Amino acid dipepetide frequency for Streptomyces qinglanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.399AlaAla: 24.399 ± 0.206	1.078AlaCys: 1.078 ± 0.028	8.721AlaAsp: 8.721 ± 0.08	9.992AlaGlu: 9.992 ± 0.102	3.369AlaPhe: 3.369 ± 0.042	14.448AlaGly: 14.448 ± 0.13	3.022AlaHis: 3.022 ± 0.044	2.528AlaIle: 2.528 ± 0.041	2.52AlaLys: 2.52 ± 0.048	15.158AlaLeu: 15.158 ± 0.134	2.321AlaMet: 2.321 ± 0.043	1.608AlaAsn: 1.608 ± 0.033	8.097AlaPro: 8.097 ± 0.113	3.756AlaGln: 3.756 ± 0.049	11.486AlaArg: 11.486 ± 0.101	5.533AlaSer: 5.533 ± 0.059	6.433AlaThr: 6.433 ± 0.069	12.441AlaVal: 12.441 ± 0.12	1.754AlaTrp: 1.754 ± 0.037	2.458AlaTyr: 2.458 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.197CysAla: 1.197 ± 0.033	0.108CysCys: 0.108 ± 0.008	0.439CysAsp: 0.439 ± 0.018	0.421CysGlu: 0.421 ± 0.017	0.242CysPhe: 0.242 ± 0.014	0.993CysGly: 0.993 ± 0.026	0.176CysHis: 0.176 ± 0.009	0.159CysIle: 0.159 ± 0.01	0.1CysLys: 0.1 ± 0.007	0.718CysLeu: 0.718 ± 0.021	0.122CysMet: 0.122 ± 0.008	0.115CysAsn: 0.115 ± 0.009	0.486CysPro: 0.486 ± 0.019	0.174CysGln: 0.174 ± 0.011	0.653CysArg: 0.653 ± 0.022	0.416CysSer: 0.416 ± 0.014	0.532CysThr: 0.532 ± 0.017	0.704CysVal: 0.704 ± 0.023	0.133CysTrp: 0.133 ± 0.01	0.166CysTyr: 0.166 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.666AspAla: 7.666 ± 0.073	0.405AspCys: 0.405 ± 0.015	3.106AspAsp: 3.106 ± 0.05	3.937AspGlu: 3.937 ± 0.053	1.598AspPhe: 1.598 ± 0.033	6.618AspGly: 6.618 ± 0.069	1.311AspHis: 1.311 ± 0.028	1.745AspIle: 1.745 ± 0.037	1.081AspLys: 1.081 ± 0.028	5.689AspLeu: 5.689 ± 0.061	0.82AspMet: 0.82 ± 0.022	0.806AspAsn: 0.806 ± 0.022	4.796AspPro: 4.796 ± 0.079	1.408AspGln: 1.408 ± 0.031	5.074AspArg: 5.074 ± 0.058	2.688AspSer: 2.688 ± 0.043	2.979AspThr: 2.979 ± 0.047	4.187AspVal: 4.187 ± 0.052	0.942AspTrp: 0.942 ± 0.025	1.05AspTyr: 1.05 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	8.04GluAla: 8.04 ± 0.096	0.401GluCys: 0.401 ± 0.015	3.058GluAsp: 3.058 ± 0.046	4.239GluGlu: 4.239 ± 0.078	1.372GluPhe: 1.372 ± 0.027	4.864GluGly: 4.864 ± 0.051	1.628GluHis: 1.628 ± 0.029	2.048GluIle: 2.048 ± 0.034	1.511GluLys: 1.511 ± 0.038	7.28GluLeu: 7.28 ± 0.082	0.958GluMet: 0.958 ± 0.025	0.979GluAsn: 0.979 ± 0.023	3.867GluPro: 3.867 ± 0.062	2.552GluGln: 2.552 ± 0.051	6.12GluArg: 6.12 ± 0.072	2.759GluSer: 2.759 ± 0.047	2.912GluThr: 2.912 ± 0.044	4.601GluVal: 4.601 ± 0.064	0.768GluTrp: 0.768 ± 0.019	1.05GluTyr: 1.05 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.713PheAla: 3.713 ± 0.049	0.274PheCys: 0.274 ± 0.013	1.808PheAsp: 1.808 ± 0.032	1.417PheGlu: 1.417 ± 0.033	0.865PhePhe: 0.865 ± 0.025	2.986PheGly: 2.986 ± 0.044	0.583PheHis: 0.583 ± 0.017	0.612PheIle: 0.612 ± 0.018	0.442PheLys: 0.442 ± 0.017	2.598PheLeu: 2.598 ± 0.04	0.38PheMet: 0.38 ± 0.014	0.513PheAsn: 0.513 ± 0.02	1.329PhePro: 1.329 ± 0.029	0.635PheGln: 0.635 ± 0.021	1.846PheArg: 1.846 ± 0.034	1.357PheSer: 1.357 ± 0.031	1.823PheThr: 1.823 ± 0.039	2.142PheVal: 2.142 ± 0.04	0.401PheTrp: 0.401 ± 0.017	0.49PheTyr: 0.49 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	12.544GlyAla: 12.544 ± 0.127	0.901GlyCys: 0.901 ± 0.026	5.238GlyAsp: 5.238 ± 0.059	5.692GlyGlu: 5.692 ± 0.052	2.799GlyPhe: 2.799 ± 0.043	10.043GlyGly: 10.043 ± 0.116	2.377GlyHis: 2.377 ± 0.045	3.176GlyIle: 3.176 ± 0.052	2.426GlyLys: 2.426 ± 0.054	9.538GlyLeu: 9.538 ± 0.084	2.132GlyMet: 2.132 ± 0.037	1.671GlyAsn: 1.671 ± 0.039	6.172GlyPro: 6.172 ± 0.082	2.733GlyGln: 2.733 ± 0.052	8.304GlyArg: 8.304 ± 0.082	5.849GlySer: 5.849 ± 0.065	6.751GlyThr: 6.751 ± 0.069	7.456GlyVal: 7.456 ± 0.073	1.665GlyTrp: 1.665 ± 0.038	2.28GlyTyr: 2.28 ± 0.045	0.001GlyXaa: 0.001 ± 0.001
His	2.739HisAla: 2.739 ± 0.036	0.23HisCys: 0.23 ± 0.011	1.285HisAsp: 1.285 ± 0.029	1.265HisGlu: 1.265 ± 0.025	0.62HisPhe: 0.62 ± 0.018	2.573HisGly: 2.573 ± 0.044	0.681HisHis: 0.681 ± 0.022	0.615HisIle: 0.615 ± 0.019	0.333HisLys: 0.333 ± 0.015	2.41HisLeu: 2.41 ± 0.042	0.319HisMet: 0.319 ± 0.013	0.359HisAsn: 0.359 ± 0.017	1.941HisPro: 1.941 ± 0.037	0.657HisGln: 0.657 ± 0.02	2.298HisArg: 2.298 ± 0.039	1.066HisSer: 1.066 ± 0.026	1.417HisThr: 1.417 ± 0.032	1.547HisVal: 1.547 ± 0.031	0.354HisTrp: 0.354 ± 0.015	0.48HisTyr: 0.48 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.928IleAla: 3.928 ± 0.051	0.245IleCys: 0.245 ± 0.012	1.825IleAsp: 1.825 ± 0.041	1.747IleGlu: 1.747 ± 0.039	0.611IlePhe: 0.611 ± 0.02	3.059IleGly: 3.059 ± 0.049	0.497IleHis: 0.497 ± 0.017	0.687IleIle: 0.687 ± 0.026	0.619IleLys: 0.619 ± 0.025	2.045IleLeu: 2.045 ± 0.043	0.358IleMet: 0.358 ± 0.016	0.588IleAsn: 0.588 ± 0.019	1.563IlePro: 1.563 ± 0.032	0.604IleGln: 0.604 ± 0.017	2.046IleArg: 2.046 ± 0.038	1.496IleSer: 1.496 ± 0.03	1.708IleThr: 1.708 ± 0.035	2.282IleVal: 2.282 ± 0.047	0.314IleTrp: 0.314 ± 0.013	0.451IleTyr: 0.451 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.53LysAla: 2.53 ± 0.049	0.111LysCys: 0.111 ± 0.009	1.196LysAsp: 1.196 ± 0.034	1.145LysGlu: 1.145 ± 0.028	0.418LysPhe: 0.418 ± 0.017	1.764LysGly: 1.764 ± 0.046	0.42LysHis: 0.42 ± 0.017	0.681LysIle: 0.681 ± 0.021	0.912LysLys: 0.912 ± 0.038	1.947LysLeu: 1.947 ± 0.038	0.362LysMet: 0.362 ± 0.015	0.488LysAsn: 0.488 ± 0.02	1.203LysPro: 1.203 ± 0.028	0.727LysGln: 0.727 ± 0.027	1.461LysArg: 1.461 ± 0.031	1.073LysSer: 1.073 ± 0.028	1.096LysThr: 1.096 ± 0.032	1.622LysVal: 1.622 ± 0.038	0.235LysTrp: 0.235 ± 0.013	0.396LysTyr: 0.396 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.675LeuAla: 15.675 ± 0.131	0.91LeuCys: 0.91 ± 0.025	6.458LeuAsp: 6.458 ± 0.077	5.22LeuGlu: 5.22 ± 0.062	2.595LeuPhe: 2.595 ± 0.042	9.501LeuGly: 9.501 ± 0.093	2.426LeuHis: 2.426 ± 0.04	2.742LeuIle: 2.742 ± 0.051	1.748LeuLys: 1.748 ± 0.036	12.081LeuLeu: 12.081 ± 0.12	1.511LeuMet: 1.511 ± 0.03	1.504LeuAsn: 1.504 ± 0.036	6.787LeuPro: 6.787 ± 0.088	2.121LeuGln: 2.121 ± 0.039	9.33LeuArg: 9.33 ± 0.082	5.297LeuSer: 5.297 ± 0.058	6.555LeuThr: 6.555 ± 0.064	8.813LeuVal: 8.813 ± 0.093	1.233LeuTrp: 1.233 ± 0.026	1.739LeuTyr: 1.739 ± 0.033	0.001LeuXaa: 0.001 ± 0.001
Met	2.231MetAla: 2.231 ± 0.036	0.143MetCys: 0.143 ± 0.009	0.857MetAsp: 0.857 ± 0.021	0.749MetGlu: 0.749 ± 0.022	0.441MetPhe: 0.441 ± 0.018	1.287MetGly: 1.287 ± 0.029	0.351MetHis: 0.351 ± 0.013	0.562MetIle: 0.562 ± 0.018	0.366MetLys: 0.366 ± 0.014	1.709MetLeu: 1.709 ± 0.034	0.294MetMet: 0.294 ± 0.015	0.377MetAsn: 0.377 ± 0.016	1.119MetPro: 1.119 ± 0.024	0.433MetGln: 0.433 ± 0.015	1.438MetArg: 1.438 ± 0.026	1.264MetSer: 1.264 ± 0.029	1.306MetThr: 1.306 ± 0.033	1.259MetVal: 1.259 ± 0.029	0.201MetTrp: 0.201 ± 0.012	0.318MetTyr: 0.318 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	1.92AsnAla: 1.92 ± 0.036	0.154AsnCys: 0.154 ± 0.009	0.831AsnAsp: 0.831 ± 0.026	0.751AsnGlu: 0.751 ± 0.02	0.409AsnPhe: 0.409 ± 0.018	1.626AsnGly: 1.626 ± 0.036	0.328AsnHis: 0.328 ± 0.015	0.544AsnIle: 0.544 ± 0.02	0.372AsnLys: 0.372 ± 0.017	1.564AsnLeu: 1.564 ± 0.035	0.273AsnMet: 0.273 ± 0.013	0.326AsnAsn: 0.326 ± 0.014	1.233AsnPro: 1.233 ± 0.033	0.45AsnGln: 0.45 ± 0.017	1.211AsnArg: 1.211 ± 0.026	0.83AsnSer: 0.83 ± 0.022	0.938AsnThr: 0.938 ± 0.028	1.187AsnVal: 1.187 ± 0.026	0.267AsnTrp: 0.267 ± 0.013	0.358AsnTyr: 0.358 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.627ProAla: 9.627 ± 0.121	0.349ProCys: 0.349 ± 0.015	4.739ProAsp: 4.739 ± 0.058	4.974ProGlu: 4.974 ± 0.062	1.518ProPhe: 1.518 ± 0.026	7.935ProGly: 7.935 ± 0.102	1.591ProHis: 1.591 ± 0.031	0.962ProIle: 0.962 ± 0.027	1.011ProLys: 1.011 ± 0.028	5.511ProLeu: 5.511 ± 0.064	0.922ProMet: 0.922 ± 0.024	0.746ProAsn: 0.746 ± 0.02	4.042ProPro: 4.042 ± 0.077	2.032ProGln: 2.032 ± 0.05	4.509ProArg: 4.509 ± 0.055	3.233ProSer: 3.233 ± 0.057	2.806ProThr: 2.806 ± 0.049	5.408ProVal: 5.408 ± 0.074	0.883ProTrp: 0.883 ± 0.029	1.294ProTyr: 1.294 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.542GlnAla: 3.542 ± 0.051	0.168GlnCys: 0.168 ± 0.011	1.493GlnAsp: 1.493 ± 0.031	1.673GlnGlu: 1.673 ± 0.038	0.641GlnPhe: 0.641 ± 0.026	2.364GlnGly: 2.364 ± 0.041	0.758GlnHis: 0.758 ± 0.022	0.982GlnIle: 0.982 ± 0.03	0.535GlnLys: 0.535 ± 0.02	3.058GlnLeu: 3.058 ± 0.048	0.453GlnMet: 0.453 ± 0.016	0.424GlnAsn: 0.424 ± 0.016	1.914GlnPro: 1.914 ± 0.054	1.472GlnGln: 1.472 ± 0.048	2.531GlnArg: 2.531 ± 0.044	1.212GlnSer: 1.212 ± 0.027	1.179GlnThr: 1.179 ± 0.025	2.335GlnVal: 2.335 ± 0.041	0.392GlnTrp: 0.392 ± 0.015	0.544GlnTyr: 0.544 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.861ArgAla: 10.861 ± 0.109	0.647ArgCys: 0.647 ± 0.022	4.394ArgAsp: 4.394 ± 0.055	5.352ArgGlu: 5.352 ± 0.072	2.318ArgPhe: 2.318 ± 0.038	6.569ArgGly: 6.569 ± 0.069	2.203ArgHis: 2.203 ± 0.035	3.096ArgIle: 3.096 ± 0.047	1.787ArgLys: 1.787 ± 0.038	9.057ArgLeu: 9.057 ± 0.081	1.881ArgMet: 1.881 ± 0.031	1.401ArgAsn: 1.401 ± 0.032	5.245ArgPro: 5.245 ± 0.074	2.457ArgGln: 2.457 ± 0.045	8.352ArgArg: 8.352 ± 0.09	4.361ArgSer: 4.361 ± 0.054	6.025ArgThr: 6.025 ± 0.074	6.023ArgVal: 6.023 ± 0.058	1.39ArgTrp: 1.39 ± 0.031	1.854ArgTyr: 1.854 ± 0.031	0.001ArgXaa: 0.001 ± 0.0
Ser	7.147SerAla: 7.147 ± 0.068	0.402SerCys: 0.402 ± 0.016	2.611SerAsp: 2.611 ± 0.05	2.49SerGlu: 2.49 ± 0.052	1.525SerPhe: 1.525 ± 0.03	6.497SerGly: 6.497 ± 0.073	0.998SerHis: 0.998 ± 0.023	1.111SerIle: 1.111 ± 0.03	0.909SerLys: 0.909 ± 0.026	4.619SerLeu: 4.619 ± 0.058	1.0SerMet: 1.0 ± 0.023	0.743SerAsn: 0.743 ± 0.021	3.159SerPro: 3.159 ± 0.044	1.144SerGln: 1.144 ± 0.025	3.877SerArg: 3.877 ± 0.058	2.86SerSer: 2.86 ± 0.067	2.827SerThr: 2.827 ± 0.045	4.058SerVal: 4.058 ± 0.056	0.822SerTrp: 0.822 ± 0.023	1.154SerTyr: 1.154 ± 0.026	0.001SerXaa: 0.001 ± 0.0
Thr	8.806ThrAla: 8.806 ± 0.083	0.388ThrCys: 0.388 ± 0.018	3.299ThrAsp: 3.299 ± 0.045	3.227ThrGlu: 3.227 ± 0.051	1.479ThrPhe: 1.479 ± 0.034	6.917ThrGly: 6.917 ± 0.077	1.107ThrHis: 1.107 ± 0.028	1.276ThrIle: 1.276 ± 0.033	0.953ThrLys: 0.953 ± 0.026	5.547ThrLeu: 5.547 ± 0.061	0.841ThrMet: 0.841 ± 0.021	0.829ThrAsn: 0.829 ± 0.023	3.861ThrPro: 3.861 ± 0.05	1.18ThrGln: 1.18 ± 0.026	4.003ThrArg: 4.003 ± 0.051	2.866ThrSer: 2.866 ± 0.05	3.233ThrThr: 3.233 ± 0.049	5.868ThrVal: 5.868 ± 0.078	0.766ThrTrp: 0.766 ± 0.019	1.079ThrTyr: 1.079 ± 0.029	0.001ThrXaa: 0.001 ± 0.001
Val	10.356ValAla: 10.356 ± 0.096	0.833ValCys: 0.833 ± 0.029	4.448ValAsp: 4.448 ± 0.055	4.757ValGlu: 4.757 ± 0.056	2.294ValPhe: 2.294 ± 0.039	6.538ValGly: 6.538 ± 0.073	2.014ValHis: 2.014 ± 0.037	2.267ValIle: 2.267 ± 0.042	1.493ValLys: 1.493 ± 0.041	9.918ValLeu: 9.918 ± 0.098	1.266ValMet: 1.266 ± 0.033	1.445ValAsn: 1.445 ± 0.037	5.538ValPro: 5.538 ± 0.08	1.987ValGln: 1.987 ± 0.035	7.595ValArg: 7.595 ± 0.079	4.081ValSer: 4.081 ± 0.05	5.053ValThr: 5.053 ± 0.074	7.548ValVal: 7.548 ± 0.085	1.065ValTrp: 1.065 ± 0.026	1.35ValTyr: 1.35 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.579TrpAla: 1.579 ± 0.034	0.147TrpCys: 0.147 ± 0.009	0.783TrpAsp: 0.783 ± 0.021	0.766TrpGlu: 0.766 ± 0.024	0.477TrpPhe: 0.477 ± 0.016	1.004TrpGly: 1.004 ± 0.025	0.35TrpHis: 0.35 ± 0.015	0.481TrpIle: 0.481 ± 0.018	0.347TrpLys: 0.347 ± 0.014	1.79TrpLeu: 1.79 ± 0.035	0.269TrpMet: 0.269 ± 0.013	0.332TrpAsn: 0.332 ± 0.015	0.674TrpPro: 0.674 ± 0.021	0.605TrpGln: 0.605 ± 0.018	1.338TrpArg: 1.338 ± 0.025	0.842TrpSer: 0.842 ± 0.022	0.902TrpThr: 0.902 ± 0.022	0.887TrpVal: 0.887 ± 0.023	0.302TrpTrp: 0.302 ± 0.015	0.319TrpTyr: 0.319 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.621TyrAla: 2.621 ± 0.04	0.157TyrCys: 0.157 ± 0.009	1.312TyrAsp: 1.312 ± 0.038	1.193TyrGlu: 1.193 ± 0.025	0.625TyrPhe: 0.625 ± 0.018	2.161TyrGly: 2.161 ± 0.036	0.368TyrHis: 0.368 ± 0.016	0.4TyrIle: 0.4 ± 0.016	0.321TyrLys: 0.321 ± 0.016	2.012TyrLeu: 2.012 ± 0.034	0.222TyrMet: 0.222 ± 0.013	0.319TyrAsn: 0.319 ± 0.014	1.066TyrPro: 1.066 ± 0.027	0.542TyrGln: 0.542 ± 0.016	1.803TyrArg: 1.803 ± 0.036	0.869TyrSer: 0.869 ± 0.023	1.049TyrThr: 1.049 ± 0.025	1.478TyrVal: 1.478 ± 0.032	0.311TyrTrp: 0.311 ± 0.012	0.389TyrTyr: 0.389 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 5156 proteins (1763939 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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