Amino acid dipepetide frequency for Sphingobacterium sp. SGG-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.624AlaAla: 5.624 ± 0.075
0.643AlaCys: 0.643 ± 0.021
4.291AlaAsp: 4.291 ± 0.056
4.473AlaGlu: 4.473 ± 0.069
3.287AlaPhe: 3.287 ± 0.058
5.148AlaGly: 5.148 ± 0.075
1.364AlaHis: 1.364 ± 0.038
5.168AlaIle: 5.168 ± 0.073
4.184AlaLys: 4.184 ± 0.071
6.961AlaLeu: 6.961 ± 0.092
1.608AlaMet: 1.608 ± 0.037
3.637AlaAsn: 3.637 ± 0.061
2.424AlaPro: 2.424 ± 0.049
2.903AlaGln: 2.903 ± 0.057
2.814AlaArg: 2.814 ± 0.043
4.442AlaSer: 4.442 ± 0.063
4.191AlaThr: 4.191 ± 0.075
5.183AlaVal: 5.183 ± 0.077
0.893AlaTrp: 0.893 ± 0.025
3.164AlaTyr: 3.164 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.527CysAla: 0.527 ± 0.022
0.117CysCys: 0.117 ± 0.011
0.374CysAsp: 0.374 ± 0.022
0.37CysGlu: 0.37 ± 0.025
0.349CysPhe: 0.349 ± 0.018
0.547CysGly: 0.547 ± 0.022
0.179CysHis: 0.179 ± 0.013
0.545CysIle: 0.545 ± 0.02
0.368CysLys: 0.368 ± 0.016
0.612CysLeu: 0.612 ± 0.023
0.179CysMet: 0.179 ± 0.012
0.341CysAsn: 0.341 ± 0.015
0.311CysPro: 0.311 ± 0.018
0.249CysGln: 0.249 ± 0.014
0.321CysArg: 0.321 ± 0.015
0.463CysSer: 0.463 ± 0.021
0.439CysThr: 0.439 ± 0.019
0.435CysVal: 0.435 ± 0.019
0.075CysTrp: 0.075 ± 0.007
0.301CysTyr: 0.301 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.929AspAla: 3.929 ± 0.063
0.318AspCys: 0.318 ± 0.016
2.848AspAsp: 2.848 ± 0.055
3.558AspGlu: 3.558 ± 0.056
3.17AspPhe: 3.17 ± 0.051
4.342AspGly: 4.342 ± 0.076
1.059AspHis: 1.059 ± 0.033
4.679AspIle: 4.679 ± 0.068
3.737AspLys: 3.737 ± 0.062
5.199AspLeu: 5.199 ± 0.06
1.435AspMet: 1.435 ± 0.034
2.991AspAsn: 2.991 ± 0.052
2.432AspPro: 2.432 ± 0.049
1.896AspGln: 1.896 ± 0.04
2.742AspArg: 2.742 ± 0.046
2.757AspSer: 2.757 ± 0.048
2.813AspThr: 2.813 ± 0.056
3.825AspVal: 3.825 ± 0.063
0.876AspTrp: 0.876 ± 0.026
2.826AspTyr: 2.826 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
4.437GluAla: 4.437 ± 0.078
0.303GluCys: 0.303 ± 0.015
3.381GluAsp: 3.381 ± 0.054
4.561GluGlu: 4.561 ± 0.082
2.392GluPhe: 2.392 ± 0.042
4.036GluGly: 4.036 ± 0.054
1.148GluHis: 1.148 ± 0.029
4.467GluIle: 4.467 ± 0.058
4.342GluLys: 4.342 ± 0.068
5.569GluLeu: 5.569 ± 0.079
1.419GluMet: 1.419 ± 0.033
3.32GluAsn: 3.32 ± 0.06
1.699GluPro: 1.699 ± 0.038
2.652GluGln: 2.652 ± 0.058
3.003GluArg: 3.003 ± 0.048
2.942GluSer: 2.942 ± 0.049
3.181GluThr: 3.181 ± 0.043
4.293GluVal: 4.293 ± 0.057
0.697GluTrp: 0.697 ± 0.024
2.262GluTyr: 2.262 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.216PheAla: 3.216 ± 0.051
0.412PheCys: 0.412 ± 0.018
3.092PheAsp: 3.092 ± 0.051
2.805PheGlu: 2.805 ± 0.052
2.382PhePhe: 2.382 ± 0.055
3.448PheGly: 3.448 ± 0.056
0.933PheHis: 0.933 ± 0.026
3.087PheIle: 3.087 ± 0.059
2.621PheLys: 2.621 ± 0.051
4.088PheLeu: 4.088 ± 0.072
1.15PheMet: 1.15 ± 0.033
2.571PheAsn: 2.571 ± 0.048
1.804PhePro: 1.804 ± 0.035
1.535PheGln: 1.535 ± 0.037
2.135PheArg: 2.135 ± 0.046
3.424PheSer: 3.424 ± 0.052
2.825PheThr: 2.825 ± 0.044
3.147PheVal: 3.147 ± 0.052
0.599PheTrp: 0.599 ± 0.023
2.027PheTyr: 2.027 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.851GlyAla: 4.851 ± 0.067
0.559GlyCys: 0.559 ± 0.023
3.79GlyAsp: 3.79 ± 0.067
3.975GlyGlu: 3.975 ± 0.057
3.42GlyPhe: 3.42 ± 0.055
5.277GlyGly: 5.277 ± 0.09
1.358GlyHis: 1.358 ± 0.033
5.242GlyIle: 5.242 ± 0.066
4.676GlyLys: 4.676 ± 0.065
6.204GlyLeu: 6.204 ± 0.078
1.707GlyMet: 1.707 ± 0.04
3.911GlyAsn: 3.911 ± 0.073
1.66GlyPro: 1.66 ± 0.039
2.558GlyGln: 2.558 ± 0.046
3.146GlyArg: 3.146 ± 0.053
4.511GlySer: 4.511 ± 0.074
4.612GlyThr: 4.612 ± 0.092
5.005GlyVal: 5.005 ± 0.062
0.977GlyTrp: 0.977 ± 0.026
3.481GlyTyr: 3.481 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.38HisAla: 1.38 ± 0.031
0.163HisCys: 0.163 ± 0.011
1.01HisAsp: 1.01 ± 0.03
0.989HisGlu: 0.989 ± 0.032
1.09HisPhe: 1.09 ± 0.033
1.268HisGly: 1.268 ± 0.035
0.582HisHis: 0.582 ± 0.022
1.698HisIle: 1.698 ± 0.036
1.039HisLys: 1.039 ± 0.029
1.827HisLeu: 1.827 ± 0.039
0.403HisMet: 0.403 ± 0.017
1.007HisAsn: 1.007 ± 0.027
1.023HisPro: 1.023 ± 0.033
0.781HisGln: 0.781 ± 0.023
0.966HisArg: 0.966 ± 0.028
1.082HisSer: 1.082 ± 0.027
1.268HisThr: 1.268 ± 0.032
1.279HisVal: 1.279 ± 0.034
0.272HisTrp: 0.272 ± 0.014
0.935HisTyr: 0.935 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.673IleAla: 5.673 ± 0.075
0.642IleCys: 0.642 ± 0.03
4.399IleAsp: 4.399 ± 0.061
4.18IleGlu: 4.18 ± 0.062
2.934IlePhe: 2.934 ± 0.051
5.135IleGly: 5.135 ± 0.077
1.504IleHis: 1.504 ± 0.042
4.556IleIle: 4.556 ± 0.074
4.154IleLys: 4.154 ± 0.067
6.136IleLeu: 6.136 ± 0.077
1.313IleMet: 1.313 ± 0.033
3.462IleAsn: 3.462 ± 0.052
3.113IlePro: 3.113 ± 0.051
2.694IleGln: 2.694 ± 0.044
3.46IleArg: 3.46 ± 0.053
4.689IleSer: 4.689 ± 0.073
4.226IleThr: 4.226 ± 0.066
4.69IleVal: 4.69 ± 0.06
0.789IleTrp: 0.789 ± 0.027
2.639IleTyr: 2.639 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.395LysAla: 4.395 ± 0.08
0.238LysCys: 0.238 ± 0.014
3.762LysAsp: 3.762 ± 0.059
4.548LysGlu: 4.548 ± 0.077
2.316LysPhe: 2.316 ± 0.049
4.13LysGly: 4.13 ± 0.058
1.161LysHis: 1.161 ± 0.034
4.444LysIle: 4.444 ± 0.067
4.451LysLys: 4.451 ± 0.079
4.986LysLeu: 4.986 ± 0.07
1.6LysMet: 1.6 ± 0.035
3.548LysAsn: 3.548 ± 0.062
2.229LysPro: 2.229 ± 0.042
2.286LysGln: 2.286 ± 0.048
2.722LysArg: 2.722 ± 0.048
3.555LysSer: 3.555 ± 0.052
3.504LysThr: 3.504 ± 0.057
4.039LysVal: 4.039 ± 0.052
0.777LysTrp: 0.777 ± 0.026
2.683LysTyr: 2.683 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
6.595LeuAla: 6.595 ± 0.088
0.758LeuCys: 0.758 ± 0.026
5.086LeuAsp: 5.086 ± 0.062
5.061LeuGlu: 5.061 ± 0.068
4.627LeuPhe: 4.627 ± 0.075
5.92LeuGly: 5.92 ± 0.077
1.949LeuHis: 1.949 ± 0.046
5.806LeuIle: 5.806 ± 0.083
5.804LeuLys: 5.804 ± 0.088
9.003LeuLeu: 9.003 ± 0.118
2.047LeuMet: 2.047 ± 0.046
4.72LeuAsn: 4.72 ± 0.07
3.915LeuPro: 3.915 ± 0.054
3.608LeuGln: 3.608 ± 0.056
4.136LeuArg: 4.136 ± 0.061
6.827LeuSer: 6.827 ± 0.077
5.481LeuThr: 5.481 ± 0.088
5.36LeuVal: 5.36 ± 0.082
0.995LeuTrp: 0.995 ± 0.03
3.629LeuTyr: 3.629 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
1.745MetAla: 1.745 ± 0.036
0.141MetCys: 0.141 ± 0.012
1.356MetAsp: 1.356 ± 0.034
1.425MetGlu: 1.425 ± 0.029
0.786MetPhe: 0.786 ± 0.025
1.551MetGly: 1.551 ± 0.032
0.476MetHis: 0.476 ± 0.017
1.317MetIle: 1.317 ± 0.038
1.784MetLys: 1.784 ± 0.035
2.054MetLeu: 2.054 ± 0.038
0.576MetMet: 0.576 ± 0.022
1.217MetAsn: 1.217 ± 0.03
0.981MetPro: 0.981 ± 0.028
0.895MetGln: 0.895 ± 0.025
1.094MetArg: 1.094 ± 0.03
1.423MetSer: 1.423 ± 0.035
1.259MetThr: 1.259 ± 0.033
1.378MetVal: 1.378 ± 0.033
0.202MetTrp: 0.202 ± 0.013
0.795MetTyr: 0.795 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.615AsnAla: 3.615 ± 0.058
0.307AsnCys: 0.307 ± 0.025
2.643AsnAsp: 2.643 ± 0.05
2.81AsnGlu: 2.81 ± 0.057
2.475AsnPhe: 2.475 ± 0.047
3.901AsnGly: 3.901 ± 0.074
0.943AsnHis: 0.943 ± 0.028
4.071AsnIle: 4.071 ± 0.059
3.154AsnLys: 3.154 ± 0.052
4.558AsnLeu: 4.558 ± 0.067
1.276AsnMet: 1.276 ± 0.031
3.022AsnAsn: 3.022 ± 0.064
2.753AsnPro: 2.753 ± 0.044
1.896AsnGln: 1.896 ± 0.04
2.503AsnArg: 2.503 ± 0.053
3.125AsnSer: 3.125 ± 0.06
3.486AsnThr: 3.486 ± 0.061
3.298AsnVal: 3.298 ± 0.067
0.758AsnTrp: 0.758 ± 0.027
2.412AsnTyr: 2.412 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.721ProAla: 2.721 ± 0.064
0.218ProCys: 0.218 ± 0.012
2.617ProAsp: 2.617 ± 0.046
2.779ProGlu: 2.779 ± 0.054
1.897ProPhe: 1.897 ± 0.04
2.656ProGly: 2.656 ± 0.052
0.808ProHis: 0.808 ± 0.029
2.656ProIle: 2.656 ± 0.042
1.997ProLys: 1.997 ± 0.043
3.366ProLeu: 3.366 ± 0.047
0.732ProMet: 0.732 ± 0.026
1.982ProAsn: 1.982 ± 0.039
0.998ProPro: 0.998 ± 0.031
1.46ProGln: 1.46 ± 0.036
1.364ProArg: 1.364 ± 0.036
2.408ProSer: 2.408 ± 0.048
2.37ProThr: 2.37 ± 0.051
2.872ProVal: 2.872 ± 0.061
0.471ProTrp: 0.471 ± 0.023
1.696ProTyr: 1.696 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.795GlnAla: 2.795 ± 0.05
0.168GlnCys: 0.168 ± 0.013
1.986GlnAsp: 1.986 ± 0.038
2.529GlnGlu: 2.529 ± 0.046
1.545GlnPhe: 1.545 ± 0.036
2.408GlnGly: 2.408 ± 0.046
0.875GlnHis: 0.875 ± 0.025
2.512GlnIle: 2.512 ± 0.044
2.334GlnLys: 2.334 ± 0.05
3.654GlnLeu: 3.654 ± 0.06
0.842GlnMet: 0.842 ± 0.029
1.895GlnAsn: 1.895 ± 0.045
1.263GlnPro: 1.263 ± 0.028
1.984GlnGln: 1.984 ± 0.044
1.81GlnArg: 1.81 ± 0.042
2.158GlnSer: 2.158 ± 0.042
2.073GlnThr: 2.073 ± 0.045
2.519GlnVal: 2.519 ± 0.047
0.492GlnTrp: 0.492 ± 0.018
1.649GlnTyr: 1.649 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.908ArgAla: 2.908 ± 0.054
0.237ArgCys: 0.237 ± 0.015
2.366ArgAsp: 2.366 ± 0.046
2.817ArgGlu: 2.817 ± 0.051
2.259ArgPhe: 2.259 ± 0.042
2.644ArgGly: 2.644 ± 0.056
0.919ArgHis: 0.919 ± 0.03
3.538ArgIle: 3.538 ± 0.055
2.954ArgLys: 2.954 ± 0.054
4.242ArgLeu: 4.242 ± 0.062
1.175ArgMet: 1.175 ± 0.028
2.478ArgAsn: 2.478 ± 0.047
1.611ArgPro: 1.611 ± 0.032
1.711ArgGln: 1.711 ± 0.044
2.089ArgArg: 2.089 ± 0.044
2.56ArgSer: 2.56 ± 0.047
2.507ArgThr: 2.507 ± 0.049
2.942ArgVal: 2.942 ± 0.057
0.716ArgTrp: 0.716 ± 0.025
2.32ArgTyr: 2.32 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
4.503SerAla: 4.503 ± 0.067
0.614SerCys: 0.614 ± 0.025
3.43SerAsp: 3.43 ± 0.049
3.119SerGlu: 3.119 ± 0.051
3.396SerPhe: 3.396 ± 0.054
5.055SerGly: 5.055 ± 0.085
1.171SerHis: 1.171 ± 0.031
4.452SerIle: 4.452 ± 0.056
3.462SerLys: 3.462 ± 0.055
5.916SerLeu: 5.916 ± 0.069
1.222SerMet: 1.222 ± 0.031
3.181SerAsn: 3.181 ± 0.059
2.363SerPro: 2.363 ± 0.044
1.931SerGln: 1.931 ± 0.042
2.764SerArg: 2.764 ± 0.05
4.43SerSer: 4.43 ± 0.072
3.813SerThr: 3.813 ± 0.064
4.208SerVal: 4.208 ± 0.059
0.865SerTrp: 0.865 ± 0.026
2.937SerTyr: 2.937 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.62ThrAla: 4.62 ± 0.07
0.335ThrCys: 0.335 ± 0.017
3.452ThrAsp: 3.452 ± 0.06
3.11ThrGlu: 3.11 ± 0.052
2.916ThrPhe: 2.916 ± 0.044
4.743ThrGly: 4.743 ± 0.067
1.148ThrHis: 1.148 ± 0.032
4.216ThrIle: 4.216 ± 0.073
3.114ThrLys: 3.114 ± 0.05
5.637ThrLeu: 5.637 ± 0.07
1.085ThrMet: 1.085 ± 0.032
2.872ThrAsn: 2.872 ± 0.06
2.679ThrPro: 2.679 ± 0.068
1.861ThrGln: 1.861 ± 0.04
2.035ThrArg: 2.035 ± 0.041
3.688ThrSer: 3.688 ± 0.055
3.615ThrThr: 3.615 ± 0.062
4.453ThrVal: 4.453 ± 0.082
0.836ThrTrp: 0.836 ± 0.027
2.747ThrTyr: 2.747 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.851ValAla: 4.851 ± 0.079
0.525ValCys: 0.525 ± 0.023
4.188ValAsp: 4.188 ± 0.057
3.906ValGlu: 3.906 ± 0.059
3.192ValPhe: 3.192 ± 0.05
4.538ValGly: 4.538 ± 0.064
1.249ValHis: 1.249 ± 0.028
4.351ValIle: 4.351 ± 0.063
3.933ValLys: 3.933 ± 0.066
6.395ValLeu: 6.395 ± 0.08
1.386ValMet: 1.386 ± 0.03
3.498ValAsn: 3.498 ± 0.057
2.616ValPro: 2.616 ± 0.051
2.394ValGln: 2.394 ± 0.045
3.038ValArg: 3.038 ± 0.049
4.742ValSer: 4.742 ± 0.072
3.887ValThr: 3.887 ± 0.077
4.77ValVal: 4.77 ± 0.056
0.796ValTrp: 0.796 ± 0.026
2.691ValTyr: 2.691 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.819TrpAla: 0.819 ± 0.028
0.095TrpCys: 0.095 ± 0.009
0.757TrpAsp: 0.757 ± 0.025
0.812TrpGlu: 0.812 ± 0.025
0.574TrpPhe: 0.574 ± 0.021
0.97TrpGly: 0.97 ± 0.025
0.268TrpHis: 0.268 ± 0.016
0.785TrpIle: 0.785 ± 0.024
0.841TrpLys: 0.841 ± 0.025
1.104TrpLeu: 1.104 ± 0.032
0.368TrpMet: 0.368 ± 0.018
0.8TrpAsn: 0.8 ± 0.026
0.365TrpPro: 0.365 ± 0.018
0.539TrpGln: 0.539 ± 0.021
0.624TrpArg: 0.624 ± 0.026
0.807TrpSer: 0.807 ± 0.028
0.769TrpThr: 0.769 ± 0.027
0.775TrpVal: 0.775 ± 0.027
0.186TrpTrp: 0.186 ± 0.01
0.551TrpTyr: 0.551 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.196TyrAla: 3.196 ± 0.052
0.311TyrCys: 0.311 ± 0.015
2.604TyrAsp: 2.604 ± 0.051
2.277TyrGlu: 2.277 ± 0.045
2.296TyrPhe: 2.296 ± 0.053
3.204TyrGly: 3.204 ± 0.055
0.97TyrHis: 0.97 ± 0.031
2.798TyrIle: 2.798 ± 0.049
2.424TyrLys: 2.424 ± 0.045
3.817TyrLeu: 3.817 ± 0.063
0.93TyrMet: 0.93 ± 0.031
2.551TyrAsn: 2.551 ± 0.057
1.827TyrPro: 1.827 ± 0.039
1.66TyrGln: 1.66 ± 0.033
2.223TyrArg: 2.223 ± 0.047
2.802TyrSer: 2.802 ± 0.05
2.845TyrThr: 2.845 ± 0.055
2.475TyrVal: 2.475 ± 0.039
0.538TyrTrp: 0.538 ± 0.022
2.081TyrTyr: 2.081 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3361 proteins (1259215 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski