Amino acid dipepetide frequency for Ruminococcus sp. 1xD21-23

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.62AlaAla: 11.62 ± 0.137
1.496AlaCys: 1.496 ± 0.031
5.364AlaAsp: 5.364 ± 0.068
6.285AlaGlu: 6.285 ± 0.074
3.433AlaPhe: 3.433 ± 0.044
7.719AlaGly: 7.719 ± 0.078
1.394AlaHis: 1.394 ± 0.023
4.722AlaIle: 4.722 ± 0.05
4.259AlaLys: 4.259 ± 0.048
8.514AlaLeu: 8.514 ± 0.084
2.654AlaMet: 2.654 ± 0.041
2.591AlaAsn: 2.591 ± 0.036
3.246AlaPro: 3.246 ± 0.057
2.575AlaGln: 2.575 ± 0.04
4.554AlaArg: 4.554 ± 0.059
4.872AlaSer: 4.872 ± 0.055
3.965AlaThr: 3.965 ± 0.047
7.405AlaVal: 7.405 ± 0.065
0.954AlaTrp: 0.954 ± 0.02
2.814AlaTyr: 2.814 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.286CysAla: 1.286 ± 0.029
0.306CysCys: 0.306 ± 0.013
0.863CysAsp: 0.863 ± 0.02
0.917CysGlu: 0.917 ± 0.023
0.697CysPhe: 0.697 ± 0.018
1.557CysGly: 1.557 ± 0.025
0.336CysHis: 0.336 ± 0.014
0.922CysIle: 0.922 ± 0.023
0.722CysLys: 0.722 ± 0.022
1.348CysLeu: 1.348 ± 0.026
0.455CysMet: 0.455 ± 0.015
0.512CysAsn: 0.512 ± 0.015
0.729CysPro: 0.729 ± 0.022
0.505CysGln: 0.505 ± 0.015
0.858CysArg: 0.858 ± 0.02
0.899CysSer: 0.899 ± 0.022
0.767CysThr: 0.767 ± 0.019
1.105CysVal: 1.105 ± 0.025
0.159CysTrp: 0.159 ± 0.008
0.538CysTyr: 0.538 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.961AspAla: 4.961 ± 0.064
0.821AspCys: 0.821 ± 0.021
2.991AspAsp: 2.991 ± 0.053
4.515AspGlu: 4.515 ± 0.062
2.693AspPhe: 2.693 ± 0.036
5.087AspGly: 5.087 ± 0.077
0.953AspHis: 0.953 ± 0.023
3.608AspIle: 3.608 ± 0.042
2.802AspLys: 2.802 ± 0.04
4.905AspLeu: 4.905 ± 0.052
1.678AspMet: 1.678 ± 0.029
1.968AspAsn: 1.968 ± 0.034
2.08AspPro: 2.08 ± 0.035
1.621AspGln: 1.621 ± 0.028
2.881AspArg: 2.881 ± 0.037
2.924AspSer: 2.924 ± 0.037
2.892AspThr: 2.892 ± 0.04
3.802AspVal: 3.802 ± 0.047
0.731AspTrp: 0.731 ± 0.016
2.515AspTyr: 2.515 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.738GluAla: 6.738 ± 0.077
0.81GluCys: 0.81 ± 0.021
4.178GluAsp: 4.178 ± 0.053
6.822GluGlu: 6.822 ± 0.084
2.341GluPhe: 2.341 ± 0.036
5.121GluGly: 5.121 ± 0.059
1.258GluHis: 1.258 ± 0.028
4.71GluIle: 4.71 ± 0.053
5.577GluLys: 5.577 ± 0.068
6.392GluLeu: 6.392 ± 0.063
2.247GluMet: 2.247 ± 0.033
3.494GluAsn: 3.494 ± 0.054
2.421GluPro: 2.421 ± 0.037
2.901GluGln: 2.901 ± 0.044
4.459GluArg: 4.459 ± 0.051
3.46GluSer: 3.46 ± 0.04
3.662GluThr: 3.662 ± 0.047
4.443GluVal: 4.443 ± 0.045
0.776GluTrp: 0.776 ± 0.02
2.614GluTyr: 2.614 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.491PheAla: 3.491 ± 0.046
0.798PheCys: 0.798 ± 0.02
2.554PheAsp: 2.554 ± 0.034
2.445PheGlu: 2.445 ± 0.029
1.85PhePhe: 1.85 ± 0.034
3.265PheGly: 3.265 ± 0.043
0.834PheHis: 0.834 ± 0.022
2.269PheIle: 2.269 ± 0.04
1.588PheLys: 1.588 ± 0.028
4.01PheLeu: 4.01 ± 0.056
1.102PheMet: 1.102 ± 0.022
1.283PheAsn: 1.283 ± 0.023
1.518PhePro: 1.518 ± 0.03
1.418PheGln: 1.418 ± 0.03
1.85PheArg: 1.85 ± 0.032
2.848PheSer: 2.848 ± 0.037
2.186PheThr: 2.186 ± 0.037
2.853PheVal: 2.853 ± 0.035
0.525PheTrp: 0.525 ± 0.017
1.68PheTyr: 1.68 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
6.694GlyAla: 6.694 ± 0.077
1.386GlyCys: 1.386 ± 0.029
3.998GlyAsp: 3.998 ± 0.051
5.423GlyGlu: 5.423 ± 0.057
3.282GlyPhe: 3.282 ± 0.036
5.548GlyGly: 5.548 ± 0.081
1.312GlyHis: 1.312 ± 0.024
5.616GlyIle: 5.616 ± 0.059
4.992GlyLys: 4.992 ± 0.063
6.415GlyLeu: 6.415 ± 0.06
2.536GlyMet: 2.536 ± 0.036
3.152GlyAsn: 3.152 ± 0.051
1.81GlyPro: 1.81 ± 0.033
2.341GlyGln: 2.341 ± 0.038
4.135GlyArg: 4.135 ± 0.055
4.374GlySer: 4.374 ± 0.049
4.388GlyThr: 4.388 ± 0.047
5.463GlyVal: 5.463 ± 0.052
0.994GlyTrp: 0.994 ± 0.03
3.035GlyTyr: 3.035 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
1.272HisAla: 1.272 ± 0.022
0.307HisCys: 0.307 ± 0.011
0.897HisAsp: 0.897 ± 0.022
1.074HisGlu: 1.074 ± 0.023
0.76HisPhe: 0.76 ± 0.019
1.474HisGly: 1.474 ± 0.027
0.406HisHis: 0.406 ± 0.015
1.164HisIle: 1.164 ± 0.025
0.85HisLys: 0.85 ± 0.018
1.633HisLeu: 1.633 ± 0.028
0.513HisMet: 0.513 ± 0.014
0.647HisAsn: 0.647 ± 0.018
0.927HisPro: 0.927 ± 0.019
0.591HisGln: 0.591 ± 0.019
0.984HisArg: 0.984 ± 0.021
1.015HisSer: 1.015 ± 0.021
0.944HisThr: 0.944 ± 0.022
1.207HisVal: 1.207 ± 0.02
0.207HisTrp: 0.207 ± 0.008
0.747HisTyr: 0.747 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
5.318IleAla: 5.318 ± 0.055
1.149IleCys: 1.149 ± 0.023
3.526IleAsp: 3.526 ± 0.041
4.04IleGlu: 4.04 ± 0.048
2.399IlePhe: 2.399 ± 0.042
4.572IleGly: 4.572 ± 0.059
1.279IleHis: 1.279 ± 0.024
3.536IleIle: 3.536 ± 0.049
2.981IleLys: 2.981 ± 0.047
5.907IleLeu: 5.907 ± 0.074
1.632IleMet: 1.632 ± 0.027
2.162IleAsn: 2.162 ± 0.035
2.825IlePro: 2.825 ± 0.037
2.221IleGln: 2.221 ± 0.037
3.36IleArg: 3.36 ± 0.04
3.827IleSer: 3.827 ± 0.048
3.347IleThr: 3.347 ± 0.044
4.37IleVal: 4.37 ± 0.049
0.669IleTrp: 0.669 ± 0.019
2.28IleTyr: 2.28 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.523LysAla: 4.523 ± 0.052
0.6LysCys: 0.6 ± 0.015
3.159LysAsp: 3.159 ± 0.042
5.368LysGlu: 5.368 ± 0.067
1.497LysPhe: 1.497 ± 0.026
3.903LysGly: 3.903 ± 0.051
0.847LysHis: 0.847 ± 0.02
3.622LysIle: 3.622 ± 0.044
4.673LysLys: 4.673 ± 0.065
4.593LysLeu: 4.593 ± 0.057
1.689LysMet: 1.689 ± 0.033
2.796LysAsn: 2.796 ± 0.047
1.926LysPro: 1.926 ± 0.04
2.034LysGln: 2.034 ± 0.035
3.174LysArg: 3.174 ± 0.043
2.91LysSer: 2.91 ± 0.037
3.082LysThr: 3.082 ± 0.054
3.523LysVal: 3.523 ± 0.049
0.586LysTrp: 0.586 ± 0.016
2.07LysTyr: 2.07 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
8.724LeuAla: 8.724 ± 0.086
1.549LeuCys: 1.549 ± 0.027
5.14LeuAsp: 5.14 ± 0.049
6.387LeuGlu: 6.387 ± 0.071
3.931LeuPhe: 3.931 ± 0.059
6.419LeuGly: 6.419 ± 0.066
1.523LeuHis: 1.523 ± 0.025
5.105LeuIle: 5.105 ± 0.062
5.192LeuLys: 5.192 ± 0.052
8.619LeuLeu: 8.619 ± 0.088
2.659LeuMet: 2.659 ± 0.04
3.253LeuAsn: 3.253 ± 0.043
3.888LeuPro: 3.888 ± 0.043
2.593LeuGln: 2.593 ± 0.036
4.399LeuArg: 4.399 ± 0.049
6.043LeuSer: 6.043 ± 0.06
5.073LeuThr: 5.073 ± 0.05
6.251LeuVal: 6.251 ± 0.072
1.007LeuTrp: 1.007 ± 0.021
3.153LeuTyr: 3.153 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.901MetAla: 2.901 ± 0.043
0.355MetCys: 0.355 ± 0.011
1.768MetAsp: 1.768 ± 0.029
2.612MetGlu: 2.612 ± 0.034
0.964MetPhe: 0.964 ± 0.023
2.316MetGly: 2.316 ± 0.037
0.362MetHis: 0.362 ± 0.012
1.755MetIle: 1.755 ± 0.032
1.966MetLys: 1.966 ± 0.03
2.477MetLeu: 2.477 ± 0.034
0.84MetMet: 0.84 ± 0.019
1.366MetAsn: 1.366 ± 0.025
1.18MetPro: 1.18 ± 0.022
0.857MetGln: 0.857 ± 0.02
1.494MetArg: 1.494 ± 0.024
1.578MetSer: 1.578 ± 0.028
1.612MetThr: 1.612 ± 0.026
2.102MetVal: 2.102 ± 0.032
0.245MetTrp: 0.245 ± 0.011
0.756MetTyr: 0.756 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.873AsnAla: 2.873 ± 0.041
0.571AsnCys: 0.571 ± 0.019
1.853AsnAsp: 1.853 ± 0.034
2.382AsnGlu: 2.382 ± 0.037
1.374AsnPhe: 1.374 ± 0.028
3.255AsnGly: 3.255 ± 0.052
0.82AsnHis: 0.82 ± 0.023
2.503AsnIle: 2.503 ± 0.039
1.861AsnLys: 1.861 ± 0.033
3.483AsnLeu: 3.483 ± 0.042
1.084AsnMet: 1.084 ± 0.023
1.454AsnAsn: 1.454 ± 0.032
2.079AsnPro: 2.079 ± 0.033
1.532AsnGln: 1.532 ± 0.03
2.14AsnArg: 2.14 ± 0.035
1.956AsnSer: 1.956 ± 0.038
1.976AsnThr: 1.976 ± 0.029
2.481AsnVal: 2.481 ± 0.031
0.434AsnTrp: 0.434 ± 0.015
1.595AsnTyr: 1.595 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
3.721ProAla: 3.721 ± 0.055
0.507ProCys: 0.507 ± 0.015
2.642ProAsp: 2.642 ± 0.038
3.595ProGlu: 3.595 ± 0.047
1.701ProPhe: 1.701 ± 0.029
2.816ProGly: 2.816 ± 0.049
0.651ProHis: 0.651 ± 0.019
1.956ProIle: 1.956 ± 0.03
1.838ProLys: 1.838 ± 0.034
3.267ProLeu: 3.267 ± 0.048
0.935ProMet: 0.935 ± 0.018
1.205ProAsn: 1.205 ± 0.025
1.129ProPro: 1.129 ± 0.027
1.125ProGln: 1.125 ± 0.022
1.526ProArg: 1.526 ± 0.027
2.184ProSer: 2.184 ± 0.036
1.794ProThr: 1.794 ± 0.033
3.375ProVal: 3.375 ± 0.042
0.465ProTrp: 0.465 ± 0.015
1.438ProTyr: 1.438 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
2.795GlnAla: 2.795 ± 0.034
0.386GlnCys: 0.386 ± 0.013
1.569GlnAsp: 1.569 ± 0.031
2.723GlnGlu: 2.723 ± 0.045
1.131GlnPhe: 1.131 ± 0.022
2.21GlnGly: 2.21 ± 0.035
0.476GlnHis: 0.476 ± 0.015
2.347GlnIle: 2.347 ± 0.038
2.351GlnLys: 2.351 ± 0.035
2.777GlnLeu: 2.777 ± 0.034
1.187GlnMet: 1.187 ± 0.027
1.428GlnAsn: 1.428 ± 0.031
1.075GlnPro: 1.075 ± 0.024
1.218GlnGln: 1.218 ± 0.028
1.716GlnArg: 1.716 ± 0.029
1.616GlnSer: 1.616 ± 0.028
1.728GlnThr: 1.728 ± 0.029
2.428GlnVal: 2.428 ± 0.04
0.435GlnTrp: 0.435 ± 0.015
1.283GlnTyr: 1.283 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
4.276ArgAla: 4.276 ± 0.051
0.757ArgCys: 0.757 ± 0.019
2.767ArgAsp: 2.767 ± 0.035
4.501ArgGlu: 4.501 ± 0.048
2.272ArgPhe: 2.272 ± 0.034
3.279ArgGly: 3.279 ± 0.038
1.021ArgHis: 1.021 ± 0.025
3.541ArgIle: 3.541 ± 0.042
3.321ArgLys: 3.321 ± 0.042
4.892ArgLeu: 4.892 ± 0.051
1.721ArgMet: 1.721 ± 0.027
2.056ArgAsn: 2.056 ± 0.036
1.841ArgPro: 1.841 ± 0.035
2.078ArgGln: 2.078 ± 0.034
3.381ArgArg: 3.381 ± 0.049
2.608ArgSer: 2.608 ± 0.037
2.64ArgThr: 2.64 ± 0.035
3.314ArgVal: 3.314 ± 0.042
0.552ArgTrp: 0.552 ± 0.015
2.046ArgTyr: 2.046 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
4.583SerAla: 4.583 ± 0.051
0.905SerCys: 0.905 ± 0.022
3.106SerAsp: 3.106 ± 0.042
3.432SerGlu: 3.432 ± 0.048
2.616SerPhe: 2.616 ± 0.036
4.923SerGly: 4.923 ± 0.058
1.116SerHis: 1.116 ± 0.022
3.45SerIle: 3.45 ± 0.039
2.745SerLys: 2.745 ± 0.043
5.398SerLeu: 5.398 ± 0.049
1.756SerMet: 1.756 ± 0.031
1.964SerAsn: 1.964 ± 0.037
2.126SerPro: 2.126 ± 0.035
1.929SerGln: 1.929 ± 0.033
3.131SerArg: 3.131 ± 0.044
3.613SerSer: 3.613 ± 0.047
2.585SerThr: 2.585 ± 0.037
4.226SerVal: 4.226 ± 0.043
0.745SerTrp: 0.745 ± 0.019
2.29SerTyr: 2.29 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.782ThrAla: 4.782 ± 0.053
0.689ThrCys: 0.689 ± 0.019
3.098ThrAsp: 3.098 ± 0.046
3.471ThrGlu: 3.471 ± 0.042
2.122ThrPhe: 2.122 ± 0.033
4.657ThrGly: 4.657 ± 0.045
0.844ThrHis: 0.844 ± 0.02
3.265ThrIle: 3.265 ± 0.048
2.485ThrLys: 2.485 ± 0.035
4.614ThrLeu: 4.614 ± 0.05
1.397ThrMet: 1.397 ± 0.023
1.733ThrAsn: 1.733 ± 0.031
2.422ThrPro: 2.422 ± 0.034
1.401ThrGln: 1.401 ± 0.024
2.321ThrArg: 2.321 ± 0.031
2.836ThrSer: 2.836 ± 0.038
2.648ThrThr: 2.648 ± 0.047
4.385ThrVal: 4.385 ± 0.052
0.598ThrTrp: 0.598 ± 0.017
1.892ThrTyr: 1.892 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
6.357ValAla: 6.357 ± 0.072
1.262ValCys: 1.262 ± 0.024
3.964ValAsp: 3.964 ± 0.05
4.774ValGlu: 4.774 ± 0.048
3.131ValPhe: 3.131 ± 0.045
4.832ValGly: 4.832 ± 0.058
1.148ValHis: 1.148 ± 0.02
4.472ValIle: 4.472 ± 0.051
3.725ValLys: 3.725 ± 0.036
6.92ValLeu: 6.92 ± 0.062
2.057ValMet: 2.057 ± 0.032
2.614ValAsn: 2.614 ± 0.04
2.962ValPro: 2.962 ± 0.045
2.016ValGln: 2.016 ± 0.03
3.813ValArg: 3.813 ± 0.047
4.536ValSer: 4.536 ± 0.056
3.998ValThr: 3.998 ± 0.058
5.42ValVal: 5.42 ± 0.06
0.808ValTrp: 0.808 ± 0.02
2.55ValTyr: 2.55 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
0.763TrpAla: 0.763 ± 0.021
0.189TrpCys: 0.189 ± 0.009
0.656TrpAsp: 0.656 ± 0.018
0.901TrpGlu: 0.901 ± 0.019
0.507TrpPhe: 0.507 ± 0.017
0.866TrpGly: 0.866 ± 0.022
0.231TrpHis: 0.231 ± 0.011
0.736TrpIle: 0.736 ± 0.021
0.799TrpLys: 0.799 ± 0.019
1.1TrpLeu: 1.1 ± 0.024
0.413TrpMet: 0.413 ± 0.014
0.576TrpAsn: 0.576 ± 0.018
0.299TrpPro: 0.299 ± 0.013
0.429TrpGln: 0.429 ± 0.014
0.557TrpArg: 0.557 ± 0.018
0.578TrpSer: 0.578 ± 0.017
0.493TrpThr: 0.493 ± 0.015
0.73TrpVal: 0.73 ± 0.021
0.141TrpTrp: 0.141 ± 0.007
0.496TrpTyr: 0.496 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.757TyrAla: 2.757 ± 0.035
0.639TyrCys: 0.639 ± 0.018
2.338TyrAsp: 2.338 ± 0.039
2.757TyrGlu: 2.757 ± 0.037
1.666TyrPhe: 1.666 ± 0.032
3.074TyrGly: 3.074 ± 0.039
0.807TyrHis: 0.807 ± 0.022
2.102TyrIle: 2.102 ± 0.033
1.847TyrLys: 1.847 ± 0.032
3.645TyrLeu: 3.645 ± 0.046
0.949TyrMet: 0.949 ± 0.021
1.452TyrAsn: 1.452 ± 0.029
1.388TyrPro: 1.388 ± 0.026
1.495TyrGln: 1.495 ± 0.028
2.13TyrArg: 2.13 ± 0.034
1.964TyrSer: 1.964 ± 0.034
1.879TyrThr: 1.879 ± 0.035
2.474TyrVal: 2.474 ± 0.035
0.429TyrTrp: 0.429 ± 0.014
1.727TyrTyr: 1.727 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7725 proteins (2202755 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski