Amino acid dipepetide frequency for Tepidimicrobium xylanilyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.797AlaAla: 3.797 ± 0.095
0.564AlaCys: 0.564 ± 0.028
2.524AlaAsp: 2.524 ± 0.062
3.724AlaGlu: 3.724 ± 0.076
2.475AlaPhe: 2.475 ± 0.059
3.952AlaGly: 3.952 ± 0.096
0.815AlaHis: 0.815 ± 0.033
6.139AlaIle: 6.139 ± 0.103
4.401AlaLys: 4.401 ± 0.071
5.981AlaLeu: 5.981 ± 0.092
1.659AlaMet: 1.659 ± 0.05
2.745AlaAsn: 2.745 ± 0.055
1.456AlaPro: 1.456 ± 0.04
1.407AlaGln: 1.407 ± 0.045
2.2AlaArg: 2.2 ± 0.054
2.942AlaSer: 2.942 ± 0.073
2.689AlaThr: 2.689 ± 0.062
3.763AlaVal: 3.763 ± 0.079
0.376AlaTrp: 0.376 ± 0.023
2.189AlaTyr: 2.189 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.451CysAla: 0.451 ± 0.025
0.101CysCys: 0.101 ± 0.011
0.465CysAsp: 0.465 ± 0.025
0.519CysGlu: 0.519 ± 0.028
0.347CysPhe: 0.347 ± 0.021
0.891CysGly: 0.891 ± 0.032
0.227CysHis: 0.227 ± 0.016
0.842CysIle: 0.842 ± 0.035
0.659CysLys: 0.659 ± 0.029
0.689CysLeu: 0.689 ± 0.027
0.23CysMet: 0.23 ± 0.014
0.553CysAsn: 0.553 ± 0.03
0.463CysPro: 0.463 ± 0.023
0.228CysGln: 0.228 ± 0.015
0.349CysArg: 0.349 ± 0.021
0.563CysSer: 0.563 ± 0.024
0.437CysThr: 0.437 ± 0.024
0.473CysVal: 0.473 ± 0.023
0.065CysTrp: 0.065 ± 0.007
0.322CysTyr: 0.322 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
2.492AspAla: 2.492 ± 0.057
0.449AspCys: 0.449 ± 0.023
2.637AspAsp: 2.637 ± 0.065
5.119AspGlu: 5.119 ± 0.079
2.624AspPhe: 2.624 ± 0.052
3.752AspGly: 3.752 ± 0.075
0.67AspHis: 0.67 ± 0.029
6.369AspIle: 6.369 ± 0.085
4.882AspLys: 4.882 ± 0.079
5.323AspLeu: 5.323 ± 0.078
1.582AspMet: 1.582 ± 0.045
2.877AspAsn: 2.877 ± 0.063
1.712AspPro: 1.712 ± 0.046
1.008AspGln: 1.008 ± 0.038
2.515AspArg: 2.515 ± 0.058
2.837AspSer: 2.837 ± 0.054
2.28AspThr: 2.28 ± 0.056
3.468AspVal: 3.468 ± 0.061
0.432AspTrp: 0.432 ± 0.023
2.871AspTyr: 2.871 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
4.341GluAla: 4.341 ± 0.086
0.471GluCys: 0.471 ± 0.023
4.898GluAsp: 4.898 ± 0.078
8.585GluGlu: 8.585 ± 0.133
2.934GluPhe: 2.934 ± 0.055
5.188GluGly: 5.188 ± 0.086
0.937GluHis: 0.937 ± 0.031
8.038GluIle: 8.038 ± 0.11
7.637GluLys: 7.637 ± 0.112
7.404GluLeu: 7.404 ± 0.086
2.147GluMet: 2.147 ± 0.042
4.672GluAsn: 4.672 ± 0.079
1.889GluPro: 1.889 ± 0.054
1.66GluGln: 1.66 ± 0.045
3.632GluArg: 3.632 ± 0.071
3.32GluSer: 3.32 ± 0.071
3.089GluThr: 3.089 ± 0.058
5.079GluVal: 5.079 ± 0.086
0.505GluTrp: 0.505 ± 0.027
3.345GluTyr: 3.345 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
2.269PheAla: 2.269 ± 0.06
0.409PheCys: 0.409 ± 0.023
2.34PheAsp: 2.34 ± 0.054
2.722PheGlu: 2.722 ± 0.062
1.983PhePhe: 1.983 ± 0.054
2.959PheGly: 2.959 ± 0.051
0.618PheHis: 0.618 ± 0.027
4.476PheIle: 4.476 ± 0.087
3.326PheLys: 3.326 ± 0.067
3.838PheLeu: 3.838 ± 0.084
1.069PheMet: 1.069 ± 0.036
2.682PheAsn: 2.682 ± 0.061
1.401PhePro: 1.401 ± 0.041
1.023PheGln: 1.023 ± 0.032
1.516PheArg: 1.516 ± 0.041
2.822PheSer: 2.822 ± 0.064
2.314PheThr: 2.314 ± 0.051
2.545PheVal: 2.545 ± 0.058
0.302PheTrp: 0.302 ± 0.016
1.798PheTyr: 1.798 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
3.974GlyAla: 3.974 ± 0.079
0.777GlyCys: 0.777 ± 0.032
3.451GlyAsp: 3.451 ± 0.07
4.876GlyGlu: 4.876 ± 0.081
3.274GlyPhe: 3.274 ± 0.072
4.671GlyGly: 4.671 ± 0.102
1.146GlyHis: 1.146 ± 0.04
7.675GlyIle: 7.675 ± 0.106
5.77GlyLys: 5.77 ± 0.081
6.45GlyLeu: 6.45 ± 0.114
1.925GlyMet: 1.925 ± 0.049
3.343GlyAsn: 3.343 ± 0.085
1.583GlyPro: 1.583 ± 0.041
1.745GlyGln: 1.745 ± 0.052
2.813GlyArg: 2.813 ± 0.057
3.57GlySer: 3.57 ± 0.065
3.481GlyThr: 3.481 ± 0.065
4.781GlyVal: 4.781 ± 0.075
0.534GlyTrp: 0.534 ± 0.027
3.195GlyTyr: 3.195 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
0.755HisAla: 0.755 ± 0.031
0.159HisCys: 0.159 ± 0.014
0.659HisAsp: 0.659 ± 0.028
0.922HisGlu: 0.922 ± 0.036
0.629HisPhe: 0.629 ± 0.028
1.079HisGly: 1.079 ± 0.037
0.296HisHis: 0.296 ± 0.02
1.625HisIle: 1.625 ± 0.039
0.942HisLys: 0.942 ± 0.033
1.324HisLeu: 1.324 ± 0.038
0.356HisMet: 0.356 ± 0.018
0.78HisAsn: 0.78 ± 0.03
0.681HisPro: 0.681 ± 0.031
0.347HisGln: 0.347 ± 0.018
0.652HisArg: 0.652 ± 0.026
0.789HisSer: 0.789 ± 0.028
0.711HisThr: 0.711 ± 0.027
0.847HisVal: 0.847 ± 0.032
0.146HisTrp: 0.146 ± 0.014
0.622HisTyr: 0.622 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.063IleAla: 6.063 ± 0.094
0.906IleCys: 0.906 ± 0.034
6.431IleAsp: 6.431 ± 0.089
8.055IleGlu: 8.055 ± 0.12
4.214IlePhe: 4.214 ± 0.083
7.04IleGly: 7.04 ± 0.094
1.45IleHis: 1.45 ± 0.042
10.207IleIle: 10.207 ± 0.137
8.298IleLys: 8.298 ± 0.116
9.968IleLeu: 9.968 ± 0.132
2.477IleMet: 2.477 ± 0.055
5.641IleAsn: 5.641 ± 0.091
3.82IlePro: 3.82 ± 0.069
2.183IleGln: 2.183 ± 0.049
4.068IleArg: 4.068 ± 0.065
6.495IleSer: 6.495 ± 0.095
5.008IleThr: 5.008 ± 0.079
6.571IleVal: 6.571 ± 0.079
0.632IleTrp: 0.632 ± 0.026
3.714IleTyr: 3.714 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
4.781LysAla: 4.781 ± 0.082
0.579LysCys: 0.579 ± 0.032
5.685LysAsp: 5.685 ± 0.081
8.727LysGlu: 8.727 ± 0.141
2.633LysPhe: 2.633 ± 0.059
5.716LysGly: 5.716 ± 0.089
1.046LysHis: 1.046 ± 0.029
7.559LysIle: 7.559 ± 0.109
6.797LysLys: 6.797 ± 0.102
7.047LysLeu: 7.047 ± 0.092
2.12LysMet: 2.12 ± 0.049
4.772LysAsn: 4.772 ± 0.086
2.262LysPro: 2.262 ± 0.052
1.699LysGln: 1.699 ± 0.045
3.635LysArg: 3.635 ± 0.068
4.071LysSer: 4.071 ± 0.075
3.607LysThr: 3.607 ± 0.059
5.631LysVal: 5.631 ± 0.086
0.574LysTrp: 0.574 ± 0.025
3.691LysTyr: 3.691 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
5.652LeuAla: 5.652 ± 0.092
0.82LeuCys: 0.82 ± 0.036
5.756LeuAsp: 5.756 ± 0.084
7.412LeuGlu: 7.412 ± 0.093
3.926LeuPhe: 3.926 ± 0.087
6.752LeuGly: 6.752 ± 0.104
1.132LeuHis: 1.132 ± 0.035
9.019LeuIle: 9.019 ± 0.129
8.274LeuLys: 8.274 ± 0.115
8.911LeuLeu: 8.911 ± 0.123
2.501LeuMet: 2.501 ± 0.053
5.517LeuAsn: 5.517 ± 0.088
3.209LeuPro: 3.209 ± 0.064
2.046LeuGln: 2.046 ± 0.049
3.509LeuArg: 3.509 ± 0.067
6.38LeuSer: 6.38 ± 0.089
4.598LeuThr: 4.598 ± 0.08
5.784LeuVal: 5.784 ± 0.092
0.573LeuTrp: 0.573 ± 0.026
3.229LeuTyr: 3.229 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
1.939MetAla: 1.939 ± 0.049
0.182MetCys: 0.182 ± 0.015
1.885MetAsp: 1.885 ± 0.047
2.456MetGlu: 2.456 ± 0.053
0.897MetPhe: 0.897 ± 0.031
1.906MetGly: 1.906 ± 0.045
0.283MetHis: 0.283 ± 0.019
2.185MetIle: 2.185 ± 0.047
2.346MetLys: 2.346 ± 0.054
2.272MetLeu: 2.272 ± 0.058
0.667MetMet: 0.667 ± 0.025
1.375MetAsn: 1.375 ± 0.039
0.884MetPro: 0.884 ± 0.033
0.534MetGln: 0.534 ± 0.026
1.039MetArg: 1.039 ± 0.035
1.381MetSer: 1.381 ± 0.043
1.274MetThr: 1.274 ± 0.041
2.016MetVal: 2.016 ± 0.045
0.126MetTrp: 0.126 ± 0.011
0.816MetTyr: 0.816 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.425AsnAla: 2.425 ± 0.055
0.542AsnCys: 0.542 ± 0.026
2.189AsnAsp: 2.189 ± 0.05
3.602AsnGlu: 3.602 ± 0.068
2.207AsnPhe: 2.207 ± 0.05
3.315AsnGly: 3.315 ± 0.065
0.799AsnHis: 0.799 ± 0.029
6.838AsnIle: 6.838 ± 0.099
4.681AsnLys: 4.681 ± 0.097
5.294AsnLeu: 5.294 ± 0.08
1.753AsnMet: 1.753 ± 0.046
3.103AsnAsn: 3.103 ± 0.066
2.298AsnPro: 2.298 ± 0.054
1.374AsnGln: 1.374 ± 0.043
2.822AsnArg: 2.822 ± 0.048
3.085AsnSer: 3.085 ± 0.067
2.521AsnThr: 2.521 ± 0.054
3.295AsnVal: 3.295 ± 0.065
0.425AsnTrp: 0.425 ± 0.023
2.346AsnTyr: 2.346 ± 0.056
0.001AsnXaa: 0.001 ± 0.001
Pro
1.546ProAla: 1.546 ± 0.044
0.305ProCys: 0.305 ± 0.02
1.717ProAsp: 1.717 ± 0.059
2.561ProGlu: 2.561 ± 0.052
1.532ProPhe: 1.532 ± 0.037
1.969ProGly: 1.969 ± 0.05
0.616ProHis: 0.616 ± 0.029
3.297ProIle: 3.297 ± 0.065
2.352ProLys: 2.352 ± 0.053
2.87ProLeu: 2.87 ± 0.055
0.778ProMet: 0.778 ± 0.03
1.7ProAsn: 1.7 ± 0.046
0.82ProPro: 0.82 ± 0.028
0.796ProGln: 0.796 ± 0.036
1.091ProArg: 1.091 ± 0.034
1.848ProSer: 1.848 ± 0.05
1.748ProThr: 1.748 ± 0.048
2.297ProVal: 2.297 ± 0.059
0.269ProTrp: 0.269 ± 0.019
1.428ProTyr: 1.428 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.385GlnAla: 1.385 ± 0.04
0.195GlnCys: 0.195 ± 0.015
1.172GlnAsp: 1.172 ± 0.042
1.698GlnGlu: 1.698 ± 0.045
0.953GlnPhe: 0.953 ± 0.034
1.516GlnGly: 1.516 ± 0.04
0.31GlnHis: 0.31 ± 0.021
2.299GlnIle: 2.299 ± 0.053
1.724GlnLys: 1.724 ± 0.048
2.336GlnLeu: 2.336 ± 0.053
0.713GlnMet: 0.713 ± 0.029
1.244GlnAsn: 1.244 ± 0.036
0.587GlnPro: 0.587 ± 0.026
0.605GlnGln: 0.605 ± 0.031
1.117GlnArg: 1.117 ± 0.039
1.227GlnSer: 1.227 ± 0.035
0.943GlnThr: 0.943 ± 0.036
1.697GlnVal: 1.697 ± 0.049
0.213GlnTrp: 0.213 ± 0.015
1.007GlnTyr: 1.007 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.27ArgAla: 2.27 ± 0.056
0.414ArgCys: 0.414 ± 0.024
2.307ArgAsp: 2.307 ± 0.051
3.546ArgGlu: 3.546 ± 0.073
1.798ArgPhe: 1.798 ± 0.046
2.611ArgGly: 2.611 ± 0.061
0.517ArgHis: 0.517 ± 0.024
4.402ArgIle: 4.402 ± 0.065
3.528ArgLys: 3.528 ± 0.056
3.997ArgLeu: 3.997 ± 0.072
1.172ArgMet: 1.172 ± 0.034
2.275ArgAsn: 2.275 ± 0.045
1.114ArgPro: 1.114 ± 0.036
1.085ArgGln: 1.085 ± 0.037
2.038ArgArg: 2.038 ± 0.049
1.664ArgSer: 1.664 ± 0.048
1.818ArgThr: 1.818 ± 0.046
2.762ArgVal: 2.762 ± 0.055
0.309ArgTrp: 0.309 ± 0.021
1.709ArgTyr: 1.709 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
2.628SerAla: 2.628 ± 0.062
0.505SerCys: 0.505 ± 0.026
2.401SerAsp: 2.401 ± 0.058
3.271SerGlu: 3.271 ± 0.065
2.797SerPhe: 2.797 ± 0.058
3.956SerGly: 3.956 ± 0.068
0.948SerHis: 0.948 ± 0.032
6.325SerIle: 6.325 ± 0.081
4.705SerLys: 4.705 ± 0.079
5.911SerLeu: 5.911 ± 0.091
1.467SerMet: 1.467 ± 0.041
3.17SerAsn: 3.17 ± 0.082
1.727SerPro: 1.727 ± 0.047
1.622SerGln: 1.622 ± 0.045
2.232SerArg: 2.232 ± 0.052
3.463SerSer: 3.463 ± 0.077
2.773SerThr: 2.773 ± 0.067
3.014SerVal: 3.014 ± 0.054
0.438SerTrp: 0.438 ± 0.024
2.408SerTyr: 2.408 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
2.854ThrAla: 2.854 ± 0.069
0.385ThrCys: 0.385 ± 0.023
2.307ThrAsp: 2.307 ± 0.047
2.926ThrGlu: 2.926 ± 0.056
2.042ThrPhe: 2.042 ± 0.053
3.869ThrGly: 3.869 ± 0.075
0.799ThrHis: 0.799 ± 0.031
5.173ThrIle: 5.173 ± 0.087
3.349ThrLys: 3.349 ± 0.056
4.674ThrLeu: 4.674 ± 0.075
1.09ThrMet: 1.09 ± 0.034
2.293ThrAsn: 2.293 ± 0.049
1.77ThrPro: 1.77 ± 0.045
1.037ThrGln: 1.037 ± 0.038
1.77ThrArg: 1.77 ± 0.046
2.743ThrSer: 2.743 ± 0.064
2.61ThrThr: 2.61 ± 0.066
3.304ThrVal: 3.304 ± 0.064
0.33ThrTrp: 0.33 ± 0.022
1.829ThrTyr: 1.829 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
3.843ValAla: 3.843 ± 0.077
0.614ValCys: 0.614 ± 0.026
4.214ValAsp: 4.214 ± 0.072
5.457ValGlu: 5.457 ± 0.085
2.782ValPhe: 2.782 ± 0.056
4.443ValGly: 4.443 ± 0.091
0.944ValHis: 0.944 ± 0.031
5.991ValIle: 5.991 ± 0.083
5.142ValLys: 5.142 ± 0.071
6.264ValLeu: 6.264 ± 0.094
1.58ValMet: 1.58 ± 0.042
3.287ValAsn: 3.287 ± 0.06
2.266ValPro: 2.266 ± 0.056
1.401ValGln: 1.401 ± 0.046
2.273ValArg: 2.273 ± 0.051
3.716ValSer: 3.716 ± 0.058
3.042ValThr: 3.042 ± 0.063
4.535ValVal: 4.535 ± 0.086
0.362ValTrp: 0.362 ± 0.022
2.477ValTyr: 2.477 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.417TrpAla: 0.417 ± 0.022
0.076TrpCys: 0.076 ± 0.009
0.415TrpAsp: 0.415 ± 0.027
0.542TrpGlu: 0.542 ± 0.027
0.323TrpPhe: 0.323 ± 0.019
0.561TrpGly: 0.561 ± 0.027
0.132TrpHis: 0.132 ± 0.013
0.698TrpIle: 0.698 ± 0.03
0.512TrpLys: 0.512 ± 0.025
0.628TrpLeu: 0.628 ± 0.028
0.191TrpMet: 0.191 ± 0.016
0.411TrpAsn: 0.411 ± 0.025
0.195TrpPro: 0.195 ± 0.015
0.198TrpGln: 0.198 ± 0.016
0.259TrpArg: 0.259 ± 0.019
0.352TrpSer: 0.352 ± 0.02
0.297TrpThr: 0.297 ± 0.02
0.434TrpVal: 0.434 ± 0.023
0.085TrpTrp: 0.085 ± 0.011
0.273TrpTyr: 0.273 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.913TyrAla: 1.913 ± 0.044
0.423TyrCys: 0.423 ± 0.022
2.445TyrAsp: 2.445 ± 0.054
3.052TyrGlu: 3.052 ± 0.057
2.043TyrPhe: 2.043 ± 0.059
2.887TyrGly: 2.887 ± 0.062
0.639TyrHis: 0.639 ± 0.028
4.086TyrIle: 4.086 ± 0.074
3.305TyrLys: 3.305 ± 0.066
3.819TyrLeu: 3.819 ± 0.079
0.986TyrMet: 0.986 ± 0.036
2.474TyrAsn: 2.474 ± 0.05
1.405TyrPro: 1.405 ± 0.043
0.943TyrGln: 0.943 ± 0.033
1.806TyrArg: 1.806 ± 0.047
2.493TyrSer: 2.493 ± 0.06
1.914TyrThr: 1.914 ± 0.056
2.336TyrVal: 2.336 ± 0.055
0.301TyrTrp: 0.301 ± 0.021
2.0TyrTyr: 2.0 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.003
Statistics based on 2998 proteins (872824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski