Amino acid dipepetide frequency for Orenia marismortui

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.058AlaAla: 4.058 ± 0.098
0.449AlaCys: 0.449 ± 0.024
3.385AlaAsp: 3.385 ± 0.066
4.486AlaGlu: 4.486 ± 0.081
2.079AlaPhe: 2.079 ± 0.055
4.6AlaGly: 4.6 ± 0.085
0.87AlaHis: 0.87 ± 0.028
5.821AlaIle: 5.821 ± 0.09
5.676AlaLys: 5.676 ± 0.096
5.75AlaLeu: 5.75 ± 0.081
1.425AlaMet: 1.425 ± 0.043
2.975AlaAsn: 2.975 ± 0.06
1.469AlaPro: 1.469 ± 0.037
1.985AlaGln: 1.985 ± 0.053
2.287AlaArg: 2.287 ± 0.052
3.168AlaSer: 3.168 ± 0.064
3.035AlaThr: 3.035 ± 0.062
3.946AlaVal: 3.946 ± 0.076
0.397AlaTrp: 0.397 ± 0.019
2.05AlaTyr: 2.05 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.346CysAla: 0.346 ± 0.02
0.109CysCys: 0.109 ± 0.013
0.415CysAsp: 0.415 ± 0.022
0.463CysGlu: 0.463 ± 0.024
0.273CysPhe: 0.273 ± 0.018
0.709CysGly: 0.709 ± 0.032
0.143CysHis: 0.143 ± 0.012
0.531CysIle: 0.531 ± 0.026
0.483CysLys: 0.483 ± 0.026
0.601CysLeu: 0.601 ± 0.023
0.142CysMet: 0.142 ± 0.012
0.406CysAsn: 0.406 ± 0.023
0.426CysPro: 0.426 ± 0.026
0.294CysGln: 0.294 ± 0.02
0.309CysArg: 0.309 ± 0.025
0.533CysSer: 0.533 ± 0.023
0.331CysThr: 0.331 ± 0.02
0.365CysVal: 0.365 ± 0.02
0.059CysTrp: 0.059 ± 0.008
0.278CysTyr: 0.278 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
2.667AspAla: 2.667 ± 0.066
0.461AspCys: 0.461 ± 0.022
3.267AspAsp: 3.267 ± 0.066
4.195AspGlu: 4.195 ± 0.083
2.907AspPhe: 2.907 ± 0.056
3.473AspGly: 3.473 ± 0.084
0.911AspHis: 0.911 ± 0.035
6.124AspIle: 6.124 ± 0.074
5.69AspLys: 5.69 ± 0.082
6.777AspLeu: 6.777 ± 0.091
1.226AspMet: 1.226 ± 0.035
4.035AspAsn: 4.035 ± 0.076
1.717AspPro: 1.717 ± 0.049
2.122AspGln: 2.122 ± 0.054
2.43AspArg: 2.43 ± 0.057
3.407AspSer: 3.407 ± 0.063
2.426AspThr: 2.426 ± 0.054
3.105AspVal: 3.105 ± 0.06
0.567AspTrp: 0.567 ± 0.025
3.132AspTyr: 3.132 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
4.883GluAla: 4.883 ± 0.084
0.446GluCys: 0.446 ± 0.025
5.478GluAsp: 5.478 ± 0.082
9.024GluGlu: 9.024 ± 0.105
3.09GluPhe: 3.09 ± 0.064
4.74GluGly: 4.74 ± 0.075
1.019GluHis: 1.019 ± 0.04
7.784GluIle: 7.784 ± 0.102
6.179GluLys: 6.179 ± 0.106
8.518GluLeu: 8.518 ± 0.106
1.902GluMet: 1.902 ± 0.042
3.897GluAsn: 3.897 ± 0.068
1.366GluPro: 1.366 ± 0.048
2.109GluGln: 2.109 ± 0.051
2.985GluArg: 2.985 ± 0.055
3.758GluSer: 3.758 ± 0.069
2.72GluThr: 2.72 ± 0.054
6.28GluVal: 6.28 ± 0.093
0.542GluTrp: 0.542 ± 0.026
2.983GluTyr: 2.983 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
2.433PheAla: 2.433 ± 0.057
0.363PheCys: 0.363 ± 0.017
2.526PheAsp: 2.526 ± 0.055
2.648PheGlu: 2.648 ± 0.05
1.727PhePhe: 1.727 ± 0.058
2.715PheGly: 2.715 ± 0.064
0.537PheHis: 0.537 ± 0.027
3.897PheIle: 3.897 ± 0.072
3.392PheLys: 3.392 ± 0.059
3.862PheLeu: 3.862 ± 0.077
0.945PheMet: 0.945 ± 0.032
2.635PheAsn: 2.635 ± 0.057
1.19PhePro: 1.19 ± 0.034
0.913PheGln: 0.913 ± 0.03
1.366PheArg: 1.366 ± 0.041
3.131PheSer: 3.131 ± 0.061
1.978PheThr: 1.978 ± 0.047
2.263PheVal: 2.263 ± 0.052
0.367PheTrp: 0.367 ± 0.023
1.652PheTyr: 1.652 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
3.945GlyAla: 3.945 ± 0.08
0.643GlyCys: 0.643 ± 0.029
3.659GlyAsp: 3.659 ± 0.075
4.759GlyGlu: 4.759 ± 0.088
2.879GlyPhe: 2.879 ± 0.071
4.401GlyGly: 4.401 ± 0.085
1.074GlyHis: 1.074 ± 0.033
6.35GlyIle: 6.35 ± 0.085
4.771GlyLys: 4.771 ± 0.075
6.482GlyLeu: 6.482 ± 0.093
1.59GlyMet: 1.59 ± 0.041
2.958GlyAsn: 2.958 ± 0.078
1.319GlyPro: 1.319 ± 0.044
1.965GlyGln: 1.965 ± 0.045
2.761GlyArg: 2.761 ± 0.059
3.771GlySer: 3.771 ± 0.074
3.085GlyThr: 3.085 ± 0.067
4.989GlyVal: 4.989 ± 0.079
0.586GlyTrp: 0.586 ± 0.029
2.955GlyTyr: 2.955 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
0.724HisAla: 0.724 ± 0.032
0.152HisCys: 0.152 ± 0.013
0.727HisAsp: 0.727 ± 0.03
0.725HisGlu: 0.725 ± 0.03
0.632HisPhe: 0.632 ± 0.029
0.975HisGly: 0.975 ± 0.036
0.39HisHis: 0.39 ± 0.025
1.166HisIle: 1.166 ± 0.035
0.991HisLys: 0.991 ± 0.028
1.416HisLeu: 1.416 ± 0.036
0.251HisMet: 0.251 ± 0.018
0.843HisAsn: 0.843 ± 0.03
0.741HisPro: 0.741 ± 0.03
0.677HisGln: 0.677 ± 0.026
0.567HisArg: 0.567 ± 0.027
0.963HisSer: 0.963 ± 0.035
0.715HisThr: 0.715 ± 0.028
0.598HisVal: 0.598 ± 0.026
0.15HisTrp: 0.15 ± 0.014
0.587HisTyr: 0.587 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.947IleAla: 5.947 ± 0.086
0.655IleCys: 0.655 ± 0.028
6.183IleAsp: 6.183 ± 0.081
7.076IleGlu: 7.076 ± 0.086
3.798IlePhe: 3.798 ± 0.074
5.667IleGly: 5.667 ± 0.088
1.127IleHis: 1.127 ± 0.033
9.052IleIle: 9.052 ± 0.117
8.553IleLys: 8.553 ± 0.114
8.965IleLeu: 8.965 ± 0.116
1.823IleMet: 1.823 ± 0.041
5.852IleAsn: 5.852 ± 0.089
3.089IlePro: 3.089 ± 0.067
2.059IleGln: 2.059 ± 0.05
3.148IleArg: 3.148 ± 0.067
6.47IleSer: 6.47 ± 0.092
4.546IleThr: 4.546 ± 0.071
5.695IleVal: 5.695 ± 0.075
0.553IleTrp: 0.553 ± 0.024
3.211IleTyr: 3.211 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.108LysAla: 5.108 ± 0.081
0.452LysCys: 0.452 ± 0.024
5.618LysAsp: 5.618 ± 0.076
9.167LysGlu: 9.167 ± 0.123
3.093LysPhe: 3.093 ± 0.059
4.833LysGly: 4.833 ± 0.082
0.984LysHis: 0.984 ± 0.039
7.609LysIle: 7.609 ± 0.109
7.4LysLys: 7.4 ± 0.123
8.865LysLeu: 8.865 ± 0.12
1.941LysMet: 1.941 ± 0.051
4.512LysAsn: 4.512 ± 0.068
1.727LysPro: 1.727 ± 0.042
2.314LysGln: 2.314 ± 0.049
3.45LysArg: 3.45 ± 0.063
4.547LysSer: 4.547 ± 0.083
3.221LysThr: 3.221 ± 0.058
6.525LysVal: 6.525 ± 0.084
0.59LysTrp: 0.59 ± 0.027
3.328LysTyr: 3.328 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
7.371LeuAla: 7.371 ± 0.087
0.586LeuCys: 0.586 ± 0.027
6.402LeuAsp: 6.402 ± 0.087
8.4LeuGlu: 8.4 ± 0.113
3.922LeuPhe: 3.922 ± 0.08
6.876LeuGly: 6.876 ± 0.097
1.232LeuHis: 1.232 ± 0.037
9.217LeuIle: 9.217 ± 0.121
8.608LeuLys: 8.608 ± 0.123
9.915LeuLeu: 9.915 ± 0.138
2.071LeuMet: 2.071 ± 0.051
5.723LeuAsn: 5.723 ± 0.09
3.078LeuPro: 3.078 ± 0.06
2.348LeuGln: 2.348 ± 0.056
3.615LeuArg: 3.615 ± 0.066
7.209LeuSer: 7.209 ± 0.097
5.005LeuThr: 5.005 ± 0.082
6.593LeuVal: 6.593 ± 0.122
0.642LeuTrp: 0.642 ± 0.031
2.987LeuTyr: 2.987 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
1.512MetAla: 1.512 ± 0.047
0.102MetCys: 0.102 ± 0.01
1.152MetAsp: 1.152 ± 0.038
1.49MetGlu: 1.49 ± 0.04
0.689MetPhe: 0.689 ± 0.028
1.564MetGly: 1.564 ± 0.048
0.252MetHis: 0.252 ± 0.015
2.122MetIle: 2.122 ± 0.047
2.157MetLys: 2.157 ± 0.044
1.993MetLeu: 1.993 ± 0.047
0.559MetMet: 0.559 ± 0.028
1.221MetAsn: 1.221 ± 0.038
0.705MetPro: 0.705 ± 0.028
0.555MetGln: 0.555 ± 0.02
0.803MetArg: 0.803 ± 0.029
1.46MetSer: 1.46 ± 0.039
1.017MetThr: 1.017 ± 0.036
1.498MetVal: 1.498 ± 0.043
0.122MetTrp: 0.122 ± 0.012
0.513MetTyr: 0.513 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.299AsnAla: 2.299 ± 0.051
0.439AsnCys: 0.439 ± 0.027
2.749AsnAsp: 2.749 ± 0.061
3.111AsnGlu: 3.111 ± 0.065
2.505AsnPhe: 2.505 ± 0.052
2.774AsnGly: 2.774 ± 0.064
0.888AsnHis: 0.888 ± 0.037
5.436AsnIle: 5.436 ± 0.089
5.626AsnLys: 5.626 ± 0.097
6.873AsnLeu: 6.873 ± 0.094
1.155AsnMet: 1.155 ± 0.038
4.396AsnAsn: 4.396 ± 0.087
2.229AsnPro: 2.229 ± 0.052
2.562AsnGln: 2.562 ± 0.057
2.254AsnArg: 2.254 ± 0.05
3.691AsnSer: 3.691 ± 0.082
2.421AsnThr: 2.421 ± 0.057
2.455AsnVal: 2.455 ± 0.052
0.544AsnTrp: 0.544 ± 0.029
2.719AsnTyr: 2.719 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
1.721ProAla: 1.721 ± 0.054
0.205ProCys: 0.205 ± 0.015
1.578ProAsp: 1.578 ± 0.046
2.485ProGlu: 2.485 ± 0.054
1.254ProPhe: 1.254 ± 0.042
1.796ProGly: 1.796 ± 0.049
0.506ProHis: 0.506 ± 0.025
2.559ProIle: 2.559 ± 0.052
2.266ProLys: 2.266 ± 0.049
2.772ProLeu: 2.772 ± 0.06
0.568ProMet: 0.568 ± 0.024
1.452ProAsn: 1.452 ± 0.038
0.741ProPro: 0.741 ± 0.033
1.017ProGln: 1.017 ± 0.037
0.949ProArg: 0.949 ± 0.033
1.497ProSer: 1.497 ± 0.041
1.523ProThr: 1.523 ± 0.041
2.021ProVal: 2.021 ± 0.052
0.276ProTrp: 0.276 ± 0.019
1.225ProTyr: 1.225 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
2.141GlnAla: 2.141 ± 0.047
0.158GlnCys: 0.158 ± 0.014
1.691GlnAsp: 1.691 ± 0.044
3.122GlnGlu: 3.122 ± 0.063
1.033GlnPhe: 1.033 ± 0.035
2.143GlnGly: 2.143 ± 0.046
0.392GlnHis: 0.392 ± 0.019
2.74GlnIle: 2.74 ± 0.056
2.354GlnLys: 2.354 ± 0.054
2.92GlnLeu: 2.92 ± 0.064
0.665GlnMet: 0.665 ± 0.025
1.598GlnAsn: 1.598 ± 0.042
0.722GlnPro: 0.722 ± 0.033
1.14GlnGln: 1.14 ± 0.041
1.208GlnArg: 1.208 ± 0.037
1.633GlnSer: 1.633 ± 0.038
1.21GlnThr: 1.21 ± 0.037
2.126GlnVal: 2.126 ± 0.048
0.221GlnTrp: 0.221 ± 0.015
0.888GlnTyr: 0.888 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.057ArgAla: 2.057 ± 0.048
0.32ArgCys: 0.32 ± 0.025
2.343ArgAsp: 2.343 ± 0.056
3.189ArgGlu: 3.189 ± 0.059
1.555ArgPhe: 1.555 ± 0.04
2.39ArgGly: 2.39 ± 0.048
0.502ArgHis: 0.502 ± 0.021
3.442ArgIle: 3.442 ± 0.063
3.129ArgLys: 3.129 ± 0.061
3.944ArgLeu: 3.944 ± 0.071
0.95ArgMet: 0.95 ± 0.031
1.955ArgAsn: 1.955 ± 0.046
1.087ArgPro: 1.087 ± 0.034
1.079ArgGln: 1.079 ± 0.039
1.835ArgArg: 1.835 ± 0.051
2.042ArgSer: 2.042 ± 0.049
1.56ArgThr: 1.56 ± 0.046
2.719ArgVal: 2.719 ± 0.056
0.313ArgTrp: 0.313 ± 0.017
1.581ArgTyr: 1.581 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.19SerAla: 3.19 ± 0.062
0.524SerCys: 0.524 ± 0.028
3.493SerAsp: 3.493 ± 0.068
4.009SerGlu: 4.009 ± 0.075
2.957SerPhe: 2.957 ± 0.059
4.019SerGly: 4.019 ± 0.073
0.857SerHis: 0.857 ± 0.033
5.458SerIle: 5.458 ± 0.073
5.537SerLys: 5.537 ± 0.091
6.747SerLeu: 6.747 ± 0.093
1.184SerMet: 1.184 ± 0.035
3.853SerAsn: 3.853 ± 0.083
1.696SerPro: 1.696 ± 0.044
2.193SerGln: 2.193 ± 0.047
2.292SerArg: 2.292 ± 0.055
4.069SerSer: 4.069 ± 0.075
2.823SerThr: 2.823 ± 0.063
3.198SerVal: 3.198 ± 0.054
0.545SerTrp: 0.545 ± 0.025
2.643SerTyr: 2.643 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
3.149ThrAla: 3.149 ± 0.063
0.28ThrCys: 0.28 ± 0.019
2.509ThrAsp: 2.509 ± 0.055
3.098ThrGlu: 3.098 ± 0.066
1.678ThrPhe: 1.678 ± 0.042
3.747ThrGly: 3.747 ± 0.071
0.655ThrHis: 0.655 ± 0.028
4.304ThrIle: 4.304 ± 0.077
3.378ThrLys: 3.378 ± 0.062
4.451ThrLeu: 4.451 ± 0.063
0.904ThrMet: 0.904 ± 0.028
2.232ThrAsn: 2.232 ± 0.049
1.713ThrPro: 1.713 ± 0.046
1.152ThrGln: 1.152 ± 0.039
1.597ThrArg: 1.597 ± 0.042
2.694ThrSer: 2.694 ± 0.058
2.631ThrThr: 2.631 ± 0.086
3.103ThrVal: 3.103 ± 0.069
0.308ThrTrp: 0.308 ± 0.018
1.68ThrTyr: 1.68 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
4.27ValAla: 4.27 ± 0.09
0.465ValCys: 0.465 ± 0.026
4.479ValAsp: 4.479 ± 0.081
5.33ValGlu: 5.33 ± 0.084
2.357ValPhe: 2.357 ± 0.055
4.545ValGly: 4.545 ± 0.076
0.811ValHis: 0.811 ± 0.032
5.989ValIle: 5.989 ± 0.082
5.443ValLys: 5.443 ± 0.075
5.965ValLeu: 5.965 ± 0.128
1.368ValMet: 1.368 ± 0.036
3.461ValAsn: 3.461 ± 0.069
1.873ValPro: 1.873 ± 0.044
1.43ValGln: 1.43 ± 0.042
2.215ValArg: 2.215 ± 0.051
4.161ValSer: 4.161 ± 0.069
2.944ValThr: 2.944 ± 0.063
4.982ValVal: 4.982 ± 0.218
0.439ValTrp: 0.439 ± 0.024
2.005ValTyr: 2.005 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.395TrpAla: 0.395 ± 0.02
0.065TrpCys: 0.065 ± 0.01
0.525TrpAsp: 0.525 ± 0.025
0.612TrpGlu: 0.612 ± 0.029
0.315TrpPhe: 0.315 ± 0.02
0.563TrpGly: 0.563 ± 0.027
0.128TrpHis: 0.128 ± 0.011
0.637TrpIle: 0.637 ± 0.026
0.604TrpLys: 0.604 ± 0.029
0.795TrpLeu: 0.795 ± 0.032
0.158TrpMet: 0.158 ± 0.014
0.425TrpAsn: 0.425 ± 0.021
0.174TrpPro: 0.174 ± 0.016
0.302TrpGln: 0.302 ± 0.018
0.311TrpArg: 0.311 ± 0.018
0.504TrpSer: 0.504 ± 0.028
0.343TrpThr: 0.343 ± 0.022
0.417TrpVal: 0.417 ± 0.025
0.109TrpTrp: 0.109 ± 0.011
0.304TrpTyr: 0.304 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.698TyrAla: 1.698 ± 0.045
0.341TyrCys: 0.341 ± 0.019
2.462TyrAsp: 2.462 ± 0.079
2.313TyrGlu: 2.313 ± 0.05
1.797TyrPhe: 1.797 ± 0.047
2.413TyrGly: 2.413 ± 0.054
0.715TyrHis: 0.715 ± 0.03
3.229TyrIle: 3.229 ± 0.06
3.046TyrLys: 3.046 ± 0.062
4.189TyrLeu: 4.189 ± 0.067
0.656TyrMet: 0.656 ± 0.028
2.697TyrAsn: 2.697 ± 0.061
1.351TyrPro: 1.351 ± 0.038
1.887TyrGln: 1.887 ± 0.045
1.61TyrArg: 1.61 ± 0.044
2.58TyrSer: 2.58 ± 0.05
1.729TyrThr: 1.729 ± 0.045
1.652TyrVal: 1.652 ± 0.043
0.356TyrTrp: 0.356 ± 0.021
1.905TyrTyr: 1.905 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3116 proteins (939355 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski