Amino acid dipepetide frequency for Blueberry red ringspot virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.58AlaAla: 1.58 ± 0.792
0.0AlaCys: 0.0 ± 0.0
2.371AlaAsp: 2.371 ± 0.423
2.766AlaGlu: 2.766 ± 0.809
1.185AlaPhe: 1.185 ± 0.61
0.395AlaGly: 0.395 ± 0.359
0.395AlaHis: 0.395 ± 0.295
2.371AlaIle: 2.371 ± 1.472
4.346AlaLys: 4.346 ± 1.232
2.371AlaLeu: 2.371 ± 0.885
0.79AlaMet: 0.79 ± 0.498
2.371AlaAsn: 2.371 ± 0.659
2.371AlaPro: 2.371 ± 0.9
0.79AlaGln: 0.79 ± 0.515
0.395AlaArg: 0.395 ± 0.359
3.556AlaSer: 3.556 ± 0.949
2.371AlaThr: 2.371 ± 0.945
1.976AlaVal: 1.976 ± 0.753
0.0AlaTrp: 0.0 ± 0.0
1.185AlaTyr: 1.185 ± 0.635
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.58CysCys: 1.58 ± 0.877
0.395CysAsp: 0.395 ± 0.342
0.79CysGlu: 0.79 ± 0.391
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.395CysIle: 0.395 ± 0.435
0.79CysLys: 0.79 ± 0.5
1.58CysLeu: 1.58 ± 0.668
0.0CysMet: 0.0 ± 0.0
0.395CysAsn: 0.395 ± 0.359
1.976CysPro: 1.976 ± 0.915
1.58CysGln: 1.58 ± 0.781
0.0CysArg: 0.0 ± 0.0
0.395CysSer: 0.395 ± 0.342
0.395CysThr: 0.395 ± 0.342
0.0CysVal: 0.0 ± 0.0
0.395CysTrp: 0.395 ± 0.342
1.185CysTyr: 1.185 ± 0.582
0.0CysXaa: 0.0 ± 0.0
Asp
1.185AspAla: 1.185 ± 0.672
0.79AspCys: 0.79 ± 0.683
1.976AspAsp: 1.976 ± 0.718
3.161AspGlu: 3.161 ± 0.837
2.371AspPhe: 2.371 ± 0.983
1.185AspGly: 1.185 ± 0.742
1.185AspHis: 1.185 ± 0.552
4.346AspIle: 4.346 ± 1.217
3.951AspLys: 3.951 ± 1.12
5.136AspLeu: 5.136 ± 1.835
2.371AspMet: 2.371 ± 0.684
2.766AspAsn: 2.766 ± 1.268
1.58AspPro: 1.58 ± 0.468
2.371AspGln: 2.371 ± 0.755
1.185AspArg: 1.185 ± 0.756
3.161AspSer: 3.161 ± 1.407
4.741AspThr: 4.741 ± 1.128
2.766AspVal: 2.766 ± 1.113
0.0AspTrp: 0.0 ± 0.0
2.371AspTyr: 2.371 ± 0.639
0.0AspXaa: 0.0 ± 0.0
Glu
2.371GluAla: 2.371 ± 1.419
0.395GluCys: 0.395 ± 0.342
5.531GluAsp: 5.531 ± 0.985
11.458GluGlu: 11.458 ± 3.298
2.766GluPhe: 2.766 ± 1.238
2.766GluGly: 2.766 ± 0.845
1.976GluHis: 1.976 ± 1.141
9.482GluIle: 9.482 ± 1.767
10.273GluLys: 10.273 ± 2.241
7.902GluLeu: 7.902 ± 1.538
1.185GluMet: 1.185 ± 0.714
5.927GluAsn: 5.927 ± 1.298
3.161GluPro: 3.161 ± 1.239
5.927GluGln: 5.927 ± 1.299
3.951GluArg: 3.951 ± 0.83
4.741GluSer: 4.741 ± 1.127
1.185GluThr: 1.185 ± 0.623
2.371GluVal: 2.371 ± 0.832
1.185GluTrp: 1.185 ± 0.61
2.766GluTyr: 2.766 ± 0.798
0.0GluXaa: 0.0 ± 0.0
Phe
1.185PheAla: 1.185 ± 0.45
0.395PheCys: 0.395 ± 0.295
1.58PheAsp: 1.58 ± 0.619
2.766PheGlu: 2.766 ± 1.0
1.185PhePhe: 1.185 ± 0.885
2.371PheGly: 2.371 ± 0.894
0.395PheHis: 0.395 ± 0.407
4.741PheIle: 4.741 ± 0.687
2.766PheLys: 2.766 ± 0.908
3.161PheLeu: 3.161 ± 0.881
0.395PheMet: 0.395 ± 0.295
2.766PheAsn: 2.766 ± 1.028
1.976PhePro: 1.976 ± 0.698
1.58PheGln: 1.58 ± 0.387
1.185PheArg: 1.185 ± 0.382
3.161PheSer: 3.161 ± 1.356
1.976PheThr: 1.976 ± 0.903
1.185PheVal: 1.185 ± 0.663
0.0PheTrp: 0.0 ± 0.0
2.371PheTyr: 2.371 ± 0.945
0.0PheXaa: 0.0 ± 0.0
Gly
2.371GlyAla: 2.371 ± 0.946
0.395GlyCys: 0.395 ± 0.342
1.58GlyAsp: 1.58 ± 0.907
1.976GlyGlu: 1.976 ± 0.721
1.185GlyPhe: 1.185 ± 0.602
0.395GlyGly: 0.395 ± 0.342
1.185GlyHis: 1.185 ± 0.393
4.741GlyIle: 4.741 ± 1.317
3.161GlyLys: 3.161 ± 1.206
2.371GlyLeu: 2.371 ± 0.872
1.185GlyMet: 1.185 ± 0.578
3.556GlyAsn: 3.556 ± 1.629
1.58GlyPro: 1.58 ± 0.525
1.185GlyGln: 1.185 ± 0.874
1.976GlyArg: 1.976 ± 0.604
1.58GlySer: 1.58 ± 0.65
1.976GlyThr: 1.976 ± 0.826
1.976GlyVal: 1.976 ± 0.667
0.0GlyTrp: 0.0 ± 0.0
1.58GlyTyr: 1.58 ± 0.635
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.395HisAsp: 0.395 ± 0.342
1.58HisGlu: 1.58 ± 0.534
0.79HisPhe: 0.79 ± 0.53
0.0HisGly: 0.0 ± 0.0
0.79HisHis: 0.79 ± 0.498
3.161HisIle: 3.161 ± 0.865
2.766HisLys: 2.766 ± 0.897
1.185HisLeu: 1.185 ± 0.45
0.79HisMet: 0.79 ± 0.719
0.395HisAsn: 0.395 ± 0.295
1.58HisPro: 1.58 ± 0.794
1.185HisGln: 1.185 ± 0.759
1.185HisArg: 1.185 ± 0.867
2.371HisSer: 2.371 ± 0.8
2.371HisThr: 2.371 ± 1.175
0.0HisVal: 0.0 ± 0.0
0.395HisTrp: 0.395 ± 0.295
1.58HisTyr: 1.58 ± 0.616
0.0HisXaa: 0.0 ± 0.0
Ile
2.371IleAla: 2.371 ± 0.998
1.185IleCys: 1.185 ± 0.672
5.136IleAsp: 5.136 ± 0.951
8.297IleGlu: 8.297 ± 1.159
4.346IlePhe: 4.346 ± 1.078
3.556IleGly: 3.556 ± 1.254
3.161IleHis: 3.161 ± 0.505
9.482IleIle: 9.482 ± 2.118
9.878IleLys: 9.878 ± 2.616
11.853IleLeu: 11.853 ± 1.75
1.976IleMet: 1.976 ± 0.819
5.531IleAsn: 5.531 ± 1.068
4.346IlePro: 4.346 ± 1.34
4.741IleGln: 4.741 ± 2.133
3.951IleArg: 3.951 ± 1.203
5.927IleSer: 5.927 ± 1.363
5.531IleThr: 5.531 ± 1.609
1.976IleVal: 1.976 ± 0.61
0.395IleTrp: 0.395 ± 0.295
3.161IleTyr: 3.161 ± 1.074
0.0IleXaa: 0.0 ± 0.0
Lys
3.951LysAla: 3.951 ± 1.85
0.79LysCys: 0.79 ± 0.683
5.927LysAsp: 5.927 ± 1.695
11.458LysGlu: 11.458 ± 1.331
2.371LysPhe: 2.371 ± 1.116
4.741LysGly: 4.741 ± 0.989
1.976LysHis: 1.976 ± 0.354
7.112LysIle: 7.112 ± 0.974
8.692LysLys: 8.692 ± 2.114
6.322LysLeu: 6.322 ± 0.972
2.766LysMet: 2.766 ± 0.95
7.112LysAsn: 7.112 ± 1.929
5.136LysPro: 5.136 ± 1.67
7.902LysGln: 7.902 ± 0.958
7.112LysArg: 7.112 ± 2.443
4.346LysSer: 4.346 ± 1.029
4.741LysThr: 4.741 ± 1.016
3.951LysVal: 3.951 ± 1.421
1.185LysTrp: 1.185 ± 0.602
8.692LysTyr: 8.692 ± 1.816
0.0LysXaa: 0.0 ± 0.0
Leu
3.161LeuAla: 3.161 ± 1.317
1.58LeuCys: 1.58 ± 0.546
3.161LeuAsp: 3.161 ± 1.047
10.668LeuGlu: 10.668 ± 2.045
2.371LeuPhe: 2.371 ± 0.771
2.766LeuGly: 2.766 ± 0.594
2.766LeuHis: 2.766 ± 0.746
5.927LeuIle: 5.927 ± 1.704
8.692LeuLys: 8.692 ± 1.479
6.717LeuLeu: 6.717 ± 1.641
2.371LeuMet: 2.371 ± 0.742
3.161LeuAsn: 3.161 ± 0.778
3.951LeuPro: 3.951 ± 1.189
5.531LeuGln: 5.531 ± 1.721
3.161LeuArg: 3.161 ± 0.913
9.482LeuSer: 9.482 ± 1.923
4.346LeuThr: 4.346 ± 0.736
4.346LeuVal: 4.346 ± 1.539
1.185LeuTrp: 1.185 ± 0.525
2.766LeuTyr: 2.766 ± 0.709
0.0LeuXaa: 0.0 ± 0.0
Met
0.395MetAla: 0.395 ± 0.342
0.395MetCys: 0.395 ± 0.342
1.976MetAsp: 1.976 ± 0.756
2.766MetGlu: 2.766 ± 1.011
0.0MetPhe: 0.0 ± 0.0
0.79MetGly: 0.79 ± 0.373
0.0MetHis: 0.0 ± 0.0
3.556MetIle: 3.556 ± 1.038
3.161MetLys: 3.161 ± 1.287
1.58MetLeu: 1.58 ± 0.514
0.0MetMet: 0.0 ± 0.0
2.371MetAsn: 2.371 ± 1.205
1.185MetPro: 1.185 ± 1.078
0.79MetGln: 0.79 ± 0.472
0.0MetArg: 0.0 ± 0.0
1.58MetSer: 1.58 ± 1.051
1.58MetThr: 1.58 ± 0.715
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.79MetTyr: 0.79 ± 0.5
0.0MetXaa: 0.0 ± 0.0
Asn
2.371AsnAla: 2.371 ± 0.678
0.395AsnCys: 0.395 ± 0.435
2.766AsnAsp: 2.766 ± 0.571
3.556AsnGlu: 3.556 ± 1.229
1.58AsnPhe: 1.58 ± 0.644
3.161AsnGly: 3.161 ± 0.958
1.185AsnHis: 1.185 ± 0.706
5.531AsnIle: 5.531 ± 1.23
5.136AsnLys: 5.136 ± 1.176
7.902AsnLeu: 7.902 ± 1.769
0.79AsnMet: 0.79 ± 0.607
5.531AsnAsn: 5.531 ± 1.435
1.58AsnPro: 1.58 ± 1.058
4.741AsnGln: 4.741 ± 1.148
3.161AsnArg: 3.161 ± 0.983
2.766AsnSer: 2.766 ± 1.465
1.58AsnThr: 1.58 ± 0.683
1.58AsnVal: 1.58 ± 0.719
0.0AsnTrp: 0.0 ± 0.0
4.741AsnTyr: 4.741 ± 1.547
0.0AsnXaa: 0.0 ± 0.0
Pro
1.185ProAla: 1.185 ± 0.548
0.79ProCys: 0.79 ± 0.486
1.976ProAsp: 1.976 ± 0.49
3.556ProGlu: 3.556 ± 1.129
1.58ProPhe: 1.58 ± 0.689
2.371ProGly: 2.371 ± 0.802
1.58ProHis: 1.58 ± 0.559
3.556ProIle: 3.556 ± 0.958
7.507ProLys: 7.507 ± 1.846
3.951ProLeu: 3.951 ± 2.177
3.556ProMet: 3.556 ± 1.004
2.371ProAsn: 2.371 ± 0.924
2.371ProPro: 2.371 ± 1.128
0.79ProGln: 0.79 ± 0.869
1.58ProArg: 1.58 ± 0.619
2.371ProSer: 2.371 ± 1.123
3.556ProThr: 3.556 ± 1.044
1.58ProVal: 1.58 ± 0.367
0.79ProTrp: 0.79 ± 0.391
2.766ProTyr: 2.766 ± 0.905
0.0ProXaa: 0.0 ± 0.0
Gln
1.58GlnAla: 1.58 ± 0.869
0.395GlnCys: 0.395 ± 0.342
1.185GlnAsp: 1.185 ± 0.677
5.531GlnGlu: 5.531 ± 1.291
1.976GlnPhe: 1.976 ± 0.878
2.371GlnGly: 2.371 ± 0.696
1.185GlnHis: 1.185 ± 0.459
5.531GlnIle: 5.531 ± 1.579
5.136GlnLys: 5.136 ± 1.241
4.741GlnLeu: 4.741 ± 1.487
0.0GlnMet: 0.0 ± 0.0
1.58GlnAsn: 1.58 ± 0.59
3.556GlnPro: 3.556 ± 1.823
0.395GlnGln: 0.395 ± 0.342
3.556GlnArg: 3.556 ± 1.091
3.556GlnSer: 3.556 ± 1.37
2.766GlnThr: 2.766 ± 0.631
3.951GlnVal: 3.951 ± 0.761
0.395GlnTrp: 0.395 ± 0.342
2.766GlnTyr: 2.766 ± 0.476
0.0GlnXaa: 0.0 ± 0.0
Arg
1.58ArgAla: 1.58 ± 0.493
1.58ArgCys: 1.58 ± 0.753
1.58ArgAsp: 1.58 ± 0.616
3.161ArgGlu: 3.161 ± 1.227
2.766ArgPhe: 2.766 ± 0.89
1.976ArgGly: 1.976 ± 1.044
0.0ArgHis: 0.0 ± 0.0
3.161ArgIle: 3.161 ± 1.563
4.346ArgLys: 4.346 ± 1.257
2.766ArgLeu: 2.766 ± 1.075
1.185ArgMet: 1.185 ± 0.717
1.185ArgAsn: 1.185 ± 0.775
1.185ArgPro: 1.185 ± 0.509
1.58ArgGln: 1.58 ± 0.682
3.161ArgArg: 3.161 ± 1.176
3.161ArgSer: 3.161 ± 1.59
1.58ArgThr: 1.58 ± 0.621
0.79ArgVal: 0.79 ± 0.391
0.79ArgTrp: 0.79 ± 0.391
1.976ArgTyr: 1.976 ± 1.045
0.0ArgXaa: 0.0 ± 0.0
Ser
1.976SerAla: 1.976 ± 1.093
0.0SerCys: 0.0 ± 0.0
3.161SerAsp: 3.161 ± 0.843
5.927SerGlu: 5.927 ± 1.802
3.161SerPhe: 3.161 ± 1.528
2.371SerGly: 2.371 ± 0.452
1.58SerHis: 1.58 ± 0.953
6.322SerIle: 6.322 ± 2.553
7.112SerLys: 7.112 ± 1.615
4.346SerLeu: 4.346 ± 1.226
0.79SerMet: 0.79 ± 0.472
4.741SerAsn: 4.741 ± 1.206
3.161SerPro: 3.161 ± 1.179
4.741SerGln: 4.741 ± 0.947
0.395SerArg: 0.395 ± 0.342
3.556SerSer: 3.556 ± 0.835
4.741SerThr: 4.741 ± 1.471
1.976SerVal: 1.976 ± 1.476
0.0SerTrp: 0.0 ± 0.0
3.161SerTyr: 3.161 ± 1.012
0.0SerXaa: 0.0 ± 0.0
Thr
3.161ThrAla: 3.161 ± 0.605
0.0ThrCys: 0.0 ± 0.0
3.951ThrAsp: 3.951 ± 0.998
3.951ThrGlu: 3.951 ± 1.731
3.556ThrPhe: 3.556 ± 0.864
1.976ThrGly: 1.976 ± 0.58
0.395ThrHis: 0.395 ± 0.359
9.087ThrIle: 9.087 ± 1.087
6.322ThrLys: 6.322 ± 1.405
5.531ThrLeu: 5.531 ± 1.714
0.395ThrMet: 0.395 ± 0.359
2.766ThrAsn: 2.766 ± 0.476
2.371ThrPro: 2.371 ± 0.924
1.58ThrGln: 1.58 ± 0.781
0.395ThrArg: 0.395 ± 0.295
2.766ThrSer: 2.766 ± 1.177
1.976ThrThr: 1.976 ± 0.665
1.185ThrVal: 1.185 ± 0.793
0.0ThrTrp: 0.0 ± 0.0
1.58ThrTyr: 1.58 ± 0.829
0.0ThrXaa: 0.0 ± 0.0
Val
1.185ValAla: 1.185 ± 0.61
0.0ValCys: 0.0 ± 0.0
1.976ValAsp: 1.976 ± 0.512
1.976ValGlu: 1.976 ± 1.071
1.58ValPhe: 1.58 ± 0.676
0.79ValGly: 0.79 ± 0.814
0.79ValHis: 0.79 ± 0.498
2.766ValIle: 2.766 ± 0.903
3.951ValLys: 3.951 ± 0.852
4.741ValLeu: 4.741 ± 1.355
0.395ValMet: 0.395 ± 0.295
2.371ValAsn: 2.371 ± 0.557
3.556ValPro: 3.556 ± 1.508
0.79ValGln: 0.79 ± 0.59
0.79ValArg: 0.79 ± 0.472
1.185ValSer: 1.185 ± 0.518
3.951ValThr: 3.951 ± 1.236
0.79ValVal: 0.79 ± 0.5
0.0ValTrp: 0.0 ± 0.0
0.395ValTyr: 0.395 ± 0.295
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.395TrpPhe: 0.395 ± 0.295
0.395TrpGly: 0.395 ± 0.295
0.395TrpHis: 0.395 ± 0.359
0.395TrpIle: 0.395 ± 0.342
2.766TrpLys: 2.766 ± 1.353
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.395TrpAsn: 0.395 ± 0.295
0.395TrpPro: 0.395 ± 0.435
0.79TrpGln: 0.79 ± 0.59
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.79TrpThr: 0.79 ± 0.391
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.79TrpTyr: 0.79 ± 0.683
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.976TyrAla: 1.976 ± 0.667
1.185TyrCys: 1.185 ± 0.669
1.976TyrAsp: 1.976 ± 0.723
1.976TyrGlu: 1.976 ± 0.604
1.976TyrPhe: 1.976 ± 0.648
1.58TyrGly: 1.58 ± 0.493
1.58TyrHis: 1.58 ± 0.737
5.531TyrIle: 5.531 ± 1.072
5.531TyrLys: 5.531 ± 1.919
3.951TyrLeu: 3.951 ± 1.674
1.58TyrMet: 1.58 ± 0.945
2.766TyrAsn: 2.766 ± 0.857
2.766TyrPro: 2.766 ± 0.734
3.161TyrGln: 3.161 ± 0.89
2.371TyrArg: 2.371 ± 0.596
3.556TyrSer: 3.556 ± 1.286
0.79TyrThr: 0.79 ± 0.498
1.58TyrVal: 1.58 ± 0.869
0.79TyrTrp: 0.79 ± 0.391
3.161TyrTyr: 3.161 ± 1.513
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2532 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski