Amino acid dipepetide frequency for Acetobacteroides hydrogenigenes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.369AlaAla: 6.369 ± 0.102	0.711AlaCys: 0.711 ± 0.024	3.977AlaAsp: 3.977 ± 0.061	4.369AlaGlu: 4.369 ± 0.076	3.437AlaPhe: 3.437 ± 0.067	4.813AlaGly: 4.813 ± 0.089	1.162AlaHis: 1.162 ± 0.032	6.016AlaIle: 6.016 ± 0.09	5.558AlaLys: 5.558 ± 0.074	7.145AlaLeu: 7.145 ± 0.105	1.762AlaMet: 1.762 ± 0.046	3.74AlaAsn: 3.74 ± 0.066	2.359AlaPro: 2.359 ± 0.058	2.83AlaGln: 2.83 ± 0.056	2.708AlaArg: 2.708 ± 0.057	5.098AlaSer: 5.098 ± 0.075	4.505AlaThr: 4.505 ± 0.102	4.89AlaVal: 4.89 ± 0.079	0.707AlaTrp: 0.707 ± 0.028	2.938AlaTyr: 2.938 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.59CysAla: 0.59 ± 0.023	0.17CysCys: 0.17 ± 0.014	0.479CysAsp: 0.479 ± 0.021	0.509CysGlu: 0.509 ± 0.025	0.475CysPhe: 0.475 ± 0.019	0.86CysGly: 0.86 ± 0.033	0.188CysHis: 0.188 ± 0.014	0.692CysIle: 0.692 ± 0.028	0.552CysLys: 0.552 ± 0.023	0.755CysLeu: 0.755 ± 0.027	0.195CysMet: 0.195 ± 0.012	0.515CysAsn: 0.515 ± 0.024	0.45CysPro: 0.45 ± 0.028	0.301CysGln: 0.301 ± 0.018	0.374CysArg: 0.374 ± 0.019	0.787CysSer: 0.787 ± 0.034	0.567CysThr: 0.567 ± 0.029	0.525CysVal: 0.525 ± 0.02	0.119CysTrp: 0.119 ± 0.011	0.431CysTyr: 0.431 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.089AspAla: 4.089 ± 0.07	0.463AspCys: 0.463 ± 0.02	2.411AspAsp: 2.411 ± 0.049	3.394AspGlu: 3.394 ± 0.064	2.803AspPhe: 2.803 ± 0.062	3.887AspGly: 3.887 ± 0.074	0.723AspHis: 0.723 ± 0.027	3.998AspIle: 3.998 ± 0.064	3.684AspLys: 3.684 ± 0.062	4.527AspLeu: 4.527 ± 0.067	1.259AspMet: 1.259 ± 0.036	2.495AspAsn: 2.495 ± 0.051	1.806AspPro: 1.806 ± 0.042	1.323AspGln: 1.323 ± 0.037	2.351AspArg: 2.351 ± 0.055	3.365AspSer: 3.365 ± 0.071	2.526AspThr: 2.526 ± 0.065	3.705AspVal: 3.705 ± 0.06	0.614AspTrp: 0.614 ± 0.029	2.434AspTyr: 2.434 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.622GluAla: 4.622 ± 0.083	0.471GluCys: 0.471 ± 0.023	2.618GluAsp: 2.618 ± 0.054	4.466GluGlu: 4.466 ± 0.101	2.614GluPhe: 2.614 ± 0.055	3.743GluGly: 3.743 ± 0.071	1.113GluHis: 1.113 ± 0.032	4.297GluIle: 4.297 ± 0.069	5.095GluLys: 5.095 ± 0.071	6.0GluLeu: 6.0 ± 0.083	1.976GluMet: 1.976 ± 0.049	3.218GluAsn: 3.218 ± 0.053	1.732GluPro: 1.732 ± 0.037	2.499GluGln: 2.499 ± 0.051	2.992GluArg: 2.992 ± 0.065	3.178GluSer: 3.178 ± 0.057	2.659GluThr: 2.659 ± 0.052	4.781GluVal: 4.781 ± 0.074	0.716GluTrp: 0.716 ± 0.026	2.359GluTyr: 2.359 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.514PheAla: 3.514 ± 0.065	0.515PheCys: 0.515 ± 0.025	3.03PheAsp: 3.03 ± 0.054	2.879PheGlu: 2.879 ± 0.054	2.468PhePhe: 2.468 ± 0.056	3.687PheGly: 3.687 ± 0.065	0.686PheHis: 0.686 ± 0.03	3.178PheIle: 3.178 ± 0.057	2.932PheLys: 2.932 ± 0.046	3.98PheLeu: 3.98 ± 0.067	1.171PheMet: 1.171 ± 0.035	2.533PheAsn: 2.533 ± 0.053	1.637PhePro: 1.637 ± 0.038	1.171PheGln: 1.171 ± 0.031	1.967PheArg: 1.967 ± 0.044	3.525PheSer: 3.525 ± 0.066	2.993PheThr: 2.993 ± 0.062	3.17PheVal: 3.17 ± 0.061	0.58PheTrp: 0.58 ± 0.027	2.008PheTyr: 2.008 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.866GlyAla: 4.866 ± 0.086	0.837GlyCys: 0.837 ± 0.04	3.36GlyAsp: 3.36 ± 0.064	3.752GlyGlu: 3.752 ± 0.063	3.572GlyPhe: 3.572 ± 0.065	4.945GlyGly: 4.945 ± 0.101	1.131GlyHis: 1.131 ± 0.032	5.616GlyIle: 5.616 ± 0.08	5.393GlyLys: 5.393 ± 0.076	5.907GlyLeu: 5.907 ± 0.077	1.873GlyMet: 1.873 ± 0.048	3.477GlyAsn: 3.477 ± 0.071	1.409GlyPro: 1.409 ± 0.037	1.94GlyGln: 1.94 ± 0.047	2.686GlyArg: 2.686 ± 0.06	4.583GlySer: 4.583 ± 0.08	3.922GlyThr: 3.922 ± 0.106	5.264GlyVal: 5.264 ± 0.075	0.882GlyTrp: 0.882 ± 0.03	3.366GlyTyr: 3.366 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.999HisAla: 0.999 ± 0.032	0.206HisCys: 0.206 ± 0.013	0.762HisAsp: 0.762 ± 0.025	0.901HisGlu: 0.901 ± 0.027	0.969HisPhe: 0.969 ± 0.036	1.085HisGly: 1.085 ± 0.033	0.429HisHis: 0.429 ± 0.023	1.254HisIle: 1.254 ± 0.033	0.995HisLys: 0.995 ± 0.034	1.64HisLeu: 1.64 ± 0.046	0.355HisMet: 0.355 ± 0.019	0.807HisAsn: 0.807 ± 0.03	0.957HisPro: 0.957 ± 0.029	0.609HisGln: 0.609 ± 0.025	0.804HisArg: 0.804 ± 0.028	1.118HisSer: 1.118 ± 0.031	0.917HisThr: 0.917 ± 0.028	0.922HisVal: 0.922 ± 0.029	0.186HisTrp: 0.186 ± 0.013	0.713HisTyr: 0.713 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.137IleAla: 6.137 ± 0.085	0.775IleCys: 0.775 ± 0.031	4.294IleAsp: 4.294 ± 0.07	4.567IleGlu: 4.567 ± 0.072	3.209IlePhe: 3.209 ± 0.059	5.007IleGly: 5.007 ± 0.076	1.072IleHis: 1.072 ± 0.031	4.666IleIle: 4.666 ± 0.088	4.658IleLys: 4.658 ± 0.074	6.065IleLeu: 6.065 ± 0.086	1.382IleMet: 1.382 ± 0.038	3.673IleAsn: 3.673 ± 0.066	3.369IlePro: 3.369 ± 0.056	1.898IleGln: 1.898 ± 0.042	3.045IleArg: 3.045 ± 0.053	5.424IleSer: 5.424 ± 0.082	4.224IleThr: 4.224 ± 0.08	5.007IleVal: 5.007 ± 0.073	0.666IleTrp: 0.666 ± 0.029	2.546IleTyr: 2.546 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	5.389LysAla: 5.389 ± 0.071	0.5LysCys: 0.5 ± 0.025	3.953LysAsp: 3.953 ± 0.072	5.218LysGlu: 5.218 ± 0.088	2.551LysPhe: 2.551 ± 0.055	5.073LysGly: 5.073 ± 0.077	1.257LysHis: 1.257 ± 0.035	4.462LysIle: 4.462 ± 0.065	5.227LysLys: 5.227 ± 0.089	6.106LysLeu: 6.106 ± 0.086	2.214LysMet: 2.214 ± 0.047	3.764LysAsn: 3.764 ± 0.063	2.649LysPro: 2.649 ± 0.051	2.564LysGln: 2.564 ± 0.044	3.299LysArg: 3.299 ± 0.055	4.309LysSer: 4.309 ± 0.069	3.573LysThr: 3.573 ± 0.057	5.397LysVal: 5.397 ± 0.07	0.7LysTrp: 0.7 ± 0.028	2.759LysTyr: 2.759 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.98LeuAla: 6.98 ± 0.09	0.899LeuCys: 0.899 ± 0.03	4.634LeuAsp: 4.634 ± 0.078	5.216LeuGlu: 5.216 ± 0.08	4.462LeuPhe: 4.462 ± 0.086	6.046LeuGly: 6.046 ± 0.086	1.473LeuHis: 1.473 ± 0.042	5.854LeuIle: 5.854 ± 0.083	6.943LeuLys: 6.943 ± 0.076	9.354LeuLeu: 9.354 ± 0.137	2.269LeuMet: 2.269 ± 0.049	4.829LeuAsn: 4.829 ± 0.072	3.729LeuPro: 3.729 ± 0.058	2.852LeuGln: 2.852 ± 0.045	4.009LeuArg: 4.009 ± 0.064	7.151LeuSer: 7.151 ± 0.105	5.262LeuThr: 5.262 ± 0.08	6.192LeuVal: 6.192 ± 0.077	0.876LeuTrp: 0.876 ± 0.03	3.327LeuTyr: 3.327 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.118MetAla: 2.118 ± 0.047	0.169MetCys: 0.169 ± 0.012	1.182MetAsp: 1.182 ± 0.038	1.566MetGlu: 1.566 ± 0.04	0.94MetPhe: 0.94 ± 0.031	1.842MetGly: 1.842 ± 0.045	0.442MetHis: 0.442 ± 0.022	1.329MetIle: 1.329 ± 0.033	1.961MetLys: 1.961 ± 0.045	2.804MetLeu: 2.804 ± 0.063	0.685MetMet: 0.685 ± 0.026	1.249MetAsn: 1.249 ± 0.033	1.09MetPro: 1.09 ± 0.033	0.887MetGln: 0.887 ± 0.024	1.212MetArg: 1.212 ± 0.038	1.506MetSer: 1.506 ± 0.037	1.036MetThr: 1.036 ± 0.032	2.0MetVal: 2.0 ± 0.045	0.208MetTrp: 0.208 ± 0.014	0.702MetTyr: 0.702 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.824AsnAla: 3.824 ± 0.066	0.373AsnCys: 0.373 ± 0.018	2.776AsnAsp: 2.776 ± 0.053	3.032AsnGlu: 3.032 ± 0.058	2.385AsnPhe: 2.385 ± 0.058	4.171AsnGly: 4.171 ± 0.083	0.941AsnHis: 0.941 ± 0.031	3.896AsnIle: 3.896 ± 0.072	3.063AsnLys: 3.063 ± 0.062	4.878AsnLeu: 4.878 ± 0.069	1.169AsnMet: 1.169 ± 0.033	2.518AsnAsn: 2.518 ± 0.063	2.712AsnPro: 2.712 ± 0.052	1.752AsnGln: 1.752 ± 0.051	2.502AsnArg: 2.502 ± 0.053	3.461AsnSer: 3.461 ± 0.065	2.727AsnThr: 2.727 ± 0.054	3.428AsnVal: 3.428 ± 0.07	0.469AsnTrp: 0.469 ± 0.022	1.954AsnTyr: 1.954 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.551ProAla: 2.551 ± 0.057	0.296ProCys: 0.296 ± 0.018	2.025ProAsp: 2.025 ± 0.05	2.775ProGlu: 2.775 ± 0.054	1.959ProPhe: 1.959 ± 0.041	2.01ProGly: 2.01 ± 0.049	0.643ProHis: 0.643 ± 0.028	2.807ProIle: 2.807 ± 0.053	2.424ProLys: 2.424 ± 0.053	3.258ProLeu: 3.258 ± 0.061	0.833ProMet: 0.833 ± 0.027	2.209ProAsn: 2.209 ± 0.049	0.835ProPro: 0.835 ± 0.026	1.347ProGln: 1.347 ± 0.035	1.22ProArg: 1.22 ± 0.03	2.776ProSer: 2.776 ± 0.053	2.33ProThr: 2.33 ± 0.055	2.545ProVal: 2.545 ± 0.046	0.399ProTrp: 0.399 ± 0.019	1.601ProTyr: 1.601 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.214GlnAla: 2.214 ± 0.042	0.213GlnCys: 0.213 ± 0.014	1.255GlnAsp: 1.255 ± 0.034	1.984GlnGlu: 1.984 ± 0.05	1.332GlnPhe: 1.332 ± 0.039	1.892GlnGly: 1.892 ± 0.041	0.638GlnHis: 0.638 ± 0.028	2.267GlnIle: 2.267 ± 0.047	2.632GlnLys: 2.632 ± 0.055	3.251GlnLeu: 3.251 ± 0.057	0.954GlnMet: 0.954 ± 0.032	1.763GlnAsn: 1.763 ± 0.041	1.29GlnPro: 1.29 ± 0.035	1.576GlnGln: 1.576 ± 0.046	1.606GlnArg: 1.606 ± 0.047	1.97GlnSer: 1.97 ± 0.046	1.718GlnThr: 1.718 ± 0.045	2.196GlnVal: 2.196 ± 0.05	0.348GlnTrp: 0.348 ± 0.018	1.22GlnTyr: 1.22 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.577ArgAla: 2.577 ± 0.049	0.462ArgCys: 0.462 ± 0.024	1.955ArgAsp: 1.955 ± 0.047	2.615ArgGlu: 2.615 ± 0.061	2.231ArgPhe: 2.231 ± 0.044	2.458ArgGly: 2.458 ± 0.051	0.754ArgHis: 0.754 ± 0.029	3.581ArgIle: 3.581 ± 0.06	3.149ArgLys: 3.149 ± 0.066	3.903ArgLeu: 3.903 ± 0.06	1.459ArgMet: 1.459 ± 0.04	2.296ArgAsn: 2.296 ± 0.054	1.394ArgPro: 1.394 ± 0.039	1.481ArgGln: 1.481 ± 0.038	2.02ArgArg: 2.02 ± 0.048	2.689ArgSer: 2.689 ± 0.049	2.249ArgThr: 2.249 ± 0.045	2.754ArgVal: 2.754 ± 0.052	0.606ArgTrp: 0.606 ± 0.022	2.077ArgTyr: 2.077 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.675SerAla: 4.675 ± 0.075	0.743SerCys: 0.743 ± 0.03	3.325SerAsp: 3.325 ± 0.056	3.675SerGlu: 3.675 ± 0.061	3.808SerPhe: 3.808 ± 0.068	4.752SerGly: 4.752 ± 0.084	1.115SerHis: 1.115 ± 0.033	5.626SerIle: 5.626 ± 0.088	4.69SerLys: 4.69 ± 0.073	6.411SerLeu: 6.411 ± 0.105	1.535SerMet: 1.535 ± 0.036	3.516SerAsn: 3.516 ± 0.071	2.367SerPro: 2.367 ± 0.052	2.017SerGln: 2.017 ± 0.043	2.758SerArg: 2.758 ± 0.063	4.97SerSer: 4.97 ± 0.099	4.009SerThr: 4.009 ± 0.067	4.395SerVal: 4.395 ± 0.067	0.868SerTrp: 0.868 ± 0.03	3.354SerTyr: 3.354 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	4.104ThrAla: 4.104 ± 0.079	0.459ThrCys: 0.459 ± 0.022	2.762ThrAsp: 2.762 ± 0.06	2.831ThrGlu: 2.831 ± 0.056	2.786ThrPhe: 2.786 ± 0.054	3.875ThrGly: 3.875 ± 0.082	0.89ThrHis: 0.89 ± 0.028	4.56ThrIle: 4.56 ± 0.077	3.322ThrLys: 3.322 ± 0.058	5.485ThrLeu: 5.485 ± 0.091	1.088ThrMet: 1.088 ± 0.032	2.739ThrAsn: 2.739 ± 0.065	2.809ThrPro: 2.809 ± 0.063	1.625ThrGln: 1.625 ± 0.042	1.897ThrArg: 1.897 ± 0.043	4.056ThrSer: 4.056 ± 0.085	3.376ThrThr: 3.376 ± 0.082	3.854ThrVal: 3.854 ± 0.086	0.543ThrTrp: 0.543 ± 0.027	2.336ThrTyr: 2.336 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	5.972ValAla: 5.972 ± 0.082	0.732ValCys: 0.732 ± 0.028	4.26ValAsp: 4.26 ± 0.063	4.766ValGlu: 4.766 ± 0.076	2.943ValPhe: 2.943 ± 0.065	4.968ValGly: 4.968 ± 0.068	1.008ValHis: 1.008 ± 0.025	4.211ValIle: 4.211 ± 0.07	5.309ValLys: 5.309 ± 0.077	6.066ValLeu: 6.066 ± 0.084	1.55ValMet: 1.55 ± 0.036	3.636ValAsn: 3.636 ± 0.067	2.332ValPro: 2.332 ± 0.048	1.83ValGln: 1.83 ± 0.042	2.82ValArg: 2.82 ± 0.063	4.799ValSer: 4.799 ± 0.077	3.715ValThr: 3.715 ± 0.089	5.874ValVal: 5.874 ± 0.089	0.657ValTrp: 0.657 ± 0.028	2.464ValTyr: 2.464 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.724TrpAla: 0.724 ± 0.025	0.14TrpCys: 0.14 ± 0.012	0.602TrpAsp: 0.602 ± 0.028	0.591TrpGlu: 0.591 ± 0.024	0.537TrpPhe: 0.537 ± 0.026	0.851TrpGly: 0.851 ± 0.03	0.207TrpHis: 0.207 ± 0.015	0.769TrpIle: 0.769 ± 0.027	0.728TrpLys: 0.728 ± 0.026	0.997TrpLeu: 0.997 ± 0.032	0.369TrpMet: 0.369 ± 0.022	0.626TrpAsn: 0.626 ± 0.027	0.229TrpPro: 0.229 ± 0.015	0.376TrpGln: 0.376 ± 0.02	0.49TrpArg: 0.49 ± 0.026	0.739TrpSer: 0.739 ± 0.027	0.539TrpThr: 0.539 ± 0.024	0.709TrpVal: 0.709 ± 0.027	0.169TrpTrp: 0.169 ± 0.013	0.399TrpTyr: 0.399 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.777TyrAla: 2.777 ± 0.052	0.403TyrCys: 0.403 ± 0.02	2.197TyrAsp: 2.197 ± 0.047	2.044TyrGlu: 2.044 ± 0.044	2.145TyrPhe: 2.145 ± 0.045	2.816TyrGly: 2.816 ± 0.054	0.756TyrHis: 0.756 ± 0.026	2.604TyrIle: 2.604 ± 0.053	2.65TyrLys: 2.65 ± 0.055	3.822TyrLeu: 3.822 ± 0.067	0.828TyrMet: 0.828 ± 0.028	2.427TyrAsn: 2.427 ± 0.058	1.688TyrPro: 1.688 ± 0.042	1.441TyrGln: 1.441 ± 0.036	1.953TyrArg: 1.953 ± 0.049	3.104TyrSer: 3.104 ± 0.069	2.549TyrThr: 2.549 ± 0.062	2.304TyrVal: 2.304 ± 0.047	0.48TyrTrp: 0.48 ± 0.023	1.805TyrTyr: 1.805 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3211 proteins (1096128 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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