036	4.071ThrPro: 4.071 ± 0.067	1.574ThrGln: 1.574 ± 0.036	3.985ThrArg: 3.985 ± 0.061	3.668ThrSer: 3.668 ± 0.061	4.369ThrThr: 4.369 ± 0.126	5.993ThrVal: 5.993 ± 0.097	0.879ThrTrp: 0.879 ± 0.027	1.331ThrTyr: 1.331 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	11.644ValAla: 11.644 ± 0.107	0.518ValCys: 0.518 ± 0.024	5.64ValAsp: 5.64 ± 0.078	4.643ValGlu: 4.643 ± 0.065	2.876ValPhe: 2.876 ± 0.046	7.187ValGly: 7.187 ± 0.084	1.685ValHis: 1.685 ± 0.043	4.574ValIle: 4.574 ± 0.07	1.501ValLys: 1.501 ± 0.036	8.974ValLeu: 8.974 ± 0.093	1.492ValMet: 1.492 ± 0.038	1.786ValAsn: 1.786 ± 0.039	4.703ValPro: 4.703 ± 0.065	2.338ValGln: 2.338 ± 0.044	6.217ValArg: 6.217 ± 0.079	5.132ValSer: 5.132 ± 0.071	5.912ValThr: 5.912 ± 0.09	8.669ValVal: 8.669 ± 0.094	1.209ValTrp: 1.209 ± 0.033	1.586ValTyr: 1.586 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.698TrpAla: 1.698 ± 0.039	0.099TrpCys: 0.099 ± 0.01	0.87TrpAsp: 0.87 ± 0.025	0.679TrpGlu: 0.679 ± 0.024	0.584TrpPhe: 0.584 ± 0.024	1.211TrpGly: 1.211 ± 0.036	0.34TrpHis: 0.34 ± 0.016	0.81TrpIle: 0.81 ± 0.026	0.284TrpLys: 0.284 ± 0.018	1.686TrpLeu: 1.686 ± 0.038	0.387TrpMet: 0.387 ± 0.017	0.463TrpAsn: 0.463 ± 0.021	0.723TrpPro: 0.723 ± 0.025	0.562TrpGln: 0.562 ± 0.023	1.287TrpArg: 1.287 ± 0.034	1.052TrpSer: 1.052 ± 0.034	0.969TrpThr: 0.969 ± 0.025	1.205TrpVal: 1.205 ± 0.03	0.369TrpTrp: 0.369 ± 0.023	0.312TrpTyr: 0.312 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.526TyrAla: 2.526 ± 0.05	0.143TyrCys: 0.143 ± 0.011	1.436TyrAsp: 1.436 ± 0.046	1.127TyrGlu: 1.127 ± 0.032	0.713TyrPhe: 0.713 ± 0.026	2.012TyrGly: 2.012 ± 0.049	0.326TyrHis: 0.326 ± 0.017	0.787TyrIle: 0.787 ± 0.023	0.325TyrLys: 0.325 ± 0.018	2.069TyrLeu: 2.069 ± 0.046	0.286TyrMet: 0.286 ± 0.016	0.478TyrAsn: 0.478 ± 0.023	1.094TyrPro: 1.094 ± 0.033	0.602TyrGln: 0.602 ± 0.025	1.696TyrArg: 1.696 ± 0.038	1.19TyrSer: 1.19 ± 0.034	1.259TyrThr: 1.259 ± 0.038	1.622TyrVal: 1.622 ± 0.034	0.36TyrTrp: 0.36 ± 0.017	0.477TyrTyr: 0.477 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3790 proteins (1248223 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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