Amino acid dipepetide frequency for Schistosoma curassoni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.679AlaAla: 3.679 ± 0.043	0.969AlaCys: 0.969 ± 0.014	2.323AlaAsp: 2.323 ± 0.022	2.605AlaGlu: 2.605 ± 0.028	1.932AlaPhe: 1.932 ± 0.022	2.134AlaGly: 2.134 ± 0.025	1.049AlaHis: 1.049 ± 0.014	2.73AlaIle: 2.73 ± 0.023	2.337AlaLys: 2.337 ± 0.023	4.459AlaLeu: 4.459 ± 0.033	0.945AlaMet: 0.945 ± 0.014	2.367AlaAsn: 2.367 ± 0.02	1.819AlaPro: 1.819 ± 0.02	1.648AlaGln: 1.648 ± 0.02	2.327AlaArg: 2.327 ± 0.025	4.084AlaSer: 4.084 ± 0.032	2.792AlaThr: 2.792 ± 0.026	2.93AlaVal: 2.93 ± 0.026	0.419AlaTrp: 0.419 ± 0.011	1.508AlaTyr: 1.508 ± 0.015	0.003AlaXaa: 0.003 ± 0.001
Cys	0.846CysAla: 0.846 ± 0.013	0.516CysCys: 0.516 ± 0.01	1.057CysAsp: 1.057 ± 0.014	1.105CysGlu: 1.105 ± 0.015	0.901CysPhe: 0.901 ± 0.013	1.043CysGly: 1.043 ± 0.016	0.62CysHis: 0.62 ± 0.013	1.479CysIle: 1.479 ± 0.018	1.132CysLys: 1.132 ± 0.016	2.332CysLeu: 2.332 ± 0.02	0.418CysMet: 0.418 ± 0.009	1.242CysAsn: 1.242 ± 0.017	0.963CysPro: 0.963 ± 0.014	0.901CysGln: 0.901 ± 0.015	1.04CysArg: 1.04 ± 0.017	2.08CysSer: 2.08 ± 0.023	1.308CysThr: 1.308 ± 0.014	1.036CysVal: 1.036 ± 0.017	0.221CysTrp: 0.221 ± 0.006	0.675CysTyr: 0.675 ± 0.013	0.001CysXaa: 0.001 ± 0.0
Asp	2.253AspAla: 2.253 ± 0.021	0.987AspCys: 0.987 ± 0.013	4.72AspAsp: 4.72 ± 0.245	3.561AspGlu: 3.561 ± 0.033	2.016AspPhe: 2.016 ± 0.02	2.499AspGly: 2.499 ± 0.027	1.526AspHis: 1.526 ± 0.019	3.592AspIle: 3.592 ± 0.033	2.773AspLys: 2.773 ± 0.025	5.085AspLeu: 5.085 ± 0.035	1.017AspMet: 1.017 ± 0.014	3.672AspAsn: 3.672 ± 0.032	2.281AspPro: 2.281 ± 0.02	2.075AspGln: 2.075 ± 0.021	2.387AspArg: 2.387 ± 0.023	4.535AspSer: 4.535 ± 0.03	2.614AspThr: 2.614 ± 0.021	3.516AspVal: 3.516 ± 0.172	0.6AspTrp: 0.6 ± 0.011	1.89AspTyr: 1.89 ± 0.021	0.005AspXaa: 0.005 ± 0.001
Glu	2.971GluAla: 2.971 ± 0.03	1.04GluCys: 1.04 ± 0.015	3.058GluAsp: 3.058 ± 0.028	4.363GluGlu: 4.363 ± 0.051	2.027GluPhe: 2.027 ± 0.018	2.023GluGly: 2.023 ± 0.023	1.426GluHis: 1.426 ± 0.017	3.643GluIle: 3.643 ± 0.027	3.81GluLys: 3.81 ± 0.033	5.674GluLeu: 5.674 ± 0.043	1.297GluMet: 1.297 ± 0.017	3.79GluAsn: 3.79 ± 0.027	1.68GluPro: 1.68 ± 0.02	2.584GluGln: 2.584 ± 0.024	2.799GluArg: 2.799 ± 0.031	4.434GluSer: 4.434 ± 0.032	3.297GluThr: 3.297 ± 0.024	2.816GluVal: 2.816 ± 0.024	0.591GluTrp: 0.591 ± 0.011	1.744GluTyr: 1.744 ± 0.018	0.004GluXaa: 0.004 ± 0.001
Phe	1.594PheAla: 1.594 ± 0.017	0.85PheCys: 0.85 ± 0.014	2.168PheAsp: 2.168 ± 0.024	1.879PheGlu: 1.879 ± 0.019	1.407PhePhe: 1.407 ± 0.019	1.816PheGly: 1.816 ± 0.019	1.212PheHis: 1.212 ± 0.016	2.947PheIle: 2.947 ± 0.025	1.997PheLys: 1.997 ± 0.019	3.531PheLeu: 3.531 ± 0.03	0.863PheMet: 0.863 ± 0.013	2.661PheAsn: 2.661 ± 0.023	1.648PhePro: 1.648 ± 0.015	1.525PheGln: 1.525 ± 0.017	1.854PheArg: 1.854 ± 0.021	3.478PheSer: 3.478 ± 0.031	2.626PheThr: 2.626 ± 0.024	2.163PheVal: 2.163 ± 0.023	0.355PheTrp: 0.355 ± 0.008	1.411PheTyr: 1.411 ± 0.019	0.004PheXaa: 0.004 ± 0.001
Gly	1.854GlyAla: 1.854 ± 0.024	0.9GlyCys: 0.9 ± 0.014	2.201GlyAsp: 2.201 ± 0.031	2.273GlyGlu: 2.273 ± 0.032	2.017GlyPhe: 2.017 ± 0.021	2.866GlyGly: 2.866 ± 0.041	1.251GlyHis: 1.251 ± 0.016	2.87GlyIle: 2.87 ± 0.027	2.859GlyLys: 2.859 ± 0.027	4.264GlyLeu: 4.264 ± 0.034	0.886GlyMet: 0.886 ± 0.015	2.379GlyAsn: 2.379 ± 0.025	1.845GlyPro: 1.845 ± 0.043	1.734GlyGln: 1.734 ± 0.02	2.474GlyArg: 2.474 ± 0.027	4.184GlySer: 4.184 ± 0.037	2.414GlyThr: 2.414 ± 0.024	2.541GlyVal: 2.541 ± 0.026	0.544GlyTrp: 0.544 ± 0.01	1.546GlyTyr: 1.546 ± 0.02	0.003GlyXaa: 0.003 ± 0.001
His	0.915HisAla: 0.915 ± 0.014	0.647HisCys: 0.647 ± 0.012	1.309HisAsp: 1.309 ± 0.02	1.501HisGlu: 1.501 ± 0.014	1.18HisPhe: 1.18 ± 0.014	1.297HisGly: 1.297 ± 0.016	1.735HisHis: 1.735 ± 0.038	1.837HisIle: 1.837 ± 0.02	1.672HisLys: 1.672 ± 0.016	3.049HisLeu: 3.049 ± 0.026	0.567HisMet: 0.567 ± 0.012	1.851HisAsn: 1.851 ± 0.024	1.333HisPro: 1.333 ± 0.018	1.445HisGln: 1.445 ± 0.017	1.474HisArg: 1.474 ± 0.017	2.929HisSer: 2.929 ± 0.028	1.658HisThr: 1.658 ± 0.017	1.39HisVal: 1.39 ± 0.016	0.372HisTrp: 0.372 ± 0.008	1.05HisTyr: 1.05 ± 0.016	0.003HisXaa: 0.003 ± 0.001
Ile	2.712IleAla: 2.712 ± 0.024	1.457IleCys: 1.457 ± 0.021	3.869IleAsp: 3.869 ± 0.032	3.563IleGlu: 3.563 ± 0.031	2.385IlePhe: 2.385 ± 0.026	2.929IleGly: 2.929 ± 0.028	2.256IleHis: 2.256 ± 0.025	4.85IleIle: 4.85 ± 0.047	3.913IleLys: 3.913 ± 0.032	5.958IleLeu: 5.958 ± 0.042	1.388IleMet: 1.388 ± 0.018	4.978IleAsn: 4.978 ± 0.045	3.307IlePro: 3.307 ± 0.029	3.188IleGln: 3.188 ± 0.029	3.188IleArg: 3.188 ± 0.026	6.298IleSer: 6.298 ± 0.035	4.52IleThr: 4.52 ± 0.05	3.229IleVal: 3.229 ± 0.025	0.791IleTrp: 0.791 ± 0.012	2.126IleTyr: 2.126 ± 0.021	0.004IleXaa: 0.004 ± 0.001
Lys	2.976LysAla: 2.976 ± 0.027	1.353LysCys: 1.353 ± 0.018	2.55LysAsp: 2.55 ± 0.023	3.593LysGlu: 3.593 ± 0.029	2.096LysPhe: 2.096 ± 0.021	1.885LysGly: 1.885 ± 0.031	1.749LysHis: 1.749 ± 0.02	3.644LysIle: 3.644 ± 0.026	3.684LysLys: 3.684 ± 0.036	5.792LysLeu: 5.792 ± 0.034	1.333LysMet: 1.333 ± 0.015	3.38LysAsn: 3.38 ± 0.027	2.534LysPro: 2.534 ± 0.025	3.043LysGln: 3.043 ± 0.027	3.334LysArg: 3.334 ± 0.026	5.676LysSer: 5.676 ± 0.041	3.613LysThr: 3.613 ± 0.029	2.8LysVal: 2.8 ± 0.026	0.576LysTrp: 0.576 ± 0.011	2.069LysTyr: 2.069 ± 0.022	0.005LysXaa: 0.005 ± 0.001
Leu	4.542LeuAla: 4.542 ± 0.032	2.077LeuCys: 2.077 ± 0.021	5.011LeuAsp: 5.011 ± 0.036	4.745LeuGlu: 4.745 ± 0.04	3.944LeuPhe: 3.944 ± 0.029	3.831LeuGly: 3.831 ± 0.03	2.666LeuHis: 2.666 ± 0.022	6.172LeuIle: 6.172 ± 0.043	5.733LeuLys: 5.733 ± 0.035	10.067LeuLeu: 10.067 ± 0.072	2.11LeuMet: 2.11 ± 0.051	6.683LeuAsn: 6.683 ± 0.045	4.902LeuPro: 4.902 ± 0.033	3.978LeuGln: 3.978 ± 0.032	5.086LeuArg: 5.086 ± 0.033	9.676LeuSer: 9.676 ± 0.048	5.721LeuThr: 5.721 ± 0.039	4.764LeuVal: 4.764 ± 0.032	0.955LeuTrp: 0.955 ± 0.015	2.908LeuTyr: 2.908 ± 0.028	0.008LeuXaa: 0.008 ± 0.001
Met	1.007MetAla: 1.007 ± 0.015	0.377MetCys: 0.377 ± 0.008	1.133MetAsp: 1.133 ± 0.014	1.374MetGlu: 1.374 ± 0.017	0.821MetPhe: 0.821 ± 0.015	0.835MetGly: 0.835 ± 0.014	0.499MetHis: 0.499 ± 0.01	1.369MetIle: 1.369 ± 0.017	1.735MetLys: 1.735 ± 0.018	2.108MetLeu: 2.108 ± 0.048	0.874MetMet: 0.874 ± 0.055	1.933MetAsn: 1.933 ± 0.022	0.809MetPro: 0.809 ± 0.012	0.898MetGln: 0.898 ± 0.016	0.979MetArg: 0.979 ± 0.012	1.736MetSer: 1.736 ± 0.018	1.217MetThr: 1.217 ± 0.016	1.133MetVal: 1.133 ± 0.014	0.203MetTrp: 0.203 ± 0.006	0.621MetTyr: 0.621 ± 0.012	0.002MetXaa: 0.002 ± 0.001
Asn	2.482AsnAla: 2.482 ± 0.02	1.313AsnCys: 1.313 ± 0.016	4.13AsnAsp: 4.13 ± 0.04	4.058AsnGlu: 4.058 ± 0.029	2.182AsnPhe: 2.182 ± 0.019	2.706AsnGly: 2.706 ± 0.022	2.238AsnHis: 2.238 ± 0.028	4.909AsnIle: 4.909 ± 0.037	3.999AsnLys: 3.999 ± 0.036	5.649AsnLeu: 5.649 ± 0.04	1.351AsnMet: 1.351 ± 0.016	9.13AsnAsn: 9.13 ± 0.122	2.993AsnPro: 2.993 ± 0.025	3.261AsnGln: 3.261 ± 0.029	2.96AsnArg: 2.96 ± 0.025	7.307AsnSer: 7.307 ± 0.051	4.642AsnThr: 4.642 ± 0.065	3.314AsnVal: 3.314 ± 0.024	0.671AsnTrp: 0.671 ± 0.011	2.344AsnTyr: 2.344 ± 0.023	0.005AsnXaa: 0.005 ± 0.001
Pro	1.808ProAla: 1.808 ± 0.021	0.892ProCys: 0.892 ± 0.013	2.39ProAsp: 2.39 ± 0.022	2.289ProGlu: 2.289 ± 0.021	1.6ProPhe: 1.6 ± 0.018	2.303ProGly: 2.303 ± 0.054	1.156ProHis: 1.156 ± 0.017	3.276ProIle: 3.276 ± 0.028	2.211ProLys: 2.211 ± 0.024	3.828ProLeu: 3.828 ± 0.029	0.894ProMet: 0.894 ± 0.012	2.847ProAsn: 2.847 ± 0.023	2.904ProPro: 2.904 ± 0.042	1.526ProGln: 1.526 ± 0.021	1.888ProArg: 1.888 ± 0.022	4.741ProSer: 4.741 ± 0.039	3.201ProThr: 3.201 ± 0.023	3.051ProVal: 3.051 ± 0.024	0.365ProTrp: 0.365 ± 0.008	1.401ProTyr: 1.401 ± 0.016	0.002ProXaa: 0.002 ± 0.001
Gln	1.866GlnAla: 1.866 ± 0.02	0.94GlnCys: 0.94 ± 0.015	1.528GlnAsp: 1.528 ± 0.016	2.146GlnGlu: 2.146 ± 0.022	1.643GlnPhe: 1.643 ± 0.017	1.464GlnGly: 1.464 ± 0.019	1.352GlnHis: 1.352 ± 0.017	2.904GlnIle: 2.904 ± 0.023	2.25GlnLys: 2.25 ± 0.021	5.204GlnLeu: 5.204 ± 0.045	1.116GlnMet: 1.116 ± 0.015	2.659GlnAsn: 2.659 ± 0.026	1.848GlnPro: 1.848 ± 0.021	3.425GlnGln: 3.425 ± 0.051	2.157GlnArg: 2.157 ± 0.02	4.3GlnSer: 4.3 ± 0.035	2.521GlnThr: 2.521 ± 0.024	2.02GlnVal: 2.02 ± 0.022	0.482GlnTrp: 0.482 ± 0.009	1.432GlnTyr: 1.432 ± 0.017	0.002GlnXaa: 0.002 ± 0.001
Arg	2.141ArgAla: 2.141 ± 0.021	0.978ArgCys: 0.978 ± 0.013	2.088ArgAsp: 2.088 ± 0.019	2.528ArgGlu: 2.528 ± 0.029	2.051ArgPhe: 2.051 ± 0.02	2.01ArgGly: 2.01 ± 0.027	1.512ArgHis: 1.512 ± 0.02	3.454ArgIle: 3.454 ± 0.026	3.431ArgLys: 3.431 ± 0.031	5.195ArgLeu: 5.195 ± 0.038	1.191ArgMet: 1.191 ± 0.016	2.929ArgAsn: 2.929 ± 0.027	2.198ArgPro: 2.198 ± 0.025	2.439ArgGln: 2.439 ± 0.023	3.573ArgArg: 3.573 ± 0.031	4.262ArgSer: 4.262 ± 0.039	2.884ArgThr: 2.884 ± 0.024	2.347ArgVal: 2.347 ± 0.023	0.607ArgTrp: 0.607 ± 0.012	1.647ArgTyr: 1.647 ± 0.019	0.004ArgXaa: 0.004 ± 0.001
Ser	3.909SerAla: 3.909 ± 0.032	2.114SerCys: 2.114 ± 0.021	5.094SerAsp: 5.094 ± 0.034	4.777SerGlu: 4.777 ± 0.036	3.659SerPhe: 3.659 ± 0.029	4.592SerGly: 4.592 ± 0.036	2.591SerHis: 2.591 ± 0.026	6.516SerIle: 6.516 ± 0.047	5.284SerLys: 5.284 ± 0.038	8.644SerLeu: 8.644 ± 0.044	2.074SerMet: 2.074 ± 0.017	7.475SerAsn: 7.475 ± 0.061	4.414SerPro: 4.414 ± 0.038	3.73SerGln: 3.73 ± 0.026	4.422SerArg: 4.422 ± 0.037	14.108SerSer: 14.108 ± 0.136	7.256SerThr: 7.256 ± 0.061	5.675SerVal: 5.675 ± 0.038	0.803SerTrp: 0.803 ± 0.012	2.705SerTyr: 2.705 ± 0.024	0.005SerXaa: 0.005 ± 0.001
Thr	3.026ThrAla: 3.026 ± 0.03	1.269ThrCys: 1.269 ± 0.018	3.354ThrAsp: 3.354 ± 0.025	3.383ThrGlu: 3.383 ± 0.028	2.139ThrPhe: 2.139 ± 0.018	2.936ThrGly: 2.936 ± 0.027	1.472ThrHis: 1.472 ± 0.017	4.376ThrIle: 4.376 ± 0.051	3.288ThrLys: 3.288 ± 0.023	5.433ThrLeu: 5.433 ± 0.035	1.364ThrMet: 1.364 ± 0.018	5.229ThrAsn: 5.229 ± 0.06	2.773ThrPro: 2.773 ± 0.028	2.182ThrGln: 2.182 ± 0.02	2.67ThrArg: 2.67 ± 0.023	7.082ThrSer: 7.082 ± 0.069	8.291ThrThr: 8.291 ± 0.273	3.613ThrVal: 3.613 ± 0.03	0.612ThrTrp: 0.612 ± 0.011	1.843ThrTyr: 1.843 ± 0.02	0.009ThrXaa: 0.009 ± 0.001
Val	2.685ValAla: 2.685 ± 0.028	1.265ValCys: 1.265 ± 0.017	3.336ValAsp: 3.336 ± 0.165	2.933ValGlu: 2.933 ± 0.027	2.04ValPhe: 2.04 ± 0.019	2.795ValGly: 2.795 ± 0.028	1.563ValHis: 1.563 ± 0.022	3.42ValIle: 3.42 ± 0.025	3.214ValLys: 3.214 ± 0.026	4.853ValLeu: 4.853 ± 0.034	1.048ValMet: 1.048 ± 0.016	3.558ValAsn: 3.558 ± 0.023	2.396ValPro: 2.396 ± 0.023	1.984ValGln: 1.984 ± 0.02	2.609ValArg: 2.609 ± 0.024	5.063ValSer: 5.063 ± 0.033	3.296ValThr: 3.296 ± 0.026	3.237ValVal: 3.237 ± 0.038	0.533ValTrp: 0.533 ± 0.009	1.758ValTyr: 1.758 ± 0.018	0.004ValXaa: 0.004 ± 0.001
Trp	0.38TrpAla: 0.38 ± 0.008	0.217TrpCys: 0.217 ± 0.006	0.522TrpAsp: 0.522 ± 0.011	0.57TrpGlu: 0.57 ± 0.01	0.422TrpPhe: 0.422 ± 0.009	0.342TrpGly: 0.342 ± 0.008	0.229TrpHis: 0.229 ± 0.006	0.904TrpIle: 0.904 ± 0.014	0.806TrpLys: 0.806 ± 0.012	1.013TrpLeu: 1.013 ± 0.014	0.244TrpMet: 0.244 ± 0.007	0.795TrpAsn: 0.795 ± 0.013	0.47TrpPro: 0.47 ± 0.009	0.306TrpGln: 0.306 ± 0.008	0.605TrpArg: 0.605 ± 0.012	0.883TrpSer: 0.883 ± 0.013	0.647TrpThr: 0.647 ± 0.011	0.423TrpVal: 0.423 ± 0.009	0.124TrpTrp: 0.124 ± 0.005	0.304TrpTyr: 0.304 ± 0.009	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.409TyrAla: 1.409 ± 0.017	0.752TyrCys: 0.752 ± 0.013	1.759TyrAsp: 1.759 ± 0.02	1.825TyrGlu: 1.825 ± 0.021	1.523TyrPhe: 1.523 ± 0.016	1.594TyrGly: 1.594 ± 0.021	1.109TyrHis: 1.109 ± 0.016	2.013TyrIle: 2.013 ± 0.02	1.553TyrLys: 1.553 ± 0.017	3.436TyrLeu: 3.436 ± 0.032	0.681TyrMet: 0.681 ± 0.012	2.082TyrAsn: 2.082 ± 0.025	1.452TyrPro: 1.452 ± 0.016	1.382TyrGln: 1.382 ± 0.018	1.639TyrArg: 1.639 ± 0.018	2.983TyrSer: 2.983 ± 0.026	1.821TyrThr: 1.821 ± 0.021	1.586TyrVal: 1.586 ± 0.018	0.382TyrTrp: 0.382 ± 0.009	1.312TyrTyr: 1.312 ± 0.02	0.003TyrXaa: 0.003 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.001	0.002XaaCys: 0.002 ± 0.001	0.004XaaAsp: 0.004 ± 0.001	0.003XaaGlu: 0.003 ± 0.001	0.003XaaPhe: 0.003 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.006XaaIle: 0.006 ± 0.001	0.004XaaLys: 0.004 ± 0.001	0.006XaaLeu: 0.006 ± 0.001	0.003XaaMet: 0.003 ± 0.001	0.004XaaAsn: 0.004 ± 0.001	0.003XaaPro: 0.003 ± 0.001	0.004XaaGln: 0.004 ± 0.001	0.005XaaArg: 0.005 ± 0.001	0.007XaaSer: 0.007 ± 0.001	0.007XaaThr: 0.007 ± 0.001	0.005XaaVal: 0.005 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.003XaaTyr: 0.003 ± 0.001	1.098XaaXaa: 1.098 ± 0.101

Statistics based on 22688 proteins (5552202 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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