Amino acid dipepetide frequency for Butyrivibrio virus Idris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.606AlaAla: 16.606 ± 2.282
0.522AlaCys: 0.522 ± 0.219
6.789AlaAsp: 6.789 ± 0.786
7.624AlaGlu: 7.624 ± 1.048
2.089AlaPhe: 2.089 ± 0.412
7.311AlaGly: 7.311 ± 0.962
1.044AlaHis: 1.044 ± 0.343
5.744AlaIle: 5.744 ± 1.178
5.953AlaLys: 5.953 ± 0.785
10.026AlaLeu: 10.026 ± 1.459
1.567AlaMet: 1.567 ± 0.366
4.595AlaAsn: 4.595 ± 0.63
2.298AlaPro: 2.298 ± 0.447
4.595AlaGln: 4.595 ± 1.0
3.446AlaArg: 3.446 ± 0.498
3.864AlaSer: 3.864 ± 0.855
5.744AlaThr: 5.744 ± 0.883
5.222AlaVal: 5.222 ± 0.816
0.836AlaTrp: 0.836 ± 0.342
3.238AlaTyr: 3.238 ± 0.578
0.0AlaXaa: 0.0 ± 0.0
Cys
0.418CysAla: 0.418 ± 0.194
0.627CysCys: 0.627 ± 0.295
0.94CysAsp: 0.94 ± 0.371
0.94CysGlu: 0.94 ± 0.308
0.418CysPhe: 0.418 ± 0.189
0.731CysGly: 0.731 ± 0.288
0.209CysHis: 0.209 ± 0.182
0.94CysIle: 0.94 ± 0.358
0.836CysLys: 0.836 ± 0.268
0.522CysLeu: 0.522 ± 0.234
0.209CysMet: 0.209 ± 0.151
0.627CysAsn: 0.627 ± 0.244
0.313CysPro: 0.313 ± 0.187
0.209CysGln: 0.209 ± 0.188
0.627CysArg: 0.627 ± 0.266
0.418CysSer: 0.418 ± 0.229
0.731CysThr: 0.731 ± 0.265
0.627CysVal: 0.627 ± 0.23
0.313CysTrp: 0.313 ± 0.274
0.731CysTyr: 0.731 ± 0.246
0.0CysXaa: 0.0 ± 0.0
Asp
4.491AspAla: 4.491 ± 0.674
0.522AspCys: 0.522 ± 0.246
4.282AspAsp: 4.282 ± 0.609
6.057AspGlu: 6.057 ± 0.794
2.402AspPhe: 2.402 ± 0.381
5.535AspGly: 5.535 ± 0.897
1.253AspHis: 1.253 ± 0.484
4.7AspIle: 4.7 ± 0.808
3.238AspLys: 3.238 ± 0.497
4.386AspLeu: 4.386 ± 0.663
1.671AspMet: 1.671 ± 0.411
3.446AspAsn: 3.446 ± 0.514
0.0AspPro: 0.0 ± 0.0
1.253AspGln: 1.253 ± 0.387
1.775AspArg: 1.775 ± 0.428
2.298AspSer: 2.298 ± 0.417
4.595AspThr: 4.595 ± 0.668
3.76AspVal: 3.76 ± 0.676
0.627AspTrp: 0.627 ± 0.223
3.655AspTyr: 3.655 ± 0.495
0.0AspXaa: 0.0 ± 0.0
Glu
7.206GluAla: 7.206 ± 1.173
0.418GluCys: 0.418 ± 0.202
3.238GluAsp: 3.238 ± 0.693
3.551GluGlu: 3.551 ± 0.679
1.88GluPhe: 1.88 ± 0.44
5.222GluGly: 5.222 ± 0.746
1.149GluHis: 1.149 ± 0.295
4.178GluIle: 4.178 ± 0.746
5.326GluLys: 5.326 ± 1.066
9.399GluLeu: 9.399 ± 0.987
1.462GluMet: 1.462 ± 0.502
3.238GluAsn: 3.238 ± 0.482
2.715GluPro: 2.715 ± 0.614
4.804GluGln: 4.804 ± 0.726
3.551GluArg: 3.551 ± 0.672
4.282GluSer: 4.282 ± 0.644
4.178GluThr: 4.178 ± 0.631
3.655GluVal: 3.655 ± 0.518
0.731GluTrp: 0.731 ± 0.295
4.804GluTyr: 4.804 ± 0.697
0.0GluXaa: 0.0 ± 0.0
Phe
1.88PheAla: 1.88 ± 0.515
0.418PheCys: 0.418 ± 0.195
1.567PheAsp: 1.567 ± 0.417
2.089PheGlu: 2.089 ± 0.434
0.418PhePhe: 0.418 ± 0.216
1.671PheGly: 1.671 ± 0.356
0.104PheHis: 0.104 ± 0.116
2.82PheIle: 2.82 ± 0.643
2.924PheLys: 2.924 ± 0.582
1.253PheLeu: 1.253 ± 0.399
1.462PheMet: 1.462 ± 0.365
1.671PheAsn: 1.671 ± 0.503
0.627PhePro: 0.627 ± 0.291
0.313PheGln: 0.313 ± 0.19
1.984PheArg: 1.984 ± 0.421
2.402PheSer: 2.402 ± 0.38
2.298PheThr: 2.298 ± 0.415
1.671PheVal: 1.671 ± 0.449
0.522PheTrp: 0.522 ± 0.27
1.462PheTyr: 1.462 ± 0.398
0.0PheXaa: 0.0 ± 0.0
Gly
4.7GlyAla: 4.7 ± 0.947
0.94GlyCys: 0.94 ± 0.321
3.551GlyAsp: 3.551 ± 0.502
4.386GlyGlu: 4.386 ± 0.721
2.298GlyPhe: 2.298 ± 0.391
3.029GlyGly: 3.029 ± 0.791
0.418GlyHis: 0.418 ± 0.237
4.595GlyIle: 4.595 ± 0.887
5.744GlyLys: 5.744 ± 0.721
5.013GlyLeu: 5.013 ± 0.841
1.671GlyMet: 1.671 ± 0.334
3.551GlyAsn: 3.551 ± 0.654
0.0GlyPro: 0.0 ± 0.0
2.507GlyGln: 2.507 ± 0.378
2.715GlyArg: 2.715 ± 0.54
3.551GlySer: 3.551 ± 0.691
4.178GlyThr: 4.178 ± 0.947
5.431GlyVal: 5.431 ± 0.879
1.253GlyTrp: 1.253 ± 0.395
4.282GlyTyr: 4.282 ± 0.813
0.0GlyXaa: 0.0 ± 0.0
His
0.522HisAla: 0.522 ± 0.229
0.522HisCys: 0.522 ± 0.199
0.522HisAsp: 0.522 ± 0.248
0.836HisGlu: 0.836 ± 0.268
0.522HisPhe: 0.522 ± 0.222
0.94HisGly: 0.94 ± 0.302
0.836HisHis: 0.836 ± 0.424
1.149HisIle: 1.149 ± 0.333
1.044HisLys: 1.044 ± 0.445
1.253HisLeu: 1.253 ± 0.382
0.209HisMet: 0.209 ± 0.129
0.836HisAsn: 0.836 ± 0.273
0.313HisPro: 0.313 ± 0.172
0.418HisGln: 0.418 ± 0.235
0.522HisArg: 0.522 ± 0.191
0.836HisSer: 0.836 ± 0.327
1.149HisThr: 1.149 ± 0.348
1.149HisVal: 1.149 ± 0.4
0.104HisTrp: 0.104 ± 0.097
0.627HisTyr: 0.627 ± 0.407
0.0HisXaa: 0.0 ± 0.0
Ile
6.475IleAla: 6.475 ± 1.026
1.044IleCys: 1.044 ± 0.38
4.073IleAsp: 4.073 ± 0.649
6.162IleGlu: 6.162 ± 0.637
1.253IlePhe: 1.253 ± 0.328
2.193IleGly: 2.193 ± 0.481
0.627IleHis: 0.627 ± 0.318
3.969IleIle: 3.969 ± 1.084
5.013IleLys: 5.013 ± 0.818
3.342IleLeu: 3.342 ± 0.565
1.671IleMet: 1.671 ± 0.415
4.386IleAsn: 4.386 ± 0.666
3.342IlePro: 3.342 ± 0.618
1.775IleGln: 1.775 ± 0.554
1.88IleArg: 1.88 ± 0.416
3.029IleSer: 3.029 ± 0.504
5.222IleThr: 5.222 ± 0.828
4.804IleVal: 4.804 ± 0.542
1.149IleTrp: 1.149 ± 0.313
2.82IleTyr: 2.82 ± 0.631
0.0IleXaa: 0.0 ± 0.0
Lys
8.564LysAla: 8.564 ± 0.946
0.522LysCys: 0.522 ± 0.239
4.073LysAsp: 4.073 ± 0.499
5.326LysGlu: 5.326 ± 0.889
1.671LysPhe: 1.671 ± 0.43
4.491LysGly: 4.491 ± 0.571
0.731LysHis: 0.731 ± 0.488
3.342LysIle: 3.342 ± 0.484
5.744LysLys: 5.744 ± 0.877
6.162LysLeu: 6.162 ± 0.85
1.88LysMet: 1.88 ± 0.32
3.133LysAsn: 3.133 ± 0.559
2.402LysPro: 2.402 ± 0.66
3.133LysGln: 3.133 ± 0.483
5.117LysArg: 5.117 ± 0.935
3.238LysSer: 3.238 ± 0.635
3.969LysThr: 3.969 ± 0.574
4.909LysVal: 4.909 ± 0.58
1.044LysTrp: 1.044 ± 0.316
3.238LysTyr: 3.238 ± 0.679
0.0LysXaa: 0.0 ± 0.0
Leu
7.624LeuAla: 7.624 ± 0.732
0.627LeuCys: 0.627 ± 0.3
3.969LeuAsp: 3.969 ± 0.656
7.311LeuGlu: 7.311 ± 0.669
2.402LeuPhe: 2.402 ± 0.454
4.491LeuGly: 4.491 ± 0.64
1.358LeuHis: 1.358 ± 0.462
3.969LeuIle: 3.969 ± 0.536
6.893LeuLys: 6.893 ± 0.95
7.415LeuLeu: 7.415 ± 1.073
1.88LeuMet: 1.88 ± 0.447
3.238LeuAsn: 3.238 ± 0.542
3.029LeuPro: 3.029 ± 0.961
5.117LeuGln: 5.117 ± 0.697
3.342LeuArg: 3.342 ± 0.558
3.969LeuSer: 3.969 ± 0.444
6.057LeuThr: 6.057 ± 0.745
6.162LeuVal: 6.162 ± 0.828
0.418LeuTrp: 0.418 ± 0.173
3.029LeuTyr: 3.029 ± 0.521
0.0LeuXaa: 0.0 ± 0.0
Met
2.924MetAla: 2.924 ± 0.483
0.0MetCys: 0.0 ± 0.0
0.731MetAsp: 0.731 ± 0.34
1.358MetGlu: 1.358 ± 0.318
0.418MetPhe: 0.418 ± 0.227
1.149MetGly: 1.149 ± 0.41
0.313MetHis: 0.313 ± 0.163
1.044MetIle: 1.044 ± 0.397
1.567MetLys: 1.567 ± 0.401
3.029MetLeu: 3.029 ± 0.629
0.0MetMet: 0.0 ± 0.0
0.94MetAsn: 0.94 ± 0.282
0.836MetPro: 0.836 ± 0.3
2.507MetGln: 2.507 ± 0.406
1.149MetArg: 1.149 ± 0.357
2.402MetSer: 2.402 ± 0.507
1.462MetThr: 1.462 ± 0.381
0.94MetVal: 0.94 ± 0.278
0.209MetTrp: 0.209 ± 0.155
0.209MetTyr: 0.209 ± 0.147
0.0MetXaa: 0.0 ± 0.0
Asn
4.491AsnAla: 4.491 ± 0.56
0.313AsnCys: 0.313 ± 0.179
2.924AsnAsp: 2.924 ± 0.715
2.924AsnGlu: 2.924 ± 0.599
1.044AsnPhe: 1.044 ± 0.289
5.117AsnGly: 5.117 ± 0.889
0.627AsnHis: 0.627 ± 0.275
3.969AsnIle: 3.969 ± 0.643
2.82AsnLys: 2.82 ± 0.529
2.507AsnLeu: 2.507 ± 0.397
2.611AsnMet: 2.611 ± 0.505
2.82AsnAsn: 2.82 ± 0.781
1.044AsnPro: 1.044 ± 0.362
0.627AsnGln: 0.627 ± 0.263
1.984AsnArg: 1.984 ± 0.412
2.715AsnSer: 2.715 ± 0.573
4.386AsnThr: 4.386 ± 1.01
3.655AsnVal: 3.655 ± 0.594
0.836AsnTrp: 0.836 ± 0.349
2.298AsnTyr: 2.298 ± 0.304
0.0AsnXaa: 0.0 ± 0.0
Pro
2.402ProAla: 2.402 ± 0.485
0.418ProCys: 0.418 ± 0.197
1.253ProAsp: 1.253 ± 0.301
2.82ProGlu: 2.82 ± 0.474
1.044ProPhe: 1.044 ± 0.352
0.0ProGly: 0.0 ± 0.0
0.627ProHis: 0.627 ± 0.218
1.358ProIle: 1.358 ± 0.369
1.567ProLys: 1.567 ± 0.384
2.193ProLeu: 2.193 ± 0.337
0.313ProMet: 0.313 ± 0.246
1.149ProAsn: 1.149 ± 0.412
0.313ProPro: 0.313 ± 0.149
1.88ProGln: 1.88 ± 0.562
0.731ProArg: 0.731 ± 0.28
1.358ProSer: 1.358 ± 0.368
2.507ProThr: 2.507 ± 0.488
2.82ProVal: 2.82 ± 0.609
0.104ProTrp: 0.104 ± 0.107
1.567ProTyr: 1.567 ± 0.351
0.0ProXaa: 0.0 ± 0.0
Gln
4.282GlnAla: 4.282 ± 0.872
0.313GlnCys: 0.313 ± 0.19
1.775GlnAsp: 1.775 ± 0.474
3.133GlnGlu: 3.133 ± 0.493
1.462GlnPhe: 1.462 ± 0.451
2.924GlnGly: 2.924 ± 0.539
0.627GlnHis: 0.627 ± 0.299
3.238GlnIle: 3.238 ± 0.656
2.715GlnLys: 2.715 ± 0.52
4.909GlnLeu: 4.909 ± 0.838
0.313GlnMet: 0.313 ± 0.213
1.88GlnAsn: 1.88 ± 0.467
2.193GlnPro: 2.193 ± 0.592
4.386GlnGln: 4.386 ± 0.8
2.402GlnArg: 2.402 ± 0.502
1.044GlnSer: 1.044 ± 0.309
2.193GlnThr: 2.193 ± 0.361
2.402GlnVal: 2.402 ± 0.559
0.522GlnTrp: 0.522 ± 0.251
2.507GlnTyr: 2.507 ± 0.435
0.0GlnXaa: 0.0 ± 0.0
Arg
3.655ArgAla: 3.655 ± 0.526
0.522ArgCys: 0.522 ± 0.206
2.507ArgAsp: 2.507 ± 0.491
3.655ArgGlu: 3.655 ± 0.699
0.94ArgPhe: 0.94 ± 0.36
1.775ArgGly: 1.775 ± 0.446
1.253ArgHis: 1.253 ± 0.354
2.298ArgIle: 2.298 ± 0.516
3.551ArgLys: 3.551 ± 0.714
3.969ArgLeu: 3.969 ± 0.651
0.627ArgMet: 0.627 ± 0.193
2.193ArgAsn: 2.193 ± 0.445
0.627ArgPro: 0.627 ± 0.272
1.984ArgGln: 1.984 ± 0.476
2.193ArgArg: 2.193 ± 0.562
1.775ArgSer: 1.775 ± 0.448
2.924ArgThr: 2.924 ± 0.565
3.76ArgVal: 3.76 ± 0.906
0.627ArgTrp: 0.627 ± 0.229
2.298ArgTyr: 2.298 ± 0.509
0.0ArgXaa: 0.0 ± 0.0
Ser
5.222SerAla: 5.222 ± 0.661
1.253SerCys: 1.253 ± 0.362
3.342SerAsp: 3.342 ± 0.486
3.238SerGlu: 3.238 ± 0.613
1.567SerPhe: 1.567 ± 0.347
3.655SerGly: 3.655 ± 0.891
0.836SerHis: 0.836 ± 0.295
4.178SerIle: 4.178 ± 0.534
3.446SerLys: 3.446 ± 0.541
2.402SerLeu: 2.402 ± 0.378
1.253SerMet: 1.253 ± 0.339
2.715SerAsn: 2.715 ± 0.662
1.149SerPro: 1.149 ± 0.348
1.775SerGln: 1.775 ± 0.348
1.775SerArg: 1.775 ± 0.332
2.089SerSer: 2.089 ± 0.432
2.402SerThr: 2.402 ± 0.53
3.551SerVal: 3.551 ± 0.519
0.836SerTrp: 0.836 ± 0.262
1.775SerTyr: 1.775 ± 0.403
0.0SerXaa: 0.0 ± 0.0
Thr
7.206ThrAla: 7.206 ± 0.922
0.522ThrCys: 0.522 ± 0.273
4.909ThrAsp: 4.909 ± 0.765
4.491ThrGlu: 4.491 ± 0.546
3.342ThrPhe: 3.342 ± 0.452
4.595ThrGly: 4.595 ± 0.747
0.731ThrHis: 0.731 ± 0.269
3.029ThrIle: 3.029 ± 0.53
4.595ThrLys: 4.595 ± 0.751
6.266ThrLeu: 6.266 ± 0.715
0.836ThrMet: 0.836 ± 0.251
2.402ThrAsn: 2.402 ± 0.579
3.133ThrPro: 3.133 ± 0.511
2.611ThrGln: 2.611 ± 0.448
2.611ThrArg: 2.611 ± 0.368
4.073ThrSer: 4.073 ± 0.757
4.178ThrThr: 4.178 ± 0.619
4.595ThrVal: 4.595 ± 0.606
0.522ThrTrp: 0.522 ± 0.223
2.402ThrTyr: 2.402 ± 0.484
0.0ThrXaa: 0.0 ± 0.0
Val
5.744ValAla: 5.744 ± 0.937
0.627ValCys: 0.627 ± 0.232
4.595ValAsp: 4.595 ± 0.757
4.491ValGlu: 4.491 ± 0.666
2.089ValPhe: 2.089 ± 0.339
4.073ValGly: 4.073 ± 0.54
0.522ValHis: 0.522 ± 0.293
5.222ValIle: 5.222 ± 0.873
5.849ValLys: 5.849 ± 0.714
4.595ValLeu: 4.595 ± 0.69
2.298ValMet: 2.298 ± 0.366
3.969ValAsn: 3.969 ± 0.612
1.253ValPro: 1.253 ± 0.389
2.82ValGln: 2.82 ± 0.811
2.611ValArg: 2.611 ± 0.586
3.342ValSer: 3.342 ± 0.607
4.909ValThr: 4.909 ± 0.775
4.595ValVal: 4.595 ± 0.753
0.209ValTrp: 0.209 ± 0.137
2.924ValTyr: 2.924 ± 0.48
0.0ValXaa: 0.0 ± 0.0
Trp
0.94TrpAla: 0.94 ± 0.327
0.209TrpCys: 0.209 ± 0.137
0.627TrpAsp: 0.627 ± 0.297
0.209TrpGlu: 0.209 ± 0.142
0.522TrpPhe: 0.522 ± 0.294
1.044TrpGly: 1.044 ± 0.411
0.418TrpHis: 0.418 ± 0.231
0.627TrpIle: 0.627 ± 0.211
0.418TrpLys: 0.418 ± 0.189
1.358TrpLeu: 1.358 ± 0.396
0.104TrpMet: 0.104 ± 0.108
0.627TrpAsn: 0.627 ± 0.226
0.0TrpPro: 0.0 ± 0.0
1.462TrpGln: 1.462 ± 0.431
0.836TrpArg: 0.836 ± 0.275
0.522TrpSer: 0.522 ± 0.238
0.209TrpThr: 0.209 ± 0.133
0.418TrpVal: 0.418 ± 0.19
0.104TrpTrp: 0.104 ± 0.116
0.522TrpTyr: 0.522 ± 0.211
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.76TyrAla: 3.76 ± 0.443
1.044TyrCys: 1.044 ± 0.359
4.282TyrAsp: 4.282 ± 0.74
4.386TyrGlu: 4.386 ± 0.635
1.775TyrPhe: 1.775 ± 0.46
3.864TyrGly: 3.864 ± 0.77
0.627TyrHis: 0.627 ± 0.25
3.864TyrIle: 3.864 ± 0.599
3.446TyrLys: 3.446 ± 0.552
2.298TyrLeu: 2.298 ± 0.512
1.044TyrMet: 1.044 ± 0.42
2.298TyrAsn: 2.298 ± 0.54
0.836TyrPro: 0.836 ± 0.302
1.044TyrGln: 1.044 ± 0.341
1.88TyrArg: 1.88 ± 0.444
1.253TyrSer: 1.253 ± 0.336
3.76TyrThr: 3.76 ± 0.831
2.715TyrVal: 2.715 ± 0.456
0.209TyrTrp: 0.209 ± 0.132
2.193TyrTyr: 2.193 ± 0.531
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (9576 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski