Amino acid dipepetide frequency for Feline coronavirus (strain FIPV WSU-79/1146) (FCoV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.474AlaAla: 4.474 ± 0.945
2.46AlaCys: 2.46 ± 0.618
2.311AlaAsp: 2.311 ± 0.367
2.237AlaGlu: 2.237 ± 0.527
4.026AlaPhe: 4.026 ± 0.551
3.504AlaGly: 3.504 ± 0.676
0.746AlaHis: 0.746 ± 0.214
5.667AlaIle: 5.667 ± 0.896
4.996AlaLys: 4.996 ± 0.83
5.443AlaLeu: 5.443 ± 1.054
1.417AlaMet: 1.417 ± 0.252
3.43AlaAsn: 3.43 ± 0.374
1.417AlaPro: 1.417 ± 0.32
1.268AlaGln: 1.268 ± 0.462
2.759AlaArg: 2.759 ± 0.445
3.952AlaSer: 3.952 ± 0.882
3.579AlaThr: 3.579 ± 0.624
4.623AlaVal: 4.623 ± 0.752
0.671AlaTrp: 0.671 ± 0.145
4.474AlaTyr: 4.474 ± 0.808
0.0AlaXaa: 0.0 ± 0.0
Cys
1.417CysAla: 1.417 ± 0.237
0.895CysCys: 0.895 ± 0.272
2.162CysAsp: 2.162 ± 0.569
0.82CysGlu: 0.82 ± 0.252
1.342CysPhe: 1.342 ± 0.181
2.908CysGly: 2.908 ± 0.857
0.447CysHis: 0.447 ± 0.185
2.311CysIle: 2.311 ± 0.752
1.566CysLys: 1.566 ± 0.34
2.237CysLeu: 2.237 ± 0.824
0.746CysMet: 0.746 ± 0.22
2.013CysAsn: 2.013 ± 0.356
1.193CysPro: 1.193 ± 0.205
0.447CysGln: 0.447 ± 0.194
0.596CysArg: 0.596 ± 0.221
1.789CysSer: 1.789 ± 0.389
2.61CysThr: 2.61 ± 0.417
2.61CysVal: 2.61 ± 0.567
0.522CysTrp: 0.522 ± 0.195
2.46CysTyr: 2.46 ± 0.454
0.0CysXaa: 0.0 ± 0.0
Asp
4.474AspAla: 4.474 ± 0.862
1.789AspCys: 1.789 ± 0.459
2.759AspAsp: 2.759 ± 0.26
2.535AspGlu: 2.535 ± 0.406
3.43AspPhe: 3.43 ± 0.656
3.952AspGly: 3.952 ± 0.44
1.417AspHis: 1.417 ± 0.344
2.535AspIle: 2.535 ± 0.448
3.504AspLys: 3.504 ± 0.455
5.741AspLeu: 5.741 ± 0.665
1.118AspMet: 1.118 ± 0.478
2.833AspAsn: 2.833 ± 0.365
1.566AspPro: 1.566 ± 0.36
0.895AspGln: 0.895 ± 0.453
1.939AspArg: 1.939 ± 0.21
3.653AspSer: 3.653 ± 0.418
2.088AspThr: 2.088 ± 0.545
6.114AspVal: 6.114 ± 1.041
0.895AspTrp: 0.895 ± 0.338
3.43AspTyr: 3.43 ± 0.596
0.0AspXaa: 0.0 ± 0.0
Glu
2.535GluAla: 2.535 ± 0.451
1.491GluCys: 1.491 ± 0.186
3.504GluAsp: 3.504 ± 0.815
2.759GluGlu: 2.759 ± 0.475
2.833GluPhe: 2.833 ± 0.529
3.355GluGly: 3.355 ± 0.432
1.268GluHis: 1.268 ± 0.333
2.162GluIle: 2.162 ± 0.467
2.982GluLys: 2.982 ± 0.612
3.281GluLeu: 3.281 ± 0.362
0.596GluMet: 0.596 ± 0.169
3.057GluAsn: 3.057 ± 0.581
1.64GluPro: 1.64 ± 0.257
2.162GluGln: 2.162 ± 0.303
1.715GluArg: 1.715 ± 0.722
3.132GluSer: 3.132 ± 0.913
1.417GluThr: 1.417 ± 0.593
3.877GluVal: 3.877 ± 0.546
0.447GluTrp: 0.447 ± 0.329
1.789GluTyr: 1.789 ± 0.342
0.0GluXaa: 0.0 ± 0.0
Phe
2.759PheAla: 2.759 ± 0.429
1.566PheCys: 1.566 ± 0.422
4.026PheAsp: 4.026 ± 0.683
2.684PheGlu: 2.684 ± 0.514
2.833PhePhe: 2.833 ± 0.416
3.579PheGly: 3.579 ± 0.319
0.298PheHis: 0.298 ± 0.228
3.281PheIle: 3.281 ± 0.751
4.548PheLys: 4.548 ± 0.875
3.43PheLeu: 3.43 ± 0.686
1.417PheMet: 1.417 ± 0.576
4.026PheAsn: 4.026 ± 0.738
0.522PhePro: 0.522 ± 0.148
0.522PheGln: 0.522 ± 0.567
0.969PheArg: 0.969 ± 0.167
3.504PheSer: 3.504 ± 1.181
3.281PheThr: 3.281 ± 0.513
7.158PheVal: 7.158 ± 0.759
1.044PheTrp: 1.044 ± 0.481
3.355PheTyr: 3.355 ± 0.604
0.0PheXaa: 0.0 ± 0.0
Gly
4.548GlyAla: 4.548 ± 0.693
1.789GlyCys: 1.789 ± 0.393
5.145GlyAsp: 5.145 ± 0.788
3.057GlyGlu: 3.057 ± 0.686
4.548GlyPhe: 4.548 ± 0.485
4.101GlyGly: 4.101 ± 0.586
0.671GlyHis: 0.671 ± 0.149
2.684GlyIle: 2.684 ± 0.497
4.474GlyLys: 4.474 ± 0.839
4.623GlyLeu: 4.623 ± 0.65
1.491GlyMet: 1.491 ± 0.195
3.281GlyAsn: 3.281 ± 0.34
1.417GlyPro: 1.417 ± 0.394
0.82GlyGln: 0.82 ± 0.39
1.715GlyArg: 1.715 ± 1.052
4.697GlySer: 4.697 ± 0.781
4.026GlyThr: 4.026 ± 0.553
6.86GlyVal: 6.86 ± 0.791
0.224GlyTrp: 0.224 ± 0.204
2.908GlyTyr: 2.908 ± 0.383
0.0GlyXaa: 0.0 ± 0.0
His
1.193HisAla: 1.193 ± 0.561
0.447HisCys: 0.447 ± 0.127
1.268HisAsp: 1.268 ± 0.293
0.522HisGlu: 0.522 ± 0.415
1.193HisPhe: 1.193 ± 0.223
0.969HisGly: 0.969 ± 0.223
0.373HisHis: 0.373 ± 0.282
0.895HisIle: 0.895 ± 0.167
1.789HisLys: 1.789 ± 0.592
1.939HisLeu: 1.939 ± 0.593
0.373HisMet: 0.373 ± 0.315
1.491HisAsn: 1.491 ± 0.238
0.596HisPro: 0.596 ± 0.324
0.224HisGln: 0.224 ± 0.226
0.298HisArg: 0.298 ± 0.162
0.671HisSer: 0.671 ± 0.349
1.342HisThr: 1.342 ± 0.998
2.088HisVal: 2.088 ± 0.411
0.149HisTrp: 0.149 ± 0.114
0.596HisTyr: 0.596 ± 0.24
0.0HisXaa: 0.0 ± 0.0
Ile
4.175IleAla: 4.175 ± 0.607
1.417IleCys: 1.417 ± 0.354
2.759IleAsp: 2.759 ± 0.941
2.759IleGlu: 2.759 ± 0.302
2.46IlePhe: 2.46 ± 0.562
3.877IleGly: 3.877 ± 0.618
0.671IleHis: 0.671 ± 0.23
3.281IleIle: 3.281 ± 0.771
3.579IleLys: 3.579 ± 0.534
4.921IleLeu: 4.921 ± 1.254
1.268IleMet: 1.268 ± 0.317
3.43IleAsn: 3.43 ± 0.641
2.535IlePro: 2.535 ± 0.672
1.566IleGln: 1.566 ± 0.61
2.088IleArg: 2.088 ± 0.307
2.908IleSer: 2.908 ± 0.739
3.132IleThr: 3.132 ± 0.616
6.487IleVal: 6.487 ± 1.064
0.447IleTrp: 0.447 ± 0.185
2.311IleTyr: 2.311 ± 0.542
0.0IleXaa: 0.0 ± 0.0
Lys
4.324LysAla: 4.324 ± 0.872
2.46LysCys: 2.46 ± 0.663
3.952LysAsp: 3.952 ± 0.712
2.684LysGlu: 2.684 ± 0.531
2.759LysPhe: 2.759 ± 0.373
2.759LysGly: 2.759 ± 0.762
2.162LysHis: 2.162 ± 0.504
3.952LysIle: 3.952 ± 0.649
2.535LysLys: 2.535 ± 0.545
6.561LysLeu: 6.561 ± 0.854
2.162LysMet: 2.162 ± 0.495
3.206LysAsn: 3.206 ± 0.467
3.057LysPro: 3.057 ± 0.737
2.759LysGln: 2.759 ± 0.529
1.491LysArg: 1.491 ± 0.396
4.846LysSer: 4.846 ± 0.931
3.952LysThr: 3.952 ± 0.646
4.921LysVal: 4.921 ± 0.792
0.373LysTrp: 0.373 ± 0.202
3.206LysTyr: 3.206 ± 0.608
0.0LysXaa: 0.0 ± 0.0
Leu
4.623LeuAla: 4.623 ± 0.739
2.982LeuCys: 2.982 ± 0.421
4.25LeuAsp: 4.25 ± 0.514
5.667LeuGlu: 5.667 ± 0.509
4.324LeuPhe: 4.324 ± 0.733
5.517LeuGly: 5.517 ± 1.432
1.566LeuHis: 1.566 ± 0.675
3.952LeuIle: 3.952 ± 1.147
6.039LeuLys: 6.039 ± 0.801
8.947LeuLeu: 8.947 ± 5.326
1.342LeuMet: 1.342 ± 0.403
4.921LeuAsn: 4.921 ± 1.027
3.579LeuPro: 3.579 ± 0.652
3.355LeuGln: 3.355 ± 0.567
2.088LeuArg: 2.088 ± 0.97
6.412LeuSer: 6.412 ± 0.756
5.517LeuThr: 5.517 ± 0.683
6.636LeuVal: 6.636 ± 2.03
1.789LeuTrp: 1.789 ± 0.358
3.504LeuTyr: 3.504 ± 0.564
0.0LeuXaa: 0.0 ± 0.0
Met
1.939MetAla: 1.939 ± 0.537
0.895MetCys: 0.895 ± 0.338
0.895MetAsp: 0.895 ± 0.314
0.298MetGlu: 0.298 ± 0.368
0.522MetPhe: 0.522 ± 0.194
1.417MetGly: 1.417 ± 0.317
0.746MetHis: 0.746 ± 0.276
1.715MetIle: 1.715 ± 0.296
0.746MetLys: 0.746 ± 0.163
2.759MetLeu: 2.759 ± 0.618
0.596MetMet: 0.596 ± 0.214
0.298MetAsn: 0.298 ± 0.2
1.268MetPro: 1.268 ± 0.471
0.969MetGln: 0.969 ± 0.287
0.895MetArg: 0.895 ± 0.288
1.268MetSer: 1.268 ± 0.471
1.864MetThr: 1.864 ± 0.355
1.64MetVal: 1.64 ± 0.381
0.075MetTrp: 0.075 ± 0.211
1.268MetTyr: 1.268 ± 0.215
0.0MetXaa: 0.0 ± 0.0
Asn
4.101AsnAla: 4.101 ± 0.61
1.864AsnCys: 1.864 ± 0.443
1.864AsnAsp: 1.864 ± 0.214
2.684AsnGlu: 2.684 ± 0.332
2.759AsnPhe: 2.759 ± 0.475
5.741AsnGly: 5.741 ± 0.793
0.746AsnHis: 0.746 ± 0.242
2.908AsnIle: 2.908 ± 0.981
2.46AsnLys: 2.46 ± 0.578
4.474AsnLeu: 4.474 ± 0.556
1.566AsnMet: 1.566 ± 0.346
4.921AsnAsn: 4.921 ± 1.068
1.864AsnPro: 1.864 ± 0.307
1.342AsnGln: 1.342 ± 0.927
1.417AsnArg: 1.417 ± 0.473
4.772AsnSer: 4.772 ± 0.425
3.579AsnThr: 3.579 ± 0.679
7.009AsnVal: 7.009 ± 1.082
0.522AsnTrp: 0.522 ± 0.513
1.789AsnTyr: 1.789 ± 0.525
0.0AsnXaa: 0.0 ± 0.0
Pro
2.311ProAla: 2.311 ± 0.627
0.596ProCys: 0.596 ± 0.129
2.237ProAsp: 2.237 ± 0.917
1.118ProGlu: 1.118 ± 0.218
1.789ProPhe: 1.789 ± 0.452
2.311ProGly: 2.311 ± 0.614
0.596ProHis: 0.596 ± 0.253
1.939ProIle: 1.939 ± 0.386
2.088ProLys: 2.088 ± 0.546
2.759ProLeu: 2.759 ± 0.409
0.373ProMet: 0.373 ± 0.094
1.118ProAsn: 1.118 ± 0.251
1.118ProPro: 1.118 ± 0.222
1.118ProGln: 1.118 ± 0.469
1.193ProArg: 1.193 ± 0.716
3.281ProSer: 3.281 ± 0.59
2.162ProThr: 2.162 ± 0.337
3.43ProVal: 3.43 ± 0.528
0.82ProTrp: 0.82 ± 0.195
0.746ProTyr: 0.746 ± 0.338
0.0ProXaa: 0.0 ± 0.0
Gln
2.237GlnAla: 2.237 ± 0.683
0.447GlnCys: 0.447 ± 0.194
1.64GlnAsp: 1.64 ± 0.28
1.268GlnGlu: 1.268 ± 0.362
1.193GlnPhe: 1.193 ± 0.678
1.789GlnGly: 1.789 ± 0.279
0.522GlnHis: 0.522 ± 0.898
1.342GlnIle: 1.342 ± 0.743
1.417GlnLys: 1.417 ± 0.427
3.355GlnLeu: 3.355 ± 0.919
0.447GlnMet: 0.447 ± 0.216
0.746GlnAsn: 0.746 ± 0.244
1.417GlnPro: 1.417 ± 0.331
0.895GlnGln: 0.895 ± 0.265
1.491GlnArg: 1.491 ± 0.915
2.088GlnSer: 2.088 ± 0.353
2.013GlnThr: 2.013 ± 0.357
2.759GlnVal: 2.759 ± 0.545
0.298GlnTrp: 0.298 ± 0.219
1.491GlnTyr: 1.491 ± 0.252
0.0GlnXaa: 0.0 ± 0.0
Arg
1.715ArgAla: 1.715 ± 0.386
1.417ArgCys: 1.417 ± 0.386
1.64ArgAsp: 1.64 ± 0.544
0.746ArgGlu: 0.746 ± 0.205
2.386ArgPhe: 2.386 ± 0.423
1.342ArgGly: 1.342 ± 0.722
0.596ArgHis: 0.596 ± 0.402
1.193ArgIle: 1.193 ± 0.551
2.61ArgLys: 2.61 ± 0.37
2.386ArgLeu: 2.386 ± 1.348
0.298ArgMet: 0.298 ± 0.124
2.311ArgAsn: 2.311 ± 0.558
1.118ArgPro: 1.118 ± 0.385
1.491ArgGln: 1.491 ± 0.32
1.118ArgArg: 1.118 ± 0.434
2.759ArgSer: 2.759 ± 2.263
2.46ArgThr: 2.46 ± 0.945
2.311ArgVal: 2.311 ± 1.022
0.373ArgTrp: 0.373 ± 0.163
0.746ArgTyr: 0.746 ± 0.523
0.0ArgXaa: 0.0 ± 0.0
Ser
4.548SerAla: 4.548 ± 0.676
0.969SerCys: 0.969 ± 0.489
3.952SerAsp: 3.952 ± 0.594
2.982SerGlu: 2.982 ± 0.402
4.026SerPhe: 4.026 ± 0.467
4.623SerGly: 4.623 ± 0.82
1.044SerHis: 1.044 ± 0.613
4.101SerIle: 4.101 ± 0.502
4.474SerLys: 4.474 ± 0.942
5.219SerLeu: 5.219 ± 0.781
1.566SerMet: 1.566 ± 0.363
3.355SerAsn: 3.355 ± 0.49
1.268SerPro: 1.268 ± 0.258
2.386SerGln: 2.386 ± 0.703
2.162SerArg: 2.162 ± 1.831
4.548SerSer: 4.548 ± 0.462
4.101SerThr: 4.101 ± 0.935
8.276SerVal: 8.276 ± 1.045
0.969SerTrp: 0.969 ± 0.548
3.653SerTyr: 3.653 ± 0.688
0.0SerXaa: 0.0 ± 0.0
Thr
4.399ThrAla: 4.399 ± 1.398
2.162ThrCys: 2.162 ± 0.35
3.057ThrAsp: 3.057 ± 0.385
2.088ThrGlu: 2.088 ± 0.212
3.206ThrPhe: 3.206 ± 0.428
3.728ThrGly: 3.728 ± 0.992
0.895ThrHis: 0.895 ± 0.552
4.026ThrIle: 4.026 ± 0.569
2.684ThrLys: 2.684 ± 0.603
6.263ThrLeu: 6.263 ± 0.966
1.491ThrMet: 1.491 ± 0.387
3.877ThrAsn: 3.877 ± 0.631
3.281ThrPro: 3.281 ± 0.465
2.46ThrGln: 2.46 ± 0.228
1.789ThrArg: 1.789 ± 0.782
3.803ThrSer: 3.803 ± 0.627
5.07ThrThr: 5.07 ± 0.411
5.294ThrVal: 5.294 ± 0.839
0.969ThrTrp: 0.969 ± 0.398
2.162ThrTyr: 2.162 ± 0.591
0.0ThrXaa: 0.0 ± 0.0
Val
4.324ValAla: 4.324 ± 0.69
3.43ValCys: 3.43 ± 0.474
4.697ValAsp: 4.697 ± 0.692
6.114ValGlu: 6.114 ± 1.204
4.846ValPhe: 4.846 ± 0.515
3.803ValGly: 3.803 ± 0.403
2.311ValHis: 2.311 ± 0.572
5.517ValIle: 5.517 ± 1.371
7.605ValLys: 7.605 ± 1.582
8.724ValLeu: 8.724 ± 2.089
2.162ValMet: 2.162 ± 0.671
6.561ValAsn: 6.561 ± 0.604
2.237ValPro: 2.237 ± 0.476
2.759ValGln: 2.759 ± 1.051
3.281ValArg: 3.281 ± 0.738
7.083ValSer: 7.083 ± 0.55
6.934ValThr: 6.934 ± 0.539
9.171ValVal: 9.171 ± 1.381
0.82ValTrp: 0.82 ± 0.184
3.653ValTyr: 3.653 ± 0.523
0.0ValXaa: 0.0 ± 0.0
Trp
0.447TrpAla: 0.447 ± 0.185
0.298TrpCys: 0.298 ± 0.124
1.193TrpAsp: 1.193 ± 0.223
0.447TrpGlu: 0.447 ± 0.091
1.417TrpPhe: 1.417 ± 0.219
0.224TrpGly: 0.224 ± 0.229
0.224TrpHis: 0.224 ± 0.204
0.447TrpIle: 0.447 ± 0.18
0.522TrpLys: 0.522 ± 0.168
1.491TrpLeu: 1.491 ± 0.445
0.149TrpMet: 0.149 ± 0.202
1.118TrpAsn: 1.118 ± 0.399
0.671TrpPro: 0.671 ± 0.449
0.149TrpGln: 0.149 ± 0.06
0.373TrpArg: 0.373 ± 0.169
0.746TrpSer: 0.746 ± 0.452
0.671TrpThr: 0.671 ± 0.28
0.522TrpVal: 0.522 ± 0.163
0.075TrpTrp: 0.075 ± 0.211
0.596TrpTyr: 0.596 ± 0.326
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.908TyrAla: 2.908 ± 0.628
1.715TyrCys: 1.715 ± 0.301
3.43TyrAsp: 3.43 ± 0.917
2.535TyrGlu: 2.535 ± 0.52
2.908TyrPhe: 2.908 ± 0.464
3.579TyrGly: 3.579 ± 0.534
1.118TyrHis: 1.118 ± 0.159
2.162TyrIle: 2.162 ± 0.268
3.504TyrLys: 3.504 ± 0.497
2.46TyrLeu: 2.46 ± 0.383
1.417TyrMet: 1.417 ± 0.415
2.386TyrAsn: 2.386 ± 0.568
1.342TyrPro: 1.342 ± 0.341
1.268TyrGln: 1.268 ± 0.2
1.64TyrArg: 1.64 ± 0.266
2.311TyrSer: 2.311 ± 0.641
2.908TyrThr: 2.908 ± 0.484
4.25TyrVal: 4.25 ± 0.731
0.298TyrTrp: 0.298 ± 0.153
2.982TyrTyr: 2.982 ± 0.44
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (13413 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski