Amino acid dipepetide frequency for Dioscorea nummularia-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.957AlaAla: 2.957 ± 1.271
0.422AlaCys: 0.422 ± 0.235
1.69AlaAsp: 1.69 ± 0.906
4.647AlaGlu: 4.647 ± 1.467
2.112AlaPhe: 2.112 ± 0.644
0.422AlaGly: 0.422 ± 0.598
0.0AlaHis: 0.0 ± 0.0
4.647AlaIle: 4.647 ± 1.337
4.225AlaLys: 4.225 ± 1.528
5.07AlaLeu: 5.07 ± 1.452
0.0AlaMet: 0.0 ± 0.0
2.112AlaAsn: 2.112 ± 1.176
2.112AlaPro: 2.112 ± 0.827
2.112AlaGln: 2.112 ± 0.827
1.267AlaArg: 1.267 ± 0.706
2.957AlaSer: 2.957 ± 0.618
2.535AlaThr: 2.535 ± 0.811
1.69AlaVal: 1.69 ± 0.817
0.0AlaTrp: 0.0 ± 0.0
1.267AlaTyr: 1.267 ± 0.838
0.0AlaXaa: 0.0 ± 0.0
Cys
0.422CysAla: 0.422 ± 0.235
0.845CysCys: 0.845 ± 0.47
1.267CysAsp: 1.267 ± 0.73
0.845CysGlu: 0.845 ± 1.05
1.267CysPhe: 1.267 ± 1.66
0.422CysGly: 0.422 ± 0.235
0.422CysHis: 0.422 ± 0.598
1.267CysIle: 1.267 ± 0.73
1.69CysLys: 1.69 ± 0.484
1.69CysLeu: 1.69 ± 1.562
0.422CysMet: 0.422 ± 0.235
0.845CysAsn: 0.845 ± 0.47
0.845CysPro: 0.845 ± 0.47
0.422CysGln: 0.422 ± 0.235
2.535CysArg: 2.535 ± 0.84
1.267CysSer: 1.267 ± 0.706
0.0CysThr: 0.0 ± 0.0
0.845CysVal: 0.845 ± 0.47
0.0CysTrp: 0.0 ± 0.0
1.267CysTyr: 1.267 ± 0.706
0.0CysXaa: 0.0 ± 0.0
Asp
0.845AspAla: 0.845 ± 0.453
0.422AspCys: 0.422 ± 0.235
2.535AspAsp: 2.535 ± 0.84
2.535AspGlu: 2.535 ± 0.811
2.112AspPhe: 2.112 ± 0.827
1.69AspGly: 1.69 ± 0.484
0.422AspHis: 0.422 ± 0.235
6.337AspIle: 6.337 ± 1.817
4.225AspLys: 4.225 ± 0.566
6.337AspLeu: 6.337 ± 0.181
0.845AspMet: 0.845 ± 0.387
5.492AspAsn: 5.492 ± 0.887
1.69AspPro: 1.69 ± 0.83
2.535AspGln: 2.535 ± 0.984
0.845AspArg: 0.845 ± 0.453
2.112AspSer: 2.112 ± 0.502
1.69AspThr: 1.69 ± 0.941
0.422AspVal: 0.422 ± 0.235
1.69AspTrp: 1.69 ± 0.484
2.535AspTyr: 2.535 ± 1.411
0.0AspXaa: 0.0 ± 0.0
Glu
2.112GluAla: 2.112 ± 1.732
0.422GluCys: 0.422 ± 0.235
4.225GluAsp: 4.225 ± 1.815
8.027GluGlu: 8.027 ± 2.302
3.802GluPhe: 3.802 ± 1.374
5.07GluGly: 5.07 ± 1.948
0.422GluHis: 0.422 ± 0.235
5.915GluIle: 5.915 ± 1.264
8.872GluLys: 8.872 ± 4.164
9.294GluLeu: 9.294 ± 2.171
2.535GluMet: 2.535 ± 0.792
4.647GluAsn: 4.647 ± 0.911
1.69GluPro: 1.69 ± 0.484
3.38GluGln: 3.38 ± 1.273
0.845GluArg: 0.845 ± 0.47
3.38GluSer: 3.38 ± 0.631
6.76GluThr: 6.76 ± 2.059
4.225GluVal: 4.225 ± 1.986
1.267GluTrp: 1.267 ± 0.706
1.69GluTyr: 1.69 ± 0.652
0.0GluXaa: 0.0 ± 0.0
Phe
2.112PheAla: 2.112 ± 1.161
1.69PheCys: 1.69 ± 0.941
0.845PheAsp: 0.845 ± 0.453
2.112PheGlu: 2.112 ± 1.015
1.69PhePhe: 1.69 ± 0.906
1.69PheGly: 1.69 ± 0.484
1.267PheHis: 1.267 ± 0.841
2.535PheIle: 2.535 ± 0.84
2.112PheLys: 2.112 ± 0.502
2.957PheLeu: 2.957 ± 1.647
0.0PheMet: 0.0 ± 0.0
1.69PheAsn: 1.69 ± 0.906
2.535PhePro: 2.535 ± 0.84
2.535PheGln: 2.535 ± 0.984
1.267PheArg: 1.267 ± 0.406
4.225PheSer: 4.225 ± 1.004
3.38PheThr: 3.38 ± 2.097
2.112PheVal: 2.112 ± 1.481
0.422PheTrp: 0.422 ± 0.235
2.112PheTyr: 2.112 ± 0.827
0.0PheXaa: 0.0 ± 0.0
Gly
1.69GlyAla: 1.69 ± 0.484
0.422GlyCys: 0.422 ± 0.235
0.845GlyAsp: 0.845 ± 0.453
5.915GlyGlu: 5.915 ± 1.264
2.535GlyPhe: 2.535 ± 0.96
0.845GlyGly: 0.845 ± 0.47
2.112GlyHis: 2.112 ± 1.343
1.69GlyIle: 1.69 ± 0.484
4.225GlyLys: 4.225 ± 0.817
5.07GlyLeu: 5.07 ± 1.452
0.845GlyMet: 0.845 ± 0.453
3.38GlyAsn: 3.38 ± 1.813
1.69GlyPro: 1.69 ± 1.627
2.112GlyGln: 2.112 ± 0.669
2.112GlyArg: 2.112 ± 0.502
2.112GlySer: 2.112 ± 1.176
0.845GlyThr: 0.845 ± 0.47
2.957GlyVal: 2.957 ± 1.052
0.845GlyTrp: 0.845 ± 0.453
0.845GlyTyr: 0.845 ± 0.47
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.422HisCys: 0.422 ± 0.893
0.0HisAsp: 0.0 ± 0.0
0.845HisGlu: 0.845 ± 0.47
0.845HisPhe: 0.845 ± 0.47
2.112HisGly: 2.112 ± 0.827
0.845HisHis: 0.845 ± 0.453
3.38HisIle: 3.38 ± 0.473
1.69HisLys: 1.69 ± 2.37
1.267HisLeu: 1.267 ± 0.406
0.422HisMet: 0.422 ± 0.235
2.112HisAsn: 2.112 ± 2.388
0.422HisPro: 0.422 ± 0.235
0.845HisGln: 0.845 ± 0.909
2.535HisArg: 2.535 ± 0.984
0.845HisSer: 0.845 ± 0.47
2.112HisThr: 2.112 ± 1.343
1.267HisVal: 1.267 ± 0.73
0.0HisTrp: 0.0 ± 0.0
0.845HisTyr: 0.845 ± 0.453
0.0HisXaa: 0.0 ± 0.0
Ile
3.38IleAla: 3.38 ± 0.631
1.69IleCys: 1.69 ± 0.753
4.647IleAsp: 4.647 ± 1.955
5.915IleGlu: 5.915 ± 2.578
2.957IlePhe: 2.957 ± 0.861
5.492IleGly: 5.492 ± 1.69
2.112IleHis: 2.112 ± 0.644
10.139IleIle: 10.139 ± 2.024
3.802IleLys: 3.802 ± 0.962
11.829IleLeu: 11.829 ± 1.489
1.267IleMet: 1.267 ± 0.406
2.112IleAsn: 2.112 ± 0.502
4.225IlePro: 4.225 ± 1.257
5.07IleGln: 5.07 ± 0.818
4.647IleArg: 4.647 ± 0.668
5.915IleSer: 5.915 ± 0.789
5.915IleThr: 5.915 ± 1.723
2.112IleVal: 2.112 ± 1.176
0.0IleTrp: 0.0 ± 0.0
1.69IleTyr: 1.69 ± 0.484
0.0IleXaa: 0.0 ± 0.0
Lys
3.802LysAla: 3.802 ± 1.72
1.267LysCys: 1.267 ± 0.706
4.225LysAsp: 4.225 ± 1.725
8.027LysGlu: 8.027 ± 2.2
4.225LysPhe: 4.225 ± 1.76
4.225LysGly: 4.225 ± 1.283
1.69LysHis: 1.69 ± 0.753
7.605LysIle: 7.605 ± 1.362
4.647LysLys: 4.647 ± 1.241
9.717LysLeu: 9.717 ± 4.076
2.535LysMet: 2.535 ± 0.811
4.647LysAsn: 4.647 ± 3.439
3.802LysPro: 3.802 ± 0.552
2.535LysGln: 2.535 ± 1.229
3.38LysArg: 3.38 ± 2.77
4.225LysSer: 4.225 ± 1.939
4.225LysThr: 4.225 ± 2.633
4.225LysVal: 4.225 ± 1.724
1.267LysTrp: 1.267 ± 0.406
2.957LysTyr: 2.957 ± 1.274
0.0LysXaa: 0.0 ± 0.0
Leu
4.647LeuAla: 4.647 ± 1.955
2.535LeuCys: 2.535 ± 1.365
6.76LeuAsp: 6.76 ± 1.405
10.984LeuGlu: 10.984 ± 4.013
1.267LeuPhe: 1.267 ± 0.406
3.802LeuGly: 3.802 ± 1.498
3.38LeuHis: 3.38 ± 1.172
6.76LeuIle: 6.76 ± 1.674
8.872LeuLys: 8.872 ± 2.485
11.829LeuLeu: 11.829 ± 3.59
1.267LeuMet: 1.267 ± 0.406
6.76LeuAsn: 6.76 ± 1.715
6.76LeuPro: 6.76 ± 2.059
8.027LeuGln: 8.027 ± 1.093
1.69LeuArg: 1.69 ± 0.484
6.337LeuSer: 6.337 ± 2.169
5.915LeuThr: 5.915 ± 3.499
2.957LeuVal: 2.957 ± 1.052
0.422LeuTrp: 0.422 ± 0.598
2.535LeuTyr: 2.535 ± 0.84
0.0LeuXaa: 0.0 ± 0.0
Met
2.112MetAla: 2.112 ± 0.827
0.0MetCys: 0.0 ± 0.0
1.69MetAsp: 1.69 ± 0.484
1.69MetGlu: 1.69 ± 0.652
0.0MetPhe: 0.0 ± 0.0
0.422MetGly: 0.422 ± 0.235
0.422MetHis: 0.422 ± 0.235
1.69MetIle: 1.69 ± 0.484
0.422MetLys: 0.422 ± 0.235
1.267MetLeu: 1.267 ± 0.406
0.422MetMet: 0.422 ± 0.235
0.422MetAsn: 0.422 ± 0.235
1.267MetPro: 1.267 ± 0.406
0.845MetGln: 0.845 ± 0.47
0.422MetArg: 0.422 ± 0.235
1.267MetSer: 1.267 ± 0.838
1.267MetThr: 1.267 ± 1.034
1.267MetVal: 1.267 ± 0.73
0.422MetTrp: 0.422 ± 0.235
0.845MetTyr: 0.845 ± 0.47
0.0MetXaa: 0.0 ± 0.0
Asn
2.112AsnAla: 2.112 ± 1.481
1.69AsnCys: 1.69 ± 0.484
1.69AsnAsp: 1.69 ± 0.941
0.845AsnGlu: 0.845 ± 0.47
2.535AsnPhe: 2.535 ± 0.811
0.0AsnGly: 0.0 ± 0.0
0.845AsnHis: 0.845 ± 0.47
5.492AsnIle: 5.492 ± 1.045
5.915AsnLys: 5.915 ± 1.074
8.45AsnLeu: 8.45 ± 3.49
1.69AsnMet: 1.69 ± 0.698
4.225AsnAsn: 4.225 ± 1.257
0.845AsnPro: 0.845 ± 0.47
4.647AsnGln: 4.647 ± 1.203
2.957AsnArg: 2.957 ± 1.465
2.112AsnSer: 2.112 ± 0.669
2.535AsnThr: 2.535 ± 1.613
3.38AsnVal: 3.38 ± 1.32
1.69AsnTrp: 1.69 ± 0.484
2.957AsnTyr: 2.957 ± 1.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.112ProAla: 2.112 ± 1.481
0.0ProCys: 0.0 ± 0.0
2.112ProAsp: 2.112 ± 0.827
2.535ProGlu: 2.535 ± 1.411
1.267ProPhe: 1.267 ± 0.406
1.267ProGly: 1.267 ± 0.406
0.845ProHis: 0.845 ± 0.47
2.957ProIle: 2.957 ± 1.647
3.38ProLys: 3.38 ± 1.634
3.802ProLeu: 3.802 ± 1.498
0.0ProMet: 0.0 ± 0.0
1.69ProAsn: 1.69 ± 0.941
2.535ProPro: 2.535 ± 1.411
3.802ProGln: 3.802 ± 1.115
2.535ProArg: 2.535 ± 1.36
3.802ProSer: 3.802 ± 1.498
3.38ProThr: 3.38 ± 0.672
3.38ProVal: 3.38 ± 0.632
0.0ProTrp: 0.0 ± 0.0
1.267ProTyr: 1.267 ± 0.406
0.0ProXaa: 0.0 ± 0.0
Gln
2.957GlnAla: 2.957 ± 0.861
0.845GlnCys: 0.845 ± 0.453
2.957GlnAsp: 2.957 ± 0.861
3.38GlnGlu: 3.38 ± 1.273
1.69GlnPhe: 1.69 ± 0.906
2.535GlnGly: 2.535 ± 1.229
2.535GlnHis: 2.535 ± 0.997
6.337GlnIle: 6.337 ± 1.311
5.07GlnLys: 5.07 ± 2.258
5.07GlnLeu: 5.07 ± 0.835
0.0GlnMet: 0.0 ± 0.0
3.802GlnAsn: 3.802 ± 1.083
3.38GlnPro: 3.38 ± 1.273
5.07GlnGln: 5.07 ± 0.818
2.957GlnArg: 2.957 ± 1.249
2.535GlnSer: 2.535 ± 1.229
2.112GlnThr: 2.112 ± 0.887
2.957GlnVal: 2.957 ± 1.651
0.845GlnTrp: 0.845 ± 0.453
2.535GlnTyr: 2.535 ± 0.811
0.0GlnXaa: 0.0 ± 0.0
Arg
1.69ArgAla: 1.69 ± 0.484
1.69ArgCys: 1.69 ± 0.652
1.69ArgAsp: 1.69 ± 0.906
0.845ArgGlu: 0.845 ± 1.05
0.422ArgPhe: 0.422 ± 0.893
2.112ArgGly: 2.112 ± 0.827
1.267ArgHis: 1.267 ± 1.66
4.225ArgIle: 4.225 ± 1.257
4.225ArgLys: 4.225 ± 0.876
3.38ArgLeu: 3.38 ± 1.882
1.267ArgMet: 1.267 ± 0.661
3.38ArgAsn: 3.38 ± 0.473
2.112ArgPro: 2.112 ± 1.176
3.38ArgGln: 3.38 ± 1.751
2.112ArgArg: 2.112 ± 1.176
2.957ArgSer: 2.957 ± 0.861
3.802ArgThr: 3.802 ± 0.817
1.267ArgVal: 1.267 ± 0.706
1.267ArgTrp: 1.267 ± 0.406
2.112ArgTyr: 2.112 ± 0.644
0.0ArgXaa: 0.0 ± 0.0
Ser
2.957SerAla: 2.957 ± 1.052
0.422SerCys: 0.422 ± 0.235
2.535SerAsp: 2.535 ± 0.84
4.225SerGlu: 4.225 ± 0.489
2.535SerPhe: 2.535 ± 1.365
3.802SerGly: 3.802 ± 1.498
1.267SerHis: 1.267 ± 1.927
4.647SerIle: 4.647 ± 0.724
6.76SerLys: 6.76 ± 0.205
5.07SerLeu: 5.07 ± 2.73
2.112SerMet: 2.112 ± 0.844
1.267SerAsn: 1.267 ± 0.838
2.535SerPro: 2.535 ± 0.997
3.802SerGln: 3.802 ± 1.811
4.225SerArg: 4.225 ± 0.489
4.225SerSer: 4.225 ± 0.767
5.07SerThr: 5.07 ± 1.912
2.112SerVal: 2.112 ± 0.669
0.0SerTrp: 0.0 ± 0.0
2.957SerTyr: 2.957 ± 1.487
0.0SerXaa: 0.0 ± 0.0
Thr
3.802ThrAla: 3.802 ± 0.96
0.845ThrCys: 0.845 ± 0.781
4.225ThrAsp: 4.225 ± 1.257
8.45ThrGlu: 8.45 ± 3.573
2.957ThrPhe: 2.957 ± 0.861
2.535ThrGly: 2.535 ± 0.84
1.267ThrHis: 1.267 ± 0.406
3.802ThrIle: 3.802 ± 1.511
5.492ThrLys: 5.492 ± 1.482
5.492ThrLeu: 5.492 ± 1.482
0.422ThrMet: 0.422 ± 0.235
0.845ThrAsn: 0.845 ± 0.453
2.535ThrPro: 2.535 ± 0.582
2.957ThrGln: 2.957 ± 1.81
2.112ThrArg: 2.112 ± 0.844
5.915ThrSer: 5.915 ± 2.622
3.802ThrThr: 3.802 ± 0.817
1.69ThrVal: 1.69 ± 0.484
0.422ThrTrp: 0.422 ± 0.598
1.267ThrTyr: 1.267 ± 0.706
0.0ThrXaa: 0.0 ± 0.0
Val
1.69ValAla: 1.69 ± 0.484
1.267ValCys: 1.267 ± 0.706
1.267ValAsp: 1.267 ± 0.838
1.267ValGlu: 1.267 ± 0.999
1.267ValPhe: 1.267 ± 0.838
2.535ValGly: 2.535 ± 0.811
0.845ValHis: 0.845 ± 0.47
3.38ValIle: 3.38 ± 1.273
3.802ValLys: 3.802 ± 2.618
2.957ValLeu: 2.957 ± 0.861
1.267ValMet: 1.267 ± 0.706
4.647ValAsn: 4.647 ± 1.337
1.267ValPro: 1.267 ± 0.706
3.802ValGln: 3.802 ± 0.42
2.112ValArg: 2.112 ± 0.844
2.535ValSer: 2.535 ± 0.96
1.267ValThr: 1.267 ± 0.706
1.267ValVal: 1.267 ± 2.154
0.845ValTrp: 0.845 ± 1.2
2.957ValTyr: 2.957 ± 1.076
0.0ValXaa: 0.0 ± 0.0
Trp
0.422TrpAla: 0.422 ± 0.598
0.0TrpCys: 0.0 ± 0.0
0.422TrpAsp: 0.422 ± 0.235
2.535TrpGlu: 2.535 ± 0.582
0.0TrpPhe: 0.0 ± 0.0
0.845TrpGly: 0.845 ± 0.453
0.0TrpHis: 0.0 ± 0.0
0.422TrpIle: 0.422 ± 0.235
0.845TrpLys: 0.845 ± 0.47
1.267TrpLeu: 1.267 ± 1.034
0.0TrpMet: 0.0 ± 0.0
0.845TrpAsn: 0.845 ± 0.47
0.0TrpPro: 0.0 ± 0.0
0.422TrpGln: 0.422 ± 0.235
1.69TrpArg: 1.69 ± 0.906
0.0TrpSer: 0.0 ± 0.0
1.69TrpThr: 1.69 ± 0.484
0.845TrpVal: 0.845 ± 0.453
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.422TyrAla: 0.422 ± 0.235
1.69TyrCys: 1.69 ± 0.753
2.112TyrAsp: 2.112 ± 0.644
2.957TyrGlu: 2.957 ± 1.647
3.802TyrPhe: 3.802 ± 1.72
1.267TyrGly: 1.267 ± 0.999
0.845TyrHis: 0.845 ± 1.785
1.69TyrIle: 1.69 ± 0.484
2.957TyrLys: 2.957 ± 0.583
1.69TyrLeu: 1.69 ± 1.562
0.422TyrMet: 0.422 ± 0.235
1.69TyrAsn: 1.69 ± 0.941
0.422TyrPro: 0.422 ± 0.235
1.267TyrGln: 1.267 ± 0.706
2.957TyrArg: 2.957 ± 1.052
3.802TyrSer: 3.802 ± 0.821
2.535TyrThr: 2.535 ± 2.068
1.267TyrVal: 1.267 ± 0.706
0.845TyrTrp: 0.845 ± 0.47
1.69TyrTyr: 1.69 ± 2.099
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2368 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski