Amino acid dipepetide frequency for Edaphobacter dinghuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.572AlaAla: 12.572 ± 0.15	0.853AlaCys: 0.853 ± 0.025	4.872AlaAsp: 4.872 ± 0.067	5.965AlaGlu: 5.965 ± 0.077	3.74AlaPhe: 3.74 ± 0.06	8.284AlaGly: 8.284 ± 0.091	2.161AlaHis: 2.161 ± 0.042	5.888AlaIle: 5.888 ± 0.083	4.394AlaLys: 4.394 ± 0.077	10.279AlaLeu: 10.279 ± 0.098	2.813AlaMet: 2.813 ± 0.063	3.506AlaAsn: 3.506 ± 0.067	4.664AlaPro: 4.664 ± 0.075	4.165AlaGln: 4.165 ± 0.066	5.3AlaArg: 5.3 ± 0.076	6.718AlaSer: 6.718 ± 0.087	6.432AlaThr: 6.432 ± 0.092	7.369AlaVal: 7.369 ± 0.085	1.21AlaTrp: 1.21 ± 0.033	2.475AlaTyr: 2.475 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.861CysAla: 0.861 ± 0.028	0.134CysCys: 0.134 ± 0.013	0.47CysAsp: 0.47 ± 0.02	0.433CysGlu: 0.433 ± 0.017	0.375CysPhe: 0.375 ± 0.017	0.901CysGly: 0.901 ± 0.03	0.245CysHis: 0.245 ± 0.014	0.467CysIle: 0.467 ± 0.019	0.264CysLys: 0.264 ± 0.015	0.773CysLeu: 0.773 ± 0.027	0.214CysMet: 0.214 ± 0.013	0.285CysAsn: 0.285 ± 0.015	0.412CysPro: 0.412 ± 0.019	0.198CysGln: 0.198 ± 0.013	0.461CysArg: 0.461 ± 0.018	0.633CysSer: 0.633 ± 0.024	0.484CysThr: 0.484 ± 0.019	0.629CysVal: 0.629 ± 0.027	0.11CysTrp: 0.11 ± 0.009	0.238CysTyr: 0.238 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.56AspAla: 5.56 ± 0.062	0.42AspCys: 0.42 ± 0.018	2.415AspAsp: 2.415 ± 0.052	2.943AspGlu: 2.943 ± 0.061	2.207AspPhe: 2.207 ± 0.05	4.309AspGly: 4.309 ± 0.065	1.211AspHis: 1.211 ± 0.032	2.641AspIle: 2.641 ± 0.044	1.849AspLys: 1.849 ± 0.043	5.168AspLeu: 5.168 ± 0.068	0.987AspMet: 0.987 ± 0.03	1.566AspAsn: 1.566 ± 0.042	2.933AspPro: 2.933 ± 0.044	1.786AspGln: 1.786 ± 0.038	2.947AspArg: 2.947 ± 0.058	2.862AspSer: 2.862 ± 0.043	2.714AspThr: 2.714 ± 0.051	3.67AspVal: 3.67 ± 0.055	0.789AspTrp: 0.789 ± 0.029	1.585AspTyr: 1.585 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	5.672GluAla: 5.672 ± 0.078	0.393GluCys: 0.393 ± 0.015	2.625GluAsp: 2.625 ± 0.05	3.251GluGlu: 3.251 ± 0.069	1.938GluPhe: 1.938 ± 0.043	3.618GluGly: 3.618 ± 0.054	1.337GluHis: 1.337 ± 0.036	3.335GluIle: 3.335 ± 0.06	2.528GluLys: 2.528 ± 0.052	5.34GluLeu: 5.34 ± 0.079	1.558GluMet: 1.558 ± 0.037	1.789GluAsn: 1.789 ± 0.039	2.149GluPro: 2.149 ± 0.043	2.54GluGln: 2.54 ± 0.055	3.744GluArg: 3.744 ± 0.068	3.095GluSer: 3.095 ± 0.05	3.185GluThr: 3.185 ± 0.051	3.702GluVal: 3.702 ± 0.056	0.698GluTrp: 0.698 ± 0.021	1.318GluTyr: 1.318 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.158PheAla: 4.158 ± 0.056	0.428PheCys: 0.428 ± 0.019	2.456PheAsp: 2.456 ± 0.043	2.078PheGlu: 2.078 ± 0.045	1.833PhePhe: 1.833 ± 0.044	3.648PheGly: 3.648 ± 0.065	1.094PheHis: 1.094 ± 0.031	1.761PheIle: 1.761 ± 0.033	1.177PheLys: 1.177 ± 0.032	3.874PheLeu: 3.874 ± 0.063	0.766PheMet: 0.766 ± 0.023	1.495PheAsn: 1.495 ± 0.044	1.86PhePro: 1.86 ± 0.041	1.293PheGln: 1.293 ± 0.033	2.146PheArg: 2.146 ± 0.037	2.895PheSer: 2.895 ± 0.062	2.508PheThr: 2.508 ± 0.05	2.796PheVal: 2.796 ± 0.053	0.543PheTrp: 0.543 ± 0.021	1.256PheTyr: 1.256 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.246GlyAla: 7.246 ± 0.095	0.787GlyCys: 0.787 ± 0.028	3.76GlyAsp: 3.76 ± 0.061	3.833GlyGlu: 3.833 ± 0.056	3.509GlyPhe: 3.509 ± 0.052	6.464GlyGly: 6.464 ± 0.112	1.851GlyHis: 1.851 ± 0.041	4.664GlyIle: 4.664 ± 0.072	3.814GlyLys: 3.814 ± 0.062	7.402GlyLeu: 7.402 ± 0.097	2.062GlyMet: 2.062 ± 0.039	2.885GlyAsn: 2.885 ± 0.059	3.04GlyPro: 3.04 ± 0.05	2.873GlyGln: 2.873 ± 0.052	4.33GlyArg: 4.33 ± 0.065	5.291GlySer: 5.291 ± 0.087	5.309GlyThr: 5.309 ± 0.09	6.007GlyVal: 6.007 ± 0.08	1.215GlyTrp: 1.215 ± 0.034	2.494GlyTyr: 2.494 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.209HisAla: 2.209 ± 0.046	0.258HisCys: 0.258 ± 0.014	1.189HisAsp: 1.189 ± 0.031	1.206HisGlu: 1.206 ± 0.033	1.087HisPhe: 1.087 ± 0.022	2.012HisGly: 2.012 ± 0.045	0.672HisHis: 0.672 ± 0.022	1.243HisIle: 1.243 ± 0.029	0.681HisLys: 0.681 ± 0.024	2.449HisLeu: 2.449 ± 0.052	0.519HisMet: 0.519 ± 0.022	0.721HisAsn: 0.721 ± 0.023	1.526HisPro: 1.526 ± 0.037	0.804HisGln: 0.804 ± 0.024	1.468HisArg: 1.468 ± 0.035	1.339HisSer: 1.339 ± 0.032	1.316HisThr: 1.316 ± 0.03	1.608HisVal: 1.608 ± 0.035	0.368HisTrp: 0.368 ± 0.017	0.709HisTyr: 0.709 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.534IleAla: 6.534 ± 0.086	0.536IleCys: 0.536 ± 0.021	3.255IleAsp: 3.255 ± 0.06	3.262IleGlu: 3.262 ± 0.051	2.204IlePhe: 2.204 ± 0.045	4.588IleGly: 4.588 ± 0.068	1.233IleHis: 1.233 ± 0.031	2.227IleIle: 2.227 ± 0.055	1.63IleLys: 1.63 ± 0.039	5.08IleLeu: 5.08 ± 0.075	0.827IleMet: 0.827 ± 0.027	1.877IleAsn: 1.877 ± 0.033	2.975IlePro: 2.975 ± 0.051	1.832IleGln: 1.832 ± 0.042	3.115IleArg: 3.115 ± 0.052	3.691IleSer: 3.691 ± 0.058	3.418IleThr: 3.418 ± 0.057	4.098IleVal: 4.098 ± 0.069	0.584IleTrp: 0.584 ± 0.022	1.505IleTyr: 1.505 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.91LysAla: 3.91 ± 0.071	0.225LysCys: 0.225 ± 0.015	2.08LysAsp: 2.08 ± 0.047	2.113LysGlu: 2.113 ± 0.05	1.309LysPhe: 1.309 ± 0.033	2.592LysGly: 2.592 ± 0.048	0.893LysHis: 0.893 ± 0.026	2.34LysIle: 2.34 ± 0.046	2.085LysLys: 2.085 ± 0.062	4.145LysLeu: 4.145 ± 0.061	1.149LysMet: 1.149 ± 0.034	1.477LysAsn: 1.477 ± 0.029	2.209LysPro: 2.209 ± 0.048	1.733LysGln: 1.733 ± 0.038	2.322LysArg: 2.322 ± 0.046	2.455LysSer: 2.455 ± 0.045	2.578LysThr: 2.578 ± 0.045	2.84LysVal: 2.84 ± 0.059	0.428LysTrp: 0.428 ± 0.018	1.062LysTyr: 1.062 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.73LeuAla: 10.73 ± 0.118	0.902LeuCys: 0.902 ± 0.027	5.092LeuAsp: 5.092 ± 0.068	5.082LeuGlu: 5.082 ± 0.073	3.821LeuPhe: 3.821 ± 0.06	7.351LeuGly: 7.351 ± 0.085	2.473LeuHis: 2.473 ± 0.046	4.96LeuIle: 4.96 ± 0.07	3.955LeuLys: 3.955 ± 0.055	10.187LeuLeu: 10.187 ± 0.131	2.175LeuMet: 2.175 ± 0.042	3.598LeuAsn: 3.598 ± 0.053	5.452LeuPro: 5.452 ± 0.07	3.604LeuGln: 3.604 ± 0.059	6.489LeuArg: 6.489 ± 0.084	6.824LeuSer: 6.824 ± 0.084	6.279LeuThr: 6.279 ± 0.079	6.453LeuVal: 6.453 ± 0.094	1.196LeuTrp: 1.196 ± 0.038	2.436LeuTyr: 2.436 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.474MetAla: 2.474 ± 0.049	0.166MetCys: 0.166 ± 0.011	1.12MetAsp: 1.12 ± 0.03	1.232MetGlu: 1.232 ± 0.035	0.715MetPhe: 0.715 ± 0.025	1.655MetGly: 1.655 ± 0.04	0.542MetHis: 0.542 ± 0.019	1.105MetIle: 1.105 ± 0.03	1.239MetLys: 1.239 ± 0.034	2.392MetLeu: 2.392 ± 0.052	0.676MetMet: 0.676 ± 0.023	0.894MetAsn: 0.894 ± 0.027	1.353MetPro: 1.353 ± 0.037	1.066MetGln: 1.066 ± 0.032	1.613MetArg: 1.613 ± 0.036	1.635MetSer: 1.635 ± 0.035	1.613MetThr: 1.613 ± 0.037	1.607MetVal: 1.607 ± 0.039	0.222MetTrp: 0.222 ± 0.014	0.462MetTyr: 0.462 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.592AsnAla: 3.592 ± 0.064	0.309AsnCys: 0.309 ± 0.015	1.701AsnAsp: 1.701 ± 0.032	1.661AsnGlu: 1.661 ± 0.038	1.559AsnPhe: 1.559 ± 0.041	3.117AsnGly: 3.117 ± 0.057	0.793AsnHis: 0.793 ± 0.027	2.011AsnIle: 2.011 ± 0.044	1.134AsnLys: 1.134 ± 0.031	3.562AsnLeu: 3.562 ± 0.055	0.692AsnMet: 0.692 ± 0.02	1.354AsnAsn: 1.354 ± 0.048	2.467AsnPro: 2.467 ± 0.051	1.366AsnGln: 1.366 ± 0.037	1.944AsnArg: 1.944 ± 0.035	2.245AsnSer: 2.245 ± 0.058	2.141AsnThr: 2.141 ± 0.051	2.505AsnVal: 2.505 ± 0.049	0.498AsnTrp: 0.498 ± 0.021	1.215AsnTyr: 1.215 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	5.287ProAla: 5.287 ± 0.078	0.331ProCys: 0.331 ± 0.017	2.919ProAsp: 2.919 ± 0.053	3.391ProGlu: 3.391 ± 0.057	1.956ProPhe: 1.956 ± 0.04	4.251ProGly: 4.251 ± 0.059	1.206ProHis: 1.206 ± 0.034	2.62ProIle: 2.62 ± 0.047	2.011ProLys: 2.011 ± 0.041	4.581ProLeu: 4.581 ± 0.061	1.146ProMet: 1.146 ± 0.03	1.994ProAsn: 1.994 ± 0.05	2.459ProPro: 2.459 ± 0.06	2.097ProGln: 2.097 ± 0.051	2.38ProArg: 2.38 ± 0.048	3.56ProSer: 3.56 ± 0.057	3.247ProThr: 3.247 ± 0.055	3.893ProVal: 3.893 ± 0.063	0.664ProTrp: 0.664 ± 0.023	1.355ProTyr: 1.355 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.824GlnAla: 3.824 ± 0.058	0.248GlnCys: 0.248 ± 0.015	1.572GlnAsp: 1.572 ± 0.037	1.735GlnGlu: 1.735 ± 0.039	1.493GlnPhe: 1.493 ± 0.037	2.431GlnGly: 2.431 ± 0.044	0.947GlnHis: 0.947 ± 0.029	2.295GlnIle: 2.295 ± 0.045	1.589GlnLys: 1.589 ± 0.036	3.67GlnLeu: 3.67 ± 0.06	1.143GlnMet: 1.143 ± 0.028	1.507GlnAsn: 1.507 ± 0.035	2.146GlnPro: 2.146 ± 0.044	2.208GlnGln: 2.208 ± 0.05	2.507GlnArg: 2.507 ± 0.046	2.519GlnSer: 2.519 ± 0.047	2.478GlnThr: 2.478 ± 0.051	2.611GlnVal: 2.611 ± 0.04	0.536GlnTrp: 0.536 ± 0.022	1.066GlnTyr: 1.066 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.175ArgAla: 5.175 ± 0.065	0.452ArgCys: 0.452 ± 0.017	2.891ArgAsp: 2.891 ± 0.05	3.553ArgGlu: 3.553 ± 0.073	2.504ArgPhe: 2.504 ± 0.048	3.697ArgGly: 3.697 ± 0.055	1.37ArgHis: 1.37 ± 0.033	3.681ArgIle: 3.681 ± 0.063	2.584ArgLys: 2.584 ± 0.051	5.716ArgLeu: 5.716 ± 0.077	1.686ArgMet: 1.686 ± 0.041	2.175ArgAsn: 2.175 ± 0.041	2.669ArgPro: 2.669 ± 0.057	2.307ArgGln: 2.307 ± 0.046	4.001ArgArg: 4.001 ± 0.063	3.683ArgSer: 3.683 ± 0.058	3.341ArgThr: 3.341 ± 0.053	3.977ArgVal: 3.977 ± 0.065	0.914ArgTrp: 0.914 ± 0.026	1.821ArgTyr: 1.821 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.503SerAla: 6.503 ± 0.08	0.601SerCys: 0.601 ± 0.025	3.157SerAsp: 3.157 ± 0.051	3.149SerGlu: 3.149 ± 0.058	2.767SerPhe: 2.767 ± 0.052	5.944SerGly: 5.944 ± 0.095	1.412SerHis: 1.412 ± 0.033	3.798SerIle: 3.798 ± 0.062	2.452SerLys: 2.452 ± 0.042	6.578SerLeu: 6.578 ± 0.079	1.497SerMet: 1.497 ± 0.029	2.388SerAsn: 2.388 ± 0.057	3.468SerPro: 3.468 ± 0.061	2.278SerGln: 2.278 ± 0.048	3.436SerArg: 3.436 ± 0.052	4.889SerSer: 4.889 ± 0.085	4.133SerThr: 4.133 ± 0.074	4.578SerVal: 4.578 ± 0.054	0.821SerTrp: 0.821 ± 0.028	1.878SerTyr: 1.878 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.413ThrAla: 6.413 ± 0.089	0.495ThrCys: 0.495 ± 0.02	2.959ThrAsp: 2.959 ± 0.047	2.856ThrGlu: 2.856 ± 0.048	2.536ThrPhe: 2.536 ± 0.045	5.491ThrGly: 5.491 ± 0.092	1.4ThrHis: 1.4 ± 0.035	3.615ThrIle: 3.615 ± 0.068	2.243ThrLys: 2.243 ± 0.049	6.443ThrLeu: 6.443 ± 0.077	1.284ThrMet: 1.284 ± 0.029	2.161ThrAsn: 2.161 ± 0.051	3.968ThrPro: 3.968 ± 0.06	2.206ThrGln: 2.206 ± 0.046	3.02ThrArg: 3.02 ± 0.042	4.022ThrSer: 4.022 ± 0.07	3.929ThrThr: 3.929 ± 0.079	4.809ThrVal: 4.809 ± 0.074	0.744ThrTrp: 0.744 ± 0.026	1.662ThrTyr: 1.662 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.338ValAla: 7.338 ± 0.098	0.663ValCys: 0.663 ± 0.026	3.829ValAsp: 3.829 ± 0.055	4.137ValGlu: 4.137 ± 0.069	2.711ValPhe: 2.711 ± 0.051	5.188ValGly: 5.188 ± 0.076	1.568ValHis: 1.568 ± 0.034	3.783ValIle: 3.783 ± 0.054	2.71ValLys: 2.71 ± 0.052	7.297ValLeu: 7.297 ± 0.089	1.644ValMet: 1.644 ± 0.041	2.538ValAsn: 2.538 ± 0.052	3.66ValPro: 3.66 ± 0.059	2.514ValGln: 2.514 ± 0.044	4.271ValArg: 4.271 ± 0.06	4.726ValSer: 4.726 ± 0.064	4.622ValThr: 4.622 ± 0.063	5.645ValVal: 5.645 ± 0.078	0.873ValTrp: 0.873 ± 0.027	1.716ValTyr: 1.716 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.943TrpAla: 0.943 ± 0.03	0.134TrpCys: 0.134 ± 0.009	0.634TrpAsp: 0.634 ± 0.024	0.524TrpGlu: 0.524 ± 0.019	0.547TrpPhe: 0.547 ± 0.023	0.878TrpGly: 0.878 ± 0.025	0.342TrpHis: 0.342 ± 0.016	0.795TrpIle: 0.795 ± 0.029	0.68TrpLys: 0.68 ± 0.024	1.449TrpLeu: 1.449 ± 0.039	0.43TrpMet: 0.43 ± 0.019	0.591TrpAsn: 0.591 ± 0.022	0.557TrpPro: 0.557 ± 0.023	0.63TrpGln: 0.63 ± 0.026	0.852TrpArg: 0.852 ± 0.028	0.874TrpSer: 0.874 ± 0.03	0.79TrpThr: 0.79 ± 0.027	0.791TrpVal: 0.791 ± 0.027	0.222TrpTrp: 0.222 ± 0.013	0.377TrpTyr: 0.377 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.658TyrAla: 2.658 ± 0.047	0.253TyrCys: 0.253 ± 0.014	1.57TyrAsp: 1.57 ± 0.035	1.411TyrGlu: 1.411 ± 0.034	1.255TyrPhe: 1.255 ± 0.033	2.418TyrGly: 2.418 ± 0.053	0.632TyrHis: 0.632 ± 0.022	1.244TyrIle: 1.244 ± 0.031	0.926TyrLys: 0.926 ± 0.028	2.672TyrLeu: 2.672 ± 0.056	0.512TyrMet: 0.512 ± 0.018	1.064TyrAsn: 1.064 ± 0.037	1.379TyrPro: 1.379 ± 0.034	1.023TyrGln: 1.023 ± 0.029	1.853TyrArg: 1.853 ± 0.039	1.771TyrSer: 1.771 ± 0.041	1.741TyrThr: 1.741 ± 0.044	1.847TyrVal: 1.847 ± 0.043	0.404TyrTrp: 0.404 ± 0.019	0.797TyrTyr: 0.797 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3723 proteins (1291713 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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