Amino acid dipepetide frequency for Arthrobacter globiformis NBRC 12137

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.66AlaAla: 21.66 ± 0.202	0.793AlaCys: 0.793 ± 0.023	7.302AlaAsp: 7.302 ± 0.068	8.103AlaGlu: 8.103 ± 0.094	3.668AlaPhe: 3.668 ± 0.054	14.016AlaGly: 14.016 ± 0.101	2.235AlaHis: 2.235 ± 0.041	4.972AlaIle: 4.972 ± 0.061	3.706AlaLys: 3.706 ± 0.054	12.898AlaLeu: 12.898 ± 0.126	2.745AlaMet: 2.745 ± 0.045	2.759AlaAsn: 2.759 ± 0.043	6.252AlaPro: 6.252 ± 0.078	3.711AlaGln: 3.711 ± 0.054	7.779AlaArg: 7.779 ± 0.079	7.256AlaSer: 7.256 ± 0.079	6.807AlaThr: 6.807 ± 0.086	11.656AlaVal: 11.656 ± 0.097	1.68AlaTrp: 1.68 ± 0.039	2.331AlaTyr: 2.331 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.731CysAla: 0.731 ± 0.023	0.063CysCys: 0.063 ± 0.007	0.349CysAsp: 0.349 ± 0.017	0.3CysGlu: 0.3 ± 0.014	0.212CysPhe: 0.212 ± 0.012	0.723CysGly: 0.723 ± 0.023	0.161CysHis: 0.161 ± 0.01	0.249CysIle: 0.249 ± 0.014	0.101CysLys: 0.101 ± 0.008	0.593CysLeu: 0.593 ± 0.023	0.118CysMet: 0.118 ± 0.01	0.143CysAsn: 0.143 ± 0.011	0.359CysPro: 0.359 ± 0.017	0.161CysGln: 0.161 ± 0.011	0.411CysArg: 0.411 ± 0.018	0.428CysSer: 0.428 ± 0.018	0.408CysThr: 0.408 ± 0.015	0.443CysVal: 0.443 ± 0.021	0.119CysTrp: 0.119 ± 0.01	0.142CysTyr: 0.142 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.161AspAla: 7.161 ± 0.079	0.292AspCys: 0.292 ± 0.015	3.016AspAsp: 3.016 ± 0.058	3.248AspGlu: 3.248 ± 0.056	1.928AspPhe: 1.928 ± 0.037	5.88AspGly: 5.88 ± 0.074	1.195AspHis: 1.195 ± 0.031	2.42AspIle: 2.42 ± 0.043	1.325AspLys: 1.325 ± 0.027	5.459AspLeu: 5.459 ± 0.061	0.932AspMet: 0.932 ± 0.024	1.118AspAsn: 1.118 ± 0.028	3.721AspPro: 3.721 ± 0.05	1.605AspGln: 1.605 ± 0.034	3.567AspArg: 3.567 ± 0.055	2.777AspSer: 2.777 ± 0.041	2.744AspThr: 2.744 ± 0.05	4.904AspVal: 4.904 ± 0.059	0.892AspTrp: 0.892 ± 0.025	1.284AspTyr: 1.284 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.266GluAla: 7.266 ± 0.081	0.31GluCys: 0.31 ± 0.015	2.993GluAsp: 2.993 ± 0.058	3.272GluGlu: 3.272 ± 0.054	1.747GluPhe: 1.747 ± 0.035	3.979GluGly: 3.979 ± 0.062	1.445GluHis: 1.445 ± 0.032	2.478GluIle: 2.478 ± 0.047	1.709GluLys: 1.709 ± 0.039	6.694GluLeu: 6.694 ± 0.081	0.961GluMet: 0.961 ± 0.028	1.418GluAsn: 1.418 ± 0.027	2.991GluPro: 2.991 ± 0.052	2.264GluGln: 2.264 ± 0.042	4.031GluArg: 4.031 ± 0.052	2.968GluSer: 2.968 ± 0.041	3.014GluThr: 3.014 ± 0.047	4.011GluVal: 4.011 ± 0.064	0.805GluTrp: 0.805 ± 0.025	1.146GluTyr: 1.146 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.039PheAla: 4.039 ± 0.061	0.254PheCys: 0.254 ± 0.014	2.06PheAsp: 2.06 ± 0.036	1.686PheGlu: 1.686 ± 0.041	1.195PhePhe: 1.195 ± 0.031	3.515PheGly: 3.515 ± 0.051	0.637PheHis: 0.637 ± 0.02	1.393PheIle: 1.393 ± 0.032	0.764PheLys: 0.764 ± 0.022	3.029PheLeu: 3.029 ± 0.047	0.58PheMet: 0.58 ± 0.021	0.909PheAsn: 0.909 ± 0.024	1.604PhePro: 1.604 ± 0.035	0.869PheGln: 0.869 ± 0.025	1.946PheArg: 1.946 ± 0.042	2.075PheSer: 2.075 ± 0.039	2.121PheThr: 2.121 ± 0.045	2.474PheVal: 2.474 ± 0.045	0.483PheTrp: 0.483 ± 0.018	0.734PheTyr: 0.734 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.477GlyAla: 10.477 ± 0.097	0.657GlyCys: 0.657 ± 0.023	4.397GlyAsp: 4.397 ± 0.063	4.532GlyGlu: 4.532 ± 0.067	3.377GlyPhe: 3.377 ± 0.051	8.049GlyGly: 8.049 ± 0.101	2.079GlyHis: 2.079 ± 0.038	4.766GlyIle: 4.766 ± 0.054	3.091GlyLys: 3.091 ± 0.046	9.43GlyLeu: 9.43 ± 0.076	2.046GlyMet: 2.046 ± 0.037	2.443GlyAsn: 2.443 ± 0.044	4.492GlyPro: 4.492 ± 0.048	3.215GlyGln: 3.215 ± 0.049	6.185GlyArg: 6.185 ± 0.064	6.042GlySer: 6.042 ± 0.073	6.501GlyThr: 6.501 ± 0.064	7.274GlyVal: 7.274 ± 0.076	1.645GlyTrp: 1.645 ± 0.038	2.391GlyTyr: 2.391 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.331HisAla: 2.331 ± 0.043	0.172HisCys: 0.172 ± 0.01	1.163HisAsp: 1.163 ± 0.027	1.159HisGlu: 1.159 ± 0.029	0.708HisPhe: 0.708 ± 0.019	2.008HisGly: 2.008 ± 0.04	0.65HisHis: 0.65 ± 0.025	0.832HisIle: 0.832 ± 0.023	0.437HisLys: 0.437 ± 0.017	2.058HisLeu: 2.058 ± 0.038	0.381HisMet: 0.381 ± 0.016	0.499HisAsn: 0.499 ± 0.016	1.472HisPro: 1.472 ± 0.034	0.635HisGln: 0.635 ± 0.02	1.571HisArg: 1.571 ± 0.034	1.206HisSer: 1.206 ± 0.028	1.071HisThr: 1.071 ± 0.031	1.569HisVal: 1.569 ± 0.032	0.32HisTrp: 0.32 ± 0.014	0.468HisTyr: 0.468 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.81IleAla: 5.81 ± 0.075	0.336IleCys: 0.336 ± 0.015	2.6IleAsp: 2.6 ± 0.048	2.405IleGlu: 2.405 ± 0.043	1.385IlePhe: 1.385 ± 0.035	4.236IleGly: 4.236 ± 0.062	0.864IleHis: 0.864 ± 0.025	1.9IleIle: 1.9 ± 0.042	1.118IleLys: 1.118 ± 0.03	3.877IleLeu: 3.877 ± 0.056	0.741IleMet: 0.741 ± 0.023	1.27IleAsn: 1.27 ± 0.032	2.312IlePro: 2.312 ± 0.041	1.172IleGln: 1.172 ± 0.032	2.761IleArg: 2.761 ± 0.044	2.692IleSer: 2.692 ± 0.046	2.727IleThr: 2.727 ± 0.045	3.471IleVal: 3.471 ± 0.052	0.499IleTrp: 0.499 ± 0.02	0.831IleTyr: 0.831 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.703LysAla: 3.703 ± 0.057	0.107LysCys: 0.107 ± 0.008	1.739LysAsp: 1.739 ± 0.041	1.488LysGlu: 1.488 ± 0.037	0.794LysPhe: 0.794 ± 0.027	2.027LysGly: 2.027 ± 0.047	0.579LysHis: 0.579 ± 0.018	1.275LysIle: 1.275 ± 0.03	0.99LysLys: 0.99 ± 0.033	2.679LysLeu: 2.679 ± 0.048	0.614LysMet: 0.614 ± 0.02	0.772LysAsn: 0.772 ± 0.021	1.686LysPro: 1.686 ± 0.039	0.862LysGln: 0.862 ± 0.028	1.656LysArg: 1.656 ± 0.035	1.639LysSer: 1.639 ± 0.037	1.633LysThr: 1.633 ± 0.03	2.346LysVal: 2.346 ± 0.048	0.311LysTrp: 0.311 ± 0.015	0.644LysTyr: 0.644 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.507LeuAla: 14.507 ± 0.143	0.657LeuCys: 0.657 ± 0.02	6.011LeuAsp: 6.011 ± 0.071	5.458LeuGlu: 5.458 ± 0.066	2.998LeuPhe: 2.998 ± 0.049	9.319LeuGly: 9.319 ± 0.083	2.016LeuHis: 2.016 ± 0.042	4.308LeuIle: 4.308 ± 0.067	2.759LeuLys: 2.759 ± 0.048	10.57LeuLeu: 10.57 ± 0.143	1.889LeuMet: 1.889 ± 0.035	2.538LeuAsn: 2.538 ± 0.045	5.879LeuPro: 5.879 ± 0.065	2.983LeuGln: 2.983 ± 0.048	6.76LeuArg: 6.76 ± 0.08	5.961LeuSer: 5.961 ± 0.065	5.989LeuThr: 5.989 ± 0.071	8.351LeuVal: 8.351 ± 0.082	1.23LeuTrp: 1.23 ± 0.03	1.702LeuTyr: 1.702 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.58MetAla: 2.58 ± 0.048	0.118MetCys: 0.118 ± 0.01	0.979MetAsp: 0.979 ± 0.025	0.883MetGlu: 0.883 ± 0.023	0.614MetPhe: 0.614 ± 0.022	1.619MetGly: 1.619 ± 0.034	0.358MetHis: 0.358 ± 0.017	0.855MetIle: 0.855 ± 0.027	0.613MetLys: 0.613 ± 0.023	1.927MetLeu: 1.927 ± 0.04	0.39MetMet: 0.39 ± 0.018	0.58MetAsn: 0.58 ± 0.023	1.122MetPro: 1.122 ± 0.027	0.559MetGln: 0.559 ± 0.015	1.135MetArg: 1.135 ± 0.028	1.489MetSer: 1.489 ± 0.033	1.656MetThr: 1.656 ± 0.028	1.553MetVal: 1.553 ± 0.032	0.219MetTrp: 0.219 ± 0.015	0.329MetTyr: 0.329 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.922AsnAla: 2.922 ± 0.052	0.163AsnCys: 0.163 ± 0.011	1.263AsnAsp: 1.263 ± 0.034	1.167AsnGlu: 1.167 ± 0.029	0.819AsnPhe: 0.819 ± 0.024	2.542AsnGly: 2.542 ± 0.052	0.506AsnHis: 0.506 ± 0.021	1.118AsnIle: 1.118 ± 0.029	0.62AsnLys: 0.62 ± 0.023	2.305AsnLeu: 2.305 ± 0.044	0.499AsnMet: 0.499 ± 0.018	0.695AsnAsn: 0.695 ± 0.023	1.895AsnPro: 1.895 ± 0.036	0.793AsnGln: 0.793 ± 0.022	1.565AsnArg: 1.565 ± 0.034	1.449AsnSer: 1.449 ± 0.033	1.439AsnThr: 1.439 ± 0.033	1.952AsnVal: 1.952 ± 0.032	0.386AsnTrp: 0.386 ± 0.016	0.608AsnTyr: 0.608 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.379ProAla: 8.379 ± 0.102	0.242ProCys: 0.242 ± 0.013	3.753ProAsp: 3.753 ± 0.047	4.111ProGlu: 4.111 ± 0.066	1.687ProPhe: 1.687 ± 0.035	5.877ProGly: 5.877 ± 0.071	1.101ProHis: 1.101 ± 0.028	1.62ProIle: 1.62 ± 0.038	1.411ProLys: 1.411 ± 0.029	5.092ProLeu: 5.092 ± 0.072	1.007ProMet: 1.007 ± 0.026	1.203ProAsn: 1.203 ± 0.03	2.288ProPro: 2.288 ± 0.051	1.714ProGln: 1.714 ± 0.036	2.949ProArg: 2.949 ± 0.048	3.228ProSer: 3.228 ± 0.042	2.788ProThr: 2.788 ± 0.05	5.084ProVal: 5.084 ± 0.065	0.828ProTrp: 0.828 ± 0.025	1.062ProTyr: 1.062 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.898GlnAla: 3.898 ± 0.055	0.148GlnCys: 0.148 ± 0.011	1.656GlnAsp: 1.656 ± 0.038	1.633GlnGlu: 1.633 ± 0.036	0.914GlnPhe: 0.914 ± 0.022	2.436GlnGly: 2.436 ± 0.04	0.757GlnHis: 0.757 ± 0.026	1.397GlnIle: 1.397 ± 0.036	0.905GlnLys: 0.905 ± 0.026	3.7GlnLeu: 3.7 ± 0.053	0.603GlnMet: 0.603 ± 0.019	0.768GlnAsn: 0.768 ± 0.025	1.915GlnPro: 1.915 ± 0.039	1.359GlnGln: 1.359 ± 0.032	2.301GlnArg: 2.301 ± 0.048	1.596GlnSer: 1.596 ± 0.037	1.573GlnThr: 1.573 ± 0.034	2.342GlnVal: 2.342 ± 0.041	0.521GlnTrp: 0.521 ± 0.021	0.698GlnTyr: 0.698 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.956ArgAla: 6.956 ± 0.073	0.379ArgCys: 0.379 ± 0.016	3.405ArgAsp: 3.405 ± 0.049	3.813ArgGlu: 3.813 ± 0.059	2.204ArgPhe: 2.204 ± 0.042	4.764ArgGly: 4.764 ± 0.059	1.561ArgHis: 1.561 ± 0.034	3.297ArgIle: 3.297 ± 0.047	1.974ArgLys: 1.974 ± 0.044	6.908ArgLeu: 6.908 ± 0.085	1.455ArgMet: 1.455 ± 0.029	1.812ArgAsn: 1.812 ± 0.036	3.548ArgPro: 3.548 ± 0.061	2.381ArgGln: 2.381 ± 0.042	5.547ArgArg: 5.547 ± 0.084	3.899ArgSer: 3.899 ± 0.054	4.006ArgThr: 4.006 ± 0.051	4.612ArgVal: 4.612 ± 0.065	1.045ArgTrp: 1.045 ± 0.031	1.519ArgTyr: 1.519 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.493SerAla: 7.493 ± 0.08	0.373SerCys: 0.373 ± 0.018	2.884SerAsp: 2.884 ± 0.043	2.885SerGlu: 2.885 ± 0.045	2.094SerPhe: 2.094 ± 0.034	6.339SerGly: 6.339 ± 0.069	1.124SerHis: 1.124 ± 0.029	2.401SerIle: 2.401 ± 0.038	1.532SerLys: 1.532 ± 0.032	5.884SerLeu: 5.884 ± 0.054	1.326SerMet: 1.326 ± 0.03	1.387SerAsn: 1.387 ± 0.032	3.371SerPro: 3.371 ± 0.05	1.724SerGln: 1.724 ± 0.036	3.843SerArg: 3.843 ± 0.059	3.706SerSer: 3.706 ± 0.051	3.559SerThr: 3.559 ± 0.042	4.893SerVal: 4.893 ± 0.061	0.904SerTrp: 0.904 ± 0.026	1.37SerTyr: 1.37 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.325ThrAla: 8.325 ± 0.08	0.315ThrCys: 0.315 ± 0.016	3.152ThrAsp: 3.152 ± 0.048	3.068ThrGlu: 3.068 ± 0.047	1.885ThrPhe: 1.885 ± 0.039	6.149ThrGly: 6.149 ± 0.074	1.098ThrHis: 1.098 ± 0.028	2.412ThrIle: 2.412 ± 0.044	1.491ThrLys: 1.491 ± 0.032	5.582ThrLeu: 5.582 ± 0.067	1.027ThrMet: 1.027 ± 0.028	1.313ThrAsn: 1.313 ± 0.033	3.76ThrPro: 3.76 ± 0.05	1.498ThrGln: 1.498 ± 0.037	3.162ThrArg: 3.162 ± 0.049	3.512ThrSer: 3.512 ± 0.049	3.491ThrThr: 3.491 ± 0.055	5.712ThrVal: 5.712 ± 0.061	0.702ThrTrp: 0.702 ± 0.022	1.232ThrTyr: 1.232 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.269ValAla: 10.269 ± 0.099	0.556ValCys: 0.556 ± 0.019	4.758ValAsp: 4.758 ± 0.063	4.545ValGlu: 4.545 ± 0.062	2.763ValPhe: 2.763 ± 0.048	6.523ValGly: 6.523 ± 0.072	1.657ValHis: 1.657 ± 0.036	3.864ValIle: 3.864 ± 0.061	2.063ValLys: 2.063 ± 0.038	9.222ValLeu: 9.222 ± 0.096	1.587ValMet: 1.587 ± 0.035	2.035ValAsn: 2.035 ± 0.038	4.921ValPro: 4.921 ± 0.061	2.412ValGln: 2.412 ± 0.038	5.333ValArg: 5.333 ± 0.061	5.016ValSer: 5.016 ± 0.053	5.251ValThr: 5.251 ± 0.063	7.68ValVal: 7.68 ± 0.092	1.002ValTrp: 1.002 ± 0.03	1.5ValTyr: 1.5 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.484TrpAla: 1.484 ± 0.032	0.116TrpCys: 0.116 ± 0.009	0.738TrpAsp: 0.738 ± 0.026	0.654TrpGlu: 0.654 ± 0.024	0.541TrpPhe: 0.541 ± 0.021	1.033TrpGly: 1.033 ± 0.03	0.361TrpHis: 0.361 ± 0.017	0.674TrpIle: 0.674 ± 0.021	0.42TrpLys: 0.42 ± 0.018	1.782TrpLeu: 1.782 ± 0.04	0.335TrpMet: 0.335 ± 0.014	0.494TrpAsn: 0.494 ± 0.02	0.691TrpPro: 0.691 ± 0.024	0.569TrpGln: 0.569 ± 0.019	0.991TrpArg: 0.991 ± 0.03	0.831TrpSer: 0.831 ± 0.026	0.902TrpThr: 0.902 ± 0.026	1.009TrpVal: 1.009 ± 0.029	0.279TrpTrp: 0.279 ± 0.015	0.302TrpTyr: 0.302 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.337TyrAla: 2.337 ± 0.047	0.161TyrCys: 0.161 ± 0.009	1.248TyrAsp: 1.248 ± 0.029	1.094TyrGlu: 1.094 ± 0.029	0.835TyrPhe: 0.835 ± 0.025	2.057TyrGly: 2.057 ± 0.038	0.327TyrHis: 0.327 ± 0.015	0.775TyrIle: 0.775 ± 0.024	0.515TyrLys: 0.515 ± 0.02	2.198TyrLeu: 2.198 ± 0.039	0.339TyrMet: 0.339 ± 0.015	0.552TyrAsn: 0.552 ± 0.021	1.143TyrPro: 1.143 ± 0.031	0.633TyrGln: 0.633 ± 0.023	1.594TyrArg: 1.594 ± 0.037	1.323TyrSer: 1.323 ± 0.031	1.204TyrThr: 1.204 ± 0.029	1.62TyrVal: 1.62 ± 0.032	0.336TyrTrp: 0.336 ± 0.017	0.531TyrTyr: 0.531 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4524 proteins (1468277 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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