Amino acid dipepetide frequency for Halovirus HCTV-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.014AlaAla: 5.014 ± 0.554
0.769AlaCys: 0.769 ± 0.152
5.813AlaAsp: 5.813 ± 0.406
7.29AlaGlu: 7.29 ± 0.564
1.753AlaPhe: 1.753 ± 0.212
5.29AlaGly: 5.29 ± 0.436
1.507AlaHis: 1.507 ± 0.226
2.461AlaIle: 2.461 ± 0.261
2.891AlaLys: 2.891 ± 0.234
4.767AlaLeu: 4.767 ± 0.381
1.599AlaMet: 1.599 ± 0.201
2.276AlaAsn: 2.276 ± 0.382
2.061AlaPro: 2.061 ± 0.391
2.737AlaGln: 2.737 ± 0.236
4.644AlaArg: 4.644 ± 0.35
4.029AlaSer: 4.029 ± 0.386
3.783AlaThr: 3.783 ± 0.392
4.552AlaVal: 4.552 ± 0.453
1.292AlaTrp: 1.292 ± 0.218
2.522AlaTyr: 2.522 ± 0.23
0.0AlaXaa: 0.0 ± 0.0
Cys
0.953CysAla: 0.953 ± 0.165
0.154CysCys: 0.154 ± 0.062
1.169CysAsp: 1.169 ± 0.222
1.077CysGlu: 1.077 ± 0.185
0.215CysPhe: 0.215 ± 0.085
1.753CysGly: 1.753 ± 0.293
0.523CysHis: 0.523 ± 0.153
0.246CysIle: 0.246 ± 0.084
0.338CysLys: 0.338 ± 0.117
0.584CysLeu: 0.584 ± 0.131
0.338CysMet: 0.338 ± 0.121
0.431CysAsn: 0.431 ± 0.116
1.077CysPro: 1.077 ± 0.204
0.4CysGln: 0.4 ± 0.11
0.677CysArg: 0.677 ± 0.143
0.8CysSer: 0.8 ± 0.204
0.523CysThr: 0.523 ± 0.109
0.677CysVal: 0.677 ± 0.168
0.338CysTrp: 0.338 ± 0.102
0.338CysTyr: 0.338 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
7.382AspAla: 7.382 ± 0.536
0.861AspCys: 0.861 ± 0.158
11.38AspAsp: 11.38 ± 1.019
12.611AspGlu: 12.611 ± 1.127
3.322AspPhe: 3.322 ± 0.287
8.581AspGly: 8.581 ± 0.552
1.507AspHis: 1.507 ± 0.212
3.814AspIle: 3.814 ± 0.404
2.614AspLys: 2.614 ± 0.287
7.32AspLeu: 7.32 ± 0.582
2.215AspMet: 2.215 ± 0.266
3.414AspAsn: 3.414 ± 0.291
3.999AspPro: 3.999 ± 0.435
1.969AspGln: 1.969 ± 0.256
4.644AspArg: 4.644 ± 0.355
4.614AspSer: 4.614 ± 0.357
5.321AspThr: 5.321 ± 0.549
6.89AspVal: 6.89 ± 0.429
1.661AspTrp: 1.661 ± 0.221
2.953AspTyr: 2.953 ± 0.313
0.0AspXaa: 0.0 ± 0.0
Glu
7.044GluAla: 7.044 ± 0.604
1.415GluCys: 1.415 ± 0.297
10.027GluAsp: 10.027 ± 0.7
12.303GluGlu: 12.303 ± 0.95
3.414GluPhe: 3.414 ± 0.33
6.244GluGly: 6.244 ± 0.526
3.199GluHis: 3.199 ± 0.337
4.429GluIle: 4.429 ± 0.359
4.583GluLys: 4.583 ± 0.352
5.813GluLeu: 5.813 ± 0.401
3.291GluMet: 3.291 ± 0.369
4.183GluAsn: 4.183 ± 0.34
3.66GluPro: 3.66 ± 0.451
4.183GluGln: 4.183 ± 0.334
6.428GluArg: 6.428 ± 0.56
5.26GluSer: 5.26 ± 0.421
5.26GluThr: 5.26 ± 0.355
8.766GluVal: 8.766 ± 0.558
2.184GluTrp: 2.184 ± 0.275
3.537GluTyr: 3.537 ± 0.322
0.0GluXaa: 0.0 ± 0.0
Phe
1.692PheAla: 1.692 ± 0.221
0.461PheCys: 0.461 ± 0.111
3.599PheAsp: 3.599 ± 0.341
3.137PheGlu: 3.137 ± 0.315
0.707PhePhe: 0.707 ± 0.163
2.737PheGly: 2.737 ± 0.295
0.554PheHis: 0.554 ± 0.133
1.415PheIle: 1.415 ± 0.194
1.23PheLys: 1.23 ± 0.237
2.092PheLeu: 2.092 ± 0.323
0.707PheMet: 0.707 ± 0.16
1.107PheAsn: 1.107 ± 0.156
0.923PhePro: 0.923 ± 0.189
1.077PheGln: 1.077 ± 0.16
1.415PheArg: 1.415 ± 0.167
2.184PheSer: 2.184 ± 0.26
1.753PheThr: 1.753 ± 0.265
2.368PheVal: 2.368 ± 0.269
0.83PheTrp: 0.83 ± 0.156
1.23PheTyr: 1.23 ± 0.203
0.0PheXaa: 0.0 ± 0.0
Gly
4.86GlyAla: 4.86 ± 0.417
0.646GlyCys: 0.646 ± 0.133
8.028GlyAsp: 8.028 ± 0.738
8.059GlyGlu: 8.059 ± 0.539
2.43GlyPhe: 2.43 ± 0.336
6.49GlyGly: 6.49 ± 0.606
1.63GlyHis: 1.63 ± 0.201
2.768GlyIle: 2.768 ± 0.304
3.137GlyLys: 3.137 ± 0.296
3.968GlyLeu: 3.968 ± 0.408
1.999GlyMet: 1.999 ± 0.238
2.891GlyAsn: 2.891 ± 0.287
1.815GlyPro: 1.815 ± 0.224
2.799GlyGln: 2.799 ± 0.305
4.675GlyArg: 4.675 ± 0.385
4.275GlySer: 4.275 ± 0.472
4.675GlyThr: 4.675 ± 0.449
5.352GlyVal: 5.352 ± 0.35
1.261GlyTrp: 1.261 ± 0.204
2.83GlyTyr: 2.83 ± 0.269
0.0GlyXaa: 0.0 ± 0.0
His
1.538HisAla: 1.538 ± 0.2
0.431HisCys: 0.431 ± 0.128
1.476HisAsp: 1.476 ± 0.214
2.399HisGlu: 2.399 ± 0.284
0.861HisPhe: 0.861 ± 0.138
1.999HisGly: 1.999 ± 0.284
1.046HisHis: 1.046 ± 0.217
0.953HisIle: 0.953 ± 0.172
0.769HisLys: 0.769 ± 0.149
1.969HisLeu: 1.969 ± 0.285
0.431HisMet: 0.431 ± 0.131
1.046HisAsn: 1.046 ± 0.176
1.261HisPro: 1.261 ± 0.169
0.707HisGln: 0.707 ± 0.139
1.753HisArg: 1.753 ± 0.231
1.107HisSer: 1.107 ± 0.158
1.077HisThr: 1.077 ± 0.161
1.63HisVal: 1.63 ± 0.275
0.246HisTrp: 0.246 ± 0.077
0.953HisTyr: 0.953 ± 0.185
0.0HisXaa: 0.0 ± 0.0
Ile
2.245IleAla: 2.245 ± 0.249
0.4IleCys: 0.4 ± 0.111
2.984IleAsp: 2.984 ± 0.336
4.614IleGlu: 4.614 ± 0.352
1.169IlePhe: 1.169 ± 0.221
2.768IleGly: 2.768 ± 0.377
1.138IleHis: 1.138 ± 0.183
1.23IleIle: 1.23 ± 0.188
1.599IleLys: 1.599 ± 0.263
3.168IleLeu: 3.168 ± 0.253
0.769IleMet: 0.769 ± 0.16
1.538IleAsn: 1.538 ± 0.225
2.122IlePro: 2.122 ± 0.229
1.753IleGln: 1.753 ± 0.245
2.184IleArg: 2.184 ± 0.247
2.799IleSer: 2.799 ± 0.259
2.522IleThr: 2.522 ± 0.328
2.891IleVal: 2.891 ± 0.296
0.523IleTrp: 0.523 ± 0.116
1.046IleTyr: 1.046 ± 0.19
0.0IleXaa: 0.0 ± 0.0
Lys
2.799LysAla: 2.799 ± 0.31
0.461LysCys: 0.461 ± 0.153
2.86LysAsp: 2.86 ± 0.319
3.506LysGlu: 3.506 ± 0.311
1.384LysPhe: 1.384 ± 0.191
1.907LysGly: 1.907 ± 0.24
1.384LysHis: 1.384 ± 0.199
1.476LysIle: 1.476 ± 0.234
1.722LysLys: 1.722 ± 0.275
3.23LysLeu: 3.23 ± 0.318
0.83LysMet: 0.83 ± 0.191
1.815LysAsn: 1.815 ± 0.205
1.353LysPro: 1.353 ± 0.198
1.538LysGln: 1.538 ± 0.183
3.076LysArg: 3.076 ± 0.315
2.399LysSer: 2.399 ± 0.296
2.645LysThr: 2.645 ± 0.272
3.076LysVal: 3.076 ± 0.289
0.769LysTrp: 0.769 ± 0.164
1.815LysTyr: 1.815 ± 0.248
0.0LysXaa: 0.0 ± 0.0
Leu
5.506LeuAla: 5.506 ± 0.567
0.83LeuCys: 0.83 ± 0.156
7.167LeuAsp: 7.167 ± 0.487
6.521LeuGlu: 6.521 ± 0.451
1.753LeuPhe: 1.753 ± 0.216
4.398LeuGly: 4.398 ± 0.424
1.692LeuHis: 1.692 ± 0.244
2.368LeuIle: 2.368 ± 0.262
2.83LeuLys: 2.83 ± 0.299
4.921LeuLeu: 4.921 ± 0.506
1.815LeuMet: 1.815 ± 0.226
2.061LeuAsn: 2.061 ± 0.223
2.461LeuPro: 2.461 ± 0.256
2.092LeuGln: 2.092 ± 0.255
4.46LeuArg: 4.46 ± 0.342
4.583LeuSer: 4.583 ± 0.485
4.245LeuThr: 4.245 ± 0.332
4.737LeuVal: 4.737 ± 0.397
0.738LeuTrp: 0.738 ± 0.134
2.061LeuTyr: 2.061 ± 0.282
0.0LeuXaa: 0.0 ± 0.0
Met
1.507MetAla: 1.507 ± 0.217
0.185MetCys: 0.185 ± 0.083
1.999MetAsp: 1.999 ± 0.254
2.245MetGlu: 2.245 ± 0.254
0.615MetPhe: 0.615 ± 0.139
2.061MetGly: 2.061 ± 0.264
0.277MetHis: 0.277 ± 0.097
0.584MetIle: 0.584 ± 0.095
1.292MetLys: 1.292 ± 0.198
1.292MetLeu: 1.292 ± 0.192
0.431MetMet: 0.431 ± 0.129
0.953MetAsn: 0.953 ± 0.142
1.353MetPro: 1.353 ± 0.176
0.677MetGln: 0.677 ± 0.134
1.599MetArg: 1.599 ± 0.22
2.43MetSer: 2.43 ± 0.274
2.338MetThr: 2.338 ± 0.283
1.63MetVal: 1.63 ± 0.275
0.246MetTrp: 0.246 ± 0.087
0.646MetTyr: 0.646 ± 0.16
0.0MetXaa: 0.0 ± 0.0
Asn
2.707AsnAla: 2.707 ± 0.31
0.584AsnCys: 0.584 ± 0.133
3.691AsnAsp: 3.691 ± 0.306
2.83AsnGlu: 2.83 ± 0.237
0.738AsnPhe: 0.738 ± 0.169
2.768AsnGly: 2.768 ± 0.274
0.554AsnHis: 0.554 ± 0.119
1.753AsnIle: 1.753 ± 0.28
1.107AsnLys: 1.107 ± 0.195
2.799AsnLeu: 2.799 ± 0.263
0.923AsnMet: 0.923 ± 0.155
1.323AsnAsn: 1.323 ± 0.262
2.922AsnPro: 2.922 ± 0.356
1.569AsnGln: 1.569 ± 0.173
2.245AsnArg: 2.245 ± 0.256
2.307AsnSer: 2.307 ± 0.298
1.692AsnThr: 1.692 ± 0.271
2.891AsnVal: 2.891 ± 0.265
0.83AsnTrp: 0.83 ± 0.174
1.353AsnTyr: 1.353 ± 0.221
0.0AsnXaa: 0.0 ± 0.0
Pro
2.799ProAla: 2.799 ± 0.298
0.4ProCys: 0.4 ± 0.103
5.444ProAsp: 5.444 ± 0.388
4.829ProGlu: 4.829 ± 0.529
1.507ProPhe: 1.507 ± 0.215
2.645ProGly: 2.645 ± 0.244
0.769ProHis: 0.769 ± 0.169
1.446ProIle: 1.446 ± 0.229
1.292ProLys: 1.292 ± 0.218
2.153ProLeu: 2.153 ± 0.23
1.015ProMet: 1.015 ± 0.177
1.569ProAsn: 1.569 ± 0.189
1.107ProPro: 1.107 ± 0.18
1.107ProGln: 1.107 ± 0.226
1.969ProArg: 1.969 ± 0.254
2.553ProSer: 2.553 ± 0.298
2.307ProThr: 2.307 ± 0.293
2.491ProVal: 2.491 ± 0.263
0.615ProTrp: 0.615 ± 0.118
1.077ProTyr: 1.077 ± 0.201
0.0ProXaa: 0.0 ± 0.0
Gln
3.076GlnAla: 3.076 ± 0.334
0.308GlnCys: 0.308 ± 0.1
2.799GlnAsp: 2.799 ± 0.276
3.506GlnGlu: 3.506 ± 0.34
1.2GlnPhe: 1.2 ± 0.217
1.999GlnGly: 1.999 ± 0.235
0.615GlnHis: 0.615 ± 0.126
1.661GlnIle: 1.661 ± 0.266
1.969GlnLys: 1.969 ± 0.32
2.553GlnLeu: 2.553 ± 0.276
1.046GlnMet: 1.046 ± 0.163
1.599GlnAsn: 1.599 ± 0.219
1.107GlnPro: 1.107 ± 0.199
1.415GlnGln: 1.415 ± 0.217
1.815GlnArg: 1.815 ± 0.246
2.245GlnSer: 2.245 ± 0.265
2.03GlnThr: 2.03 ± 0.288
2.953GlnVal: 2.953 ± 0.307
0.554GlnTrp: 0.554 ± 0.109
1.138GlnTyr: 1.138 ± 0.204
0.0GlnXaa: 0.0 ± 0.0
Arg
3.875ArgAla: 3.875 ± 0.328
0.861ArgCys: 0.861 ± 0.195
4.675ArgAsp: 4.675 ± 0.399
5.598ArgGlu: 5.598 ± 0.439
2.276ArgPhe: 2.276 ± 0.259
4.521ArgGly: 4.521 ± 0.377
1.261ArgHis: 1.261 ± 0.22
2.522ArgIle: 2.522 ± 0.293
2.799ArgLys: 2.799 ± 0.309
4.491ArgLeu: 4.491 ± 0.389
1.538ArgMet: 1.538 ± 0.19
2.245ArgAsn: 2.245 ± 0.246
1.969ArgPro: 1.969 ± 0.259
2.307ArgGln: 2.307 ± 0.277
4.521ArgArg: 4.521 ± 0.424
3.906ArgSer: 3.906 ± 0.368
2.984ArgThr: 2.984 ± 0.369
4.86ArgVal: 4.86 ± 0.363
1.107ArgTrp: 1.107 ± 0.206
2.553ArgTyr: 2.553 ± 0.274
0.0ArgXaa: 0.0 ± 0.0
Ser
2.984SerAla: 2.984 ± 0.284
0.923SerCys: 0.923 ± 0.162
6.09SerAsp: 6.09 ± 0.499
5.936SerGlu: 5.936 ± 0.464
2.245SerPhe: 2.245 ± 0.301
5.413SerGly: 5.413 ± 0.405
1.169SerHis: 1.169 ± 0.163
2.399SerIle: 2.399 ± 0.248
2.737SerLys: 2.737 ± 0.312
4.398SerLeu: 4.398 ± 0.363
1.077SerMet: 1.077 ± 0.156
2.245SerAsn: 2.245 ± 0.248
2.461SerPro: 2.461 ± 0.282
1.969SerGln: 1.969 ± 0.249
3.691SerArg: 3.691 ± 0.401
4.337SerSer: 4.337 ± 0.419
3.906SerThr: 3.906 ± 0.387
4.152SerVal: 4.152 ± 0.325
1.015SerTrp: 1.015 ± 0.183
2.092SerTyr: 2.092 ± 0.259
0.0SerXaa: 0.0 ± 0.0
Thr
3.568ThrAla: 3.568 ± 0.32
0.83ThrCys: 0.83 ± 0.18
5.475ThrAsp: 5.475 ± 0.441
4.829ThrGlu: 4.829 ± 0.389
2.522ThrPhe: 2.522 ± 0.305
4.921ThrGly: 4.921 ± 0.417
1.323ThrHis: 1.323 ± 0.193
2.86ThrIle: 2.86 ± 0.342
2.307ThrLys: 2.307 ± 0.276
3.691ThrLeu: 3.691 ± 0.304
1.23ThrMet: 1.23 ± 0.179
1.969ThrAsn: 1.969 ± 0.29
2.645ThrPro: 2.645 ± 0.235
2.645ThrGln: 2.645 ± 0.282
3.045ThrArg: 3.045 ± 0.28
2.953ThrSer: 2.953 ± 0.416
4.029ThrThr: 4.029 ± 0.388
3.783ThrVal: 3.783 ± 0.348
1.384ThrTrp: 1.384 ± 0.259
1.722ThrTyr: 1.722 ± 0.177
0.0ThrXaa: 0.0 ± 0.0
Val
4.398ValAla: 4.398 ± 0.396
1.015ValCys: 1.015 ± 0.192
6.797ValAsp: 6.797 ± 0.457
8.274ValGlu: 8.274 ± 0.508
1.753ValPhe: 1.753 ± 0.256
4.675ValGly: 4.675 ± 0.38
2.184ValHis: 2.184 ± 0.267
2.83ValIle: 2.83 ± 0.26
2.86ValLys: 2.86 ± 0.238
4.983ValLeu: 4.983 ± 0.357
1.692ValMet: 1.692 ± 0.219
2.768ValAsn: 2.768 ± 0.304
2.984ValPro: 2.984 ± 0.289
2.953ValGln: 2.953 ± 0.317
4.644ValArg: 4.644 ± 0.449
5.321ValSer: 5.321 ± 0.37
4.122ValThr: 4.122 ± 0.333
5.444ValVal: 5.444 ± 0.506
1.015ValTrp: 1.015 ± 0.172
2.461ValTyr: 2.461 ± 0.285
0.0ValXaa: 0.0 ± 0.0
Trp
0.892TrpAla: 0.892 ± 0.197
0.308TrpCys: 0.308 ± 0.1
1.969TrpAsp: 1.969 ± 0.249
1.907TrpGlu: 1.907 ± 0.216
0.492TrpPhe: 0.492 ± 0.118
0.615TrpGly: 0.615 ± 0.154
0.431TrpHis: 0.431 ± 0.105
0.646TrpIle: 0.646 ± 0.159
0.861TrpLys: 0.861 ± 0.169
1.107TrpLeu: 1.107 ± 0.197
0.646TrpMet: 0.646 ± 0.157
1.046TrpAsn: 1.046 ± 0.191
0.277TrpPro: 0.277 ± 0.089
0.707TrpGln: 0.707 ± 0.136
1.292TrpArg: 1.292 ± 0.187
1.046TrpSer: 1.046 ± 0.168
0.892TrpThr: 0.892 ± 0.159
1.507TrpVal: 1.507 ± 0.248
0.308TrpTrp: 0.308 ± 0.091
0.677TrpTyr: 0.677 ± 0.151
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.215TyrAla: 2.215 ± 0.237
0.769TyrCys: 0.769 ± 0.185
3.629TyrAsp: 3.629 ± 0.318
3.752TyrGlu: 3.752 ± 0.325
0.861TyrPhe: 0.861 ± 0.185
2.799TyrGly: 2.799 ± 0.299
0.892TyrHis: 0.892 ± 0.185
1.599TyrIle: 1.599 ± 0.213
1.138TyrLys: 1.138 ± 0.195
1.938TyrLeu: 1.938 ± 0.225
0.738TyrMet: 0.738 ± 0.149
1.107TyrAsn: 1.107 ± 0.168
1.538TyrPro: 1.538 ± 0.221
0.984TyrGln: 0.984 ± 0.169
2.092TyrArg: 2.092 ± 0.298
2.092TyrSer: 2.092 ± 0.23
1.63TyrThr: 1.63 ± 0.215
2.522TyrVal: 2.522 ± 0.269
0.707TyrTrp: 0.707 ± 0.181
1.569TyrTyr: 1.569 ± 0.225
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 166 proteins (32513 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski