Amino acid dipepetide frequency for Vibrio tapetis subsp. tapetis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.798AlaAla: 6.798 ± 0.103
0.918AlaCys: 0.918 ± 0.026
4.19AlaAsp: 4.19 ± 0.069
4.985AlaGlu: 4.985 ± 0.06
3.423AlaPhe: 3.423 ± 0.055
5.448AlaGly: 5.448 ± 0.078
1.615AlaHis: 1.615 ± 0.032
5.803AlaIle: 5.803 ± 0.074
5.017AlaLys: 5.017 ± 0.072
9.439AlaLeu: 9.439 ± 0.083
2.673AlaMet: 2.673 ± 0.04
3.62AlaAsn: 3.62 ± 0.043
2.689AlaPro: 2.689 ± 0.051
3.737AlaGln: 3.737 ± 0.06
3.405AlaArg: 3.405 ± 0.047
5.491AlaSer: 5.491 ± 0.065
4.447AlaThr: 4.447 ± 0.055
5.4AlaVal: 5.4 ± 0.076
0.885AlaTrp: 0.885 ± 0.029
2.254AlaTyr: 2.254 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.787CysAla: 0.787 ± 0.021
0.162CysCys: 0.162 ± 0.011
0.612CysAsp: 0.612 ± 0.019
0.652CysGlu: 0.652 ± 0.021
0.515CysPhe: 0.515 ± 0.019
0.882CysGly: 0.882 ± 0.028
0.373CysHis: 0.373 ± 0.018
0.643CysIle: 0.643 ± 0.02
0.473CysLys: 0.473 ± 0.019
1.038CysLeu: 1.038 ± 0.022
0.27CysMet: 0.27 ± 0.015
0.411CysAsn: 0.411 ± 0.018
0.452CysPro: 0.452 ± 0.018
0.471CysGln: 0.471 ± 0.017
0.49CysArg: 0.49 ± 0.017
0.786CysSer: 0.786 ± 0.025
0.514CysThr: 0.514 ± 0.02
0.742CysVal: 0.742 ± 0.021
0.141CysTrp: 0.141 ± 0.01
0.377CysTyr: 0.377 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.251AspAla: 4.251 ± 0.071
0.603AspCys: 0.603 ± 0.021
3.019AspAsp: 3.019 ± 0.068
3.874AspGlu: 3.874 ± 0.055
2.507AspPhe: 2.507 ± 0.042
3.724AspGly: 3.724 ± 0.076
1.21AspHis: 1.21 ± 0.033
3.937AspIle: 3.937 ± 0.054
3.363AspLys: 3.363 ± 0.049
5.221AspLeu: 5.221 ± 0.065
1.394AspMet: 1.394 ± 0.033
2.534AspAsn: 2.534 ± 0.043
1.851AspPro: 1.851 ± 0.042
1.999AspGln: 1.999 ± 0.037
2.189AspArg: 2.189 ± 0.035
3.533AspSer: 3.533 ± 0.064
2.734AspThr: 2.734 ± 0.066
4.035AspVal: 4.035 ± 0.068
0.824AspTrp: 0.824 ± 0.028
2.028AspTyr: 2.028 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
4.915GluAla: 4.915 ± 0.066
0.576GluCys: 0.576 ± 0.021
2.775GluAsp: 2.775 ± 0.056
3.671GluGlu: 3.671 ± 0.06
2.502GluPhe: 2.502 ± 0.043
3.433GluGly: 3.433 ± 0.051
1.672GluHis: 1.672 ± 0.032
3.723GluIle: 3.723 ± 0.044
3.789GluLys: 3.789 ± 0.052
7.269GluLeu: 7.269 ± 0.08
1.791GluMet: 1.791 ± 0.034
2.643GluAsn: 2.643 ± 0.047
1.974GluPro: 1.974 ± 0.041
4.084GluGln: 4.084 ± 0.057
3.352GluArg: 3.352 ± 0.049
4.136GluSer: 4.136 ± 0.052
3.129GluThr: 3.129 ± 0.049
4.228GluVal: 4.228 ± 0.053
0.839GluTrp: 0.839 ± 0.022
1.812GluTyr: 1.812 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.419PheAla: 3.419 ± 0.054
0.58PheCys: 0.58 ± 0.019
2.788PheAsp: 2.788 ± 0.047
2.681PheGlu: 2.681 ± 0.043
1.756PhePhe: 1.756 ± 0.04
3.211PheGly: 3.211 ± 0.051
0.863PheHis: 0.863 ± 0.023
2.704PheIle: 2.704 ± 0.038
2.05PheLys: 2.05 ± 0.037
3.446PheLeu: 3.446 ± 0.058
1.061PheMet: 1.061 ± 0.028
2.106PheAsn: 2.106 ± 0.039
1.37PhePro: 1.37 ± 0.027
1.316PheGln: 1.316 ± 0.028
1.502PheArg: 1.502 ± 0.026
3.533PheSer: 3.533 ± 0.049
2.33PheThr: 2.33 ± 0.038
3.006PheVal: 3.006 ± 0.051
0.54PheTrp: 0.54 ± 0.019
1.323PheTyr: 1.323 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
4.99GlyAla: 4.99 ± 0.066
0.897GlyCys: 0.897 ± 0.025
3.56GlyAsp: 3.56 ± 0.062
4.303GlyGlu: 4.303 ± 0.055
3.266GlyPhe: 3.266 ± 0.046
4.547GlyGly: 4.547 ± 0.072
1.538GlyHis: 1.538 ± 0.033
4.53GlyIle: 4.53 ± 0.062
3.903GlyLys: 3.903 ± 0.052
6.785GlyLeu: 6.785 ± 0.073
1.983GlyMet: 1.983 ± 0.041
2.569GlyAsn: 2.569 ± 0.056
1.475GlyPro: 1.475 ± 0.027
2.785GlyGln: 2.785 ± 0.046
2.887GlyArg: 2.887 ± 0.043
4.246GlySer: 4.246 ± 0.058
3.307GlyThr: 3.307 ± 0.077
5.053GlyVal: 5.053 ± 0.063
0.937GlyTrp: 0.937 ± 0.026
2.573GlyTyr: 2.573 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.682HisAla: 1.682 ± 0.034
0.336HisCys: 0.336 ± 0.015
1.25HisAsp: 1.25 ± 0.031
1.19HisGlu: 1.19 ± 0.031
1.098HisPhe: 1.098 ± 0.026
1.499HisGly: 1.499 ± 0.03
0.741HisHis: 0.741 ± 0.023
1.443HisIle: 1.443 ± 0.03
1.106HisLys: 1.106 ± 0.027
2.302HisLeu: 2.302 ± 0.042
0.518HisMet: 0.518 ± 0.019
0.944HisAsn: 0.944 ± 0.024
1.117HisPro: 1.117 ± 0.031
1.337HisGln: 1.337 ± 0.028
1.087HisArg: 1.087 ± 0.03
1.595HisSer: 1.595 ± 0.029
1.128HisThr: 1.128 ± 0.03
1.334HisVal: 1.334 ± 0.03
0.369HisTrp: 0.369 ± 0.015
0.894HisTyr: 0.894 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.105IleAla: 6.105 ± 0.067
0.728IleCys: 0.728 ± 0.021
4.185IleAsp: 4.185 ± 0.051
4.935IleGlu: 4.935 ± 0.054
2.192IlePhe: 2.192 ± 0.044
4.673IleGly: 4.673 ± 0.059
1.242IleHis: 1.242 ± 0.028
3.616IleIle: 3.616 ± 0.051
3.511IleLys: 3.511 ± 0.047
5.277IleLeu: 5.277 ± 0.065
1.367IleMet: 1.367 ± 0.029
3.083IleAsn: 3.083 ± 0.042
2.548IlePro: 2.548 ± 0.044
2.355IleGln: 2.355 ± 0.038
2.75IleArg: 2.75 ± 0.045
4.871IleSer: 4.871 ± 0.066
3.739IleThr: 3.739 ± 0.072
4.172IleVal: 4.172 ± 0.056
0.655IleTrp: 0.655 ± 0.022
1.732IleTyr: 1.732 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.814LysAla: 4.814 ± 0.068
0.39LysCys: 0.39 ± 0.016
2.855LysAsp: 2.855 ± 0.043
3.399LysGlu: 3.399 ± 0.054
1.625LysPhe: 1.625 ± 0.029
3.527LysGly: 3.527 ± 0.052
1.451LysHis: 1.451 ± 0.031
3.043LysIle: 3.043 ± 0.048
3.434LysLys: 3.434 ± 0.056
5.598LysLeu: 5.598 ± 0.051
1.61LysMet: 1.61 ± 0.032
2.406LysAsn: 2.406 ± 0.038
2.514LysPro: 2.514 ± 0.042
3.174LysGln: 3.174 ± 0.047
2.899LysArg: 2.899 ± 0.046
3.639LysSer: 3.639 ± 0.05
3.13LysThr: 3.13 ± 0.045
3.75LysVal: 3.75 ± 0.051
0.618LysTrp: 0.618 ± 0.02
1.53LysTyr: 1.53 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
9.313LeuAla: 9.313 ± 0.096
1.123LeuCys: 1.123 ± 0.03
5.844LeuAsp: 5.844 ± 0.063
6.346LeuGlu: 6.346 ± 0.072
4.255LeuPhe: 4.255 ± 0.068
6.812LeuGly: 6.812 ± 0.069
2.081LeuHis: 2.081 ± 0.04
6.378LeuIle: 6.378 ± 0.072
5.523LeuLys: 5.523 ± 0.068
10.315LeuLeu: 10.315 ± 0.106
2.718LeuMet: 2.718 ± 0.045
4.926LeuAsn: 4.926 ± 0.06
4.511LeuPro: 4.511 ± 0.063
3.46LeuGln: 3.46 ± 0.054
4.277LeuArg: 4.277 ± 0.069
8.213LeuSer: 8.213 ± 0.076
6.294LeuThr: 6.294 ± 0.077
7.099LeuVal: 7.099 ± 0.092
1.059LeuTrp: 1.059 ± 0.026
2.64LeuTyr: 2.64 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.529MetAla: 2.529 ± 0.043
0.23MetCys: 0.23 ± 0.012
1.313MetAsp: 1.313 ± 0.026
1.286MetGlu: 1.286 ± 0.03
1.001MetPhe: 1.001 ± 0.027
1.741MetGly: 1.741 ± 0.035
0.494MetHis: 0.494 ± 0.014
1.561MetIle: 1.561 ± 0.029
1.61MetLys: 1.61 ± 0.029
2.909MetLeu: 2.909 ± 0.049
0.871MetMet: 0.871 ± 0.026
1.22MetAsn: 1.22 ± 0.026
1.264MetPro: 1.264 ± 0.029
1.094MetGln: 1.094 ± 0.031
1.243MetArg: 1.243 ± 0.027
2.126MetSer: 2.126 ± 0.036
1.707MetThr: 1.707 ± 0.032
1.919MetVal: 1.919 ± 0.039
0.253MetTrp: 0.253 ± 0.012
0.572MetTyr: 0.572 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.454AsnAla: 3.454 ± 0.052
0.412AsnCys: 0.412 ± 0.016
2.476AsnAsp: 2.476 ± 0.054
2.631AsnGlu: 2.631 ± 0.045
1.592AsnPhe: 1.592 ± 0.03
3.081AsnGly: 3.081 ± 0.055
1.099AsnHis: 1.099 ± 0.028
2.926AsnIle: 2.926 ± 0.039
2.656AsnLys: 2.656 ± 0.048
4.168AsnLeu: 4.168 ± 0.055
1.116AsnMet: 1.116 ± 0.028
2.105AsnAsn: 2.105 ± 0.043
2.058AsnPro: 2.058 ± 0.042
2.356AsnGln: 2.356 ± 0.042
2.055AsnArg: 2.055 ± 0.035
2.887AsnSer: 2.887 ± 0.042
2.45AsnThr: 2.45 ± 0.051
2.856AsnVal: 2.856 ± 0.048
0.61AsnTrp: 0.61 ± 0.02
1.397AsnTyr: 1.397 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
2.738ProAla: 2.738 ± 0.048
0.355ProCys: 0.355 ± 0.013
2.149ProAsp: 2.149 ± 0.036
2.993ProGlu: 2.993 ± 0.06
1.683ProPhe: 1.683 ± 0.034
1.83ProGly: 1.83 ± 0.04
0.807ProHis: 0.807 ± 0.022
2.629ProIle: 2.629 ± 0.043
2.052ProLys: 2.052 ± 0.041
3.934ProLeu: 3.934 ± 0.055
1.043ProMet: 1.043 ± 0.025
1.852ProAsn: 1.852 ± 0.031
1.04ProPro: 1.04 ± 0.028
1.492ProGln: 1.492 ± 0.024
1.234ProArg: 1.234 ± 0.029
2.68ProSer: 2.68 ± 0.044
2.303ProThr: 2.303 ± 0.04
2.801ProVal: 2.801 ± 0.043
0.494ProTrp: 0.494 ± 0.02
1.262ProTyr: 1.262 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.205GlnAla: 4.205 ± 0.06
0.47GlnCys: 0.47 ± 0.018
2.197GlnAsp: 2.197 ± 0.039
2.449GlnGlu: 2.449 ± 0.035
1.85GlnPhe: 1.85 ± 0.038
2.942GlnGly: 2.942 ± 0.046
1.213GlnHis: 1.213 ± 0.026
2.602GlnIle: 2.602 ± 0.045
2.213GlnLys: 2.213 ± 0.036
5.127GlnLeu: 5.127 ± 0.073
1.121GlnMet: 1.121 ± 0.031
1.735GlnAsn: 1.735 ± 0.036
1.647GlnPro: 1.647 ± 0.032
2.804GlnGln: 2.804 ± 0.047
2.204GlnArg: 2.204 ± 0.042
3.188GlnSer: 3.188 ± 0.05
2.379GlnThr: 2.379 ± 0.043
3.237GlnVal: 3.237 ± 0.047
0.65GlnTrp: 0.65 ± 0.021
1.431GlnTyr: 1.431 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.184ArgAla: 3.184 ± 0.044
0.474ArgCys: 0.474 ± 0.018
2.398ArgAsp: 2.398 ± 0.04
2.755ArgGlu: 2.755 ± 0.04
2.172ArgPhe: 2.172 ± 0.039
2.398ArgGly: 2.398 ± 0.042
1.12ArgHis: 1.12 ± 0.026
2.972ArgIle: 2.972 ± 0.049
2.484ArgLys: 2.484 ± 0.045
4.835ArgLeu: 4.835 ± 0.062
1.168ArgMet: 1.168 ± 0.026
2.004ArgAsn: 2.004 ± 0.036
1.457ArgPro: 1.457 ± 0.035
2.105ArgGln: 2.105 ± 0.039
2.252ArgArg: 2.252 ± 0.047
2.832ArgSer: 2.832 ± 0.047
2.253ArgThr: 2.253 ± 0.04
3.103ArgVal: 3.103 ± 0.049
0.643ArgTrp: 0.643 ± 0.02
1.739ArgTyr: 1.739 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.519SerAla: 5.519 ± 0.061
0.654SerCys: 0.654 ± 0.021
3.963SerAsp: 3.963 ± 0.058
4.354SerGlu: 4.354 ± 0.057
3.096SerPhe: 3.096 ± 0.043
4.997SerGly: 4.997 ± 0.063
1.711SerHis: 1.711 ± 0.031
4.669SerIle: 4.669 ± 0.06
3.723SerLys: 3.723 ± 0.053
7.384SerLeu: 7.384 ± 0.076
1.916SerMet: 1.916 ± 0.034
3.173SerAsn: 3.173 ± 0.052
2.569SerPro: 2.569 ± 0.044
3.195SerGln: 3.195 ± 0.047
2.989SerArg: 2.989 ± 0.049
4.979SerSer: 4.979 ± 0.067
3.715SerThr: 3.715 ± 0.05
4.934SerVal: 4.934 ± 0.06
0.905SerTrp: 0.905 ± 0.025
2.196SerTyr: 2.196 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
4.368ThrAla: 4.368 ± 0.066
0.514ThrCys: 0.514 ± 0.018
2.969ThrAsp: 2.969 ± 0.067
3.129ThrGlu: 3.129 ± 0.046
2.165ThrPhe: 2.165 ± 0.045
3.88ThrGly: 3.88 ± 0.081
1.373ThrHis: 1.373 ± 0.041
3.496ThrIle: 3.496 ± 0.063
2.835ThrLys: 2.835 ± 0.048
6.225ThrLeu: 6.225 ± 0.078
1.297ThrMet: 1.297 ± 0.03
2.324ThrAsn: 2.324 ± 0.042
2.642ThrPro: 2.642 ± 0.041
2.605ThrGln: 2.605 ± 0.052
2.298ThrArg: 2.298 ± 0.044
3.762ThrSer: 3.762 ± 0.062
3.121ThrThr: 3.121 ± 0.062
3.802ThrVal: 3.802 ± 0.06
0.638ThrTrp: 0.638 ± 0.018
1.505ThrTyr: 1.505 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
6.087ValAla: 6.087 ± 0.068
0.804ValCys: 0.804 ± 0.025
4.022ValAsp: 4.022 ± 0.064
4.638ValGlu: 4.638 ± 0.069
2.811ValPhe: 2.811 ± 0.047
4.64ValGly: 4.64 ± 0.056
1.243ValHis: 1.243 ± 0.03
4.753ValIle: 4.753 ± 0.053
3.611ValLys: 3.611 ± 0.054
6.744ValLeu: 6.744 ± 0.073
2.015ValMet: 2.015 ± 0.036
3.082ValAsn: 3.082 ± 0.045
2.478ValPro: 2.478 ± 0.039
2.288ValGln: 2.288 ± 0.043
2.934ValArg: 2.934 ± 0.046
5.167ValSer: 5.167 ± 0.062
4.283ValThr: 4.283 ± 0.079
5.276ValVal: 5.276 ± 0.064
0.772ValTrp: 0.772 ± 0.021
1.865ValTyr: 1.865 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.811TrpAla: 0.811 ± 0.027
0.161TrpCys: 0.161 ± 0.011
0.621TrpAsp: 0.621 ± 0.02
0.54TrpGlu: 0.54 ± 0.02
0.617TrpPhe: 0.617 ± 0.02
0.752TrpGly: 0.752 ± 0.024
0.348TrpHis: 0.348 ± 0.015
0.659TrpIle: 0.659 ± 0.02
0.599TrpLys: 0.599 ± 0.019
1.79TrpLeu: 1.79 ± 0.041
0.354TrpMet: 0.354 ± 0.016
0.502TrpAsn: 0.502 ± 0.018
0.438TrpPro: 0.438 ± 0.016
0.935TrpGln: 0.935 ± 0.029
0.629TrpArg: 0.629 ± 0.021
0.798TrpSer: 0.798 ± 0.025
0.521TrpThr: 0.521 ± 0.026
0.866TrpVal: 0.866 ± 0.026
0.189TrpTrp: 0.189 ± 0.012
0.369TrpTyr: 0.369 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.267TyrAla: 2.267 ± 0.041
0.405TyrCys: 0.405 ± 0.016
1.644TyrAsp: 1.644 ± 0.039
1.501TyrGlu: 1.501 ± 0.034
1.458TyrPhe: 1.458 ± 0.031
2.117TyrGly: 2.117 ± 0.043
0.779TyrHis: 0.779 ± 0.024
1.648TyrIle: 1.648 ± 0.032
1.455TyrLys: 1.455 ± 0.03
3.382TyrLeu: 3.382 ± 0.046
0.655TyrMet: 0.655 ± 0.021
1.148TyrAsn: 1.148 ± 0.029
1.278TyrPro: 1.278 ± 0.03
2.072TyrGln: 2.072 ± 0.041
1.673TyrArg: 1.673 ± 0.033
2.177TyrSer: 2.177 ± 0.044
1.459TyrThr: 1.459 ± 0.034
1.901TyrVal: 1.901 ± 0.037
0.478TyrTrp: 0.478 ± 0.018
1.002TyrTyr: 1.002 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5392 proteins (1632385 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski