Amino acid dipepetide frequency for Klebsiella phage vB_KpnP_IME335

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.235AlaAla: 9.235 ± 0.983
0.666AlaCys: 0.666 ± 0.226
6.24AlaAsp: 6.24 ± 0.735
5.408AlaGlu: 5.408 ± 0.644
3.744AlaPhe: 3.744 ± 0.521
7.072AlaGly: 7.072 ± 1.069
1.331AlaHis: 1.331 ± 0.266
4.493AlaIle: 4.493 ± 0.554
6.739AlaLys: 6.739 ± 0.781
7.987AlaLeu: 7.987 ± 0.82
2.829AlaMet: 2.829 ± 0.648
4.742AlaAsn: 4.742 ± 0.559
2.912AlaPro: 2.912 ± 0.48
3.661AlaGln: 3.661 ± 0.558
5.325AlaArg: 5.325 ± 0.652
5.575AlaSer: 5.575 ± 0.749
3.744AlaThr: 3.744 ± 0.457
5.741AlaVal: 5.741 ± 0.663
1.165AlaTrp: 1.165 ± 0.374
3.245AlaTyr: 3.245 ± 0.433
0.0AlaXaa: 0.0 ± 0.0
Cys
0.499CysAla: 0.499 ± 0.189
0.083CysCys: 0.083 ± 0.079
0.666CysAsp: 0.666 ± 0.281
0.998CysGlu: 0.998 ± 0.339
0.333CysPhe: 0.333 ± 0.172
0.832CysGly: 0.832 ± 0.228
0.333CysHis: 0.333 ± 0.187
0.499CysIle: 0.499 ± 0.196
0.416CysLys: 0.416 ± 0.143
0.915CysLeu: 0.915 ± 0.272
0.0CysMet: 0.0 ± 0.0
0.333CysAsn: 0.333 ± 0.166
0.582CysPro: 0.582 ± 0.2
0.499CysGln: 0.499 ± 0.173
0.499CysArg: 0.499 ± 0.263
0.582CysSer: 0.582 ± 0.236
0.166CysThr: 0.166 ± 0.118
0.666CysVal: 0.666 ± 0.213
0.166CysTrp: 0.166 ± 0.108
0.333CysTyr: 0.333 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
5.658AspAla: 5.658 ± 0.598
0.749AspCys: 0.749 ± 0.258
4.659AspAsp: 4.659 ± 0.749
3.91AspGlu: 3.91 ± 0.572
3.078AspPhe: 3.078 ± 0.382
6.323AspGly: 6.323 ± 0.695
0.998AspHis: 0.998 ± 0.253
2.995AspIle: 2.995 ± 0.499
4.077AspLys: 4.077 ± 0.656
4.659AspLeu: 4.659 ± 0.736
2.33AspMet: 2.33 ± 0.364
2.33AspAsn: 2.33 ± 0.338
2.995AspPro: 2.995 ± 0.492
2.33AspGln: 2.33 ± 0.45
2.829AspArg: 2.829 ± 0.552
3.827AspSer: 3.827 ± 0.418
4.077AspThr: 4.077 ± 0.556
4.576AspVal: 4.576 ± 0.476
0.832AspTrp: 0.832 ± 0.276
2.08AspTyr: 2.08 ± 0.302
0.0AspXaa: 0.0 ± 0.0
Glu
7.322GluAla: 7.322 ± 0.927
0.749GluCys: 0.749 ± 0.29
4.576GluAsp: 4.576 ± 0.638
5.741GluGlu: 5.741 ± 1.047
2.995GluPhe: 2.995 ± 0.481
5.242GluGly: 5.242 ± 0.657
1.83GluHis: 1.83 ± 0.499
2.662GluIle: 2.662 ± 0.42
2.995GluLys: 2.995 ± 0.583
6.407GluLeu: 6.407 ± 0.892
1.914GluMet: 1.914 ± 0.624
2.08GluAsn: 2.08 ± 0.377
2.33GluPro: 2.33 ± 0.667
3.245GluGln: 3.245 ± 0.638
4.077GluArg: 4.077 ± 0.554
4.326GluSer: 4.326 ± 0.489
2.829GluThr: 2.829 ± 0.419
4.909GluVal: 4.909 ± 0.627
0.499GluTrp: 0.499 ± 0.197
2.746GluTyr: 2.746 ± 0.439
0.0GluXaa: 0.0 ± 0.0
Phe
2.746PheAla: 2.746 ± 0.427
0.333PheCys: 0.333 ± 0.197
2.995PheAsp: 2.995 ± 0.478
2.163PheGlu: 2.163 ± 0.369
0.915PhePhe: 0.915 ± 0.221
3.078PheGly: 3.078 ± 0.61
0.666PheHis: 0.666 ± 0.265
1.83PheIle: 1.83 ± 0.429
2.33PheLys: 2.33 ± 0.293
2.995PheLeu: 2.995 ± 0.549
1.082PheMet: 1.082 ± 0.3
2.163PheAsn: 2.163 ± 0.396
1.498PhePro: 1.498 ± 0.421
1.248PheGln: 1.248 ± 0.305
1.747PheArg: 1.747 ± 0.401
2.33PheSer: 2.33 ± 0.465
2.496PheThr: 2.496 ± 0.434
2.246PheVal: 2.246 ± 0.41
0.333PheTrp: 0.333 ± 0.145
0.749PheTyr: 0.749 ± 0.213
0.0PheXaa: 0.0 ± 0.0
Gly
6.739GlyAla: 6.739 ± 0.969
0.666GlyCys: 0.666 ± 0.239
5.741GlyAsp: 5.741 ± 0.568
4.909GlyGlu: 4.909 ± 0.686
2.579GlyPhe: 2.579 ± 0.318
5.824GlyGly: 5.824 ± 0.834
1.83GlyHis: 1.83 ± 0.403
4.909GlyIle: 4.909 ± 0.761
5.491GlyLys: 5.491 ± 0.703
7.072GlyLeu: 7.072 ± 0.678
1.83GlyMet: 1.83 ± 0.428
2.912GlyAsn: 2.912 ± 0.468
1.664GlyPro: 1.664 ± 0.509
2.829GlyGln: 2.829 ± 0.463
4.16GlyArg: 4.16 ± 0.35
5.575GlySer: 5.575 ± 0.633
4.077GlyThr: 4.077 ± 0.556
5.325GlyVal: 5.325 ± 0.927
1.747GlyTrp: 1.747 ± 0.409
3.411GlyTyr: 3.411 ± 0.538
0.0GlyXaa: 0.0 ± 0.0
His
1.331HisAla: 1.331 ± 0.297
0.582HisCys: 0.582 ± 0.18
1.414HisAsp: 1.414 ± 0.292
1.914HisGlu: 1.914 ± 0.437
0.749HisPhe: 0.749 ± 0.246
1.414HisGly: 1.414 ± 0.371
0.499HisHis: 0.499 ± 0.187
1.248HisIle: 1.248 ± 0.386
1.165HisLys: 1.165 ± 0.33
1.331HisLeu: 1.331 ± 0.391
0.666HisMet: 0.666 ± 0.211
0.25HisAsn: 0.25 ± 0.141
0.832HisPro: 0.832 ± 0.196
0.582HisGln: 0.582 ± 0.212
0.416HisArg: 0.416 ± 0.144
0.749HisSer: 0.749 ± 0.207
0.915HisThr: 0.915 ± 0.213
1.498HisVal: 1.498 ± 0.33
0.166HisTrp: 0.166 ± 0.102
1.082HisTyr: 1.082 ± 0.213
0.0HisXaa: 0.0 ± 0.0
Ile
4.826IleAla: 4.826 ± 0.494
0.582IleCys: 0.582 ± 0.191
3.162IleAsp: 3.162 ± 0.512
2.912IleGlu: 2.912 ± 0.583
0.666IlePhe: 0.666 ± 0.224
3.494IleGly: 3.494 ± 0.482
0.915IleHis: 0.915 ± 0.313
2.829IleIle: 2.829 ± 0.551
3.328IleLys: 3.328 ± 0.443
3.411IleLeu: 3.411 ± 0.604
1.165IleMet: 1.165 ± 0.286
2.08IleAsn: 2.08 ± 0.565
2.995IlePro: 2.995 ± 0.551
1.747IleGln: 1.747 ± 0.458
3.411IleArg: 3.411 ± 0.565
3.078IleSer: 3.078 ± 0.476
2.579IleThr: 2.579 ± 0.591
3.162IleVal: 3.162 ± 0.52
0.416IleTrp: 0.416 ± 0.178
1.747IleTyr: 1.747 ± 0.474
0.0IleXaa: 0.0 ± 0.0
Lys
7.987LysAla: 7.987 ± 0.96
0.499LysCys: 0.499 ± 0.199
3.744LysAsp: 3.744 ± 0.573
5.575LysGlu: 5.575 ± 0.725
2.33LysPhe: 2.33 ± 0.37
5.824LysGly: 5.824 ± 0.957
1.664LysHis: 1.664 ± 0.374
2.496LysIle: 2.496 ± 0.415
3.328LysLys: 3.328 ± 0.785
5.491LysLeu: 5.491 ± 0.638
1.498LysMet: 1.498 ± 0.361
2.662LysAsn: 2.662 ± 0.371
2.246LysPro: 2.246 ± 0.604
2.33LysGln: 2.33 ± 0.373
3.494LysArg: 3.494 ± 0.606
3.245LysSer: 3.245 ± 0.532
3.078LysThr: 3.078 ± 0.485
5.242LysVal: 5.242 ± 0.611
0.832LysTrp: 0.832 ± 0.325
1.747LysTyr: 1.747 ± 0.362
0.0LysXaa: 0.0 ± 0.0
Leu
7.655LeuAla: 7.655 ± 1.026
0.25LeuCys: 0.25 ± 0.131
4.992LeuAsp: 4.992 ± 0.468
6.989LeuGlu: 6.989 ± 0.976
2.496LeuPhe: 2.496 ± 0.363
5.242LeuGly: 5.242 ± 0.589
1.248LeuHis: 1.248 ± 0.317
3.411LeuIle: 3.411 ± 0.663
6.739LeuLys: 6.739 ± 0.576
6.157LeuLeu: 6.157 ± 0.827
2.33LeuMet: 2.33 ± 0.278
4.493LeuAsn: 4.493 ± 0.77
3.162LeuPro: 3.162 ± 0.466
3.494LeuGln: 3.494 ± 0.49
4.909LeuArg: 4.909 ± 0.545
4.826LeuSer: 4.826 ± 0.589
4.826LeuThr: 4.826 ± 0.644
5.075LeuVal: 5.075 ± 0.645
1.498LeuTrp: 1.498 ± 0.4
2.746LeuTyr: 2.746 ± 0.444
0.0LeuXaa: 0.0 ± 0.0
Met
3.245MetAla: 3.245 ± 0.42
0.166MetCys: 0.166 ± 0.111
1.914MetAsp: 1.914 ± 0.389
1.498MetGlu: 1.498 ± 0.314
0.915MetPhe: 0.915 ± 0.227
1.83MetGly: 1.83 ± 0.307
0.666MetHis: 0.666 ± 0.216
1.082MetIle: 1.082 ± 0.272
1.414MetLys: 1.414 ± 0.341
2.746MetLeu: 2.746 ± 0.517
0.749MetMet: 0.749 ± 0.241
0.749MetAsn: 0.749 ± 0.188
0.666MetPro: 0.666 ± 0.203
2.163MetGln: 2.163 ± 0.411
1.165MetArg: 1.165 ± 0.287
1.414MetSer: 1.414 ± 0.425
1.914MetThr: 1.914 ± 0.371
1.664MetVal: 1.664 ± 0.362
0.0MetTrp: 0.0 ± 0.0
0.582MetTyr: 0.582 ± 0.178
0.0MetXaa: 0.0 ± 0.0
Asn
4.077AsnAla: 4.077 ± 0.573
0.416AsnCys: 0.416 ± 0.183
2.246AsnAsp: 2.246 ± 0.347
2.496AsnGlu: 2.496 ± 0.474
1.83AsnPhe: 1.83 ± 0.505
4.326AsnGly: 4.326 ± 0.566
0.25AsnHis: 0.25 ± 0.126
2.579AsnIle: 2.579 ± 0.504
2.163AsnLys: 2.163 ± 0.403
2.912AsnLeu: 2.912 ± 0.506
0.998AsnMet: 0.998 ± 0.31
1.165AsnAsn: 1.165 ± 0.281
2.33AsnPro: 2.33 ± 0.321
1.248AsnGln: 1.248 ± 0.233
1.83AsnArg: 1.83 ± 0.445
3.078AsnSer: 3.078 ± 0.572
1.997AsnThr: 1.997 ± 0.339
3.078AsnVal: 3.078 ± 0.628
0.749AsnTrp: 0.749 ± 0.26
1.664AsnTyr: 1.664 ± 0.371
0.0AsnXaa: 0.0 ± 0.0
Pro
3.162ProAla: 3.162 ± 0.429
0.499ProCys: 0.499 ± 0.209
2.08ProAsp: 2.08 ± 0.398
4.41ProGlu: 4.41 ± 0.58
1.581ProPhe: 1.581 ± 0.239
2.246ProGly: 2.246 ± 0.441
0.499ProHis: 0.499 ± 0.172
1.165ProIle: 1.165 ± 0.314
2.829ProLys: 2.829 ± 0.544
2.746ProLeu: 2.746 ± 0.431
0.832ProMet: 0.832 ± 0.261
1.997ProAsn: 1.997 ± 0.401
0.915ProPro: 0.915 ± 0.331
1.165ProGln: 1.165 ± 0.25
1.83ProArg: 1.83 ± 0.372
1.914ProSer: 1.914 ± 0.322
2.08ProThr: 2.08 ± 0.512
2.912ProVal: 2.912 ± 0.408
0.832ProTrp: 0.832 ± 0.184
1.914ProTyr: 1.914 ± 0.365
0.0ProXaa: 0.0 ± 0.0
Gln
4.077GlnAla: 4.077 ± 0.573
0.25GlnCys: 0.25 ± 0.129
2.246GlnAsp: 2.246 ± 0.262
2.662GlnGlu: 2.662 ± 0.425
1.664GlnPhe: 1.664 ± 0.273
2.912GlnGly: 2.912 ± 0.467
0.333GlnHis: 0.333 ± 0.172
1.747GlnIle: 1.747 ± 0.377
3.245GlnLys: 3.245 ± 0.484
4.243GlnLeu: 4.243 ± 0.499
1.248GlnMet: 1.248 ± 0.436
1.331GlnAsn: 1.331 ± 0.27
1.747GlnPro: 1.747 ± 0.22
3.411GlnGln: 3.411 ± 0.499
2.33GlnArg: 2.33 ± 0.473
2.33GlnSer: 2.33 ± 0.394
1.664GlnThr: 1.664 ± 0.399
2.579GlnVal: 2.579 ± 0.422
0.666GlnTrp: 0.666 ± 0.202
1.747GlnTyr: 1.747 ± 0.502
0.0GlnXaa: 0.0 ± 0.0
Arg
4.659ArgAla: 4.659 ± 0.748
0.832ArgCys: 0.832 ± 0.256
3.578ArgAsp: 3.578 ± 0.56
3.994ArgGlu: 3.994 ± 0.583
1.664ArgPhe: 1.664 ± 0.332
4.077ArgGly: 4.077 ± 0.493
0.998ArgHis: 0.998 ± 0.333
3.162ArgIle: 3.162 ± 0.527
3.494ArgLys: 3.494 ± 0.53
4.077ArgLeu: 4.077 ± 0.65
1.331ArgMet: 1.331 ± 0.346
2.163ArgAsn: 2.163 ± 0.324
2.163ArgPro: 2.163 ± 0.336
2.662ArgGln: 2.662 ± 0.462
2.579ArgArg: 2.579 ± 0.381
3.744ArgSer: 3.744 ± 0.307
2.912ArgThr: 2.912 ± 0.442
3.661ArgVal: 3.661 ± 0.666
0.832ArgTrp: 0.832 ± 0.244
1.165ArgTyr: 1.165 ± 0.254
0.0ArgXaa: 0.0 ± 0.0
Ser
4.742SerAla: 4.742 ± 0.681
0.582SerCys: 0.582 ± 0.198
4.41SerAsp: 4.41 ± 0.64
3.245SerGlu: 3.245 ± 0.412
2.912SerPhe: 2.912 ± 0.464
5.242SerGly: 5.242 ± 0.775
1.498SerHis: 1.498 ± 0.372
2.746SerIle: 2.746 ± 0.465
4.243SerLys: 4.243 ± 0.527
5.075SerLeu: 5.075 ± 0.821
1.331SerMet: 1.331 ± 0.315
1.997SerAsn: 1.997 ± 0.525
1.83SerPro: 1.83 ± 0.375
2.579SerGln: 2.579 ± 0.475
3.328SerArg: 3.328 ± 0.507
2.496SerSer: 2.496 ± 0.447
4.243SerThr: 4.243 ± 0.804
3.91SerVal: 3.91 ± 0.547
0.915SerTrp: 0.915 ± 0.383
2.413SerTyr: 2.413 ± 0.47
0.0SerXaa: 0.0 ± 0.0
Thr
4.326ThrAla: 4.326 ± 0.718
0.499ThrCys: 0.499 ± 0.205
3.494ThrAsp: 3.494 ± 0.449
3.328ThrGlu: 3.328 ± 0.588
2.163ThrPhe: 2.163 ± 0.404
4.992ThrGly: 4.992 ± 0.665
0.832ThrHis: 0.832 ± 0.192
3.078ThrIle: 3.078 ± 0.433
3.994ThrLys: 3.994 ± 0.502
5.158ThrLeu: 5.158 ± 0.749
1.498ThrMet: 1.498 ± 0.278
1.997ThrAsn: 1.997 ± 0.502
2.829ThrPro: 2.829 ± 0.342
2.413ThrGln: 2.413 ± 0.442
2.413ThrArg: 2.413 ± 0.42
3.411ThrSer: 3.411 ± 0.537
2.246ThrThr: 2.246 ± 0.596
3.827ThrVal: 3.827 ± 0.607
0.666ThrTrp: 0.666 ± 0.283
1.498ThrTyr: 1.498 ± 0.419
0.0ThrXaa: 0.0 ± 0.0
Val
6.407ValAla: 6.407 ± 0.77
0.416ValCys: 0.416 ± 0.153
3.827ValAsp: 3.827 ± 0.561
4.16ValGlu: 4.16 ± 0.489
1.83ValPhe: 1.83 ± 0.502
4.992ValGly: 4.992 ± 0.557
0.998ValHis: 0.998 ± 0.343
3.245ValIle: 3.245 ± 0.447
4.326ValLys: 4.326 ± 0.47
5.491ValLeu: 5.491 ± 0.63
1.331ValMet: 1.331 ± 0.276
3.494ValAsn: 3.494 ± 0.647
2.579ValPro: 2.579 ± 0.484
2.413ValGln: 2.413 ± 0.328
4.16ValArg: 4.16 ± 0.607
4.659ValSer: 4.659 ± 0.826
6.074ValThr: 6.074 ± 0.878
4.576ValVal: 4.576 ± 0.552
0.998ValTrp: 0.998 ± 0.321
2.413ValTyr: 2.413 ± 0.494
0.0ValXaa: 0.0 ± 0.0
Trp
0.915TrpAla: 0.915 ± 0.245
0.333TrpCys: 0.333 ± 0.169
0.582TrpAsp: 0.582 ± 0.225
1.165TrpGlu: 1.165 ± 0.28
0.333TrpPhe: 0.333 ± 0.128
0.915TrpGly: 0.915 ± 0.251
0.416TrpHis: 0.416 ± 0.211
0.666TrpIle: 0.666 ± 0.355
1.165TrpLys: 1.165 ± 0.356
1.165TrpLeu: 1.165 ± 0.303
0.333TrpMet: 0.333 ± 0.14
0.666TrpAsn: 0.666 ± 0.186
0.333TrpPro: 0.333 ± 0.141
0.666TrpGln: 0.666 ± 0.219
0.998TrpArg: 0.998 ± 0.281
0.998TrpSer: 0.998 ± 0.325
0.582TrpThr: 0.582 ± 0.214
1.498TrpVal: 1.498 ± 0.362
0.499TrpTrp: 0.499 ± 0.164
0.083TrpTyr: 0.083 ± 0.078
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.246TyrAla: 2.246 ± 0.489
0.25TyrCys: 0.25 ± 0.135
2.746TyrAsp: 2.746 ± 0.483
1.997TyrGlu: 1.997 ± 0.379
1.165TyrPhe: 1.165 ± 0.221
3.494TyrGly: 3.494 ± 0.4
0.998TyrHis: 0.998 ± 0.305
1.664TyrIle: 1.664 ± 0.346
1.83TyrLys: 1.83 ± 0.409
2.496TyrLeu: 2.496 ± 0.459
1.165TyrMet: 1.165 ± 0.228
1.83TyrAsn: 1.83 ± 0.482
0.998TyrPro: 0.998 ± 0.287
1.747TyrGln: 1.747 ± 0.479
2.246TyrArg: 2.246 ± 0.377
1.581TyrSer: 1.581 ± 0.442
2.163TyrThr: 2.163 ± 0.466
2.246TyrVal: 2.246 ± 0.369
0.499TyrTrp: 0.499 ± 0.178
1.331TyrTyr: 1.331 ± 0.415
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 45 proteins (12020 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski