Amino acid dipepetide frequency for Shewanella fodinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.96AlaAla: 10.96 ± 0.138	1.129AlaCys: 1.129 ± 0.037	5.788AlaAsp: 5.788 ± 0.072	6.137AlaGlu: 6.137 ± 0.072	3.415AlaPhe: 3.415 ± 0.056	6.884AlaGly: 6.884 ± 0.084	1.804AlaHis: 1.804 ± 0.038	5.858AlaIle: 5.858 ± 0.078	4.883AlaLys: 4.883 ± 0.092	11.432AlaLeu: 11.432 ± 0.124	2.907AlaMet: 2.907 ± 0.044	3.601AlaAsn: 3.601 ± 0.06	3.444AlaPro: 3.444 ± 0.063	4.592AlaGln: 4.592 ± 0.067	4.529AlaArg: 4.529 ± 0.068	5.546AlaSer: 5.546 ± 0.074	5.135AlaThr: 5.135 ± 0.083	6.916AlaVal: 6.916 ± 0.087	1.093AlaTrp: 1.093 ± 0.033	2.425AlaTyr: 2.425 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.909CysAla: 0.909 ± 0.029	0.225CysCys: 0.225 ± 0.017	0.606CysAsp: 0.606 ± 0.021	0.564CysGlu: 0.564 ± 0.021	0.445CysPhe: 0.445 ± 0.023	1.055CysGly: 1.055 ± 0.033	0.523CysHis: 0.523 ± 0.033	0.551CysIle: 0.551 ± 0.022	0.356CysLys: 0.356 ± 0.019	1.044CysLeu: 1.044 ± 0.027	0.253CysMet: 0.253 ± 0.015	0.371CysAsn: 0.371 ± 0.018	0.537CysPro: 0.537 ± 0.029	0.596CysGln: 0.596 ± 0.026	0.653CysArg: 0.653 ± 0.026	0.728CysSer: 0.728 ± 0.03	0.476CysThr: 0.476 ± 0.02	0.676CysVal: 0.676 ± 0.026	0.168CysTrp: 0.168 ± 0.014	0.359CysTyr: 0.359 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.185AspAla: 5.185 ± 0.071	0.544AspCys: 0.544 ± 0.021	3.131AspAsp: 3.131 ± 0.069	3.438AspGlu: 3.438 ± 0.052	2.242AspPhe: 2.242 ± 0.042	4.073AspGly: 4.073 ± 0.07	0.999AspHis: 0.999 ± 0.033	3.545AspIle: 3.545 ± 0.058	3.018AspLys: 3.018 ± 0.051	4.891AspLeu: 4.891 ± 0.073	1.422AspMet: 1.422 ± 0.036	2.503AspAsn: 2.503 ± 0.053	2.239AspPro: 2.239 ± 0.043	1.758AspGln: 1.758 ± 0.04	2.345AspArg: 2.345 ± 0.049	3.278AspSer: 3.278 ± 0.058	2.787AspThr: 2.787 ± 0.048	3.741AspVal: 3.741 ± 0.068	0.913AspTrp: 0.913 ± 0.029	1.985AspTyr: 1.985 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.184GluAla: 5.184 ± 0.073	0.448GluCys: 0.448 ± 0.021	2.459GluAsp: 2.459 ± 0.051	2.787GluGlu: 2.787 ± 0.064	2.016GluPhe: 2.016 ± 0.041	3.04GluGly: 3.04 ± 0.058	1.545GluHis: 1.545 ± 0.037	3.174GluIle: 3.174 ± 0.048	2.765GluLys: 2.765 ± 0.054	6.975GluLeu: 6.975 ± 0.089	1.611GluMet: 1.611 ± 0.033	1.928GluAsn: 1.928 ± 0.043	2.018GluPro: 2.018 ± 0.045	4.103GluGln: 4.103 ± 0.071	3.333GluArg: 3.333 ± 0.061	2.689GluSer: 2.689 ± 0.053	2.68GluThr: 2.68 ± 0.052	3.898GluVal: 3.898 ± 0.058	0.634GluTrp: 0.634 ± 0.02	1.558GluTyr: 1.558 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.871PheAla: 3.871 ± 0.06	0.546PheCys: 0.546 ± 0.02	2.442PheAsp: 2.442 ± 0.05	2.013PheGlu: 2.013 ± 0.04	1.508PhePhe: 1.508 ± 0.047	3.036PheGly: 3.036 ± 0.054	0.815PheHis: 0.815 ± 0.027	2.263PheIle: 2.263 ± 0.052	1.578PheLys: 1.578 ± 0.039	3.113PheLeu: 3.113 ± 0.062	1.001PheMet: 1.001 ± 0.03	1.816PheAsn: 1.816 ± 0.042	1.435PhePro: 1.435 ± 0.035	1.199PheGln: 1.199 ± 0.029	1.821PheArg: 1.821 ± 0.041	2.905PheSer: 2.905 ± 0.049	2.022PheThr: 2.022 ± 0.045	2.484PheVal: 2.484 ± 0.044	0.517PheTrp: 0.517 ± 0.022	1.332PheTyr: 1.332 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.813GlyAla: 5.813 ± 0.085	0.979GlyCys: 0.979 ± 0.033	3.745GlyAsp: 3.745 ± 0.066	3.976GlyGlu: 3.976 ± 0.057	3.191GlyPhe: 3.191 ± 0.051	4.783GlyGly: 4.783 ± 0.069	1.672GlyHis: 1.672 ± 0.039	4.659GlyIle: 4.659 ± 0.076	3.995GlyLys: 3.995 ± 0.066	7.281GlyLeu: 7.281 ± 0.086	2.06GlyMet: 2.06 ± 0.04	2.83GlyAsn: 2.83 ± 0.056	1.833GlyPro: 1.833 ± 0.037	3.086GlyGln: 3.086 ± 0.048	3.566GlyArg: 3.566 ± 0.062	4.183GlySer: 4.183 ± 0.079	3.493GlyThr: 3.493 ± 0.056	5.241GlyVal: 5.241 ± 0.071	0.963GlyTrp: 0.963 ± 0.033	2.565GlyTyr: 2.565 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.791HisAla: 1.791 ± 0.043	0.391HisCys: 0.391 ± 0.019	1.134HisAsp: 1.134 ± 0.033	1.103HisGlu: 1.103 ± 0.031	1.061HisPhe: 1.061 ± 0.032	1.812HisGly: 1.812 ± 0.044	0.731HisHis: 0.731 ± 0.028	1.335HisIle: 1.335 ± 0.034	1.003HisLys: 1.003 ± 0.031	2.473HisLeu: 2.473 ± 0.043	0.529HisMet: 0.529 ± 0.022	0.861HisAsn: 0.861 ± 0.027	1.297HisPro: 1.297 ± 0.036	1.344HisGln: 1.344 ± 0.034	1.14HisArg: 1.14 ± 0.034	1.415HisSer: 1.415 ± 0.034	1.038HisThr: 1.038 ± 0.028	1.16HisVal: 1.16 ± 0.031	0.484HisTrp: 0.484 ± 0.02	0.978HisTyr: 0.978 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.269IleAla: 6.269 ± 0.087	0.681IleCys: 0.681 ± 0.024	3.51IleAsp: 3.51 ± 0.052	3.385IleGlu: 3.385 ± 0.055	1.84IlePhe: 1.84 ± 0.046	4.27IleGly: 4.27 ± 0.07	1.206IleHis: 1.206 ± 0.032	3.045IleIle: 3.045 ± 0.058	2.675IleLys: 2.675 ± 0.054	4.653IleLeu: 4.653 ± 0.078	1.169IleMet: 1.169 ± 0.038	2.652IleAsn: 2.652 ± 0.056	2.491IlePro: 2.491 ± 0.047	1.961IleGln: 1.961 ± 0.047	2.992IleArg: 2.992 ± 0.049	4.038IleSer: 4.038 ± 0.06	3.137IleThr: 3.137 ± 0.06	3.604IleVal: 3.604 ± 0.063	0.628IleTrp: 0.628 ± 0.024	1.553IleTyr: 1.553 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.856LysAla: 4.856 ± 0.074	0.318LysCys: 0.318 ± 0.019	2.35LysAsp: 2.35 ± 0.054	2.323LysGlu: 2.323 ± 0.049	1.361LysPhe: 1.361 ± 0.033	3.082LysGly: 3.082 ± 0.058	1.004LysHis: 1.004 ± 0.027	2.381LysIle: 2.381 ± 0.045	1.968LysLys: 1.968 ± 0.051	5.291LysLeu: 5.291 ± 0.064	1.173LysMet: 1.173 ± 0.029	1.519LysAsn: 1.519 ± 0.039	2.206LysPro: 2.206 ± 0.042	2.829LysGln: 2.829 ± 0.05	2.567LysArg: 2.567 ± 0.042	2.56LysSer: 2.56 ± 0.048	2.499LysThr: 2.499 ± 0.048	3.515LysVal: 3.515 ± 0.065	0.461LysTrp: 0.461 ± 0.021	1.21LysTyr: 1.21 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	12.158LeuAla: 12.158 ± 0.12	1.26LeuCys: 1.26 ± 0.036	5.85LeuAsp: 5.85 ± 0.081	5.684LeuGlu: 5.684 ± 0.09	4.125LeuPhe: 4.125 ± 0.072	7.424LeuGly: 7.424 ± 0.088	2.289LeuHis: 2.289 ± 0.05	5.286LeuIle: 5.286 ± 0.078	5.05LeuLys: 5.05 ± 0.067	14.188LeuLeu: 14.188 ± 0.184	2.885LeuMet: 2.885 ± 0.057	3.984LeuAsn: 3.984 ± 0.058	5.777LeuPro: 5.777 ± 0.086	6.36LeuGln: 6.36 ± 0.103	5.428LeuArg: 5.428 ± 0.069	7.653LeuSer: 7.653 ± 0.084	6.225LeuThr: 6.225 ± 0.08	7.491LeuVal: 7.491 ± 0.089	1.389LeuTrp: 1.389 ± 0.042	2.909LeuTyr: 2.909 ± 0.054	0.001LeuXaa: 0.001 ± 0.001
Met	2.86MetAla: 2.86 ± 0.054	0.224MetCys: 0.224 ± 0.014	1.269MetAsp: 1.269 ± 0.032	1.238MetGlu: 1.238 ± 0.027	0.796MetPhe: 0.796 ± 0.028	1.721MetGly: 1.721 ± 0.039	0.475MetHis: 0.475 ± 0.022	1.206MetIle: 1.206 ± 0.033	1.34MetLys: 1.34 ± 0.033	3.238MetLeu: 3.238 ± 0.049	0.786MetMet: 0.786 ± 0.026	0.949MetAsn: 0.949 ± 0.027	1.325MetPro: 1.325 ± 0.034	1.314MetGln: 1.314 ± 0.034	1.277MetArg: 1.277 ± 0.036	1.854MetSer: 1.854 ± 0.032	1.662MetThr: 1.662 ± 0.039	1.862MetVal: 1.862 ± 0.043	0.233MetTrp: 0.233 ± 0.015	0.491MetTyr: 0.491 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.607AsnAla: 3.607 ± 0.062	0.424AsnCys: 0.424 ± 0.022	1.98AsnAsp: 1.98 ± 0.047	1.857AsnGlu: 1.857 ± 0.045	1.328AsnPhe: 1.328 ± 0.036	3.037AsnGly: 3.037 ± 0.062	0.862AsnHis: 0.862 ± 0.028	2.324AsnIle: 2.324 ± 0.042	1.614AsnLys: 1.614 ± 0.046	3.719AsnLeu: 3.719 ± 0.059	0.906AsnMet: 0.906 ± 0.028	1.613AsnAsn: 1.613 ± 0.041	2.094AsnPro: 2.094 ± 0.042	1.798AsnGln: 1.798 ± 0.037	2.049AsnArg: 2.049 ± 0.044	2.372AsnSer: 2.372 ± 0.043	1.98AsnThr: 1.98 ± 0.042	2.252AsnVal: 2.252 ± 0.044	0.576AsnTrp: 0.576 ± 0.023	1.223AsnTyr: 1.223 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.034ProAla: 4.034 ± 0.065	0.326ProCys: 0.326 ± 0.017	2.388ProAsp: 2.388 ± 0.052	3.121ProGlu: 3.121 ± 0.053	1.665ProPhe: 1.665 ± 0.034	2.912ProGly: 2.912 ± 0.05	0.94ProHis: 0.94 ± 0.027	2.08ProIle: 2.08 ± 0.04	1.914ProLys: 1.914 ± 0.046	5.139ProLeu: 5.139 ± 0.078	1.128ProMet: 1.128 ± 0.029	1.371ProAsn: 1.371 ± 0.033	1.451ProPro: 1.451 ± 0.04	2.645ProGln: 2.645 ± 0.06	1.66ProArg: 1.66 ± 0.04	2.295ProSer: 2.295 ± 0.038	2.123ProThr: 2.123 ± 0.047	3.347ProVal: 3.347 ± 0.056	0.619ProTrp: 0.619 ± 0.025	1.275ProTyr: 1.275 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.005GlnAla: 5.005 ± 0.073	0.439GlnCys: 0.439 ± 0.022	2.098GlnAsp: 2.098 ± 0.047	2.296GlnGlu: 2.296 ± 0.044	1.853GlnPhe: 1.853 ± 0.048	3.221GlnGly: 3.221 ± 0.055	1.594GlnHis: 1.594 ± 0.035	2.653GlnIle: 2.653 ± 0.043	1.975GlnLys: 1.975 ± 0.044	7.663GlnLeu: 7.663 ± 0.123	1.342GlnMet: 1.342 ± 0.034	1.375GlnAsn: 1.375 ± 0.032	2.394GlnPro: 2.394 ± 0.054	5.776GlnGln: 5.776 ± 0.137	3.267GlnArg: 3.267 ± 0.051	2.679GlnSer: 2.679 ± 0.048	2.378GlnThr: 2.378 ± 0.041	3.501GlnVal: 3.501 ± 0.059	0.842GlnTrp: 0.842 ± 0.03	1.524GlnTyr: 1.524 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	4.047ArgAla: 4.047 ± 0.058	0.574ArgCys: 0.574 ± 0.022	2.808ArgAsp: 2.808 ± 0.054	3.013ArgGlu: 3.013 ± 0.053	2.303ArgPhe: 2.303 ± 0.047	2.945ArgGly: 2.945 ± 0.05	1.443ArgHis: 1.443 ± 0.032	3.132ArgIle: 3.132 ± 0.055	2.353ArgLys: 2.353 ± 0.045	6.117ArgLeu: 6.117 ± 0.084	1.336ArgMet: 1.336 ± 0.033	1.99ArgAsn: 1.99 ± 0.047	1.917ArgPro: 1.917 ± 0.044	3.31ArgGln: 3.31 ± 0.055	3.074ArgArg: 3.074 ± 0.052	2.795ArgSer: 2.795 ± 0.053	2.208ArgThr: 2.208 ± 0.044	3.312ArgVal: 3.312 ± 0.055	0.823ArgTrp: 0.823 ± 0.026	2.058ArgTyr: 2.058 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.965SerAla: 5.965 ± 0.07	0.72SerCys: 0.72 ± 0.03	3.324SerAsp: 3.324 ± 0.06	3.33SerGlu: 3.33 ± 0.056	2.447SerPhe: 2.447 ± 0.047	5.024SerGly: 5.024 ± 0.07	1.534SerHis: 1.534 ± 0.036	3.213SerIle: 3.213 ± 0.055	2.601SerLys: 2.601 ± 0.05	6.842SerLeu: 6.842 ± 0.076	1.573SerMet: 1.573 ± 0.036	2.306SerAsn: 2.306 ± 0.051	2.39SerPro: 2.39 ± 0.051	2.927SerGln: 2.927 ± 0.053	3.306SerArg: 3.306 ± 0.058	3.846SerSer: 3.846 ± 0.069	2.79SerThr: 2.79 ± 0.055	4.197SerVal: 4.197 ± 0.072	0.869SerTrp: 0.869 ± 0.028	1.961SerTyr: 1.961 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.329ThrAla: 5.329 ± 0.078	0.5ThrCys: 0.5 ± 0.02	3.006ThrAsp: 3.006 ± 0.061	3.02ThrGlu: 3.02 ± 0.054	1.724ThrPhe: 1.724 ± 0.039	3.99ThrGly: 3.99 ± 0.061	1.138ThrHis: 1.138 ± 0.029	2.804ThrIle: 2.804 ± 0.052	1.803ThrLys: 1.803 ± 0.042	6.547ThrLeu: 6.547 ± 0.077	1.111ThrMet: 1.111 ± 0.033	1.669ThrAsn: 1.669 ± 0.042	2.816ThrPro: 2.816 ± 0.048	2.35ThrGln: 2.35 ± 0.047	2.315ThrArg: 2.315 ± 0.046	3.013ThrSer: 3.013 ± 0.051	2.791ThrThr: 2.791 ± 0.056	3.831ThrVal: 3.831 ± 0.057	0.505ThrTrp: 0.505 ± 0.022	1.297ThrTyr: 1.297 ± 0.036	0.001ThrXaa: 0.001 ± 0.001
Val	7.246ValAla: 7.246 ± 0.099	0.782ValCys: 0.782 ± 0.027	3.994ValAsp: 3.994 ± 0.07	3.702ValGlu: 3.702 ± 0.069	2.488ValPhe: 2.488 ± 0.048	4.513ValGly: 4.513 ± 0.062	1.256ValHis: 1.256 ± 0.033	4.258ValIle: 4.258 ± 0.061	3.148ValLys: 3.148 ± 0.061	7.194ValLeu: 7.194 ± 0.078	1.975ValMet: 1.975 ± 0.045	2.862ValAsn: 2.862 ± 0.05	2.823ValPro: 2.823 ± 0.049	2.519ValGln: 2.519 ± 0.05	3.25ValArg: 3.25 ± 0.055	4.735ValSer: 4.735 ± 0.073	4.315ValThr: 4.315 ± 0.062	5.257ValVal: 5.257 ± 0.07	0.738ValTrp: 0.738 ± 0.027	1.764ValTyr: 1.764 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.869TrpAla: 0.869 ± 0.028	0.187TrpCys: 0.187 ± 0.012	0.585TrpAsp: 0.585 ± 0.024	0.488TrpGlu: 0.488 ± 0.022	0.573TrpPhe: 0.573 ± 0.026	0.8TrpGly: 0.8 ± 0.03	0.446TrpHis: 0.446 ± 0.021	0.601TrpIle: 0.601 ± 0.024	0.413TrpLys: 0.413 ± 0.019	2.116TrpLeu: 2.116 ± 0.046	0.331TrpMet: 0.331 ± 0.018	0.391TrpAsn: 0.391 ± 0.02	0.548TrpPro: 0.548 ± 0.022	1.331TrpGln: 1.331 ± 0.044	0.872TrpArg: 0.872 ± 0.028	0.706TrpSer: 0.706 ± 0.026	0.435TrpThr: 0.435 ± 0.02	0.817TrpVal: 0.817 ± 0.029	0.224TrpTrp: 0.224 ± 0.015	0.397TrpTyr: 0.397 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.518TyrAla: 2.518 ± 0.046	0.395TyrCys: 0.395 ± 0.02	1.569TyrAsp: 1.569 ± 0.042	1.37TyrGlu: 1.37 ± 0.036	1.335TyrPhe: 1.335 ± 0.036	2.294TyrGly: 2.294 ± 0.044	0.805TyrHis: 0.805 ± 0.024	1.391TyrIle: 1.391 ± 0.034	1.022TyrLys: 1.022 ± 0.029	3.501TyrLeu: 3.501 ± 0.065	0.62TyrMet: 0.62 ± 0.024	1.025TyrAsn: 1.025 ± 0.032	1.398TyrPro: 1.398 ± 0.038	2.08TyrGln: 2.08 ± 0.042	2.114TyrArg: 2.114 ± 0.043	1.875TyrSer: 1.875 ± 0.048	1.384TyrThr: 1.384 ± 0.04	1.716TyrVal: 1.716 ± 0.032	0.45TyrTrp: 0.45 ± 0.021	1.043TyrTyr: 1.043 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 3662 proteins (1185354 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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