Amino acid dipepetide frequency for Tautonia plasticadhaerens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.437AlaAla: 13.437 ± 0.108	1.101AlaCys: 1.101 ± 0.021	7.455AlaAsp: 7.455 ± 0.064	8.459AlaGlu: 8.459 ± 0.081	3.962AlaPhe: 3.962 ± 0.042	10.763AlaGly: 10.763 ± 0.084	1.776AlaHis: 1.776 ± 0.034	5.154AlaIle: 5.154 ± 0.048	2.071AlaLys: 2.071 ± 0.037	12.173AlaLeu: 12.173 ± 0.096	2.66AlaMet: 2.66 ± 0.038	1.953AlaAsn: 1.953 ± 0.036	6.558AlaPro: 6.558 ± 0.074	2.4AlaGln: 2.4 ± 0.031	10.158AlaArg: 10.158 ± 0.083	7.189AlaSer: 7.189 ± 0.057	5.303AlaThr: 5.303 ± 0.056	8.577AlaVal: 8.577 ± 0.074	1.761AlaTrp: 1.761 ± 0.034	2.173AlaTyr: 2.173 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.683CysAla: 0.683 ± 0.018	0.163CysCys: 0.163 ± 0.011	0.553CysAsp: 0.553 ± 0.015	0.477CysGlu: 0.477 ± 0.015	0.272CysPhe: 0.272 ± 0.012	0.907CysGly: 0.907 ± 0.022	0.352CysHis: 0.352 ± 0.015	0.253CysIle: 0.253 ± 0.01	0.18CysLys: 0.18 ± 0.007	0.954CysLeu: 0.954 ± 0.02	0.141CysMet: 0.141 ± 0.008	0.19CysAsn: 0.19 ± 0.007	0.673CysPro: 0.673 ± 0.019	0.236CysGln: 0.236 ± 0.009	0.907CysArg: 0.907 ± 0.02	0.514CysSer: 0.514 ± 0.014	0.376CysThr: 0.376 ± 0.013	0.587CysVal: 0.587 ± 0.015	0.192CysTrp: 0.192 ± 0.009	0.234CysTyr: 0.234 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.42AspAla: 7.42 ± 0.071	0.467AspCys: 0.467 ± 0.016	4.511AspAsp: 4.511 ± 0.053	4.461AspGlu: 4.461 ± 0.053	1.977AspPhe: 1.977 ± 0.034	6.824AspGly: 6.824 ± 0.083	1.491AspHis: 1.491 ± 0.023	1.468AspIle: 1.468 ± 0.025	0.729AspLys: 0.729 ± 0.02	7.234AspLeu: 7.234 ± 0.067	0.701AspMet: 0.701 ± 0.018	0.888AspAsn: 0.888 ± 0.022	6.144AspPro: 6.144 ± 0.071	1.666AspGln: 1.666 ± 0.031	7.925AspArg: 7.925 ± 0.073	2.702AspSer: 2.702 ± 0.034	1.995AspThr: 1.995 ± 0.035	3.959AspVal: 3.959 ± 0.045	1.072AspTrp: 1.072 ± 0.024	1.351AspTyr: 1.351 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	9.123GluAla: 9.123 ± 0.085	0.382GluCys: 0.382 ± 0.015	3.312GluAsp: 3.312 ± 0.039	3.884GluGlu: 3.884 ± 0.05	1.926GluPhe: 1.926 ± 0.03	5.949GluGly: 5.949 ± 0.047	1.419GluHis: 1.419 ± 0.028	2.447GluIle: 2.447 ± 0.037	1.27GluLys: 1.27 ± 0.029	6.253GluLeu: 6.253 ± 0.053	1.052GluMet: 1.052 ± 0.023	1.017GluAsn: 1.017 ± 0.022	4.457GluPro: 4.457 ± 0.051	2.28GluGln: 2.28 ± 0.031	5.251GluArg: 5.251 ± 0.054	3.25GluSer: 3.25 ± 0.032	2.69GluThr: 2.69 ± 0.035	5.243GluVal: 5.243 ± 0.053	0.766GluTrp: 0.766 ± 0.02	1.155GluTyr: 1.155 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.518PheAla: 3.518 ± 0.038	0.301PheCys: 0.301 ± 0.011	2.691PheAsp: 2.691 ± 0.035	2.338PheGlu: 2.338 ± 0.034	1.085PhePhe: 1.085 ± 0.022	3.393PheGly: 3.393 ± 0.044	0.689PheHis: 0.689 ± 0.016	0.942PheIle: 0.942 ± 0.02	0.546PheLys: 0.546 ± 0.016	3.377PheLeu: 3.377 ± 0.039	0.428PheMet: 0.428 ± 0.014	0.772PheAsn: 0.772 ± 0.019	1.757PhePro: 1.757 ± 0.027	0.786PheGln: 0.786 ± 0.017	2.81PheArg: 2.81 ± 0.037	1.896PheSer: 1.896 ± 0.03	1.462PheThr: 1.462 ± 0.024	2.461PheVal: 2.461 ± 0.033	0.468PheTrp: 0.468 ± 0.016	0.746PheTyr: 0.746 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	8.752GlyAla: 8.752 ± 0.078	0.9GlyCys: 0.9 ± 0.021	5.97GlyAsp: 5.97 ± 0.062	5.783GlyGlu: 5.783 ± 0.047	3.243GlyPhe: 3.243 ± 0.043	9.84GlyGly: 9.84 ± 0.108	2.062GlyHis: 2.062 ± 0.031	3.693GlyIle: 3.693 ± 0.04	2.251GlyLys: 2.251 ± 0.035	10.214GlyLeu: 10.214 ± 0.077	2.171GlyMet: 2.171 ± 0.04	1.961GlyAsn: 1.961 ± 0.081	7.113GlyPro: 7.113 ± 0.074	2.721GlyGln: 2.721 ± 0.043	9.809GlyArg: 9.809 ± 0.077	5.695GlySer: 5.695 ± 0.058	4.91GlyThr: 4.91 ± 0.058	6.763GlyVal: 6.763 ± 0.069	1.686GlyTrp: 1.686 ± 0.029	2.112GlyTyr: 2.112 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.026HisAla: 2.026 ± 0.031	0.246HisCys: 0.246 ± 0.01	1.225HisAsp: 1.225 ± 0.022	1.119HisGlu: 1.119 ± 0.022	0.7HisPhe: 0.7 ± 0.018	1.876HisGly: 1.876 ± 0.031	0.618HisHis: 0.618 ± 0.017	0.533HisIle: 0.533 ± 0.016	0.32HisLys: 0.32 ± 0.011	2.302HisLeu: 2.302 ± 0.033	0.267HisMet: 0.267 ± 0.01	0.404HisAsn: 0.404 ± 0.014	1.724HisPro: 1.724 ± 0.029	0.512HisGln: 0.512 ± 0.015	2.093HisArg: 2.093 ± 0.031	0.892HisSer: 0.892 ± 0.02	0.704HisThr: 0.704 ± 0.017	1.362HisVal: 1.362 ± 0.025	0.39HisTrp: 0.39 ± 0.011	0.514HisTyr: 0.514 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.968IleAla: 4.968 ± 0.046	0.368IleCys: 0.368 ± 0.012	3.29IleAsp: 3.29 ± 0.038	2.924IleGlu: 2.924 ± 0.035	1.063IlePhe: 1.063 ± 0.02	4.09IleGly: 4.09 ± 0.055	0.716IleHis: 0.716 ± 0.018	1.183IleIle: 1.183 ± 0.025	0.806IleLys: 0.806 ± 0.019	3.69IleLeu: 3.69 ± 0.042	0.439IleMet: 0.439 ± 0.012	0.894IleAsn: 0.894 ± 0.019	2.55IlePro: 2.55 ± 0.032	0.9IleGln: 0.9 ± 0.02	3.809IleArg: 3.809 ± 0.039	1.903IleSer: 1.903 ± 0.031	1.781IleThr: 1.781 ± 0.027	2.914IleVal: 2.914 ± 0.037	0.496IleTrp: 0.496 ± 0.015	0.84IleTyr: 0.84 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.604LysAla: 2.604 ± 0.04	0.138LysCys: 0.138 ± 0.007	1.099LysAsp: 1.099 ± 0.024	1.096LysGlu: 1.096 ± 0.025	0.56LysPhe: 0.56 ± 0.016	1.744LysGly: 1.744 ± 0.033	0.404LysHis: 0.404 ± 0.015	0.838LysIle: 0.838 ± 0.022	0.695LysLys: 0.695 ± 0.022	1.97LysLeu: 1.97 ± 0.03	0.337LysMet: 0.337 ± 0.011	0.426LysAsn: 0.426 ± 0.014	1.353LysPro: 1.353 ± 0.027	0.624LysGln: 0.624 ± 0.016	1.527LysArg: 1.527 ± 0.026	1.017LysSer: 1.017 ± 0.022	1.033LysThr: 1.033 ± 0.022	1.688LysVal: 1.688 ± 0.035	0.236LysTrp: 0.236 ± 0.01	0.484LysTyr: 0.484 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	13.791LeuAla: 13.791 ± 0.109	0.926LeuCys: 0.926 ± 0.02	7.571LeuAsp: 7.571 ± 0.067	5.871LeuGlu: 5.871 ± 0.059	2.943LeuPhe: 2.943 ± 0.042	10.274LeuGly: 10.274 ± 0.077	1.798LeuHis: 1.798 ± 0.032	4.304LeuIle: 4.304 ± 0.045	2.304LeuLys: 2.304 ± 0.031	10.534LeuLeu: 10.534 ± 0.093	1.756LeuMet: 1.756 ± 0.029	1.947LeuAsn: 1.947 ± 0.032	6.247LeuPro: 6.247 ± 0.052	2.139LeuGln: 2.139 ± 0.031	8.663LeuArg: 8.663 ± 0.071	5.483LeuSer: 5.483 ± 0.042	4.705LeuThr: 4.705 ± 0.045	8.055LeuVal: 8.055 ± 0.065	1.325LeuTrp: 1.325 ± 0.028	1.996LeuTyr: 1.996 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.437MetAla: 2.437 ± 0.035	0.109MetCys: 0.109 ± 0.006	0.959MetAsp: 0.959 ± 0.021	0.897MetGlu: 0.897 ± 0.019	0.443MetPhe: 0.443 ± 0.014	1.541MetGly: 1.541 ± 0.03	0.327MetHis: 0.327 ± 0.01	0.955MetIle: 0.955 ± 0.02	0.515MetLys: 0.515 ± 0.015	1.857MetLeu: 1.857 ± 0.031	0.402MetMet: 0.402 ± 0.015	0.501MetAsn: 0.501 ± 0.013	1.391MetPro: 1.391 ± 0.025	0.461MetGln: 0.461 ± 0.014	1.366MetArg: 1.366 ± 0.024	1.136MetSer: 1.136 ± 0.022	1.294MetThr: 1.294 ± 0.024	1.223MetVal: 1.223 ± 0.025	0.142MetTrp: 0.142 ± 0.008	0.25MetTyr: 0.25 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.116AsnAla: 2.116 ± 0.036	0.198AsnCys: 0.198 ± 0.009	1.126AsnAsp: 1.126 ± 0.026	0.957AsnGlu: 0.957 ± 0.022	0.715AsnPhe: 0.715 ± 0.018	1.707AsnGly: 1.707 ± 0.033	0.432AsnHis: 0.432 ± 0.013	0.683AsnIle: 0.683 ± 0.017	0.329AsnLys: 0.329 ± 0.012	2.222AsnLeu: 2.222 ± 0.042	0.301AsnMet: 0.301 ± 0.011	0.534AsnAsn: 0.534 ± 0.019	1.675AsnPro: 1.675 ± 0.026	0.573AsnGln: 0.573 ± 0.016	1.741AsnArg: 1.741 ± 0.028	0.949AsnSer: 0.949 ± 0.025	0.923AsnThr: 0.923 ± 0.031	1.417AsnVal: 1.417 ± 0.03	0.32AsnTrp: 0.32 ± 0.011	0.539AsnTyr: 0.539 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.786ProAla: 7.786 ± 0.074	0.416ProCys: 0.416 ± 0.014	5.731ProAsp: 5.731 ± 0.057	5.792ProGlu: 5.792 ± 0.055	2.059ProPhe: 2.059 ± 0.03	8.606ProGly: 8.606 ± 0.09	1.124ProHis: 1.124 ± 0.023	3.069ProIle: 3.069 ± 0.031	1.295ProLys: 1.295 ± 0.023	5.108ProLeu: 5.108 ± 0.044	1.475ProMet: 1.475 ± 0.024	1.348ProAsn: 1.348 ± 0.027	5.534ProPro: 5.534 ± 0.079	1.35ProGln: 1.35 ± 0.032	4.994ProArg: 4.994 ± 0.051	4.396ProSer: 4.396 ± 0.049	3.555ProThr: 3.555 ± 0.045	4.66ProVal: 4.66 ± 0.045	0.937ProTrp: 0.937 ± 0.019	1.222ProTyr: 1.222 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.403GlnAla: 3.403 ± 0.048	0.232GlnCys: 0.232 ± 0.009	1.295GlnAsp: 1.295 ± 0.027	1.398GlnGlu: 1.398 ± 0.025	0.935GlnPhe: 0.935 ± 0.021	2.321GlnGly: 2.321 ± 0.038	0.501GlnHis: 0.501 ± 0.014	1.096GlnIle: 1.096 ± 0.021	0.55GlnLys: 0.55 ± 0.018	2.482GlnLeu: 2.482 ± 0.037	0.509GlnMet: 0.509 ± 0.012	0.482GlnAsn: 0.482 ± 0.017	1.487GlnPro: 1.487 ± 0.027	0.907GlnGln: 0.907 ± 0.028	1.843GlnArg: 1.843 ± 0.027	1.321GlnSer: 1.321 ± 0.024	1.083GlnThr: 1.083 ± 0.021	2.252GlnVal: 2.252 ± 0.036	0.341GlnTrp: 0.341 ± 0.012	0.562GlnTyr: 0.562 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.314ArgAla: 9.314 ± 0.072	0.823ArgCys: 0.823 ± 0.021	5.238ArgAsp: 5.238 ± 0.05	5.159ArgGlu: 5.159 ± 0.049	3.387ArgPhe: 3.387 ± 0.032	7.06ArgGly: 7.06 ± 0.058	1.961ArgHis: 1.961 ± 0.033	3.888ArgIle: 3.888 ± 0.045	1.835ArgLys: 1.835 ± 0.029	10.173ArgLeu: 10.173 ± 0.086	1.855ArgMet: 1.855 ± 0.028	1.604ArgAsn: 1.604 ± 0.026	6.873ArgPro: 6.873 ± 0.071	2.396ArgGln: 2.396 ± 0.033	9.564ArgArg: 9.564 ± 0.082	5.502ArgSer: 5.502 ± 0.053	3.861ArgThr: 3.861 ± 0.041	6.373ArgVal: 6.373 ± 0.061	1.704ArgTrp: 1.704 ± 0.03	1.979ArgTyr: 1.979 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.033SerAla: 6.033 ± 0.056	0.568SerCys: 0.568 ± 0.015	2.957SerAsp: 2.957 ± 0.035	2.734SerGlu: 2.734 ± 0.033	1.835SerPhe: 1.835 ± 0.027	6.346SerGly: 6.346 ± 0.068	1.05SerHis: 1.05 ± 0.022	2.454SerIle: 2.454 ± 0.029	1.195SerLys: 1.195 ± 0.021	5.19SerLeu: 5.19 ± 0.041	1.108SerMet: 1.108 ± 0.02	1.255SerAsn: 1.255 ± 0.023	4.567SerPro: 4.567 ± 0.059	1.355SerGln: 1.355 ± 0.023	4.882SerArg: 4.882 ± 0.05	3.145SerSer: 3.145 ± 0.041	2.912SerThr: 2.912 ± 0.035	3.571SerVal: 3.571 ± 0.04	1.035SerTrp: 1.035 ± 0.021	1.422SerTyr: 1.422 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	4.882ThrAla: 4.882 ± 0.061	0.432ThrCys: 0.432 ± 0.013	2.616ThrAsp: 2.616 ± 0.034	2.211ThrGlu: 2.211 ± 0.029	1.816ThrPhe: 1.816 ± 0.031	4.655ThrGly: 4.655 ± 0.044	0.841ThrHis: 0.841 ± 0.019	2.505ThrIle: 2.505 ± 0.039	0.869ThrLys: 0.869 ± 0.023	5.226ThrLeu: 5.226 ± 0.053	0.817ThrMet: 0.817 ± 0.016	0.99ThrAsn: 0.99 ± 0.022	3.595ThrPro: 3.595 ± 0.052	0.947ThrGln: 0.947 ± 0.019	3.49ThrArg: 3.49 ± 0.038	2.457ThrSer: 2.457 ± 0.033	2.492ThrThr: 2.492 ± 0.041	3.609ThrVal: 3.609 ± 0.043	0.739ThrTrp: 0.739 ± 0.019	1.11ThrTyr: 1.11 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	9.047ValAla: 9.047 ± 0.065	0.64ValCys: 0.64 ± 0.018	4.923ValAsp: 4.923 ± 0.048	5.419ValGlu: 5.419 ± 0.054	2.218ValPhe: 2.218 ± 0.03	6.674ValGly: 6.674 ± 0.049	1.317ValHis: 1.317 ± 0.021	2.976ValIle: 2.976 ± 0.04	1.366ValLys: 1.366 ± 0.028	7.636ValLeu: 7.636 ± 0.063	1.154ValMet: 1.154 ± 0.026	1.46ValAsn: 1.46 ± 0.028	4.703ValPro: 4.703 ± 0.053	1.631ValGln: 1.631 ± 0.029	6.099ValArg: 6.099 ± 0.052	4.156ValSer: 4.156 ± 0.043	3.524ValThr: 3.524 ± 0.047	6.97ValVal: 6.97 ± 0.063	0.818ValTrp: 0.818 ± 0.022	1.429ValTyr: 1.429 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.601TrpAla: 1.601 ± 0.03	0.174TrpCys: 0.174 ± 0.008	1.033TrpAsp: 1.033 ± 0.027	0.82TrpGlu: 0.82 ± 0.02	0.514TrpPhe: 0.514 ± 0.014	1.149TrpGly: 1.149 ± 0.02	0.362TrpHis: 0.362 ± 0.014	0.622TrpIle: 0.622 ± 0.014	0.337TrpLys: 0.337 ± 0.011	1.727TrpLeu: 1.727 ± 0.035	0.322TrpMet: 0.322 ± 0.012	0.332TrpAsn: 0.332 ± 0.012	0.863TrpPro: 0.863 ± 0.02	0.439TrpGln: 0.439 ± 0.014	1.332TrpArg: 1.332 ± 0.023	0.981TrpSer: 0.981 ± 0.021	0.791TrpThr: 0.791 ± 0.019	1.034TrpVal: 1.034 ± 0.019	0.286TrpTrp: 0.286 ± 0.011	0.339TrpTyr: 0.339 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.143TyrAla: 2.143 ± 0.028	0.259TyrCys: 0.259 ± 0.008	1.431TyrAsp: 1.431 ± 0.027	1.328TyrGlu: 1.328 ± 0.027	0.813TyrPhe: 0.813 ± 0.02	1.93TyrGly: 1.93 ± 0.035	0.587TyrHis: 0.587 ± 0.016	0.563TyrIle: 0.563 ± 0.017	0.412TyrLys: 0.412 ± 0.013	2.308TyrLeu: 2.308 ± 0.033	0.31TyrMet: 0.31 ± 0.011	0.5TyrAsn: 0.5 ± 0.016	1.19TyrPro: 1.19 ± 0.025	0.68TyrGln: 0.68 ± 0.017	2.283TyrArg: 2.283 ± 0.033	1.031TyrSer: 1.031 ± 0.019	0.908TyrThr: 0.908 ± 0.021	1.44TyrVal: 1.44 ± 0.024	0.344TyrTrp: 0.344 ± 0.012	0.626TyrTyr: 0.626 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7326 proteins (2572131 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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