Amino acid dipepetide frequency for Brugia timori

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.804AlaAla: 4.804 ± 0.058	1.181AlaCys: 1.181 ± 0.021	3.065AlaAsp: 3.065 ± 0.027	4.039AlaGlu: 4.039 ± 0.037	2.552AlaPhe: 2.552 ± 0.029	2.908AlaGly: 2.908 ± 0.039	1.338AlaHis: 1.338 ± 0.018	4.056AlaIle: 4.056 ± 0.036	3.636AlaLys: 3.636 ± 0.032	5.987AlaLeu: 5.987 ± 0.05	1.534AlaMet: 1.534 ± 0.02	2.847AlaAsn: 2.847 ± 0.031	2.117AlaPro: 2.117 ± 0.025	2.348AlaGln: 2.348 ± 0.03	3.107AlaArg: 3.107 ± 0.036	4.57AlaSer: 4.57 ± 0.036	3.523AlaThr: 3.523 ± 0.033	4.562AlaVal: 4.562 ± 0.039	0.573AlaTrp: 0.573 ± 0.014	1.774AlaTyr: 1.774 ± 0.023	0.007AlaXaa: 0.007 ± 0.001
Cys	1.263CysAla: 1.263 ± 0.02	0.698CysCys: 0.698 ± 0.015	1.227CysAsp: 1.227 ± 0.021	1.269CysGlu: 1.269 ± 0.02	1.139CysPhe: 1.139 ± 0.016	1.305CysGly: 1.305 ± 0.021	0.586CysHis: 0.586 ± 0.013	1.547CysIle: 1.547 ± 0.024	1.243CysLys: 1.243 ± 0.023	2.055CysLeu: 2.055 ± 0.025	0.554CysMet: 0.554 ± 0.014	1.107CysAsn: 1.107 ± 0.019	0.965CysPro: 0.965 ± 0.021	0.835CysGln: 0.835 ± 0.018	1.304CysArg: 1.304 ± 0.02	2.017CysSer: 2.017 ± 0.026	1.165CysThr: 1.165 ± 0.02	1.249CysVal: 1.249 ± 0.019	0.258CysTrp: 0.258 ± 0.008	0.769CysTyr: 0.769 ± 0.017	0.003CysXaa: 0.003 ± 0.001
Asp	3.165AspAla: 3.165 ± 0.032	1.109AspCys: 1.109 ± 0.019	4.043AspAsp: 4.043 ± 0.046	4.586AspGlu: 4.586 ± 0.042	2.434AspPhe: 2.434 ± 0.025	3.186AspGly: 3.186 ± 0.031	1.123AspHis: 1.123 ± 0.018	3.634AspIle: 3.634 ± 0.031	2.906AspLys: 2.906 ± 0.026	4.738AspLeu: 4.738 ± 0.038	1.279AspMet: 1.279 ± 0.02	2.568AspAsn: 2.568 ± 0.033	1.935AspPro: 1.935 ± 0.024	1.74AspGln: 1.74 ± 0.021	2.746AspArg: 2.746 ± 0.03	3.905AspSer: 3.905 ± 0.037	2.424AspThr: 2.424 ± 0.027	3.382AspVal: 3.382 ± 0.033	0.641AspTrp: 0.641 ± 0.014	1.765AspTyr: 1.765 ± 0.021	0.005AspXaa: 0.005 ± 0.001
Glu	3.85GluAla: 3.85 ± 0.032	1.29GluCys: 1.29 ± 0.02	3.203GluAsp: 3.203 ± 0.034	5.311GluGlu: 5.311 ± 0.059	2.319GluPhe: 2.319 ± 0.027	2.64GluGly: 2.64 ± 0.031	1.429GluHis: 1.429 ± 0.021	4.5GluIle: 4.5 ± 0.037	5.37GluLys: 5.37 ± 0.051	6.033GluLeu: 6.033 ± 0.051	2.048GluMet: 2.048 ± 0.026	3.821GluAsn: 3.821 ± 0.036	1.915GluPro: 1.915 ± 0.024	3.109GluGln: 3.109 ± 0.034	4.109GluArg: 4.109 ± 0.041	4.286GluSer: 4.286 ± 0.039	3.405GluThr: 3.405 ± 0.033	3.625GluVal: 3.625 ± 0.036	0.724GluTrp: 0.724 ± 0.013	1.954GluTyr: 1.954 ± 0.025	0.006GluXaa: 0.006 ± 0.001
Phe	2.735PheAla: 2.735 ± 0.026	1.224PheCys: 1.224 ± 0.019	2.544PheAsp: 2.544 ± 0.029	2.6PheGlu: 2.6 ± 0.026	2.495PhePhe: 2.495 ± 0.032	2.623PheGly: 2.623 ± 0.03	1.196PheHis: 1.196 ± 0.016	3.211PheIle: 3.211 ± 0.033	2.13PheLys: 2.13 ± 0.025	4.492PheLeu: 4.492 ± 0.036	1.195PheMet: 1.195 ± 0.018	1.974PheAsn: 1.974 ± 0.022	1.786PhePro: 1.786 ± 0.023	1.622PheGln: 1.622 ± 0.02	2.329PheArg: 2.329 ± 0.026	3.728PheSer: 3.728 ± 0.034	2.41PheThr: 2.41 ± 0.029	2.899PheVal: 2.899 ± 0.026	0.554PheTrp: 0.554 ± 0.012	1.668PheTyr: 1.668 ± 0.023	0.013PheXaa: 0.013 ± 0.002
Gly	2.8GlyAla: 2.8 ± 0.034	1.056GlyCys: 1.056 ± 0.018	2.655GlyAsp: 2.655 ± 0.029	2.899GlyGlu: 2.899 ± 0.032	2.175GlyPhe: 2.175 ± 0.025	2.927GlyGly: 2.927 ± 0.048	1.221GlyHis: 1.221 ± 0.017	3.483GlyIle: 3.483 ± 0.03	3.176GlyLys: 3.176 ± 0.03	3.992GlyLeu: 3.992 ± 0.034	1.267GlyMet: 1.267 ± 0.02	2.573GlyAsn: 2.573 ± 0.031	1.57GlyPro: 1.57 ± 0.024	1.788GlyGln: 1.788 ± 0.022	2.956GlyArg: 2.956 ± 0.033	3.921GlySer: 3.921 ± 0.039	2.914GlyThr: 2.914 ± 0.033	2.764GlyVal: 2.764 ± 0.027	0.61GlyTrp: 0.61 ± 0.012	1.714GlyTyr: 1.714 ± 0.021	0.008GlyXaa: 0.008 ± 0.001
His	1.354HisAla: 1.354 ± 0.018	0.691HisCys: 0.691 ± 0.015	1.087HisAsp: 1.087 ± 0.017	1.342HisGlu: 1.342 ± 0.022	1.389HisPhe: 1.389 ± 0.02	1.213HisGly: 1.213 ± 0.018	0.773HisHis: 0.773 ± 0.016	1.616HisIle: 1.616 ± 0.023	1.144HisLys: 1.144 ± 0.019	2.558HisLeu: 2.558 ± 0.026	0.605HisMet: 0.605 ± 0.012	1.069HisAsn: 1.069 ± 0.02	1.086HisPro: 1.086 ± 0.016	1.018HisGln: 1.018 ± 0.017	1.5HisArg: 1.5 ± 0.023	2.044HisSer: 2.044 ± 0.027	1.122HisThr: 1.122 ± 0.014	1.374HisVal: 1.374 ± 0.021	0.315HisTrp: 0.315 ± 0.009	0.96HisTyr: 0.96 ± 0.014	0.004HisXaa: 0.004 ± 0.001
Ile	4.415IleAla: 4.415 ± 0.036	1.754IleCys: 1.754 ± 0.027	3.778IleAsp: 3.778 ± 0.031	4.027IleGlu: 4.027 ± 0.038	3.301IlePhe: 3.301 ± 0.031	3.307IleGly: 3.307 ± 0.033	1.591IleHis: 1.591 ± 0.021	4.687IleIle: 4.687 ± 0.047	3.527IleLys: 3.527 ± 0.028	6.111IleLeu: 6.111 ± 0.05	1.6IleMet: 1.6 ± 0.022	3.33IleAsn: 3.33 ± 0.033	2.93IlePro: 2.93 ± 0.03	2.379IleGln: 2.379 ± 0.03	3.734IleArg: 3.734 ± 0.03	6.006IleSer: 6.006 ± 0.042	3.886IleThr: 3.886 ± 0.036	4.012IleVal: 4.012 ± 0.03	0.748IleTrp: 0.748 ± 0.013	2.223IleTyr: 2.223 ± 0.025	0.009IleXaa: 0.009 ± 0.002
Lys	3.399LysAla: 3.399 ± 0.035	1.405LysCys: 1.405 ± 0.02	2.947LysAsp: 2.947 ± 0.031	4.436LysGlu: 4.436 ± 0.042	2.522LysPhe: 2.522 ± 0.024	2.521LysGly: 2.521 ± 0.031	1.532LysHis: 1.532 ± 0.022	4.265LysIle: 4.265 ± 0.033	5.193LysLys: 5.193 ± 0.06	6.135LysLeu: 6.135 ± 0.047	1.909LysMet: 1.909 ± 0.021	3.379LysAsn: 3.379 ± 0.031	2.208LysPro: 2.208 ± 0.026	2.812LysGln: 2.812 ± 0.031	4.061LysArg: 4.061 ± 0.035	4.289LysSer: 4.289 ± 0.033	3.265LysThr: 3.265 ± 0.024	3.44LysVal: 3.44 ± 0.037	0.733LysTrp: 0.733 ± 0.014	2.162LysTyr: 2.162 ± 0.025	0.01LysXaa: 0.01 ± 0.002
Leu	5.77LeuAla: 5.77 ± 0.046	2.178LeuCys: 2.178 ± 0.026	4.652LeuAsp: 4.652 ± 0.04	5.768LeuGlu: 5.768 ± 0.052	4.528LeuPhe: 4.528 ± 0.041	3.797LeuGly: 3.797 ± 0.037	2.565LeuHis: 2.565 ± 0.029	6.231LeuIle: 6.231 ± 0.047	6.263LeuLys: 6.263 ± 0.043	10.352LeuLeu: 10.352 ± 0.066	2.47LeuMet: 2.47 ± 0.027	4.71LeuAsn: 4.71 ± 0.034	4.414LeuPro: 4.414 ± 0.037	4.281LeuGln: 4.281 ± 0.037	5.641LeuArg: 5.641 ± 0.042	8.037LeuSer: 8.037 ± 0.053	4.98LeuThr: 4.98 ± 0.04	5.031LeuVal: 5.031 ± 0.04	1.019LeuTrp: 1.019 ± 0.019	2.952LeuTyr: 2.952 ± 0.031	0.01LeuXaa: 0.01 ± 0.002
Met	1.581MetAla: 1.581 ± 0.02	0.481MetCys: 0.481 ± 0.011	1.463MetAsp: 1.463 ± 0.019	1.939MetGlu: 1.939 ± 0.025	1.035MetPhe: 1.035 ± 0.016	1.051MetGly: 1.051 ± 0.019	0.677MetHis: 0.677 ± 0.013	1.732MetIle: 1.732 ± 0.023	2.017MetLys: 2.017 ± 0.024	2.585MetLeu: 2.585 ± 0.026	0.743MetMet: 0.743 ± 0.015	1.486MetAsn: 1.486 ± 0.02	1.011MetPro: 1.011 ± 0.015	1.242MetGln: 1.242 ± 0.019	1.484MetArg: 1.484 ± 0.021	1.849MetSer: 1.849 ± 0.022	1.34MetThr: 1.34 ± 0.015	1.447MetVal: 1.447 ± 0.019	0.246MetTrp: 0.246 ± 0.009	0.723MetTyr: 0.723 ± 0.013	0.003MetXaa: 0.003 ± 0.001
Asn	3.073AsnAla: 3.073 ± 0.029	1.184AsnCys: 1.184 ± 0.02	3.28AsnAsp: 3.28 ± 0.035	3.797AsnGlu: 3.797 ± 0.034	2.383AsnPhe: 2.383 ± 0.026	3.008AsnGly: 3.008 ± 0.03	1.103AsnHis: 1.103 ± 0.019	3.556AsnIle: 3.556 ± 0.035	2.832AsnLys: 2.832 ± 0.03	4.48AsnLeu: 4.48 ± 0.038	1.273AsnMet: 1.273 ± 0.021	2.801AsnAsn: 2.801 ± 0.034	1.809AsnPro: 1.809 ± 0.023	1.731AsnGln: 1.731 ± 0.022	2.604AsnArg: 2.604 ± 0.025	4.174AsnSer: 4.174 ± 0.037	2.464AsnThr: 2.464 ± 0.024	3.224AsnVal: 3.224 ± 0.03	0.562AsnTrp: 0.562 ± 0.012	1.722AsnTyr: 1.722 ± 0.023	0.006AsnXaa: 0.006 ± 0.001
Pro	2.171ProAla: 2.171 ± 0.025	0.748ProCys: 0.748 ± 0.017	2.011ProAsp: 2.011 ± 0.021	2.563ProGlu: 2.563 ± 0.029	1.804ProPhe: 1.804 ± 0.021	1.81ProGly: 1.81 ± 0.024	0.886ProHis: 0.886 ± 0.015	2.445ProIle: 2.445 ± 0.029	2.226ProLys: 2.226 ± 0.024	3.702ProLeu: 3.702 ± 0.035	0.877ProMet: 0.877 ± 0.017	1.944ProAsn: 1.944 ± 0.026	2.417ProPro: 2.417 ± 0.04	1.515ProGln: 1.515 ± 0.021	1.89ProArg: 1.89 ± 0.027	3.637ProSer: 3.637 ± 0.035	2.334ProThr: 2.334 ± 0.026	2.68ProVal: 2.68 ± 0.029	0.401ProTrp: 0.401 ± 0.012	1.359ProTyr: 1.359 ± 0.02	0.007ProXaa: 0.007 ± 0.001
Gln	2.123GlnAla: 2.123 ± 0.027	0.946GlnCys: 0.946 ± 0.02	1.377GlnAsp: 1.377 ± 0.017	2.254GlnGlu: 2.254 ± 0.029	1.757GlnPhe: 1.757 ± 0.023	1.357GlnGly: 1.357 ± 0.018	1.104GlnHis: 1.104 ± 0.017	2.826GlnIle: 2.826 ± 0.028	2.849GlnLys: 2.849 ± 0.031	4.399GlnLeu: 4.399 ± 0.041	1.283GlnMet: 1.283 ± 0.016	2.159GlnAsn: 2.159 ± 0.025	1.541GlnPro: 1.541 ± 0.021	2.942GlnGln: 2.942 ± 0.057	2.54GlnArg: 2.54 ± 0.028	2.891GlnSer: 2.891 ± 0.03	2.097GlnThr: 2.097 ± 0.024	2.139GlnVal: 2.139 ± 0.025	0.5GlnTrp: 0.5 ± 0.013	1.329GlnTyr: 1.329 ± 0.02	0.004GlnXaa: 0.004 ± 0.001
Arg	2.973ArgAla: 2.973 ± 0.031	1.347ArgCys: 1.347 ± 0.022	2.65ArgAsp: 2.65 ± 0.029	3.514ArgGlu: 3.514 ± 0.038	2.489ArgPhe: 2.489 ± 0.029	2.421ArgGly: 2.421 ± 0.034	1.513ArgHis: 1.513 ± 0.025	3.884ArgIle: 3.884 ± 0.029	4.308ArgLys: 4.308 ± 0.04	5.444ArgLeu: 5.444 ± 0.04	1.525ArgMet: 1.525 ± 0.018	3.24ArgAsn: 3.24 ± 0.031	2.032ArgPro: 2.032 ± 0.026	2.446ArgGln: 2.446 ± 0.031	4.218ArgArg: 4.218 ± 0.05	4.372ArgSer: 4.372 ± 0.045	2.953ArgThr: 2.953 ± 0.029	2.825ArgVal: 2.825 ± 0.028	0.658ArgTrp: 0.658 ± 0.014	1.932ArgTyr: 1.932 ± 0.024	0.007ArgXaa: 0.007 ± 0.001
Ser	4.902SerAla: 4.902 ± 0.035	1.672SerCys: 1.672 ± 0.023	4.472SerAsp: 4.472 ± 0.039	4.709SerGlu: 4.709 ± 0.04	3.835SerPhe: 3.835 ± 0.031	4.366SerGly: 4.366 ± 0.035	1.807SerHis: 1.807 ± 0.02	4.943SerIle: 4.943 ± 0.038	4.58SerLys: 4.58 ± 0.037	7.597SerLeu: 7.597 ± 0.045	1.956SerMet: 1.956 ± 0.021	4.175SerAsn: 4.175 ± 0.037	3.2SerPro: 3.2 ± 0.033	2.839SerGln: 2.839 ± 0.028	4.138SerArg: 4.138 ± 0.039	8.697SerSer: 8.697 ± 0.077	4.926SerThr: 4.926 ± 0.039	5.176SerVal: 5.176 ± 0.038	0.796SerTrp: 0.796 ± 0.014	2.338SerTyr: 2.338 ± 0.029	0.014SerXaa: 0.014 ± 0.002
Thr	3.741ThrAla: 3.741 ± 0.032	1.112ThrCys: 1.112 ± 0.021	2.955ThrAsp: 2.955 ± 0.03	3.315ThrGlu: 3.315 ± 0.032	2.436ThrPhe: 2.436 ± 0.023	2.847ThrGly: 2.847 ± 0.033	1.119ThrHis: 1.119 ± 0.018	3.651ThrIle: 3.651 ± 0.035	3.086ThrLys: 3.086 ± 0.031	4.973ThrLeu: 4.973 ± 0.036	1.296ThrMet: 1.296 ± 0.018	2.794ThrAsn: 2.794 ± 0.031	2.276ThrPro: 2.276 ± 0.028	1.744ThrGln: 1.744 ± 0.025	2.464ThrArg: 2.464 ± 0.026	4.82ThrSer: 4.82 ± 0.04	3.87ThrThr: 3.87 ± 0.049	4.052ThrVal: 4.052 ± 0.035	0.511ThrTrp: 0.511 ± 0.011	1.635ThrTyr: 1.635 ± 0.02	0.008ThrXaa: 0.008 ± 0.002
Val	3.973ValAla: 3.973 ± 0.037	1.367ValCys: 1.367 ± 0.021	3.499ValAsp: 3.499 ± 0.03	4.049ValGlu: 4.049 ± 0.035	2.536ValPhe: 2.536 ± 0.025	2.898ValGly: 2.898 ± 0.032	1.474ValHis: 1.474 ± 0.022	4.177ValIle: 4.177 ± 0.038	3.566ValLys: 3.566 ± 0.031	5.732ValLeu: 5.732 ± 0.041	1.551ValMet: 1.551 ± 0.018	2.838ValAsn: 2.838 ± 0.031	2.547ValPro: 2.547 ± 0.03	2.337ValGln: 2.337 ± 0.025	3.224ValArg: 3.224 ± 0.034	4.582ValSer: 4.582 ± 0.033	3.468ValThr: 3.468 ± 0.028	4.031ValVal: 4.031 ± 0.037	0.62ValTrp: 0.62 ± 0.014	1.855ValTyr: 1.855 ± 0.023	0.009ValXaa: 0.009 ± 0.001
Trp	0.557TrpAla: 0.557 ± 0.012	0.247TrpCys: 0.247 ± 0.008	0.561TrpAsp: 0.561 ± 0.014	0.579TrpGlu: 0.579 ± 0.013	0.525TrpPhe: 0.525 ± 0.012	0.391TrpGly: 0.391 ± 0.01	0.289TrpHis: 0.289 ± 0.009	0.808TrpIle: 0.808 ± 0.015	0.869TrpLys: 0.869 ± 0.016	1.152TrpLeu: 1.152 ± 0.017	0.337TrpMet: 0.337 ± 0.009	0.685TrpAsn: 0.685 ± 0.015	0.411TrpPro: 0.411 ± 0.01	0.439TrpGln: 0.439 ± 0.012	0.694TrpArg: 0.694 ± 0.012	0.849TrpSer: 0.849 ± 0.015	0.617TrpThr: 0.617 ± 0.013	0.481TrpVal: 0.481 ± 0.011	0.167TrpTrp: 0.167 ± 0.007	0.387TrpTyr: 0.387 ± 0.011	0.001TrpXaa: 0.001 ± 0.001
Tyr	1.87TyrAla: 1.87 ± 0.021	0.865TyrCys: 0.865 ± 0.018	1.837TyrAsp: 1.837 ± 0.024	1.946TyrGlu: 1.946 ± 0.024	1.759TyrPhe: 1.759 ± 0.025	1.885TyrGly: 1.885 ± 0.025	0.936TyrHis: 0.936 ± 0.016	2.095TyrIle: 2.095 ± 0.024	1.691TyrLys: 1.691 ± 0.024	3.12TyrLeu: 3.12 ± 0.025	0.831TyrMet: 0.831 ± 0.017	1.559TyrAsn: 1.559 ± 0.022	1.252TyrPro: 1.252 ± 0.018	1.245TyrGln: 1.245 ± 0.018	2.002TyrArg: 2.002 ± 0.024	2.458TyrSer: 2.458 ± 0.027	1.533TyrThr: 1.533 ± 0.019	1.93TyrVal: 1.93 ± 0.025	0.406TyrTrp: 0.406 ± 0.011	1.332TyrTyr: 1.332 ± 0.023	0.005TyrXaa: 0.005 ± 0.001
Xaa	0.008XaaAla: 0.008 ± 0.001	0.006XaaCys: 0.006 ± 0.001	0.007XaaAsp: 0.007 ± 0.001	0.006XaaGlu: 0.006 ± 0.001	0.012XaaPhe: 0.012 ± 0.002	0.007XaaGly: 0.007 ± 0.001	0.003XaaHis: 0.003 ± 0.001	0.01XaaIle: 0.01 ± 0.001	0.011XaaLys: 0.011 ± 0.002	0.011XaaLeu: 0.011 ± 0.001	0.003XaaMet: 0.003 ± 0.001	0.006XaaAsn: 0.006 ± 0.001	0.004XaaPro: 0.004 ± 0.001	0.004XaaGln: 0.004 ± 0.001	0.007XaaArg: 0.007 ± 0.001	0.009XaaSer: 0.009 ± 0.001	0.008XaaThr: 0.008 ± 0.001	0.007XaaVal: 0.007 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.006XaaTyr: 0.006 ± 0.001	1.155XaaXaa: 1.155 ± 0.075

Statistics based on 15861 proteins (3895967 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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