Amino acid dipepetide frequency for Aspergillus violaceofuscus (strain CBS 115571)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.275AlaAla: 10.275 ± 0.068	1.186AlaCys: 1.186 ± 0.017	4.465AlaAsp: 4.465 ± 0.031	5.234AlaGlu: 5.234 ± 0.037	3.209AlaPhe: 3.209 ± 0.028	6.247AlaGly: 6.247 ± 0.036	2.053AlaHis: 2.053 ± 0.02	4.299AlaIle: 4.299 ± 0.031	3.484AlaLys: 3.484 ± 0.029	8.346AlaLeu: 8.346 ± 0.042	1.998AlaMet: 1.998 ± 0.019	2.808AlaAsn: 2.808 ± 0.025	4.88AlaPro: 4.88 ± 0.043	3.633AlaGln: 3.633 ± 0.032	5.395AlaArg: 5.395 ± 0.038	7.435AlaSer: 7.435 ± 0.048	5.74AlaThr: 5.74 ± 0.042	5.822AlaVal: 5.822 ± 0.042	1.291AlaTrp: 1.291 ± 0.016	2.312AlaTyr: 2.312 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.071CysAla: 1.071 ± 0.013	0.286CysCys: 0.286 ± 0.009	0.713CysAsp: 0.713 ± 0.012	0.616CysGlu: 0.616 ± 0.012	0.565CysPhe: 0.565 ± 0.01	0.974CysGly: 0.974 ± 0.016	0.357CysHis: 0.357 ± 0.009	0.731CysIle: 0.731 ± 0.013	0.445CysLys: 0.445 ± 0.009	1.446CysLeu: 1.446 ± 0.018	0.298CysMet: 0.298 ± 0.007	0.422CysAsn: 0.422 ± 0.009	0.723CysPro: 0.723 ± 0.015	0.491CysGln: 0.491 ± 0.01	0.86CysArg: 0.86 ± 0.013	1.002CysSer: 1.002 ± 0.016	0.776CysThr: 0.776 ± 0.014	0.881CysVal: 0.881 ± 0.014	0.219CysTrp: 0.219 ± 0.006	0.386CysTyr: 0.386 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.824AspAla: 4.824 ± 0.033	0.655AspCys: 0.655 ± 0.011	3.892AspAsp: 3.892 ± 0.042	4.185AspGlu: 4.185 ± 0.038	2.077AspPhe: 2.077 ± 0.023	3.89AspGly: 3.89 ± 0.028	1.342AspHis: 1.342 ± 0.017	2.743AspIle: 2.743 ± 0.026	1.923AspLys: 1.923 ± 0.019	5.26AspLeu: 5.26 ± 0.036	1.123AspMet: 1.123 ± 0.013	1.699AspAsn: 1.699 ± 0.019	3.446AspPro: 3.446 ± 0.027	1.921AspGln: 1.921 ± 0.018	3.232AspArg: 3.232 ± 0.033	3.921AspSer: 3.921 ± 0.033	2.897AspThr: 2.897 ± 0.023	3.449AspVal: 3.449 ± 0.028	0.917AspTrp: 0.917 ± 0.013	1.64AspTyr: 1.64 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.333GluAla: 5.333 ± 0.038	0.64GluCys: 0.64 ± 0.011	3.933GluAsp: 3.933 ± 0.037	5.306GluGlu: 5.306 ± 0.057	1.882GluPhe: 1.882 ± 0.018	3.772GluGly: 3.772 ± 0.029	1.407GluHis: 1.407 ± 0.018	2.927GluIle: 2.927 ± 0.025	3.1GluLys: 3.1 ± 0.033	5.111GluLeu: 5.111 ± 0.031	1.418GluMet: 1.418 ± 0.015	2.007GluAsn: 2.007 ± 0.021	2.75GluPro: 2.75 ± 0.035	2.51GluGln: 2.51 ± 0.025	3.873GluArg: 3.873 ± 0.031	4.124GluSer: 4.124 ± 0.033	3.508GluThr: 3.508 ± 0.027	3.634GluVal: 3.634 ± 0.029	0.874GluTrp: 0.874 ± 0.012	1.645GluTyr: 1.645 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.163PheAla: 3.163 ± 0.025	0.608PheCys: 0.608 ± 0.011	2.217PheAsp: 2.217 ± 0.018	2.026PheGlu: 2.026 ± 0.019	1.667PhePhe: 1.667 ± 0.022	2.755PheGly: 2.755 ± 0.027	0.992PheHis: 0.992 ± 0.014	1.725PheIle: 1.725 ± 0.018	1.232PheLys: 1.232 ± 0.016	3.659PheLeu: 3.659 ± 0.027	0.742PheMet: 0.742 ± 0.011	1.281PheAsn: 1.281 ± 0.016	2.011PhePro: 2.011 ± 0.02	1.436PheGln: 1.436 ± 0.017	2.05PheArg: 2.05 ± 0.02	2.91PheSer: 2.91 ± 0.025	2.169PheThr: 2.169 ± 0.02	2.45PheVal: 2.45 ± 0.024	0.675PheTrp: 0.675 ± 0.013	1.144PheTyr: 1.144 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	5.57GlyAla: 5.57 ± 0.041	0.964GlyCys: 0.964 ± 0.015	3.532GlyAsp: 3.532 ± 0.027	3.62GlyGlu: 3.62 ± 0.026	2.816GlyPhe: 2.816 ± 0.024	5.842GlyGly: 5.842 ± 0.048	1.694GlyHis: 1.694 ± 0.018	3.317GlyIle: 3.317 ± 0.026	2.957GlyLys: 2.957 ± 0.025	6.418GlyLeu: 6.418 ± 0.035	1.548GlyMet: 1.548 ± 0.017	2.296GlyAsn: 2.296 ± 0.026	3.391GlyPro: 3.391 ± 0.028	2.581GlyGln: 2.581 ± 0.022	4.261GlyArg: 4.261 ± 0.034	5.623GlySer: 5.623 ± 0.04	3.951GlyThr: 3.951 ± 0.028	4.655GlyVal: 4.655 ± 0.034	1.232GlyTrp: 1.232 ± 0.018	2.201GlyTyr: 2.201 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	2.103HisAla: 2.103 ± 0.021	0.371HisCys: 0.371 ± 0.009	1.358HisAsp: 1.358 ± 0.017	1.391HisGlu: 1.391 ± 0.017	0.956HisPhe: 0.956 ± 0.013	1.807HisGly: 1.807 ± 0.019	1.073HisHis: 1.073 ± 0.018	1.195HisIle: 1.195 ± 0.015	0.796HisLys: 0.796 ± 0.012	2.537HisLeu: 2.537 ± 0.022	0.484HisMet: 0.484 ± 0.009	0.831HisAsn: 0.831 ± 0.013	1.901HisPro: 1.901 ± 0.019	1.105HisGln: 1.105 ± 0.017	1.746HisArg: 1.746 ± 0.021	1.879HisSer: 1.879 ± 0.02	1.38HisThr: 1.38 ± 0.016	1.479HisVal: 1.479 ± 0.014	0.388HisTrp: 0.388 ± 0.008	0.752HisTyr: 0.752 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.149IleAla: 4.149 ± 0.033	0.771IleCys: 0.771 ± 0.011	2.687IleAsp: 2.687 ± 0.022	2.586IleGlu: 2.586 ± 0.025	1.949IlePhe: 1.949 ± 0.021	3.031IleGly: 3.031 ± 0.025	1.26IleHis: 1.26 ± 0.013	2.38IleIle: 2.38 ± 0.023	1.794IleLys: 1.794 ± 0.022	4.654IleLeu: 4.654 ± 0.036	0.909IleMet: 0.909 ± 0.013	1.631IleAsn: 1.631 ± 0.017	3.106IlePro: 3.106 ± 0.024	1.874IleGln: 1.874 ± 0.02	2.797IleArg: 2.797 ± 0.024	3.623IleSer: 3.623 ± 0.022	2.788IleThr: 2.788 ± 0.025	3.101IleVal: 3.101 ± 0.026	0.712IleTrp: 0.712 ± 0.012	1.454IleTyr: 1.454 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.657LysAla: 3.657 ± 0.03	0.461LysCys: 0.461 ± 0.011	2.258LysAsp: 2.258 ± 0.027	2.8LysGlu: 2.8 ± 0.032	1.198LysPhe: 1.198 ± 0.018	2.547LysGly: 2.547 ± 0.02	1.008LysHis: 1.008 ± 0.014	1.892LysIle: 1.892 ± 0.022	2.597LysLys: 2.597 ± 0.034	3.581LysLeu: 3.581 ± 0.027	0.833LysMet: 0.833 ± 0.012	1.415LysAsn: 1.415 ± 0.018	2.399LysPro: 2.399 ± 0.028	1.658LysGln: 1.658 ± 0.02	2.968LysArg: 2.968 ± 0.026	2.962LysSer: 2.962 ± 0.024	2.429LysThr: 2.429 ± 0.022	2.509LysVal: 2.509 ± 0.027	0.561LysTrp: 0.561 ± 0.01	1.181LysTyr: 1.181 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.503LeuAla: 8.503 ± 0.051	1.342LeuCys: 1.342 ± 0.017	5.244LeuAsp: 5.244 ± 0.034	5.545LeuGlu: 5.545 ± 0.043	3.475LeuPhe: 3.475 ± 0.029	6.252LeuGly: 6.252 ± 0.038	2.474LeuHis: 2.474 ± 0.022	4.001LeuIle: 4.001 ± 0.034	3.694LeuLys: 3.694 ± 0.029	9.152LeuLeu: 9.152 ± 0.061	1.826LeuMet: 1.826 ± 0.019	3.096LeuAsn: 3.096 ± 0.023	5.759LeuPro: 5.759 ± 0.036	4.08LeuGln: 4.08 ± 0.03	6.224LeuArg: 6.224 ± 0.036	7.493LeuSer: 7.493 ± 0.039	5.253LeuThr: 5.253 ± 0.033	5.845LeuVal: 5.845 ± 0.037	1.292LeuTrp: 1.292 ± 0.017	2.559LeuTyr: 2.559 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.121MetAla: 2.121 ± 0.022	0.248MetCys: 0.248 ± 0.006	1.162MetAsp: 1.162 ± 0.015	1.2MetGlu: 1.2 ± 0.014	0.721MetPhe: 0.721 ± 0.013	1.415MetGly: 1.415 ± 0.015	0.494MetHis: 0.494 ± 0.01	0.994MetIle: 0.994 ± 0.014	0.874MetLys: 0.874 ± 0.012	1.871MetLeu: 1.871 ± 0.02	0.56MetMet: 0.56 ± 0.012	0.734MetAsn: 0.734 ± 0.011	1.189MetPro: 1.189 ± 0.016	0.881MetGln: 0.881 ± 0.012	1.268MetArg: 1.268 ± 0.016	1.757MetSer: 1.757 ± 0.015	1.298MetThr: 1.298 ± 0.017	1.356MetVal: 1.356 ± 0.016	0.256MetTrp: 0.256 ± 0.006	0.503MetTyr: 0.503 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.971AsnAla: 2.971 ± 0.023	0.432AsnCys: 0.432 ± 0.009	1.711AsnAsp: 1.711 ± 0.019	1.808AsnGlu: 1.808 ± 0.018	1.222AsnPhe: 1.222 ± 0.015	2.571AsnGly: 2.571 ± 0.028	0.866AsnHis: 0.866 ± 0.013	1.78AsnIle: 1.78 ± 0.019	1.253AsnLys: 1.253 ± 0.017	3.161AsnLeu: 3.161 ± 0.024	0.734AsnMet: 0.734 ± 0.013	1.376AsnAsn: 1.376 ± 0.019	2.412AsnPro: 2.412 ± 0.019	1.253AsnGln: 1.253 ± 0.016	1.901AsnArg: 1.901 ± 0.018	2.469AsnSer: 2.469 ± 0.024	2.029AsnThr: 2.029 ± 0.023	2.158AsnVal: 2.158 ± 0.018	0.535AsnTrp: 0.535 ± 0.011	1.021AsnTyr: 1.021 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.72ProAla: 5.72 ± 0.042	0.611ProCys: 0.611 ± 0.013	3.238ProAsp: 3.238 ± 0.028	3.808ProGlu: 3.808 ± 0.035	2.087ProPhe: 2.087 ± 0.019	3.984ProGly: 3.984 ± 0.028	1.466ProHis: 1.466 ± 0.019	2.452ProIle: 2.452 ± 0.022	2.261ProLys: 2.261 ± 0.021	4.944ProLeu: 4.944 ± 0.034	1.039ProMet: 1.039 ± 0.017	2.001ProAsn: 2.001 ± 0.021	5.086ProPro: 5.086 ± 0.066	2.525ProGln: 2.525 ± 0.029	3.618ProArg: 3.618 ± 0.028	6.036ProSer: 6.036 ± 0.049	4.232ProThr: 4.232 ± 0.031	3.774ProVal: 3.774 ± 0.029	0.809ProTrp: 0.809 ± 0.011	1.562ProTyr: 1.562 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.667GlnAla: 3.667 ± 0.028	0.499GlnCys: 0.499 ± 0.009	2.013GlnAsp: 2.013 ± 0.018	2.396GlnGlu: 2.396 ± 0.026	1.317GlnPhe: 1.317 ± 0.015	2.464GlnGly: 2.464 ± 0.024	1.164GlnHis: 1.164 ± 0.015	1.915GlnIle: 1.915 ± 0.02	1.742GlnLys: 1.742 ± 0.02	3.671GlnLeu: 3.671 ± 0.027	0.881GlnMet: 0.881 ± 0.012	1.403GlnAsn: 1.403 ± 0.017	2.749GlnPro: 2.749 ± 0.036	2.752GlnGln: 2.752 ± 0.057	2.789GlnArg: 2.789 ± 0.025	3.138GlnSer: 3.138 ± 0.029	2.467GlnThr: 2.467 ± 0.022	2.281GlnVal: 2.281 ± 0.021	0.607GlnTrp: 0.607 ± 0.01	1.187GlnTyr: 1.187 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	5.098ArgAla: 5.098 ± 0.034	0.824ArgCys: 0.824 ± 0.012	3.377ArgAsp: 3.377 ± 0.034	3.889ArgGlu: 3.889 ± 0.035	2.287ArgPhe: 2.287 ± 0.02	3.871ArgGly: 3.871 ± 0.033	1.685ArgHis: 1.685 ± 0.019	2.885ArgIle: 2.885 ± 0.023	3.161ArgLys: 3.161 ± 0.025	5.974ArgLeu: 5.974 ± 0.04	1.318ArgMet: 1.318 ± 0.017	2.118ArgAsn: 2.118 ± 0.02	3.628ArgPro: 3.628 ± 0.033	2.707ArgGln: 2.707 ± 0.026	5.301ArgArg: 5.301 ± 0.042	4.882ArgSer: 4.882 ± 0.042	3.479ArgThr: 3.479 ± 0.03	3.712ArgVal: 3.712 ± 0.027	1.047ArgTrp: 1.047 ± 0.012	1.778ArgTyr: 1.778 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.925SerAla: 6.925 ± 0.043	0.96SerCys: 0.96 ± 0.016	4.07SerAsp: 4.07 ± 0.036	3.945SerGlu: 3.945 ± 0.036	2.99SerPhe: 2.99 ± 0.023	5.435SerGly: 5.435 ± 0.042	2.053SerHis: 2.053 ± 0.022	3.798SerIle: 3.798 ± 0.031	3.105SerLys: 3.105 ± 0.029	7.49SerLeu: 7.49 ± 0.045	1.637SerMet: 1.637 ± 0.019	2.706SerAsn: 2.706 ± 0.027	5.537SerPro: 5.537 ± 0.046	3.241SerGln: 3.241 ± 0.027	4.943SerArg: 4.943 ± 0.044	9.023SerSer: 9.023 ± 0.07	5.683SerThr: 5.683 ± 0.042	4.637SerVal: 4.637 ± 0.029	1.154SerTrp: 1.154 ± 0.015	2.091SerTyr: 2.091 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.762ThrAla: 5.762 ± 0.036	0.809ThrCys: 0.809 ± 0.013	2.913ThrAsp: 2.913 ± 0.027	3.114ThrGlu: 3.114 ± 0.024	2.22ThrPhe: 2.22 ± 0.021	4.328ThrGly: 4.328 ± 0.031	1.417ThrHis: 1.417 ± 0.016	3.069ThrIle: 3.069 ± 0.026	2.283ThrLys: 2.283 ± 0.023	5.563ThrLeu: 5.563 ± 0.036	1.185ThrMet: 1.185 ± 0.015	2.012ThrAsn: 2.012 ± 0.02	4.372ThrPro: 4.372 ± 0.037	2.205ThrGln: 2.205 ± 0.023	3.287ThrArg: 3.287 ± 0.026	5.279ThrSer: 5.279 ± 0.033	5.069ThrThr: 5.069 ± 0.058	4.061ThrVal: 4.061 ± 0.037	0.894ThrTrp: 0.894 ± 0.013	1.698ThrTyr: 1.698 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.649ValAla: 5.649 ± 0.036	0.93ValCys: 0.93 ± 0.013	3.747ValAsp: 3.747 ± 0.03	3.874ValGlu: 3.874 ± 0.028	2.523ValPhe: 2.523 ± 0.025	4.228ValGly: 4.228 ± 0.032	1.524ValHis: 1.524 ± 0.018	2.964ValIle: 2.964 ± 0.023	2.503ValLys: 2.503 ± 0.023	5.923ValLeu: 5.923 ± 0.038	1.362ValMet: 1.362 ± 0.016	2.122ValAsn: 2.122 ± 0.021	3.671ValPro: 3.671 ± 0.027	2.52ValGln: 2.52 ± 0.024	3.711ValArg: 3.711 ± 0.032	4.712ValSer: 4.712 ± 0.035	3.668ValThr: 3.668 ± 0.031	4.677ValVal: 4.677 ± 0.034	0.931ValTrp: 0.931 ± 0.014	1.873ValTyr: 1.873 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.236TrpAla: 1.236 ± 0.016	0.209TrpCys: 0.209 ± 0.006	0.9TrpAsp: 0.9 ± 0.013	0.882TrpGlu: 0.882 ± 0.014	0.56TrpPhe: 0.56 ± 0.01	0.958TrpGly: 0.958 ± 0.014	0.374TrpHis: 0.374 ± 0.009	0.756TrpIle: 0.756 ± 0.013	0.747TrpLys: 0.747 ± 0.011	1.446TrpLeu: 1.446 ± 0.019	0.385TrpMet: 0.385 ± 0.008	0.627TrpAsn: 0.627 ± 0.01	0.648TrpPro: 0.648 ± 0.011	0.593TrpGln: 0.593 ± 0.011	1.016TrpArg: 1.016 ± 0.014	1.114TrpSer: 1.114 ± 0.015	0.997TrpThr: 0.997 ± 0.015	0.967TrpVal: 0.967 ± 0.014	0.302TrpTrp: 0.302 ± 0.007	0.452TrpTyr: 0.452 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.314TyrAla: 2.314 ± 0.022	0.455TyrCys: 0.455 ± 0.009	1.607TyrAsp: 1.607 ± 0.02	1.53TyrGlu: 1.53 ± 0.017	1.189TyrPhe: 1.189 ± 0.016	2.096TyrGly: 2.096 ± 0.025	0.827TyrHis: 0.827 ± 0.012	1.435TyrIle: 1.435 ± 0.017	0.965TyrLys: 0.965 ± 0.014	2.899TyrLeu: 2.899 ± 0.024	0.623TyrMet: 0.623 ± 0.01	1.077TyrAsn: 1.077 ± 0.014	1.595TyrPro: 1.595 ± 0.017	1.138TyrGln: 1.138 ± 0.016	1.78TyrArg: 1.78 ± 0.019	2.046TyrSer: 2.046 ± 0.022	1.727TyrThr: 1.727 ± 0.02	1.666TyrVal: 1.666 ± 0.02	0.471TyrTrp: 0.471 ± 0.01	0.995TyrTyr: 0.995 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.016XaaXaa: 0.016 ± 0.012

Statistics based on 12074 proteins (5671855 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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