Amino acid dipepetide frequency for Cellulomonas cellasea DSM 20118

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.757AlaAla: 22.757 ± 0.225	0.881AlaCys: 0.881 ± 0.031	8.953AlaAsp: 8.953 ± 0.095	8.151AlaGlu: 8.151 ± 0.111	3.502AlaPhe: 3.502 ± 0.057	14.317AlaGly: 14.317 ± 0.136	3.001AlaHis: 3.001 ± 0.054	3.635AlaIle: 3.635 ± 0.054	1.867AlaLys: 1.867 ± 0.051	15.323AlaLeu: 15.323 ± 0.144	2.416AlaMet: 2.416 ± 0.046	1.891AlaAsn: 1.891 ± 0.052	8.017AlaPro: 8.017 ± 0.109	4.028AlaGln: 4.028 ± 0.059	11.309AlaArg: 11.309 ± 0.127	7.018AlaSer: 7.018 ± 0.098	8.649AlaThr: 8.649 ± 0.1	13.772AlaVal: 13.772 ± 0.134	2.398AlaTrp: 2.398 ± 0.046	2.462AlaTyr: 2.462 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.844CysAla: 0.844 ± 0.032	0.055CysCys: 0.055 ± 0.008	0.327CysAsp: 0.327 ± 0.017	0.266CysGlu: 0.266 ± 0.014	0.151CysPhe: 0.151 ± 0.011	0.633CysGly: 0.633 ± 0.024	0.131CysHis: 0.131 ± 0.011	0.117CysIle: 0.117 ± 0.011	0.053CysLys: 0.053 ± 0.007	0.525CysLeu: 0.525 ± 0.02	0.085CysMet: 0.085 ± 0.009	0.087CysAsn: 0.087 ± 0.01	0.328CysPro: 0.328 ± 0.018	0.108CysGln: 0.108 ± 0.01	0.406CysArg: 0.406 ± 0.018	0.36CysSer: 0.36 ± 0.02	0.444CysThr: 0.444 ± 0.018	0.564CysVal: 0.564 ± 0.021	0.101CysTrp: 0.101 ± 0.01	0.112CysTyr: 0.112 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.837AspAla: 9.837 ± 0.109	0.264AspCys: 0.264 ± 0.015	4.574AspAsp: 4.574 ± 0.081	4.381AspGlu: 4.381 ± 0.076	1.269AspPhe: 1.269 ± 0.04	7.224AspGly: 7.224 ± 0.107	1.328AspHis: 1.328 ± 0.034	1.389AspIle: 1.389 ± 0.04	0.676AspLys: 0.676 ± 0.029	6.823AspLeu: 6.823 ± 0.077	0.607AspMet: 0.607 ± 0.024	0.731AspAsn: 0.731 ± 0.031	4.906AspPro: 4.906 ± 0.075	1.391AspGln: 1.391 ± 0.039	4.682AspArg: 4.682 ± 0.071	2.035AspSer: 2.035 ± 0.043	2.791AspThr: 2.791 ± 0.048	7.2AspVal: 7.2 ± 0.088	0.92AspTrp: 0.92 ± 0.027	0.998AspTyr: 0.998 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.795GluAla: 6.795 ± 0.097	0.247GluCys: 0.247 ± 0.016	2.928GluAsp: 2.928 ± 0.049	2.661GluGlu: 2.661 ± 0.059	1.189GluPhe: 1.189 ± 0.03	4.02GluGly: 4.02 ± 0.07	1.793GluHis: 1.793 ± 0.043	2.035GluIle: 2.035 ± 0.039	0.85GluLys: 0.85 ± 0.029	6.675GluLeu: 6.675 ± 0.086	0.684GluMet: 0.684 ± 0.028	0.884GluAsn: 0.884 ± 0.03	3.591GluPro: 3.591 ± 0.057	2.2GluGln: 2.2 ± 0.046	5.388GluArg: 5.388 ± 0.088	2.182GluSer: 2.182 ± 0.045	2.654GluThr: 2.654 ± 0.051	5.29GluVal: 5.29 ± 0.073	0.687GluTrp: 0.687 ± 0.029	0.952GluTyr: 0.952 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.61PheAla: 3.61 ± 0.057	0.194PheCys: 0.194 ± 0.012	1.816PheAsp: 1.816 ± 0.042	1.401PheGlu: 1.401 ± 0.036	0.749PhePhe: 0.749 ± 0.029	2.691PheGly: 2.691 ± 0.05	0.486PheHis: 0.486 ± 0.021	0.543PheIle: 0.543 ± 0.025	0.317PheLys: 0.317 ± 0.017	2.332PheLeu: 2.332 ± 0.048	0.321PheMet: 0.321 ± 0.019	0.459PheAsn: 0.459 ± 0.022	1.163PhePro: 1.163 ± 0.032	0.599PheGln: 0.599 ± 0.027	1.663PheArg: 1.663 ± 0.04	1.27PheSer: 1.27 ± 0.033	1.815PheThr: 1.815 ± 0.043	2.507PheVal: 2.507 ± 0.055	0.422PheTrp: 0.422 ± 0.021	0.567PheTyr: 0.567 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	12.771GlyAla: 12.771 ± 0.136	0.601GlyCys: 0.601 ± 0.026	5.496GlyAsp: 5.496 ± 0.078	4.974GlyGlu: 4.974 ± 0.07	2.747GlyPhe: 2.747 ± 0.056	8.612GlyGly: 8.612 ± 0.111	2.135GlyHis: 2.135 ± 0.042	3.13GlyIle: 3.13 ± 0.054	1.562GlyLys: 1.562 ± 0.045	9.573GlyLeu: 9.573 ± 0.102	1.76GlyMet: 1.76 ± 0.043	1.482GlyAsn: 1.482 ± 0.041	5.348GlyPro: 5.348 ± 0.075	2.382GlyGln: 2.382 ± 0.053	7.562GlyArg: 7.562 ± 0.085	5.759GlySer: 5.759 ± 0.078	7.071GlyThr: 7.071 ± 0.106	8.961GlyVal: 8.961 ± 0.101	1.859GlyTrp: 1.859 ± 0.042	2.146GlyTyr: 2.146 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.99HisAla: 2.99 ± 0.053	0.131HisCys: 0.131 ± 0.011	1.571HisAsp: 1.571 ± 0.043	1.275HisGlu: 1.275 ± 0.037	0.448HisPhe: 0.448 ± 0.023	2.339HisGly: 2.339 ± 0.052	0.597HisHis: 0.597 ± 0.024	0.382HisIle: 0.382 ± 0.018	0.219HisLys: 0.219 ± 0.012	2.375HisLeu: 2.375 ± 0.054	0.227HisMet: 0.227 ± 0.016	0.301HisAsn: 0.301 ± 0.015	1.597HisPro: 1.597 ± 0.042	0.466HisGln: 0.466 ± 0.018	1.858HisArg: 1.858 ± 0.044	0.72HisSer: 0.72 ± 0.024	1.096HisThr: 1.096 ± 0.032	2.354HisVal: 2.354 ± 0.047	0.288HisTrp: 0.288 ± 0.016	0.371HisTyr: 0.371 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.151IleAla: 4.151 ± 0.068	0.167IleCys: 0.167 ± 0.012	2.076IleAsp: 2.076 ± 0.043	1.788IleGlu: 1.788 ± 0.05	0.615IlePhe: 0.615 ± 0.027	3.004IleGly: 3.004 ± 0.057	0.439IleHis: 0.439 ± 0.02	0.744IleIle: 0.744 ± 0.031	0.497IleLys: 0.497 ± 0.025	2.073IleLeu: 2.073 ± 0.057	0.367IleMet: 0.367 ± 0.022	0.55IleAsn: 0.55 ± 0.022	1.454IlePro: 1.454 ± 0.036	0.612IleGln: 0.612 ± 0.027	1.64IleArg: 1.64 ± 0.042	1.409IleSer: 1.409 ± 0.037	1.917IleThr: 1.917 ± 0.047	2.539IleVal: 2.539 ± 0.05	0.323IleTrp: 0.323 ± 0.019	0.458IleTyr: 0.458 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	1.755LysAla: 1.755 ± 0.054	0.063LysCys: 0.063 ± 0.009	0.81LysAsp: 0.81 ± 0.031	0.622LysGlu: 0.622 ± 0.026	0.284LysPhe: 0.284 ± 0.017	1.062LysGly: 1.062 ± 0.03	0.318LysHis: 0.318 ± 0.016	0.596LysIle: 0.596 ± 0.024	0.415LysLys: 0.415 ± 0.021	1.19LysLeu: 1.19 ± 0.036	0.212LysMet: 0.212 ± 0.013	0.3LysAsn: 0.3 ± 0.02	0.766LysPro: 0.766 ± 0.028	0.413LysGln: 0.413 ± 0.018	0.929LysArg: 0.929 ± 0.034	0.661LysSer: 0.661 ± 0.025	0.798LysThr: 0.798 ± 0.029	1.378LysVal: 1.378 ± 0.04	0.124LysTrp: 0.124 ± 0.01	0.302LysTyr: 0.302 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.569LeuAla: 16.569 ± 0.177	0.592LeuCys: 0.592 ± 0.026	7.692LeuAsp: 7.692 ± 0.097	4.882LeuGlu: 4.882 ± 0.073	2.264LeuPhe: 2.264 ± 0.051	10.045LeuGly: 10.045 ± 0.12	2.108LeuHis: 2.108 ± 0.046	2.112LeuIle: 2.112 ± 0.052	1.072LeuLys: 1.072 ± 0.036	11.022LeuLeu: 11.022 ± 0.133	1.289LeuMet: 1.289 ± 0.036	1.309LeuAsn: 1.309 ± 0.031	5.924LeuPro: 5.924 ± 0.076	2.171LeuGln: 2.171 ± 0.047	8.298LeuArg: 8.298 ± 0.092	4.621LeuSer: 4.621 ± 0.067	6.97LeuThr: 6.97 ± 0.089	11.908LeuVal: 11.908 ± 0.126	1.28LeuTrp: 1.28 ± 0.035	1.562LeuTyr: 1.562 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	1.797MetAla: 1.797 ± 0.047	0.084MetCys: 0.084 ± 0.008	0.728MetAsp: 0.728 ± 0.027	0.492MetGlu: 0.492 ± 0.019	0.407MetPhe: 0.407 ± 0.02	1.1MetGly: 1.1 ± 0.034	0.348MetHis: 0.348 ± 0.018	0.513MetIle: 0.513 ± 0.02	0.201MetLys: 0.201 ± 0.015	1.556MetLeu: 1.556 ± 0.04	0.172MetMet: 0.172 ± 0.013	0.311MetAsn: 0.311 ± 0.019	0.939MetPro: 0.939 ± 0.026	0.404MetGln: 0.404 ± 0.019	1.206MetArg: 1.206 ± 0.036	1.191MetSer: 1.191 ± 0.032	1.607MetThr: 1.607 ± 0.039	1.173MetVal: 1.173 ± 0.033	0.177MetTrp: 0.177 ± 0.012	0.233MetTyr: 0.233 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.987AsnAla: 1.987 ± 0.044	0.099AsnCys: 0.099 ± 0.01	0.911AsnAsp: 0.911 ± 0.034	0.682AsnGlu: 0.682 ± 0.025	0.423AsnPhe: 0.423 ± 0.018	1.574AsnGly: 1.574 ± 0.054	0.323AsnHis: 0.323 ± 0.016	0.487AsnIle: 0.487 ± 0.024	0.265AsnLys: 0.265 ± 0.018	1.587AsnLeu: 1.587 ± 0.036	0.192AsnMet: 0.192 ± 0.015	0.346AsnAsn: 0.346 ± 0.02	1.229AsnPro: 1.229 ± 0.037	0.455AsnGln: 0.455 ± 0.023	1.055AsnArg: 1.055 ± 0.032	0.594AsnSer: 0.594 ± 0.025	0.87AsnThr: 0.87 ± 0.031	1.423AsnVal: 1.423 ± 0.036	0.209AsnTrp: 0.209 ± 0.013	0.346AsnTyr: 0.346 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	9.166ProAla: 9.166 ± 0.104	0.244ProCys: 0.244 ± 0.015	4.775ProAsp: 4.775 ± 0.075	3.849ProGlu: 3.849 ± 0.069	1.554ProPhe: 1.554 ± 0.036	6.796ProGly: 6.796 ± 0.092	1.27ProHis: 1.27 ± 0.038	1.161ProIle: 1.161 ± 0.033	0.606ProLys: 0.606 ± 0.024	5.061ProLeu: 5.061 ± 0.075	0.861ProMet: 0.861 ± 0.026	0.803ProAsn: 0.803 ± 0.028	3.14ProPro: 3.14 ± 0.059	1.455ProGln: 1.455 ± 0.038	4.046ProArg: 4.046 ± 0.06	3.256ProSer: 3.256 ± 0.061	4.253ProThr: 4.253 ± 0.08	6.041ProVal: 6.041 ± 0.081	1.02ProTrp: 1.02 ± 0.032	1.059ProTyr: 1.059 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.452GlnAla: 3.452 ± 0.062	0.135GlnCys: 0.135 ± 0.01	1.398GlnAsp: 1.398 ± 0.041	1.192GlnGlu: 1.192 ± 0.04	0.598GlnPhe: 0.598 ± 0.025	2.033GlnGly: 2.033 ± 0.048	0.681GlnHis: 0.681 ± 0.021	0.894GlnIle: 0.894 ± 0.03	0.406GlnLys: 0.406 ± 0.022	2.822GlnLeu: 2.822 ± 0.048	0.395GlnMet: 0.395 ± 0.021	0.448GlnAsn: 0.448 ± 0.023	1.532GlnPro: 1.532 ± 0.038	1.008GlnGln: 1.008 ± 0.033	2.251GlnArg: 2.251 ± 0.044	1.135GlnSer: 1.135 ± 0.032	1.307GlnThr: 1.307 ± 0.038	2.914GlnVal: 2.914 ± 0.055	0.436GlnTrp: 0.436 ± 0.021	0.537GlnTyr: 0.537 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	11.024ArgAla: 11.024 ± 0.127	0.426ArgCys: 0.426 ± 0.022	4.448ArgAsp: 4.448 ± 0.059	4.363ArgGlu: 4.363 ± 0.072	2.135ArgPhe: 2.135 ± 0.043	6.207ArgGly: 6.207 ± 0.076	1.747ArgHis: 1.747 ± 0.044	2.507ArgIle: 2.507 ± 0.055	0.912ArgLys: 0.912 ± 0.031	8.385ArgLeu: 8.385 ± 0.107	1.492ArgMet: 1.492 ± 0.039	1.062ArgAsn: 1.062 ± 0.036	4.695ArgPro: 4.695 ± 0.073	1.815ArgGln: 1.815 ± 0.038	7.656ArgArg: 7.656 ± 0.108	4.331ArgSer: 4.331 ± 0.064	5.765ArgThr: 5.765 ± 0.079	7.076ArgVal: 7.076 ± 0.085	1.503ArgTrp: 1.503 ± 0.043	1.628ArgTyr: 1.628 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.049SerAla: 7.049 ± 0.08	0.286SerCys: 0.286 ± 0.017	2.693SerAsp: 2.693 ± 0.052	2.206SerGlu: 2.206 ± 0.05	1.431SerPhe: 1.431 ± 0.038	5.646SerGly: 5.646 ± 0.09	0.838SerHis: 0.838 ± 0.029	1.491SerIle: 1.491 ± 0.037	0.593SerLys: 0.593 ± 0.026	4.402SerLeu: 4.402 ± 0.064	0.963SerMet: 0.963 ± 0.027	0.794SerAsn: 0.794 ± 0.031	3.127SerPro: 3.127 ± 0.058	1.104SerGln: 1.104 ± 0.034	3.539SerArg: 3.539 ± 0.06	2.953SerSer: 2.953 ± 0.064	3.787SerThr: 3.787 ± 0.074	4.6SerVal: 4.6 ± 0.065	0.944SerTrp: 0.944 ± 0.032	1.044SerTyr: 1.044 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	9.017ThrAla: 9.017 ± 0.118	0.365ThrCys: 0.365 ± 0.018	3.774ThrAsp: 3.774 ± 0.057	2.978ThrGlu: 2.978 ± 0.056	1.929ThrPhe: 1.929 ± 0.049	6.98ThrGly: 6.98 ± 0.095	1.25ThrHis: 1.25 ± 0.036	1.875ThrIle: 1.875 ± 0.049	0.868ThrLys: 0.868 ± 0.032	6.242ThrLeu: 6.242 ± 0.073	0.877ThrMet: 0.877 ± 0.03	1.037ThrAsn: 1.037 ± 0.034	4.735ThrPro: 4.735 ± 0.086	1.554ThrGln: 1.554 ± 0.04	4.391ThrArg: 4.391 ± 0.064	3.696ThrSer: 3.696 ± 0.064	4.873ThrThr: 4.873 ± 0.101	6.871ThrVal: 6.871 ± 0.087	1.102ThrTrp: 1.102 ± 0.035	1.352ThrTyr: 1.352 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	14.374ValAla: 14.374 ± 0.131	0.602ValCys: 0.602 ± 0.024	6.774ValAsp: 6.774 ± 0.081	5.856ValGlu: 5.856 ± 0.079	2.201ValPhe: 2.201 ± 0.051	8.643ValGly: 8.643 ± 0.109	2.169ValHis: 2.169 ± 0.049	2.463ValIle: 2.463 ± 0.048	1.159ValLys: 1.159 ± 0.037	11.989ValLeu: 11.989 ± 0.131	1.28ValMet: 1.28 ± 0.036	1.521ValAsn: 1.521 ± 0.041	6.152ValPro: 6.152 ± 0.081	2.376ValGln: 2.376 ± 0.051	8.335ValArg: 8.335 ± 0.107	4.369ValSer: 4.369 ± 0.067	6.814ValThr: 6.814 ± 0.097	12.039ValVal: 12.039 ± 0.14	1.281ValTrp: 1.281 ± 0.034	1.539ValTyr: 1.539 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.85TrpAla: 1.85 ± 0.049	0.134TrpCys: 0.134 ± 0.011	1.012TrpAsp: 1.012 ± 0.032	0.68TrpGlu: 0.68 ± 0.028	0.533TrpPhe: 0.533 ± 0.024	1.182TrpGly: 1.182 ± 0.036	0.352TrpHis: 0.352 ± 0.017	0.412TrpIle: 0.412 ± 0.019	0.221TrpLys: 0.221 ± 0.016	1.674TrpLeu: 1.674 ± 0.041	0.265TrpMet: 0.265 ± 0.014	0.398TrpAsn: 0.398 ± 0.022	0.768TrpPro: 0.768 ± 0.027	0.541TrpGln: 0.541 ± 0.021	1.364TrpArg: 1.364 ± 0.038	1.066TrpSer: 1.066 ± 0.031	1.165TrpThr: 1.165 ± 0.032	1.438TrpVal: 1.438 ± 0.036	0.386TrpTrp: 0.386 ± 0.021	0.327TrpTyr: 0.327 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.55TyrAla: 2.55 ± 0.044	0.127TyrCys: 0.127 ± 0.011	1.272TyrAsp: 1.272 ± 0.044	1.005TyrGlu: 1.005 ± 0.032	0.497TyrPhe: 0.497 ± 0.022	1.823TyrGly: 1.823 ± 0.046	0.293TyrHis: 0.293 ± 0.019	0.336TyrIle: 0.336 ± 0.019	0.242TyrLys: 0.242 ± 0.016	2.06TyrLeu: 2.06 ± 0.048	0.177TyrMet: 0.177 ± 0.015	0.338TyrAsn: 0.338 ± 0.02	1.006TyrPro: 1.006 ± 0.03	0.497TyrGln: 0.497 ± 0.02	1.599TyrArg: 1.599 ± 0.037	0.862TyrSer: 0.862 ± 0.029	1.117TyrThr: 1.117 ± 0.037	1.888TyrVal: 1.888 ± 0.043	0.307TyrTrp: 0.307 ± 0.017	0.441TyrTyr: 0.441 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3560 proteins (1137429 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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