Amino acid dipepetide frequency for Siphoviridae sp. ctjeG17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.825AlaAla: 1.825 ± 0.463
0.707AlaCys: 0.707 ± 0.201
2.473AlaAsp: 2.473 ± 0.477
2.944AlaGlu: 2.944 ± 0.354
2.414AlaPhe: 2.414 ± 0.333
3.945AlaGly: 3.945 ± 0.475
0.765AlaHis: 0.765 ± 0.167
3.65AlaIle: 3.65 ± 0.467
3.12AlaLys: 3.12 ± 0.371
4.357AlaLeu: 4.357 ± 0.443
1.649AlaMet: 1.649 ± 0.387
3.533AlaAsn: 3.533 ± 0.525
2.061AlaPro: 2.061 ± 0.401
3.415AlaGln: 3.415 ± 0.775
2.473AlaArg: 2.473 ± 0.505
4.475AlaSer: 4.475 ± 0.572
5.181AlaThr: 5.181 ± 0.871
4.18AlaVal: 4.18 ± 0.765
0.648AlaTrp: 0.648 ± 0.157
2.708AlaTyr: 2.708 ± 0.4
0.0AlaXaa: 0.0 ± 0.0
Cys
0.824CysAla: 0.824 ± 0.199
0.412CysCys: 0.412 ± 0.188
1.119CysAsp: 1.119 ± 0.298
1.06CysGlu: 1.06 ± 0.26
0.707CysPhe: 0.707 ± 0.229
1.178CysGly: 1.178 ± 0.339
0.118CysHis: 0.118 ± 0.091
0.589CysIle: 0.589 ± 0.191
0.765CysLys: 0.765 ± 0.257
0.942CysLeu: 0.942 ± 0.253
0.236CysMet: 0.236 ± 0.113
1.295CysAsn: 1.295 ± 0.245
0.471CysPro: 0.471 ± 0.173
0.883CysGln: 0.883 ± 0.291
0.942CysArg: 0.942 ± 0.312
1.236CysSer: 1.236 ± 0.294
0.883CysThr: 0.883 ± 0.285
1.178CysVal: 1.178 ± 0.24
0.294CysTrp: 0.294 ± 0.134
0.648CysTyr: 0.648 ± 0.192
0.0CysXaa: 0.0 ± 0.0
Asp
2.767AspAla: 2.767 ± 0.484
0.707AspCys: 0.707 ± 0.215
3.356AspAsp: 3.356 ± 0.551
2.591AspGlu: 2.591 ± 0.442
2.296AspPhe: 2.296 ± 0.354
3.415AspGly: 3.415 ± 0.495
0.353AspHis: 0.353 ± 0.158
3.591AspIle: 3.591 ± 0.453
4.004AspLys: 4.004 ± 0.49
3.65AspLeu: 3.65 ± 0.406
1.295AspMet: 1.295 ± 0.269
3.238AspAsn: 3.238 ± 0.393
1.472AspPro: 1.472 ± 0.26
1.119AspGln: 1.119 ± 0.289
1.295AspArg: 1.295 ± 0.353
3.827AspSer: 3.827 ± 0.546
2.885AspThr: 2.885 ± 0.48
2.649AspVal: 2.649 ± 0.395
0.589AspTrp: 0.589 ± 0.22
2.12AspTyr: 2.12 ± 0.324
0.0AspXaa: 0.0 ± 0.0
Glu
2.885GluAla: 2.885 ± 0.479
0.589GluCys: 0.589 ± 0.189
1.884GluAsp: 1.884 ± 0.365
3.591GluGlu: 3.591 ± 0.581
2.355GluPhe: 2.355 ± 0.421
2.414GluGly: 2.414 ± 0.384
1.236GluHis: 1.236 ± 0.255
3.768GluIle: 3.768 ± 0.633
5.417GluLys: 5.417 ± 0.88
4.121GluLeu: 4.121 ± 0.665
1.236GluMet: 1.236 ± 0.273
3.415GluAsn: 3.415 ± 0.458
1.001GluPro: 1.001 ± 0.269
2.591GluGln: 2.591 ± 0.52
2.767GluArg: 2.767 ± 0.673
2.826GluSer: 2.826 ± 0.4
2.649GluThr: 2.649 ± 0.309
3.591GluVal: 3.591 ± 0.481
0.765GluTrp: 0.765 ± 0.305
3.179GluTyr: 3.179 ± 0.472
0.0GluXaa: 0.0 ± 0.0
Phe
3.12PheAla: 3.12 ± 0.356
0.942PheCys: 0.942 ± 0.263
2.767PheAsp: 2.767 ± 0.43
2.885PheGlu: 2.885 ± 0.4
2.944PhePhe: 2.944 ± 0.324
3.356PheGly: 3.356 ± 0.636
0.412PheHis: 0.412 ± 0.195
5.417PheIle: 5.417 ± 0.777
2.826PheLys: 2.826 ± 0.448
4.004PheLeu: 4.004 ± 0.574
1.236PheMet: 1.236 ± 0.301
3.591PheAsn: 3.591 ± 0.679
1.354PhePro: 1.354 ± 0.287
1.649PheGln: 1.649 ± 0.291
1.178PheArg: 1.178 ± 0.24
4.769PheSer: 4.769 ± 0.491
3.591PheThr: 3.591 ± 0.601
3.415PheVal: 3.415 ± 0.382
0.707PheTrp: 0.707 ± 0.215
2.178PheTyr: 2.178 ± 0.292
0.0PheXaa: 0.0 ± 0.0
Gly
4.357GlyAla: 4.357 ± 0.643
0.707GlyCys: 0.707 ± 0.22
3.003GlyAsp: 3.003 ± 0.439
2.649GlyGlu: 2.649 ± 0.369
2.532GlyPhe: 2.532 ± 0.412
5.77GlyGly: 5.77 ± 0.846
0.824GlyHis: 0.824 ± 0.245
4.298GlyIle: 4.298 ± 0.411
3.003GlyLys: 3.003 ± 0.441
5.475GlyLeu: 5.475 ± 0.527
1.178GlyMet: 1.178 ± 0.221
4.004GlyAsn: 4.004 ± 0.75
0.412GlyPro: 0.412 ± 0.148
2.237GlyGln: 2.237 ± 0.436
2.178GlyArg: 2.178 ± 0.386
5.77GlySer: 5.77 ± 0.726
4.416GlyThr: 4.416 ± 0.742
4.298GlyVal: 4.298 ± 0.501
0.707GlyTrp: 0.707 ± 0.237
2.473GlyTyr: 2.473 ± 0.412
0.0GlyXaa: 0.0 ± 0.0
His
0.471HisAla: 0.471 ± 0.157
0.059HisCys: 0.059 ± 0.064
0.53HisAsp: 0.53 ± 0.206
0.53HisGlu: 0.53 ± 0.185
0.648HisPhe: 0.648 ± 0.166
0.648HisGly: 0.648 ± 0.223
0.294HisHis: 0.294 ± 0.139
1.119HisIle: 1.119 ± 0.28
1.178HisLys: 1.178 ± 0.302
1.413HisLeu: 1.413 ± 0.288
0.471HisMet: 0.471 ± 0.166
0.942HisAsn: 0.942 ± 0.223
0.118HisPro: 0.118 ± 0.09
0.236HisGln: 0.236 ± 0.119
0.412HisArg: 0.412 ± 0.196
0.707HisSer: 0.707 ± 0.2
0.648HisThr: 0.648 ± 0.19
0.353HisVal: 0.353 ± 0.129
0.353HisTrp: 0.353 ± 0.154
0.824HisTyr: 0.824 ± 0.189
0.0HisXaa: 0.0 ± 0.0
Ile
4.946IleAla: 4.946 ± 0.559
1.119IleCys: 1.119 ± 0.286
3.591IleAsp: 3.591 ± 0.473
4.121IleGlu: 4.121 ± 0.519
4.651IlePhe: 4.651 ± 0.603
4.651IleGly: 4.651 ± 0.583
0.707IleHis: 0.707 ± 0.232
8.184IleIle: 8.184 ± 0.819
6.3IleLys: 6.3 ± 0.761
7.418IleLeu: 7.418 ± 0.798
2.061IleMet: 2.061 ± 0.479
6.712IleAsn: 6.712 ± 0.906
2.473IlePro: 2.473 ± 0.347
2.414IleGln: 2.414 ± 0.412
2.826IleArg: 2.826 ± 0.402
5.829IleSer: 5.829 ± 0.694
6.417IleThr: 6.417 ± 0.786
4.298IleVal: 4.298 ± 0.661
1.001IleTrp: 1.001 ± 0.231
4.298IleTyr: 4.298 ± 0.611
0.0IleXaa: 0.0 ± 0.0
Lys
2.473LysAla: 2.473 ± 0.435
0.942LysCys: 0.942 ± 0.295
2.826LysAsp: 2.826 ± 0.385
6.123LysGlu: 6.123 ± 1.061
2.885LysPhe: 2.885 ± 0.436
3.356LysGly: 3.356 ± 0.406
0.824LysHis: 0.824 ± 0.28
5.888LysIle: 5.888 ± 0.667
5.475LysLys: 5.475 ± 0.958
4.533LysLeu: 4.533 ± 0.623
2.414LysMet: 2.414 ± 0.452
5.475LysAsn: 5.475 ± 0.588
1.295LysPro: 1.295 ± 0.321
3.297LysGln: 3.297 ± 0.631
2.355LysArg: 2.355 ± 0.455
2.885LysSer: 2.885 ± 0.563
4.651LysThr: 4.651 ± 0.674
3.297LysVal: 3.297 ± 0.57
0.883LysTrp: 0.883 ± 0.231
3.12LysTyr: 3.12 ± 0.511
0.0LysXaa: 0.0 ± 0.0
Leu
4.239LeuAla: 4.239 ± 0.507
1.354LeuCys: 1.354 ± 0.296
4.004LeuAsp: 4.004 ± 0.439
3.238LeuGlu: 3.238 ± 0.347
5.299LeuPhe: 5.299 ± 0.666
3.533LeuGly: 3.533 ± 0.466
0.707LeuHis: 0.707 ± 0.236
7.477LeuIle: 7.477 ± 0.769
4.887LeuLys: 4.887 ± 0.669
7.536LeuLeu: 7.536 ± 0.85
2.414LeuMet: 2.414 ± 0.438
6.417LeuAsn: 6.417 ± 0.701
1.825LeuPro: 1.825 ± 0.356
3.062LeuGln: 3.062 ± 0.637
3.297LeuArg: 3.297 ± 0.428
7.006LeuSer: 7.006 ± 0.594
5.77LeuThr: 5.77 ± 0.698
5.593LeuVal: 5.593 ± 0.918
0.883LeuTrp: 0.883 ± 0.215
4.946LeuTyr: 4.946 ± 0.737
0.0LeuXaa: 0.0 ± 0.0
Met
2.002MetAla: 2.002 ± 0.393
0.471MetCys: 0.471 ± 0.174
0.824MetAsp: 0.824 ± 0.249
1.295MetGlu: 1.295 ± 0.324
1.413MetPhe: 1.413 ± 0.346
1.06MetGly: 1.06 ± 0.282
0.294MetHis: 0.294 ± 0.128
1.825MetIle: 1.825 ± 0.439
1.59MetLys: 1.59 ± 0.377
2.002MetLeu: 2.002 ± 0.42
0.53MetMet: 0.53 ± 0.206
2.002MetAsn: 2.002 ± 0.349
1.119MetPro: 1.119 ± 0.339
0.883MetGln: 0.883 ± 0.216
1.413MetArg: 1.413 ± 0.324
1.236MetSer: 1.236 ± 0.278
1.413MetThr: 1.413 ± 0.281
1.59MetVal: 1.59 ± 0.297
0.177MetTrp: 0.177 ± 0.098
0.53MetTyr: 0.53 ± 0.171
0.0MetXaa: 0.0 ± 0.0
Asn
4.004AsnAla: 4.004 ± 0.48
0.942AsnCys: 0.942 ± 0.225
3.062AsnAsp: 3.062 ± 0.53
3.886AsnGlu: 3.886 ± 0.45
4.298AsnPhe: 4.298 ± 0.811
4.592AsnGly: 4.592 ± 0.701
0.883AsnHis: 0.883 ± 0.243
7.418AsnIle: 7.418 ± 1.525
3.591AsnLys: 3.591 ± 0.455
5.593AsnLeu: 5.593 ± 0.629
1.295AsnMet: 1.295 ± 0.193
6.888AsnAsn: 6.888 ± 1.972
1.766AsnPro: 1.766 ± 0.343
3.238AsnGln: 3.238 ± 0.378
2.532AsnArg: 2.532 ± 0.359
3.827AsnSer: 3.827 ± 0.718
5.77AsnThr: 5.77 ± 0.917
5.063AsnVal: 5.063 ± 0.866
0.824AsnTrp: 0.824 ± 0.257
3.474AsnTyr: 3.474 ± 0.489
0.0AsnXaa: 0.0 ± 0.0
Pro
1.236ProAla: 1.236 ± 0.268
0.471ProCys: 0.471 ± 0.131
1.119ProAsp: 1.119 ± 0.258
1.236ProGlu: 1.236 ± 0.284
1.884ProPhe: 1.884 ± 0.302
0.471ProGly: 0.471 ± 0.185
0.707ProHis: 0.707 ± 0.218
1.943ProIle: 1.943 ± 0.372
2.061ProLys: 2.061 ± 0.438
3.003ProLeu: 3.003 ± 0.396
0.236ProMet: 0.236 ± 0.094
2.178ProAsn: 2.178 ± 0.394
1.413ProPro: 1.413 ± 0.442
1.295ProGln: 1.295 ± 0.328
1.236ProArg: 1.236 ± 0.314
2.061ProSer: 2.061 ± 0.398
2.237ProThr: 2.237 ± 0.407
1.707ProVal: 1.707 ± 0.331
0.236ProTrp: 0.236 ± 0.118
1.531ProTyr: 1.531 ± 0.294
0.0ProXaa: 0.0 ± 0.0
Gln
2.178GlnAla: 2.178 ± 0.59
0.648GlnCys: 0.648 ± 0.232
2.178GlnAsp: 2.178 ± 0.458
2.591GlnGlu: 2.591 ± 0.479
1.884GlnPhe: 1.884 ± 0.313
2.237GlnGly: 2.237 ± 0.331
0.412GlnHis: 0.412 ± 0.168
3.709GlnIle: 3.709 ± 0.428
2.649GlnLys: 2.649 ± 0.632
2.885GlnLeu: 2.885 ± 0.515
0.883GlnMet: 0.883 ± 0.291
2.178GlnAsn: 2.178 ± 0.326
1.649GlnPro: 1.649 ± 0.403
2.591GlnGln: 2.591 ± 0.633
2.002GlnArg: 2.002 ± 0.332
3.238GlnSer: 3.238 ± 0.47
3.003GlnThr: 3.003 ± 0.518
1.707GlnVal: 1.707 ± 0.436
0.471GlnTrp: 0.471 ± 0.191
1.413GlnTyr: 1.413 ± 0.256
0.0GlnXaa: 0.0 ± 0.0
Arg
1.825ArgAla: 1.825 ± 0.447
1.236ArgCys: 1.236 ± 0.327
1.884ArgAsp: 1.884 ± 0.324
2.532ArgGlu: 2.532 ± 0.554
1.825ArgPhe: 1.825 ± 0.262
2.414ArgGly: 2.414 ± 0.388
0.353ArgHis: 0.353 ± 0.154
1.707ArgIle: 1.707 ± 0.299
3.945ArgLys: 3.945 ± 0.739
3.356ArgLeu: 3.356 ± 0.452
1.354ArgMet: 1.354 ± 0.31
2.178ArgAsn: 2.178 ± 0.274
0.824ArgPro: 0.824 ± 0.209
1.354ArgGln: 1.354 ± 0.304
1.884ArgArg: 1.884 ± 0.36
1.825ArgSer: 1.825 ± 0.386
2.708ArgThr: 2.708 ± 0.376
1.884ArgVal: 1.884 ± 0.348
0.589ArgTrp: 0.589 ± 0.172
1.413ArgTyr: 1.413 ± 0.284
0.0ArgXaa: 0.0 ± 0.0
Ser
5.417SerAla: 5.417 ± 0.693
1.59SerCys: 1.59 ± 0.401
3.591SerAsp: 3.591 ± 0.429
3.12SerGlu: 3.12 ± 0.495
3.886SerPhe: 3.886 ± 0.691
4.946SerGly: 4.946 ± 0.595
0.707SerHis: 0.707 ± 0.214
5.534SerIle: 5.534 ± 0.573
3.709SerLys: 3.709 ± 0.489
5.24SerLeu: 5.24 ± 0.636
1.295SerMet: 1.295 ± 0.333
4.651SerAsn: 4.651 ± 0.791
2.12SerPro: 2.12 ± 0.363
2.591SerGln: 2.591 ± 0.305
2.591SerArg: 2.591 ± 0.315
6.535SerSer: 6.535 ± 1.183
5.593SerThr: 5.593 ± 0.803
4.062SerVal: 4.062 ± 0.482
0.824SerTrp: 0.824 ± 0.238
3.591SerTyr: 3.591 ± 0.575
0.0SerXaa: 0.0 ± 0.0
Thr
4.533ThrAla: 4.533 ± 0.651
0.707ThrCys: 0.707 ± 0.184
3.238ThrAsp: 3.238 ± 0.389
2.473ThrGlu: 2.473 ± 0.495
4.121ThrPhe: 4.121 ± 0.603
5.358ThrGly: 5.358 ± 0.7
1.06ThrHis: 1.06 ± 0.222
7.477ThrIle: 7.477 ± 0.692
3.179ThrLys: 3.179 ± 0.478
5.829ThrLeu: 5.829 ± 0.735
1.178ThrMet: 1.178 ± 0.201
5.534ThrAsn: 5.534 ± 0.868
2.885ThrPro: 2.885 ± 0.576
3.003ThrGln: 3.003 ± 0.494
2.12ThrArg: 2.12 ± 0.337
4.887ThrSer: 4.887 ± 0.582
6.83ThrThr: 6.83 ± 0.897
4.946ThrVal: 4.946 ± 0.927
0.294ThrTrp: 0.294 ± 0.122
3.474ThrTyr: 3.474 ± 0.43
0.0ThrXaa: 0.0 ± 0.0
Val
4.357ValAla: 4.357 ± 0.474
1.119ValCys: 1.119 ± 0.269
3.12ValAsp: 3.12 ± 0.436
2.944ValGlu: 2.944 ± 0.548
2.649ValPhe: 2.649 ± 0.412
3.415ValGly: 3.415 ± 0.411
0.471ValHis: 0.471 ± 0.174
5.122ValIle: 5.122 ± 0.514
4.062ValLys: 4.062 ± 0.655
6.476ValLeu: 6.476 ± 0.833
1.354ValMet: 1.354 ± 0.364
3.474ValAsn: 3.474 ± 0.364
2.296ValPro: 2.296 ± 0.386
2.532ValGln: 2.532 ± 0.399
1.354ValArg: 1.354 ± 0.288
4.416ValSer: 4.416 ± 0.545
4.887ValThr: 4.887 ± 0.57
5.24ValVal: 5.24 ± 0.919
1.472ValTrp: 1.472 ± 0.238
2.708ValTyr: 2.708 ± 0.373
0.0ValXaa: 0.0 ± 0.0
Trp
0.53TrpAla: 0.53 ± 0.19
0.118TrpCys: 0.118 ± 0.091
0.589TrpAsp: 0.589 ± 0.158
0.412TrpGlu: 0.412 ± 0.171
0.707TrpPhe: 0.707 ± 0.207
0.707TrpGly: 0.707 ± 0.187
0.177TrpHis: 0.177 ± 0.1
1.178TrpIle: 1.178 ± 0.299
0.824TrpLys: 0.824 ± 0.214
1.295TrpLeu: 1.295 ± 0.286
0.236TrpMet: 0.236 ± 0.101
0.824TrpAsn: 0.824 ± 0.253
0.059TrpPro: 0.059 ± 0.053
0.471TrpGln: 0.471 ± 0.163
0.412TrpArg: 0.412 ± 0.15
1.001TrpSer: 1.001 ± 0.233
0.765TrpThr: 0.765 ± 0.272
1.06TrpVal: 1.06 ± 0.294
0.236TrpTrp: 0.236 ± 0.125
0.942TrpTyr: 0.942 ± 0.202
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.532TyrAla: 2.532 ± 0.391
0.942TyrCys: 0.942 ± 0.245
2.061TyrAsp: 2.061 ± 0.303
2.061TyrGlu: 2.061 ± 0.335
2.944TyrPhe: 2.944 ± 0.425
2.826TyrGly: 2.826 ± 0.399
0.648TyrHis: 0.648 ± 0.204
4.121TyrIle: 4.121 ± 0.448
2.414TyrLys: 2.414 ± 0.354
4.357TyrLeu: 4.357 ± 0.581
1.06TyrMet: 1.06 ± 0.226
4.416TyrAsn: 4.416 ± 0.76
1.649TyrPro: 1.649 ± 0.35
1.707TyrGln: 1.707 ± 0.285
1.825TyrArg: 1.825 ± 0.303
3.238TyrSer: 3.238 ± 0.469
2.826TyrThr: 2.826 ± 0.416
3.356TyrVal: 3.356 ± 0.394
0.589TyrTrp: 0.589 ± 0.174
2.355TyrTyr: 2.355 ± 0.317
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (16986 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski