Amino acid dipepetide frequency for Lysobacter soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.021AlaAla: 17.021 ± 0.215	1.164AlaCys: 1.164 ± 0.036	7.054AlaAsp: 7.054 ± 0.09	6.552AlaGlu: 6.552 ± 0.091	4.369AlaPhe: 4.369 ± 0.06	10.364AlaGly: 10.364 ± 0.126	2.651AlaHis: 2.651 ± 0.051	5.719AlaIle: 5.719 ± 0.075	3.9AlaLys: 3.9 ± 0.093	14.79AlaLeu: 14.79 ± 0.168	3.591AlaMet: 3.591 ± 0.049	3.134AlaAsn: 3.134 ± 0.065	6.573AlaPro: 6.573 ± 0.108	5.437AlaGln: 5.437 ± 0.082	9.871AlaArg: 9.871 ± 0.122	6.837AlaSer: 6.837 ± 0.086	6.716AlaThr: 6.716 ± 0.091	8.743AlaVal: 8.743 ± 0.101	2.04AlaTrp: 2.04 ± 0.05	2.47AlaTyr: 2.47 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.026CysAla: 1.026 ± 0.029	0.098CysCys: 0.098 ± 0.01	0.48CysAsp: 0.48 ± 0.021	0.455CysGlu: 0.455 ± 0.021	0.265CysPhe: 0.265 ± 0.013	0.85CysGly: 0.85 ± 0.037	0.214CysHis: 0.214 ± 0.016	0.336CysIle: 0.336 ± 0.016	0.179CysLys: 0.179 ± 0.012	0.686CysLeu: 0.686 ± 0.024	0.12CysMet: 0.12 ± 0.01	0.208CysAsn: 0.208 ± 0.013	0.386CysPro: 0.386 ± 0.019	0.204CysGln: 0.204 ± 0.011	0.543CysArg: 0.543 ± 0.023	0.439CysSer: 0.439 ± 0.02	0.448CysThr: 0.448 ± 0.021	0.648CysVal: 0.648 ± 0.023	0.125CysTrp: 0.125 ± 0.01	0.186CysTyr: 0.186 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	9.386AspAla: 9.386 ± 0.132	0.411AspCys: 0.411 ± 0.02	3.875AspAsp: 3.875 ± 0.07	3.88AspGlu: 3.88 ± 0.063	2.133AspPhe: 2.133 ± 0.046	6.058AspGly: 6.058 ± 0.088	1.167AspHis: 1.167 ± 0.033	2.468AspIle: 2.468 ± 0.05	1.47AspLys: 1.47 ± 0.045	5.48AspLeu: 5.48 ± 0.078	1.073AspMet: 1.073 ± 0.031	1.354AspAsn: 1.354 ± 0.038	3.381AspPro: 3.381 ± 0.057	1.565AspGln: 1.565 ± 0.032	4.382AspArg: 4.382 ± 0.079	2.531AspSer: 2.531 ± 0.049	2.978AspThr: 2.978 ± 0.047	4.892AspVal: 4.892 ± 0.065	1.074AspTrp: 1.074 ± 0.035	1.647AspTyr: 1.647 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.882GluAla: 6.882 ± 0.098	0.341GluCys: 0.341 ± 0.017	2.595GluAsp: 2.595 ± 0.057	2.5GluGlu: 2.5 ± 0.056	1.834GluPhe: 1.834 ± 0.04	4.224GluGly: 4.224 ± 0.073	1.453GluHis: 1.453 ± 0.042	2.489GluIle: 2.489 ± 0.053	1.609GluLys: 1.609 ± 0.043	6.116GluLeu: 6.116 ± 0.097	1.122GluMet: 1.122 ± 0.035	1.355GluAsn: 1.355 ± 0.034	2.684GluPro: 2.684 ± 0.047	2.319GluGln: 2.319 ± 0.045	5.625GluArg: 5.625 ± 0.084	2.733GluSer: 2.733 ± 0.058	2.758GluThr: 2.758 ± 0.05	3.811GluVal: 3.811 ± 0.059	0.741GluTrp: 0.741 ± 0.029	1.176GluTyr: 1.176 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.785PheAla: 4.785 ± 0.073	0.323PheCys: 0.323 ± 0.016	3.033PheAsp: 3.033 ± 0.052	2.12PheGlu: 2.12 ± 0.045	1.256PhePhe: 1.256 ± 0.031	3.454PheGly: 3.454 ± 0.064	0.797PheHis: 0.797 ± 0.026	1.208PheIle: 1.208 ± 0.037	0.866PheLys: 0.866 ± 0.025	2.976PheLeu: 2.976 ± 0.056	0.646PheMet: 0.646 ± 0.023	1.089PheAsn: 1.089 ± 0.036	1.459PhePro: 1.459 ± 0.038	0.911PheGln: 0.911 ± 0.03	2.239PheArg: 2.239 ± 0.051	1.799PheSer: 1.799 ± 0.043	1.772PheThr: 1.772 ± 0.043	2.91PheVal: 2.91 ± 0.057	0.511PheTrp: 0.511 ± 0.024	0.812PheTyr: 0.812 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.285GlyAla: 9.285 ± 0.111	0.729GlyCys: 0.729 ± 0.028	5.022GlyAsp: 5.022 ± 0.079	5.094GlyGlu: 5.094 ± 0.071	3.467GlyPhe: 3.467 ± 0.057	7.185GlyGly: 7.185 ± 0.137	1.985GlyHis: 1.985 ± 0.043	3.843GlyIle: 3.843 ± 0.068	3.076GlyLys: 3.076 ± 0.063	8.406GlyLeu: 8.406 ± 0.112	2.204GlyMet: 2.204 ± 0.045	2.387GlyAsn: 2.387 ± 0.077	3.047GlyPro: 3.047 ± 0.05	2.762GlyGln: 2.762 ± 0.054	6.174GlyArg: 6.174 ± 0.084	4.529GlySer: 4.529 ± 0.078	4.678GlyThr: 4.678 ± 0.083	6.634GlyVal: 6.634 ± 0.083	1.639GlyTrp: 1.639 ± 0.043	2.398GlyTyr: 2.398 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	3.153HisAla: 3.153 ± 0.06	0.23HisCys: 0.23 ± 0.014	1.456HisAsp: 1.456 ± 0.04	1.227HisGlu: 1.227 ± 0.034	0.816HisPhe: 0.816 ± 0.027	2.326HisGly: 2.326 ± 0.052	0.6HisHis: 0.6 ± 0.029	0.688HisIle: 0.688 ± 0.023	0.44HisLys: 0.44 ± 0.021	2.081HisLeu: 2.081 ± 0.044	0.399HisMet: 0.399 ± 0.019	0.495HisAsn: 0.495 ± 0.018	1.39HisPro: 1.39 ± 0.037	0.558HisGln: 0.558 ± 0.023	1.786HisArg: 1.786 ± 0.039	0.951HisSer: 0.951 ± 0.03	0.972HisThr: 0.972 ± 0.037	1.784HisVal: 1.784 ± 0.042	0.395HisTrp: 0.395 ± 0.021	0.623HisTyr: 0.623 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.923IleAla: 6.923 ± 0.083	0.309IleCys: 0.309 ± 0.014	3.457IleAsp: 3.457 ± 0.054	3.139IleGlu: 3.139 ± 0.057	1.073IlePhe: 1.073 ± 0.034	4.484IleGly: 4.484 ± 0.079	0.781IleHis: 0.781 ± 0.029	1.162IleIle: 1.162 ± 0.035	1.043IleLys: 1.043 ± 0.037	2.87IleLeu: 2.87 ± 0.056	0.508IleMet: 0.508 ± 0.022	1.208IleAsn: 1.208 ± 0.039	2.057IlePro: 2.057 ± 0.047	1.01IleGln: 1.01 ± 0.03	2.701IleArg: 2.701 ± 0.051	1.945IleSer: 1.945 ± 0.039	2.181IleThr: 2.181 ± 0.047	3.712IleVal: 3.712 ± 0.065	0.436IleTrp: 0.436 ± 0.021	0.789IleTyr: 0.789 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.542LysAla: 3.542 ± 0.08	0.141LysCys: 0.141 ± 0.011	1.566LysAsp: 1.566 ± 0.045	1.252LysGlu: 1.252 ± 0.043	0.844LysPhe: 0.844 ± 0.029	2.054LysGly: 2.054 ± 0.044	0.631LysHis: 0.631 ± 0.024	1.158LysIle: 1.158 ± 0.037	1.146LysLys: 1.146 ± 0.067	3.198LysLeu: 3.198 ± 0.055	0.631LysMet: 0.631 ± 0.027	0.693LysAsn: 0.693 ± 0.03	2.094LysPro: 2.094 ± 0.058	1.205LysGln: 1.205 ± 0.037	2.283LysArg: 2.283 ± 0.053	1.41LysSer: 1.41 ± 0.043	1.554LysThr: 1.554 ± 0.046	2.123LysVal: 2.123 ± 0.054	0.344LysTrp: 0.344 ± 0.017	0.669LysTyr: 0.669 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.111LeuAla: 14.111 ± 0.161	0.917LeuCys: 0.917 ± 0.028	6.941LeuAsp: 6.941 ± 0.102	5.028LeuGlu: 5.028 ± 0.081	3.383LeuPhe: 3.383 ± 0.063	8.286LeuGly: 8.286 ± 0.108	2.395LeuHis: 2.395 ± 0.057	4.038LeuIle: 4.038 ± 0.068	3.021LeuLys: 3.021 ± 0.055	10.568LeuLeu: 10.568 ± 0.145	2.185LeuMet: 2.185 ± 0.044	2.299LeuAsn: 2.299 ± 0.049	6.14LeuPro: 6.14 ± 0.08	3.427LeuGln: 3.427 ± 0.059	8.732LeuArg: 8.732 ± 0.1	5.854LeuSer: 5.854 ± 0.076	4.948LeuThr: 4.948 ± 0.067	7.599LeuVal: 7.599 ± 0.082	1.345LeuTrp: 1.345 ± 0.04	2.119LeuTyr: 2.119 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.632MetAla: 2.632 ± 0.047	0.138MetCys: 0.138 ± 0.012	1.136MetAsp: 1.136 ± 0.031	0.983MetGlu: 0.983 ± 0.03	0.675MetPhe: 0.675 ± 0.026	1.593MetGly: 1.593 ± 0.038	0.505MetHis: 0.505 ± 0.022	0.861MetIle: 0.861 ± 0.032	0.821MetLys: 0.821 ± 0.028	2.4MetLeu: 2.4 ± 0.051	0.444MetMet: 0.444 ± 0.024	0.734MetAsn: 0.734 ± 0.026	1.477MetPro: 1.477 ± 0.034	0.94MetGln: 0.94 ± 0.028	1.888MetArg: 1.888 ± 0.043	1.529MetSer: 1.529 ± 0.03	1.398MetThr: 1.398 ± 0.036	1.417MetVal: 1.417 ± 0.04	0.239MetTrp: 0.239 ± 0.015	0.366MetTyr: 0.366 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.649AsnAla: 3.649 ± 0.068	0.201AsnCys: 0.201 ± 0.014	1.666AsnAsp: 1.666 ± 0.05	1.31AsnGlu: 1.31 ± 0.032	0.909AsnPhe: 0.909 ± 0.031	2.42AsnGly: 2.42 ± 0.062	0.482AsnHis: 0.482 ± 0.021	0.993AsnIle: 0.993 ± 0.028	0.604AsnLys: 0.604 ± 0.025	2.532AsnLeu: 2.532 ± 0.049	0.398AsnMet: 0.398 ± 0.019	0.686AsnAsn: 0.686 ± 0.028	1.727AsnPro: 1.727 ± 0.041	0.753AsnGln: 0.753 ± 0.03	1.765AsnArg: 1.765 ± 0.045	1.089AsnSer: 1.089 ± 0.037	1.362AsnThr: 1.362 ± 0.04	2.09AsnVal: 2.09 ± 0.049	0.407AsnTrp: 0.407 ± 0.02	0.656AsnTyr: 0.656 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.952ProAla: 6.952 ± 0.112	0.314ProCys: 0.314 ± 0.016	3.757ProAsp: 3.757 ± 0.059	3.252ProGlu: 3.252 ± 0.054	1.704ProPhe: 1.704 ± 0.033	4.625ProGly: 4.625 ± 0.071	1.115ProHis: 1.115 ± 0.032	2.005ProIle: 2.005 ± 0.038	1.553ProLys: 1.553 ± 0.037	5.127ProLeu: 5.127 ± 0.078	1.34ProMet: 1.34 ± 0.035	1.328ProAsn: 1.328 ± 0.035	2.905ProPro: 2.905 ± 0.063	2.059ProGln: 2.059 ± 0.045	3.555ProArg: 3.555 ± 0.061	2.829ProSer: 2.829 ± 0.049	2.689ProThr: 2.689 ± 0.052	4.337ProVal: 4.337 ± 0.067	0.798ProTrp: 0.798 ± 0.025	1.167ProTyr: 1.167 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.746GlnAla: 4.746 ± 0.085	0.263GlnCys: 0.263 ± 0.017	1.552GlnAsp: 1.552 ± 0.04	1.307GlnGlu: 1.307 ± 0.039	1.169GlnPhe: 1.169 ± 0.033	2.546GlnGly: 2.546 ± 0.053	0.798GlnHis: 0.798 ± 0.027	1.478GlnIle: 1.478 ± 0.033	0.997GlnLys: 0.997 ± 0.032	3.866GlnLeu: 3.866 ± 0.068	0.814GlnMet: 0.814 ± 0.023	0.765GlnAsn: 0.765 ± 0.024	2.03GlnPro: 2.03 ± 0.036	1.638GlnGln: 1.638 ± 0.048	3.443GlnArg: 3.443 ± 0.058	1.728GlnSer: 1.728 ± 0.04	1.613GlnThr: 1.613 ± 0.039	2.752GlnVal: 2.752 ± 0.054	0.664GlnTrp: 0.664 ± 0.026	0.76GlnTyr: 0.76 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.825ArgAla: 8.825 ± 0.111	0.571ArgCys: 0.571 ± 0.02	5.143ArgAsp: 5.143 ± 0.086	5.27ArgGlu: 5.27 ± 0.084	3.146ArgPhe: 3.146 ± 0.059	5.645ArgGly: 5.645 ± 0.067	1.92ArgHis: 1.92 ± 0.043	4.0ArgIle: 4.0 ± 0.057	2.063ArgLys: 2.063 ± 0.047	8.117ArgLeu: 8.117 ± 0.107	2.093ArgMet: 2.093 ± 0.041	2.065ArgAsn: 2.065 ± 0.039	3.487ArgPro: 3.487 ± 0.059	2.646ArgGln: 2.646 ± 0.059	6.237ArgArg: 6.237 ± 0.099	3.682ArgSer: 3.682 ± 0.055	3.809ArgThr: 3.809 ± 0.066	5.824ArgVal: 5.824 ± 0.088	1.484ArgTrp: 1.484 ± 0.036	2.243ArgTyr: 2.243 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.067SerAla: 6.067 ± 0.076	0.4SerCys: 0.4 ± 0.019	2.917SerAsp: 2.917 ± 0.049	2.458SerGlu: 2.458 ± 0.052	1.878SerPhe: 1.878 ± 0.043	4.891SerGly: 4.891 ± 0.08	1.151SerHis: 1.151 ± 0.03	2.174SerIle: 2.174 ± 0.047	1.462SerLys: 1.462 ± 0.039	5.41SerLeu: 5.41 ± 0.069	1.13SerMet: 1.13 ± 0.029	1.433SerAsn: 1.433 ± 0.038	2.839SerPro: 2.839 ± 0.057	1.791SerGln: 1.791 ± 0.042	4.036SerArg: 4.036 ± 0.064	2.74SerSer: 2.74 ± 0.056	2.813SerThr: 2.813 ± 0.054	3.693SerVal: 3.693 ± 0.061	0.771SerTrp: 0.771 ± 0.028	1.221SerTyr: 1.221 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.966ThrAla: 5.966 ± 0.081	0.389ThrCys: 0.389 ± 0.02	2.699ThrAsp: 2.699 ± 0.045	2.118ThrGlu: 2.118 ± 0.044	1.791ThrPhe: 1.791 ± 0.045	4.651ThrGly: 4.651 ± 0.069	1.17ThrHis: 1.17 ± 0.033	2.262ThrIle: 2.262 ± 0.046	1.222ThrLys: 1.222 ± 0.04	6.109ThrLeu: 6.109 ± 0.088	1.01ThrMet: 1.01 ± 0.032	1.192ThrAsn: 1.192 ± 0.033	3.781ThrPro: 3.781 ± 0.057	1.79ThrGln: 1.79 ± 0.034	3.799ThrArg: 3.799 ± 0.06	2.534ThrSer: 2.534 ± 0.055	2.915ThrThr: 2.915 ± 0.066	4.199ThrVal: 4.199 ± 0.061	0.762ThrTrp: 0.762 ± 0.024	1.17ThrTyr: 1.17 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.868ValAla: 9.868 ± 0.115	0.649ValCys: 0.649 ± 0.025	4.736ValAsp: 4.736 ± 0.07	4.64ValGlu: 4.64 ± 0.063	2.71ValPhe: 2.71 ± 0.055	5.698ValGly: 5.698 ± 0.075	1.673ValHis: 1.673 ± 0.041	3.384ValIle: 3.384 ± 0.054	2.038ValLys: 2.038 ± 0.052	8.154ValLeu: 8.154 ± 0.101	1.651ValMet: 1.651 ± 0.04	2.102ValAsn: 2.102 ± 0.046	4.034ValPro: 4.034 ± 0.058	2.487ValGln: 2.487 ± 0.051	5.683ValArg: 5.683 ± 0.076	4.009ValSer: 4.009 ± 0.058	3.86ValThr: 3.86 ± 0.067	6.326ValVal: 6.326 ± 0.09	0.942ValTrp: 0.942 ± 0.03	1.592ValTyr: 1.592 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.306TrpAla: 1.306 ± 0.037	0.126TrpCys: 0.126 ± 0.01	0.721TrpAsp: 0.721 ± 0.026	0.582TrpGlu: 0.582 ± 0.025	0.636TrpPhe: 0.636 ± 0.026	0.976TrpGly: 0.976 ± 0.034	0.392TrpHis: 0.392 ± 0.018	0.778TrpIle: 0.778 ± 0.03	0.466TrpLys: 0.466 ± 0.021	2.141TrpLeu: 2.141 ± 0.05	0.44TrpMet: 0.44 ± 0.019	0.553TrpAsn: 0.553 ± 0.024	0.806TrpPro: 0.806 ± 0.031	0.687TrpGln: 0.687 ± 0.022	1.483TrpArg: 1.483 ± 0.042	0.908TrpSer: 0.908 ± 0.027	0.822TrpThr: 0.822 ± 0.03	0.945TrpVal: 0.945 ± 0.03	0.338TrpTrp: 0.338 ± 0.022	0.355TrpTyr: 0.355 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.868TyrAla: 2.868 ± 0.052	0.18TyrCys: 0.18 ± 0.012	1.397TyrAsp: 1.397 ± 0.041	1.199TyrGlu: 1.199 ± 0.035	0.913TyrPhe: 0.913 ± 0.031	2.214TyrGly: 2.214 ± 0.051	0.491TyrHis: 0.491 ± 0.02	0.744TyrIle: 0.744 ± 0.027	0.565TyrLys: 0.565 ± 0.024	2.307TyrLeu: 2.307 ± 0.048	0.377TyrMet: 0.377 ± 0.02	0.621TyrAsn: 0.621 ± 0.025	1.112TyrPro: 1.112 ± 0.033	0.74TyrGln: 0.74 ± 0.027	2.045TyrArg: 2.045 ± 0.045	1.198TyrSer: 1.198 ± 0.033	1.245TyrThr: 1.245 ± 0.038	1.799TyrVal: 1.799 ± 0.043	0.405TyrTrp: 0.405 ± 0.021	0.594TyrTyr: 0.594 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3530 proteins (1159365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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