Amino acid dipepetide frequency for Collinsella tanakaei YIT 12063

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.332AlaAla: 15.332 ± 0.234	2.199AlaCys: 2.199 ± 0.058	7.084AlaAsp: 7.084 ± 0.117	6.386AlaGlu: 6.386 ± 0.134	4.154AlaPhe: 4.154 ± 0.082	9.795AlaGly: 9.795 ± 0.165	2.131AlaHis: 2.131 ± 0.057	5.994AlaIle: 5.994 ± 0.11	4.184AlaLys: 4.184 ± 0.096	11.488AlaLeu: 11.488 ± 0.16	3.309AlaMet: 3.309 ± 0.061	3.165AlaAsn: 3.165 ± 0.079	4.645AlaPro: 4.645 ± 0.098	3.908AlaGln: 3.908 ± 0.084	7.179AlaArg: 7.179 ± 0.122	7.224AlaSer: 7.224 ± 0.109	5.698AlaThr: 5.698 ± 0.099	8.564AlaVal: 8.564 ± 0.131	1.206AlaTrp: 1.206 ± 0.04	2.97AlaTyr: 2.97 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	1.744CysAla: 1.744 ± 0.055	0.303CysCys: 0.303 ± 0.022	1.042CysAsp: 1.042 ± 0.045	1.021CysGlu: 1.021 ± 0.04	0.526CysPhe: 0.526 ± 0.03	1.751CysGly: 1.751 ± 0.053	0.341CysHis: 0.341 ± 0.024	0.784CysIle: 0.784 ± 0.034	0.426CysLys: 0.426 ± 0.023	1.208CysLeu: 1.208 ± 0.046	0.45CysMet: 0.45 ± 0.025	0.399CysAsn: 0.399 ± 0.024	0.737CysPro: 0.737 ± 0.042	0.342CysGln: 0.342 ± 0.024	0.914CysArg: 0.914 ± 0.037	0.96CysSer: 0.96 ± 0.039	0.785CysThr: 0.785 ± 0.039	1.288CysVal: 1.288 ± 0.048	0.165CysTrp: 0.165 ± 0.014	0.359CysTyr: 0.359 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	8.152AspAla: 8.152 ± 0.124	0.809AspCys: 0.809 ± 0.036	3.871AspAsp: 3.871 ± 0.088	5.338AspGlu: 5.338 ± 0.084	2.349AspPhe: 2.349 ± 0.057	5.529AspGly: 5.529 ± 0.122	1.116AspHis: 1.116 ± 0.042	3.379AspIle: 3.379 ± 0.066	2.201AspLys: 2.201 ± 0.072	5.628AspLeu: 5.628 ± 0.092	1.694AspMet: 1.694 ± 0.045	1.701AspAsn: 1.701 ± 0.051	3.131AspPro: 3.131 ± 0.08	1.877AspGln: 1.877 ± 0.05	3.604AspArg: 3.604 ± 0.093	3.318AspSer: 3.318 ± 0.067	2.817AspThr: 2.817 ± 0.07	5.076AspVal: 5.076 ± 0.088	0.711AspTrp: 0.711 ± 0.029	2.052AspTyr: 2.052 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	6.685GluAla: 6.685 ± 0.118	0.778GluCys: 0.778 ± 0.037	3.943GluAsp: 3.943 ± 0.08	4.162GluGlu: 4.162 ± 0.105	2.079GluPhe: 2.079 ± 0.057	4.708GluGly: 4.708 ± 0.1	1.519GluHis: 1.519 ± 0.049	2.939GluIle: 2.939 ± 0.082	2.564GluLys: 2.564 ± 0.076	6.473GluLeu: 6.473 ± 0.103	1.807GluMet: 1.807 ± 0.054	2.093GluAsn: 2.093 ± 0.058	2.418GluPro: 2.418 ± 0.058	2.387GluGln: 2.387 ± 0.062	4.837GluArg: 4.837 ± 0.093	3.297GluSer: 3.297 ± 0.078	2.935GluThr: 2.935 ± 0.066	4.567GluVal: 4.567 ± 0.087	0.653GluTrp: 0.653 ± 0.029	1.659GluTyr: 1.659 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	4.134PheAla: 4.134 ± 0.087	0.677PheCys: 0.677 ± 0.037	2.884PheAsp: 2.884 ± 0.065	2.26PheGlu: 2.26 ± 0.059	1.515PhePhe: 1.515 ± 0.054	3.251PheGly: 3.251 ± 0.071	0.639PheHis: 0.639 ± 0.032	1.974PheIle: 1.974 ± 0.067	1.281PheLys: 1.281 ± 0.041	2.871PheLeu: 2.871 ± 0.079	1.041PheMet: 1.041 ± 0.038	1.178PheAsn: 1.178 ± 0.036	1.236PhePro: 1.236 ± 0.04	0.85PheGln: 0.85 ± 0.032	1.516PheArg: 1.516 ± 0.045	2.611PheSer: 2.611 ± 0.071	2.134PheThr: 2.134 ± 0.047	2.715PheVal: 2.715 ± 0.066	0.399PheTrp: 0.399 ± 0.023	1.126PheTyr: 1.126 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	8.883GlyAla: 8.883 ± 0.147	1.529GlyCys: 1.529 ± 0.05	4.773GlyAsp: 4.773 ± 0.092	5.117GlyGlu: 5.117 ± 0.096	3.379GlyPhe: 3.379 ± 0.072	6.313GlyGly: 6.313 ± 0.138	1.467GlyHis: 1.467 ± 0.052	5.036GlyIle: 5.036 ± 0.096	3.623GlyLys: 3.623 ± 0.079	6.855GlyLeu: 6.855 ± 0.105	2.605GlyMet: 2.605 ± 0.069	2.382GlyAsn: 2.382 ± 0.058	2.274GlyPro: 2.274 ± 0.057	2.039GlyGln: 2.039 ± 0.057	4.799GlyArg: 4.799 ± 0.103	5.273GlySer: 5.273 ± 0.104	4.632GlyThr: 4.632 ± 0.09	6.92GlyVal: 6.92 ± 0.103	0.895GlyTrp: 0.895 ± 0.033	2.652GlyTyr: 2.652 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	2.158HisAla: 2.158 ± 0.058	0.248HisCys: 0.248 ± 0.018	1.182HisAsp: 1.182 ± 0.042	1.189HisGlu: 1.189 ± 0.052	0.622HisPhe: 0.622 ± 0.032	1.745HisGly: 1.745 ± 0.054	0.468HisHis: 0.468 ± 0.025	1.1HisIle: 1.1 ± 0.041	0.58HisLys: 0.58 ± 0.024	1.672HisLeu: 1.672 ± 0.05	0.511HisMet: 0.511 ± 0.029	0.569HisAsn: 0.569 ± 0.028	1.032HisPro: 1.032 ± 0.039	0.495HisGln: 0.495 ± 0.03	1.076HisArg: 1.076 ± 0.037	0.922HisSer: 0.922 ± 0.039	0.945HisThr: 0.945 ± 0.037	1.628HisVal: 1.628 ± 0.044	0.149HisTrp: 0.149 ± 0.014	0.542HisTyr: 0.542 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.946IleAla: 6.946 ± 0.109	0.928IleCys: 0.928 ± 0.041	4.393IleAsp: 4.393 ± 0.085	4.027IleGlu: 4.027 ± 0.088	1.714IlePhe: 1.714 ± 0.057	3.918IleGly: 3.918 ± 0.081	0.88IleHis: 0.88 ± 0.035	2.765IleIle: 2.765 ± 0.077	2.044IleLys: 2.044 ± 0.058	3.987IleLeu: 3.987 ± 0.087	1.38IleMet: 1.38 ± 0.057	1.67IleAsn: 1.67 ± 0.056	2.392IlePro: 2.392 ± 0.06	1.311IleGln: 1.311 ± 0.047	2.55IleArg: 2.55 ± 0.065	3.387IleSer: 3.387 ± 0.07	2.986IleThr: 2.986 ± 0.075	4.107IleVal: 4.107 ± 0.084	0.491IleTrp: 0.491 ± 0.028	1.264IleTyr: 1.264 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.978LysAla: 3.978 ± 0.101	0.362LysCys: 0.362 ± 0.023	2.16LysAsp: 2.16 ± 0.06	2.083LysGlu: 2.083 ± 0.066	0.943LysPhe: 0.943 ± 0.039	2.848LysGly: 2.848 ± 0.069	0.652LysHis: 0.652 ± 0.035	2.068LysIle: 2.068 ± 0.059	2.137LysLys: 2.137 ± 0.072	3.401LysLeu: 3.401 ± 0.076	1.144LysMet: 1.144 ± 0.038	1.356LysAsn: 1.356 ± 0.045	1.806LysPro: 1.806 ± 0.062	1.222LysGln: 1.222 ± 0.04	2.704LysArg: 2.704 ± 0.063	2.055LysSer: 2.055 ± 0.061	2.404LysThr: 2.404 ± 0.069	2.806LysVal: 2.806 ± 0.082	0.325LysTrp: 0.325 ± 0.022	0.945LysTyr: 0.945 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	11.176LeuAla: 11.176 ± 0.156	1.349LeuCys: 1.349 ± 0.047	6.632LeuAsp: 6.632 ± 0.097	5.529LeuGlu: 5.529 ± 0.097	3.297LeuPhe: 3.297 ± 0.087	7.342LeuGly: 7.342 ± 0.114	1.544LeuHis: 1.544 ± 0.048	4.553LeuIle: 4.553 ± 0.101	3.26LeuLys: 3.26 ± 0.074	8.206LeuLeu: 8.206 ± 0.148	2.592LeuMet: 2.592 ± 0.062	2.527LeuAsn: 2.527 ± 0.06	4.155LeuPro: 4.155 ± 0.082	2.318LeuGln: 2.318 ± 0.061	4.984LeuArg: 4.984 ± 0.099	6.142LeuSer: 6.142 ± 0.112	4.742LeuThr: 4.742 ± 0.097	7.537LeuVal: 7.537 ± 0.122	0.755LeuTrp: 0.755 ± 0.033	2.351LeuTyr: 2.351 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	3.254MetAla: 3.254 ± 0.071	0.356MetCys: 0.356 ± 0.024	1.851MetAsp: 1.851 ± 0.053	1.433MetGlu: 1.433 ± 0.042	0.868MetPhe: 0.868 ± 0.036	2.55MetGly: 2.55 ± 0.063	0.522MetHis: 0.522 ± 0.028	1.249MetIle: 1.249 ± 0.046	1.047MetLys: 1.047 ± 0.041	2.723MetLeu: 2.723 ± 0.059	0.738MetMet: 0.738 ± 0.033	0.948MetAsn: 0.948 ± 0.04	1.411MetPro: 1.411 ± 0.048	0.909MetGln: 0.909 ± 0.038	1.837MetArg: 1.837 ± 0.051	1.864MetSer: 1.864 ± 0.053	1.542MetThr: 1.542 ± 0.042	2.182MetVal: 2.182 ± 0.059	0.232MetTrp: 0.232 ± 0.018	0.593MetTyr: 0.593 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.285AsnAla: 3.285 ± 0.071	0.38AsnCys: 0.38 ± 0.025	1.704AsnAsp: 1.704 ± 0.05	1.699AsnGlu: 1.699 ± 0.055	0.899AsnPhe: 0.899 ± 0.037	2.751AsnGly: 2.751 ± 0.093	0.554AsnHis: 0.554 ± 0.027	1.706AsnIle: 1.706 ± 0.056	1.185AsnLys: 1.185 ± 0.046	2.827AsnLeu: 2.827 ± 0.063	0.846AsnMet: 0.846 ± 0.037	0.967AsnAsn: 0.967 ± 0.048	1.902AsnPro: 1.902 ± 0.054	0.912AsnGln: 0.912 ± 0.04	1.587AsnArg: 1.587 ± 0.049	1.489AsnSer: 1.489 ± 0.056	1.525AsnThr: 1.525 ± 0.05	2.44AsnVal: 2.44 ± 0.054	0.301AsnTrp: 0.301 ± 0.018	0.863AsnTyr: 0.863 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.397ProAla: 5.397 ± 0.104	0.6ProCys: 0.6 ± 0.031	2.812ProAsp: 2.812 ± 0.077	2.793ProGlu: 2.793 ± 0.068	1.649ProPhe: 1.649 ± 0.053	3.317ProGly: 3.317 ± 0.08	0.894ProHis: 0.894 ± 0.037	1.895ProIle: 1.895 ± 0.064	1.56ProLys: 1.56 ± 0.052	3.657ProLeu: 3.657 ± 0.083	1.003ProMet: 1.003 ± 0.036	1.253ProAsn: 1.253 ± 0.037	1.003ProPro: 1.003 ± 0.042	1.697ProGln: 1.697 ± 0.05	2.335ProArg: 2.335 ± 0.055	2.766ProSer: 2.766 ± 0.062	2.187ProThr: 2.187 ± 0.066	3.737ProVal: 3.737 ± 0.076	0.491ProTrp: 0.491 ± 0.027	1.335ProTyr: 1.335 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.527GlnAla: 3.527 ± 0.072	0.277GlnCys: 0.277 ± 0.023	1.721GlnAsp: 1.721 ± 0.052	1.748GlnGlu: 1.748 ± 0.049	1.006GlnPhe: 1.006 ± 0.038	2.4GlnGly: 2.4 ± 0.06	0.542GlnHis: 0.542 ± 0.027	1.84GlnIle: 1.84 ± 0.061	1.055GlnLys: 1.055 ± 0.042	2.971GlnLeu: 2.971 ± 0.079	0.977GlnMet: 0.977 ± 0.042	0.89GlnAsn: 0.89 ± 0.037	1.243GlnPro: 1.243 ± 0.042	1.358GlnGln: 1.358 ± 0.048	2.052GlnArg: 2.052 ± 0.058	1.584GlnSer: 1.584 ± 0.049	1.69GlnThr: 1.69 ± 0.051	2.441GlnVal: 2.441 ± 0.068	0.277GlnTrp: 0.277 ± 0.02	0.726GlnTyr: 0.726 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	6.916ArgAla: 6.916 ± 0.128	0.939ArgCys: 0.939 ± 0.044	3.915ArgAsp: 3.915 ± 0.092	4.465ArgGlu: 4.465 ± 0.095	2.277ArgPhe: 2.277 ± 0.057	4.307ArgGly: 4.307 ± 0.09	1.157ArgHis: 1.157 ± 0.046	3.331ArgIle: 3.331 ± 0.069	1.987ArgLys: 1.987 ± 0.063	5.169ArgLeu: 5.169 ± 0.1	1.955ArgMet: 1.955 ± 0.055	1.568ArgAsn: 1.568 ± 0.05	2.401ArgPro: 2.401 ± 0.063	1.781ArgGln: 1.781 ± 0.054	4.517ArgArg: 4.517 ± 0.107	3.37ArgSer: 3.37 ± 0.077	2.766ArgThr: 2.766 ± 0.068	4.758ArgVal: 4.758 ± 0.102	0.577ArgTrp: 0.577 ± 0.031	1.966ArgTyr: 1.966 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.685SerAla: 6.685 ± 0.105	0.998SerCys: 0.998 ± 0.037	3.342SerAsp: 3.342 ± 0.084	3.056SerGlu: 3.056 ± 0.075	2.486SerPhe: 2.486 ± 0.062	5.332SerGly: 5.332 ± 0.096	1.158SerHis: 1.158 ± 0.04	3.594SerIle: 3.594 ± 0.069	2.278SerLys: 2.278 ± 0.064	5.71SerLeu: 5.71 ± 0.106	1.716SerMet: 1.716 ± 0.047	1.873SerAsn: 1.873 ± 0.062	2.471SerPro: 2.471 ± 0.069	1.964SerGln: 1.964 ± 0.057	3.626SerArg: 3.626 ± 0.073	4.683SerSer: 4.683 ± 0.111	3.301SerThr: 3.301 ± 0.079	4.761SerVal: 4.761 ± 0.096	0.703SerTrp: 0.703 ± 0.028	1.973SerTyr: 1.973 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	5.397ThrAla: 5.397 ± 0.097	0.888ThrCys: 0.888 ± 0.039	2.942ThrAsp: 2.942 ± 0.074	2.522ThrGlu: 2.522 ± 0.058	2.13ThrPhe: 2.13 ± 0.061	4.875ThrGly: 4.875 ± 0.1	1.059ThrHis: 1.059 ± 0.038	2.896ThrIle: 2.896 ± 0.063	1.834ThrLys: 1.834 ± 0.057	4.848ThrLeu: 4.848 ± 0.101	1.301ThrMet: 1.301 ± 0.039	1.469ThrAsn: 1.469 ± 0.052	2.813ThrPro: 2.813 ± 0.066	1.619ThrGln: 1.619 ± 0.059	2.843ThrArg: 2.843 ± 0.066	3.225ThrSer: 3.225 ± 0.072	2.781ThrThr: 2.781 ± 0.074	4.701ThrVal: 4.701 ± 0.087	0.597ThrTrp: 0.597 ± 0.03	1.662ThrTyr: 1.662 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	9.122ValAla: 9.122 ± 0.125	1.324ValCys: 1.324 ± 0.05	5.691ValAsp: 5.691 ± 0.111	5.347ValGlu: 5.347 ± 0.104	2.935ValPhe: 2.935 ± 0.066	5.56ValGly: 5.56 ± 0.091	1.375ValHis: 1.375 ± 0.045	4.174ValIle: 4.174 ± 0.084	2.793ValLys: 2.793 ± 0.083	7.537ValLeu: 7.537 ± 0.128	2.027ValMet: 2.027 ± 0.059	2.409ValAsn: 2.409 ± 0.06	3.68ValPro: 3.68 ± 0.072	2.038ValGln: 2.038 ± 0.056	4.611ValArg: 4.611 ± 0.104	5.207ValSer: 5.207 ± 0.097	4.363ValThr: 4.363 ± 0.103	6.596ValVal: 6.596 ± 0.107	0.74ValTrp: 0.74 ± 0.034	2.065ValTyr: 2.065 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.938TrpAla: 0.938 ± 0.036	0.177TrpCys: 0.177 ± 0.014	0.604TrpAsp: 0.604 ± 0.03	0.597TrpGlu: 0.597 ± 0.03	0.446TrpPhe: 0.446 ± 0.027	0.813TrpGly: 0.813 ± 0.036	0.231TrpHis: 0.231 ± 0.018	0.522TrpIle: 0.522 ± 0.029	0.365TrpLys: 0.365 ± 0.022	1.004TrpLeu: 1.004 ± 0.036	0.347TrpMet: 0.347 ± 0.023	0.373TrpAsn: 0.373 ± 0.024	0.373TrpPro: 0.373 ± 0.027	0.314TrpGln: 0.314 ± 0.022	0.693TrpArg: 0.693 ± 0.034	0.663TrpSer: 0.663 ± 0.034	0.56TrpThr: 0.56 ± 0.031	0.652TrpVal: 0.652 ± 0.034	0.14TrpTrp: 0.14 ± 0.014	0.305TrpTyr: 0.305 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.905TyrAla: 2.905 ± 0.062	0.423TyrCys: 0.423 ± 0.025	1.806TyrAsp: 1.806 ± 0.051	1.735TyrGlu: 1.735 ± 0.044	1.02TyrPhe: 1.02 ± 0.036	2.342TyrGly: 2.342 ± 0.059	0.584TyrHis: 0.584 ± 0.03	1.341TyrIle: 1.341 ± 0.046	0.997TyrLys: 0.997 ± 0.039	2.755TyrLeu: 2.755 ± 0.062	0.665TyrMet: 0.665 ± 0.032	1.032TyrAsn: 1.032 ± 0.042	1.254TyrPro: 1.254 ± 0.047	0.983TyrGln: 0.983 ± 0.036	1.858TyrArg: 1.858 ± 0.057	1.669TyrSer: 1.669 ± 0.058	1.611TyrThr: 1.611 ± 0.053	2.117TyrVal: 2.117 ± 0.063	0.308TyrTrp: 0.308 ± 0.019	0.888TyrTyr: 0.888 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2204 proteins (707062 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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