Amino acid dipepetide frequency for Thalassobacter sp. 16PALIMAR09

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.455AlaAla: 16.455 ± 0.192	1.178AlaCys: 1.178 ± 0.04	7.299AlaAsp: 7.299 ± 0.099	7.937AlaGlu: 7.937 ± 0.109	4.454AlaPhe: 4.454 ± 0.072	10.314AlaGly: 10.314 ± 0.137	2.421AlaHis: 2.421 ± 0.054	6.117AlaIle: 6.117 ± 0.087	3.931AlaLys: 3.931 ± 0.08	13.474AlaLeu: 13.474 ± 0.146	3.799AlaMet: 3.799 ± 0.064	3.108AlaAsn: 3.108 ± 0.072	6.22AlaPro: 6.22 ± 0.113	5.233AlaGln: 5.233 ± 0.092	8.352AlaArg: 8.352 ± 0.116	6.016AlaSer: 6.016 ± 0.102	6.755AlaThr: 6.755 ± 0.114	8.489AlaVal: 8.489 ± 0.099	1.468AlaTrp: 1.468 ± 0.037	2.451AlaTyr: 2.451 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.216CysAla: 1.216 ± 0.043	0.104CysCys: 0.104 ± 0.01	0.571CysAsp: 0.571 ± 0.026	0.449CysGlu: 0.449 ± 0.021	0.333CysPhe: 0.333 ± 0.02	0.912CysGly: 0.912 ± 0.032	0.253CysHis: 0.253 ± 0.018	0.439CysIle: 0.439 ± 0.023	0.23CysLys: 0.23 ± 0.016	0.85CysLeu: 0.85 ± 0.028	0.192CysMet: 0.192 ± 0.014	0.234CysAsn: 0.234 ± 0.016	0.51CysPro: 0.51 ± 0.025	0.232CysGln: 0.232 ± 0.014	0.466CysArg: 0.466 ± 0.024	0.451CysSer: 0.451 ± 0.022	0.498CysThr: 0.498 ± 0.025	0.701CysVal: 0.701 ± 0.028	0.1CysTrp: 0.1 ± 0.01	0.197CysTyr: 0.197 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.089AspAla: 8.089 ± 0.094	0.474AspCys: 0.474 ± 0.023	3.311AspAsp: 3.311 ± 0.072	3.188AspGlu: 3.188 ± 0.065	2.188AspPhe: 2.188 ± 0.047	5.437AspGly: 5.437 ± 0.133	1.315AspHis: 1.315 ± 0.042	3.384AspIle: 3.384 ± 0.078	1.561AspLys: 1.561 ± 0.044	6.343AspLeu: 6.343 ± 0.092	1.749AspMet: 1.749 ± 0.041	1.333AspAsn: 1.333 ± 0.04	3.502AspPro: 3.502 ± 0.07	1.956AspGln: 1.956 ± 0.045	3.762AspArg: 3.762 ± 0.063	2.021AspSer: 2.021 ± 0.047	3.455AspThr: 3.455 ± 0.071	4.748AspVal: 4.748 ± 0.109	1.102AspTrp: 1.102 ± 0.032	1.471AspTyr: 1.471 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.219GluAla: 8.219 ± 0.115	0.363GluCys: 0.363 ± 0.02	3.222GluAsp: 3.222 ± 0.062	2.935GluGlu: 2.935 ± 0.069	1.682GluPhe: 1.682 ± 0.047	4.644GluGly: 4.644 ± 0.072	1.14GluHis: 1.14 ± 0.039	3.661GluIle: 3.661 ± 0.064	1.927GluLys: 1.927 ± 0.05	4.903GluLeu: 4.903 ± 0.077	1.903GluMet: 1.903 ± 0.051	1.687GluAsn: 1.687 ± 0.041	2.371GluPro: 2.371 ± 0.062	1.978GluGln: 1.978 ± 0.041	3.866GluArg: 3.866 ± 0.074	1.9GluSer: 1.9 ± 0.042	3.942GluThr: 3.942 ± 0.074	4.554GluVal: 4.554 ± 0.079	0.752GluTrp: 0.752 ± 0.031	1.008GluTyr: 1.008 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.546PheAla: 4.546 ± 0.068	0.445PheCys: 0.445 ± 0.023	2.809PheAsp: 2.809 ± 0.049	2.36PheGlu: 2.36 ± 0.051	1.453PhePhe: 1.453 ± 0.045	3.65PheGly: 3.65 ± 0.063	0.664PheHis: 0.664 ± 0.026	1.662PheIle: 1.662 ± 0.048	0.972PheLys: 0.972 ± 0.029	3.235PheLeu: 3.235 ± 0.071	0.901PheMet: 0.901 ± 0.031	1.067PheAsn: 1.067 ± 0.032	1.512PhePro: 1.512 ± 0.045	1.036PheGln: 1.036 ± 0.035	1.852PheArg: 1.852 ± 0.045	2.078PheSer: 2.078 ± 0.047	2.236PheThr: 2.236 ± 0.05	2.818PheVal: 2.818 ± 0.057	0.523PheTrp: 0.523 ± 0.024	0.911PheTyr: 0.911 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.305GlyAla: 10.305 ± 0.151	0.847GlyCys: 0.847 ± 0.032	4.73GlyAsp: 4.73 ± 0.136	4.249GlyGlu: 4.249 ± 0.066	3.707GlyPhe: 3.707 ± 0.061	7.393GlyGly: 7.393 ± 0.15	1.896GlyHis: 1.896 ± 0.043	4.352GlyIle: 4.352 ± 0.077	2.98GlyLys: 2.98 ± 0.064	9.215GlyLeu: 9.215 ± 0.106	2.603GlyMet: 2.603 ± 0.053	2.158GlyAsn: 2.158 ± 0.089	3.658GlyPro: 3.658 ± 0.066	3.23GlyGln: 3.23 ± 0.072	5.114GlyArg: 5.114 ± 0.073	4.222GlySer: 4.222 ± 0.124	5.342GlyThr: 5.342 ± 0.121	6.687GlyVal: 6.687 ± 0.094	1.35GlyTrp: 1.35 ± 0.039	2.268GlyTyr: 2.268 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.38HisAla: 2.38 ± 0.052	0.227HisCys: 0.227 ± 0.014	1.184HisAsp: 1.184 ± 0.034	1.013HisGlu: 1.013 ± 0.034	0.766HisPhe: 0.766 ± 0.03	1.827HisGly: 1.827 ± 0.054	0.565HisHis: 0.565 ± 0.034	1.021HisIle: 1.021 ± 0.037	0.555HisLys: 0.555 ± 0.023	2.009HisLeu: 2.009 ± 0.043	0.568HisMet: 0.568 ± 0.026	0.482HisAsn: 0.482 ± 0.02	1.294HisPro: 1.294 ± 0.048	0.558HisGln: 0.558 ± 0.03	1.19HisArg: 1.19 ± 0.038	0.971HisSer: 0.971 ± 0.03	0.997HisThr: 0.997 ± 0.031	1.533HisVal: 1.533 ± 0.041	0.347HisTrp: 0.347 ± 0.017	0.539HisTyr: 0.539 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.178IleAla: 7.178 ± 0.095	0.606IleCys: 0.606 ± 0.024	3.493IleAsp: 3.493 ± 0.077	3.515IleGlu: 3.515 ± 0.066	1.685IlePhe: 1.685 ± 0.051	4.775IleGly: 4.775 ± 0.082	0.896IleHis: 0.896 ± 0.033	2.377IleIle: 2.377 ± 0.057	1.629IleLys: 1.629 ± 0.04	4.574IleLeu: 4.574 ± 0.073	1.211IleMet: 1.211 ± 0.041	1.5IleAsn: 1.5 ± 0.048	2.362IlePro: 2.362 ± 0.049	1.294IleGln: 1.294 ± 0.037	2.874IleArg: 2.874 ± 0.056	3.144IleSer: 3.144 ± 0.067	3.417IleThr: 3.417 ± 0.087	3.872IleVal: 3.872 ± 0.073	0.691IleTrp: 0.691 ± 0.03	1.13IleTyr: 1.13 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.888LysAla: 3.888 ± 0.077	0.193LysCys: 0.193 ± 0.015	1.833LysAsp: 1.833 ± 0.048	1.427LysGlu: 1.427 ± 0.04	0.91LysPhe: 0.91 ± 0.033	2.674LysGly: 2.674 ± 0.064	0.61LysHis: 0.61 ± 0.025	1.678LysIle: 1.678 ± 0.044	1.139LysLys: 1.139 ± 0.042	3.049LysLeu: 3.049 ± 0.055	0.881LysMet: 0.881 ± 0.031	0.732LysAsn: 0.732 ± 0.026	1.785LysPro: 1.785 ± 0.055	0.918LysGln: 0.918 ± 0.028	2.215LysArg: 2.215 ± 0.064	1.96LysSer: 1.96 ± 0.051	1.959LysThr: 1.959 ± 0.052	2.259LysVal: 2.259 ± 0.053	0.406LysTrp: 0.406 ± 0.017	0.612LysTyr: 0.612 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.207LeuAla: 12.207 ± 0.166	0.985LeuCys: 0.985 ± 0.04	5.843LeuAsp: 5.843 ± 0.084	5.584LeuGlu: 5.584 ± 0.075	3.301LeuPhe: 3.301 ± 0.073	8.463LeuGly: 8.463 ± 0.101	1.854LeuHis: 1.854 ± 0.048	5.018LeuIle: 5.018 ± 0.087	3.12LeuLys: 3.12 ± 0.066	8.346LeuLeu: 8.346 ± 0.134	2.774LeuMet: 2.774 ± 0.061	2.886LeuAsn: 2.886 ± 0.058	5.345LeuPro: 5.345 ± 0.085	2.844LeuGln: 2.844 ± 0.055	6.768LeuArg: 6.768 ± 0.095	6.764LeuSer: 6.764 ± 0.123	6.197LeuThr: 6.197 ± 0.135	6.623LeuVal: 6.623 ± 0.092	1.321LeuTrp: 1.321 ± 0.042	1.93LeuTyr: 1.93 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.647MetAla: 3.647 ± 0.063	0.228MetCys: 0.228 ± 0.016	1.563MetAsp: 1.563 ± 0.041	1.376MetGlu: 1.376 ± 0.034	0.825MetPhe: 0.825 ± 0.029	2.355MetGly: 2.355 ± 0.059	0.491MetHis: 0.491 ± 0.024	1.573MetIle: 1.573 ± 0.036	0.947MetLys: 0.947 ± 0.035	2.623MetLeu: 2.623 ± 0.051	0.845MetMet: 0.845 ± 0.036	0.856MetAsn: 0.856 ± 0.028	1.512MetPro: 1.512 ± 0.041	1.031MetGln: 1.031 ± 0.036	1.858MetArg: 1.858 ± 0.053	1.873MetSer: 1.873 ± 0.039	2.161MetThr: 2.161 ± 0.044	1.95MetVal: 1.95 ± 0.047	0.286MetTrp: 0.286 ± 0.016	0.369MetTyr: 0.369 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.49AsnAla: 3.49 ± 0.069	0.264AsnCys: 0.264 ± 0.02	1.473AsnAsp: 1.473 ± 0.042	1.227AsnGlu: 1.227 ± 0.036	0.956AsnPhe: 0.956 ± 0.03	2.481AsnGly: 2.481 ± 0.076	0.507AsnHis: 0.507 ± 0.022	1.468AsnIle: 1.468 ± 0.037	0.743AsnLys: 0.743 ± 0.029	2.604AsnLeu: 2.604 ± 0.055	0.745AsnMet: 0.745 ± 0.027	0.756AsnAsn: 0.756 ± 0.03	1.938AsnPro: 1.938 ± 0.04	0.77AsnGln: 0.77 ± 0.029	1.638AsnArg: 1.638 ± 0.041	1.256AsnSer: 1.256 ± 0.04	1.656AsnThr: 1.656 ± 0.047	2.083AsnVal: 2.083 ± 0.071	0.467AsnTrp: 0.467 ± 0.02	0.637AsnTyr: 0.637 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.543ProAla: 5.543 ± 0.095	0.394ProCys: 0.394 ± 0.019	3.63ProAsp: 3.63 ± 0.063	3.966ProGlu: 3.966 ± 0.072	1.978ProPhe: 1.978 ± 0.054	4.241ProGly: 4.241 ± 0.076	1.034ProHis: 1.034 ± 0.038	2.476ProIle: 2.476 ± 0.055	1.814ProLys: 1.814 ± 0.05	4.61ProLeu: 4.61 ± 0.086	1.348ProMet: 1.348 ± 0.042	1.573ProAsn: 1.573 ± 0.041	2.143ProPro: 2.143 ± 0.067	1.749ProGln: 1.749 ± 0.046	2.617ProArg: 2.617 ± 0.06	2.676ProSer: 2.676 ± 0.057	2.8ProThr: 2.8 ± 0.06	4.045ProVal: 4.045 ± 0.077	0.644ProTrp: 0.644 ± 0.027	1.056ProTyr: 1.056 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.221GlnAla: 4.221 ± 0.063	0.23GlnCys: 0.23 ± 0.015	1.892GlnAsp: 1.892 ± 0.039	1.677GlnGlu: 1.677 ± 0.041	1.133GlnPhe: 1.133 ± 0.032	2.693GlnGly: 2.693 ± 0.056	0.563GlnHis: 0.563 ± 0.025	2.133GlnIle: 2.133 ± 0.042	1.09GlnLys: 1.09 ± 0.035	2.929GlnLeu: 2.929 ± 0.058	1.223GlnMet: 1.223 ± 0.035	0.996GlnAsn: 0.996 ± 0.031	1.605GlnPro: 1.605 ± 0.04	1.105GlnGln: 1.105 ± 0.036	2.077GlnArg: 2.077 ± 0.051	2.055GlnSer: 2.055 ± 0.05	2.167GlnThr: 2.167 ± 0.05	2.519GlnVal: 2.519 ± 0.047	0.377GlnTrp: 0.377 ± 0.017	0.601GlnTyr: 0.601 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.068ArgAla: 8.068 ± 0.128	0.44ArgCys: 0.44 ± 0.02	4.07ArgAsp: 4.07 ± 0.065	3.443ArgGlu: 3.443 ± 0.068	2.482ArgPhe: 2.482 ± 0.047	4.393ArgGly: 4.393 ± 0.076	1.322ArgHis: 1.322 ± 0.043	3.41ArgIle: 3.41 ± 0.057	2.135ArgLys: 2.135 ± 0.058	6.456ArgLeu: 6.456 ± 0.108	1.785ArgMet: 1.785 ± 0.043	1.657ArgAsn: 1.657 ± 0.043	2.936ArgPro: 2.936 ± 0.057	2.03ArgGln: 2.03 ± 0.045	4.17ArgArg: 4.17 ± 0.094	3.091ArgSer: 3.091 ± 0.057	3.266ArgThr: 3.266 ± 0.058	4.696ArgVal: 4.696 ± 0.072	0.861ArgTrp: 0.861 ± 0.029	1.409ArgTyr: 1.409 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.078SerAla: 6.078 ± 0.127	0.422SerCys: 0.422 ± 0.02	3.442SerAsp: 3.442 ± 0.078	3.022SerGlu: 3.022 ± 0.051	2.199SerPhe: 2.199 ± 0.047	5.486SerGly: 5.486 ± 0.154	1.023SerHis: 1.023 ± 0.029	2.591SerIle: 2.591 ± 0.071	1.609SerLys: 1.609 ± 0.04	5.003SerLeu: 5.003 ± 0.097	1.479SerMet: 1.479 ± 0.04	1.498SerAsn: 1.498 ± 0.044	2.469SerPro: 2.469 ± 0.065	1.767SerGln: 1.767 ± 0.038	2.991SerArg: 2.991 ± 0.052	2.673SerSer: 2.673 ± 0.065	2.823SerThr: 2.823 ± 0.07	4.161SerVal: 4.161 ± 0.091	0.637SerTrp: 0.637 ± 0.026	1.278SerTyr: 1.278 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.971ThrAla: 6.971 ± 0.137	0.543ThrCys: 0.543 ± 0.027	3.378ThrAsp: 3.378 ± 0.085	2.983ThrGlu: 2.983 ± 0.054	2.276ThrPhe: 2.276 ± 0.051	5.767ThrGly: 5.767 ± 0.145	1.311ThrHis: 1.311 ± 0.035	2.916ThrIle: 2.916 ± 0.075	1.665ThrLys: 1.665 ± 0.046	6.758ThrLeu: 6.758 ± 0.138	1.382ThrMet: 1.382 ± 0.036	1.508ThrAsn: 1.508 ± 0.056	3.878ThrPro: 3.878 ± 0.058	2.012ThrGln: 2.012 ± 0.043	3.573ThrArg: 3.573 ± 0.064	3.171ThrSer: 3.171 ± 0.076	3.381ThrThr: 3.381 ± 0.102	4.588ThrVal: 4.588 ± 0.122	0.724ThrTrp: 0.724 ± 0.025	1.404ThrTyr: 1.404 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.967ValAla: 8.967 ± 0.101	0.648ValCys: 0.648 ± 0.03	4.321ValAsp: 4.321 ± 0.104	4.456ValGlu: 4.456 ± 0.075	2.916ValPhe: 2.916 ± 0.053	5.737ValGly: 5.737 ± 0.073	1.354ValHis: 1.354 ± 0.042	4.274ValIle: 4.274 ± 0.074	2.097ValLys: 2.097 ± 0.049	7.56ValLeu: 7.56 ± 0.095	2.078ValMet: 2.078 ± 0.044	2.11ValAsn: 2.11 ± 0.055	3.685ValPro: 3.685 ± 0.072	2.283ValGln: 2.283 ± 0.057	4.327ValArg: 4.327 ± 0.067	4.451ValSer: 4.451 ± 0.092	5.139ValThr: 5.139 ± 0.126	5.842ValVal: 5.842 ± 0.088	0.95ValTrp: 0.95 ± 0.034	1.503ValTyr: 1.503 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.41TrpAla: 1.41 ± 0.038	0.135TrpCys: 0.135 ± 0.011	0.791TrpAsp: 0.791 ± 0.028	0.66TrpGlu: 0.66 ± 0.027	0.589TrpPhe: 0.589 ± 0.03	1.026TrpGly: 1.026 ± 0.036	0.303TrpHis: 0.303 ± 0.018	0.684TrpIle: 0.684 ± 0.026	0.404TrpLys: 0.404 ± 0.02	1.56TrpLeu: 1.56 ± 0.042	0.389TrpMet: 0.389 ± 0.019	0.41TrpAsn: 0.41 ± 0.016	0.636TrpPro: 0.636 ± 0.03	0.581TrpGln: 0.581 ± 0.024	1.029TrpArg: 1.029 ± 0.031	0.761TrpSer: 0.761 ± 0.027	0.765TrpThr: 0.765 ± 0.03	0.983TrpVal: 0.983 ± 0.032	0.242TrpTrp: 0.242 ± 0.015	0.247TrpTyr: 0.247 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.593TyrAla: 2.593 ± 0.05	0.211TyrCys: 0.211 ± 0.014	1.533TyrAsp: 1.533 ± 0.035	1.19TyrGlu: 1.19 ± 0.034	0.895TyrPhe: 0.895 ± 0.028	2.039TyrGly: 2.039 ± 0.045	0.505TyrHis: 0.505 ± 0.023	0.989TyrIle: 0.989 ± 0.026	0.582TyrLys: 0.582 ± 0.024	2.074TyrLeu: 2.074 ± 0.043	0.512TyrMet: 0.512 ± 0.025	0.607TyrAsn: 0.607 ± 0.025	0.977TyrPro: 0.977 ± 0.034	0.679TyrGln: 0.679 ± 0.028	1.382TyrArg: 1.382 ± 0.044	1.119TyrSer: 1.119 ± 0.033	1.233TyrThr: 1.233 ± 0.037	1.545TyrVal: 1.545 ± 0.038	0.356TyrTrp: 0.356 ± 0.019	0.527TyrTyr: 0.527 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3345 proteins (1055750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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