Amino acid dipepetide frequency for Actibacterium atlanticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.732AlaAla: 14.732 ± 0.207	1.032AlaCys: 1.032 ± 0.036	6.96AlaAsp: 6.96 ± 0.092	7.86AlaGlu: 7.86 ± 0.111	4.149AlaPhe: 4.149 ± 0.07	9.604AlaGly: 9.604 ± 0.103	2.248AlaHis: 2.248 ± 0.051	5.458AlaIle: 5.458 ± 0.089	4.503AlaLys: 4.503 ± 0.076	13.519AlaLeu: 13.519 ± 0.152	3.715AlaMet: 3.715 ± 0.063	2.799AlaAsn: 2.799 ± 0.053	5.868AlaPro: 5.868 ± 0.1	5.335AlaGln: 5.335 ± 0.08	7.7AlaArg: 7.7 ± 0.101	5.423AlaSer: 5.423 ± 0.083	5.649AlaThr: 5.649 ± 0.088	8.024AlaVal: 8.024 ± 0.101	1.332AlaTrp: 1.332 ± 0.041	2.54AlaTyr: 2.54 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.101CysAla: 1.101 ± 0.035	0.111CysCys: 0.111 ± 0.012	0.639CysAsp: 0.639 ± 0.026	0.462CysGlu: 0.462 ± 0.02	0.346CysPhe: 0.346 ± 0.021	0.93CysGly: 0.93 ± 0.036	0.287CysHis: 0.287 ± 0.021	0.438CysIle: 0.438 ± 0.021	0.248CysLys: 0.248 ± 0.015	0.854CysLeu: 0.854 ± 0.031	0.176CysMet: 0.176 ± 0.015	0.21CysAsn: 0.21 ± 0.014	0.531CysPro: 0.531 ± 0.028	0.252CysGln: 0.252 ± 0.017	0.462CysArg: 0.462 ± 0.021	0.456CysSer: 0.456 ± 0.025	0.474CysThr: 0.474 ± 0.023	0.642CysVal: 0.642 ± 0.026	0.115CysTrp: 0.115 ± 0.011	0.208CysTyr: 0.208 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.355AspAla: 7.355 ± 0.1	0.525AspCys: 0.525 ± 0.026	3.82AspAsp: 3.82 ± 0.108	3.604AspGlu: 3.604 ± 0.08	2.446AspPhe: 2.446 ± 0.054	5.532AspGly: 5.532 ± 0.098	1.453AspHis: 1.453 ± 0.037	3.272AspIle: 3.272 ± 0.056	2.052AspLys: 2.052 ± 0.046	6.768AspLeu: 6.768 ± 0.097	1.84AspMet: 1.84 ± 0.049	1.412AspAsn: 1.412 ± 0.037	3.537AspPro: 3.537 ± 0.064	2.358AspGln: 2.358 ± 0.051	3.697AspArg: 3.697 ± 0.075	2.353AspSer: 2.353 ± 0.054	3.351AspThr: 3.351 ± 0.078	4.416AspVal: 4.416 ± 0.069	1.098AspTrp: 1.098 ± 0.036	1.637AspTyr: 1.637 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.492GluAla: 7.492 ± 0.119	0.392GluCys: 0.392 ± 0.019	3.609GluAsp: 3.609 ± 0.073	3.715GluGlu: 3.715 ± 0.078	2.008GluPhe: 2.008 ± 0.047	4.84GluGly: 4.84 ± 0.085	1.217GluHis: 1.217 ± 0.036	3.563GluIle: 3.563 ± 0.064	2.279GluLys: 2.279 ± 0.053	5.661GluLeu: 5.661 ± 0.101	1.794GluMet: 1.794 ± 0.043	1.963GluAsn: 1.963 ± 0.042	2.442GluPro: 2.442 ± 0.051	2.326GluGln: 2.326 ± 0.048	4.015GluArg: 4.015 ± 0.083	2.507GluSer: 2.507 ± 0.054	3.805GluThr: 3.805 ± 0.068	4.286GluVal: 4.286 ± 0.066	0.72GluTrp: 0.72 ± 0.029	1.202GluTyr: 1.202 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.48PheAla: 4.48 ± 0.071	0.436PheCys: 0.436 ± 0.022	2.989PheAsp: 2.989 ± 0.057	2.48PheGlu: 2.48 ± 0.051	1.483PhePhe: 1.483 ± 0.046	3.836PheGly: 3.836 ± 0.071	0.722PheHis: 0.722 ± 0.03	1.776PheIle: 1.776 ± 0.044	1.143PheLys: 1.143 ± 0.036	3.438PheLeu: 3.438 ± 0.071	1.0PheMet: 1.0 ± 0.032	1.166PheAsn: 1.166 ± 0.036	1.502PhePro: 1.502 ± 0.039	1.086PheGln: 1.086 ± 0.034	1.95PheArg: 1.95 ± 0.044	2.18PheSer: 2.18 ± 0.051	2.212PheThr: 2.212 ± 0.045	2.761PheVal: 2.761 ± 0.059	0.554PheTrp: 0.554 ± 0.025	1.044PheTyr: 1.044 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.778GlyAla: 9.778 ± 0.123	0.836GlyCys: 0.836 ± 0.031	5.005GlyAsp: 5.005 ± 0.104	4.68GlyGlu: 4.68 ± 0.067	3.803GlyPhe: 3.803 ± 0.062	7.103GlyGly: 7.103 ± 0.118	1.907GlyHis: 1.907 ± 0.046	4.216GlyIle: 4.216 ± 0.073	3.479GlyLys: 3.479 ± 0.079	8.943GlyLeu: 8.943 ± 0.11	2.559GlyMet: 2.559 ± 0.056	2.225GlyAsn: 2.225 ± 0.061	3.351GlyPro: 3.351 ± 0.057	3.344GlyGln: 3.344 ± 0.068	4.983GlyArg: 4.983 ± 0.071	4.078GlySer: 4.078 ± 0.073	4.364GlyThr: 4.364 ± 0.078	6.582GlyVal: 6.582 ± 0.088	1.421GlyTrp: 1.421 ± 0.038	2.28GlyTyr: 2.28 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.238HisAla: 2.238 ± 0.046	0.23HisCys: 0.23 ± 0.014	1.313HisAsp: 1.313 ± 0.044	1.059HisGlu: 1.059 ± 0.04	0.833HisPhe: 0.833 ± 0.03	1.896HisGly: 1.896 ± 0.051	0.537HisHis: 0.537 ± 0.028	1.047HisIle: 1.047 ± 0.035	0.612HisLys: 0.612 ± 0.025	2.202HisLeu: 2.202 ± 0.055	0.585HisMet: 0.585 ± 0.026	0.533HisAsn: 0.533 ± 0.025	1.372HisPro: 1.372 ± 0.042	0.657HisGln: 0.657 ± 0.029	1.224HisArg: 1.224 ± 0.039	0.973HisSer: 0.973 ± 0.034	0.875HisThr: 0.875 ± 0.03	1.484HisVal: 1.484 ± 0.041	0.367HisTrp: 0.367 ± 0.02	0.546HisTyr: 0.546 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.651IleAla: 6.651 ± 0.099	0.63IleCys: 0.63 ± 0.027	3.563IleAsp: 3.563 ± 0.064	3.66IleGlu: 3.66 ± 0.064	1.842IlePhe: 1.842 ± 0.045	4.657IleGly: 4.657 ± 0.069	0.921IleHis: 0.921 ± 0.034	2.319IleIle: 2.319 ± 0.057	1.704IleLys: 1.704 ± 0.04	4.678IleLeu: 4.678 ± 0.075	1.089IleMet: 1.089 ± 0.038	1.575IleAsn: 1.575 ± 0.044	2.343IlePro: 2.343 ± 0.046	1.297IleGln: 1.297 ± 0.036	2.875IleArg: 2.875 ± 0.058	3.108IleSer: 3.108 ± 0.057	3.101IleThr: 3.101 ± 0.06	3.726IleVal: 3.726 ± 0.07	0.72IleTrp: 0.72 ± 0.028	1.251IleTyr: 1.251 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.432LysAla: 4.432 ± 0.08	0.219LysCys: 0.219 ± 0.015	2.048LysAsp: 2.048 ± 0.047	1.824LysGlu: 1.824 ± 0.052	1.141LysPhe: 1.141 ± 0.033	2.973LysGly: 2.973 ± 0.06	0.721LysHis: 0.721 ± 0.03	1.89LysIle: 1.89 ± 0.038	1.382LysLys: 1.382 ± 0.042	3.538LysLeu: 3.538 ± 0.065	1.017LysMet: 1.017 ± 0.033	0.971LysAsn: 0.971 ± 0.034	2.156LysPro: 2.156 ± 0.05	1.072LysGln: 1.072 ± 0.038	2.365LysArg: 2.365 ± 0.054	2.095LysSer: 2.095 ± 0.052	2.199LysThr: 2.199 ± 0.045	2.643LysVal: 2.643 ± 0.051	0.416LysTrp: 0.416 ± 0.022	0.775LysTyr: 0.775 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.101LeuAla: 12.101 ± 0.118	0.956LeuCys: 0.956 ± 0.034	5.93LeuAsp: 5.93 ± 0.087	5.819LeuGlu: 5.819 ± 0.103	3.656LeuPhe: 3.656 ± 0.071	8.403LeuGly: 8.403 ± 0.106	1.926LeuHis: 1.926 ± 0.043	5.561LeuIle: 5.561 ± 0.083	3.608LeuLys: 3.608 ± 0.066	8.887LeuLeu: 8.887 ± 0.112	2.807LeuMet: 2.807 ± 0.054	2.985LeuAsn: 2.985 ± 0.059	5.598LeuPro: 5.598 ± 0.084	3.078LeuGln: 3.078 ± 0.058	6.71LeuArg: 6.71 ± 0.094	6.723LeuSer: 6.723 ± 0.09	6.117LeuThr: 6.117 ± 0.082	6.533LeuVal: 6.533 ± 0.095	1.246LeuTrp: 1.246 ± 0.04	2.066LeuTyr: 2.066 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.409MetAla: 3.409 ± 0.055	0.222MetCys: 0.222 ± 0.015	1.501MetAsp: 1.501 ± 0.04	1.483MetGlu: 1.483 ± 0.041	0.92MetPhe: 0.92 ± 0.031	2.357MetGly: 2.357 ± 0.05	0.528MetHis: 0.528 ± 0.025	1.612MetIle: 1.612 ± 0.042	1.18MetLys: 1.18 ± 0.033	2.583MetLeu: 2.583 ± 0.049	0.823MetMet: 0.823 ± 0.038	0.927MetAsn: 0.927 ± 0.027	1.542MetPro: 1.542 ± 0.04	1.042MetGln: 1.042 ± 0.038	1.862MetArg: 1.862 ± 0.045	1.81MetSer: 1.81 ± 0.05	1.907MetThr: 1.907 ± 0.05	1.982MetVal: 1.982 ± 0.052	0.255MetTrp: 0.255 ± 0.017	0.355MetTyr: 0.355 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.346AsnAla: 3.346 ± 0.054	0.31AsnCys: 0.31 ± 0.016	1.702AsnAsp: 1.702 ± 0.051	1.286AsnGlu: 1.286 ± 0.032	1.05AsnPhe: 1.05 ± 0.035	2.534AsnGly: 2.534 ± 0.057	0.582AsnHis: 0.582 ± 0.029	1.421AsnIle: 1.421 ± 0.04	0.856AsnLys: 0.856 ± 0.03	2.694AsnLeu: 2.694 ± 0.051	0.781AsnMet: 0.781 ± 0.031	0.713AsnAsn: 0.713 ± 0.027	1.933AsnPro: 1.933 ± 0.047	0.813AsnGln: 0.813 ± 0.024	1.786AsnArg: 1.786 ± 0.044	1.303AsnSer: 1.303 ± 0.042	1.473AsnThr: 1.473 ± 0.038	1.959AsnVal: 1.959 ± 0.047	0.467AsnTrp: 0.467 ± 0.02	0.692AsnTyr: 0.692 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.468ProAla: 5.468 ± 0.094	0.377ProCys: 0.377 ± 0.019	3.968ProAsp: 3.968 ± 0.057	4.09ProGlu: 4.09 ± 0.065	1.967ProPhe: 1.967 ± 0.045	4.195ProGly: 4.195 ± 0.075	0.991ProHis: 0.991 ± 0.035	2.358ProIle: 2.358 ± 0.045	1.976ProLys: 1.976 ± 0.045	4.528ProLeu: 4.528 ± 0.066	1.341ProMet: 1.341 ± 0.035	1.442ProAsn: 1.442 ± 0.04	2.129ProPro: 2.129 ± 0.051	1.818ProGln: 1.818 ± 0.045	2.552ProArg: 2.552 ± 0.058	2.481ProSer: 2.481 ± 0.05	2.475ProThr: 2.475 ± 0.053	4.099ProVal: 4.099 ± 0.071	0.622ProTrp: 0.622 ± 0.026	1.136ProTyr: 1.136 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.438GlnAla: 4.438 ± 0.072	0.231GlnCys: 0.231 ± 0.016	2.024GlnAsp: 2.024 ± 0.048	1.827GlnGlu: 1.827 ± 0.045	1.211GlnPhe: 1.211 ± 0.034	2.795GlnGly: 2.795 ± 0.059	0.64GlnHis: 0.64 ± 0.03	2.326GlnIle: 2.326 ± 0.045	1.243GlnLys: 1.243 ± 0.037	3.257GlnLeu: 3.257 ± 0.06	1.263GlnMet: 1.263 ± 0.034	1.123GlnAsn: 1.123 ± 0.038	1.71GlnPro: 1.71 ± 0.04	1.342GlnGln: 1.342 ± 0.047	2.196GlnArg: 2.196 ± 0.054	1.927GlnSer: 1.927 ± 0.051	2.024GlnThr: 2.024 ± 0.054	2.827GlnVal: 2.827 ± 0.06	0.405GlnTrp: 0.405 ± 0.02	0.669GlnTyr: 0.669 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.368ArgAla: 7.368 ± 0.098	0.428ArgCys: 0.428 ± 0.022	3.999ArgAsp: 3.999 ± 0.06	3.61ArgGlu: 3.61 ± 0.07	2.592ArgPhe: 2.592 ± 0.055	4.253ArgGly: 4.253 ± 0.062	1.411ArgHis: 1.411 ± 0.044	3.329ArgIle: 3.329 ± 0.069	2.443ArgLys: 2.443 ± 0.051	6.534ArgLeu: 6.534 ± 0.102	1.773ArgMet: 1.773 ± 0.042	1.72ArgAsn: 1.72 ± 0.047	2.874ArgPro: 2.874 ± 0.054	2.17ArgGln: 2.17 ± 0.045	4.239ArgArg: 4.239 ± 0.084	2.996ArgSer: 2.996 ± 0.064	2.729ArgThr: 2.729 ± 0.057	4.377ArgVal: 4.377 ± 0.068	0.883ArgTrp: 0.883 ± 0.031	1.432ArgTyr: 1.432 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.824SerAla: 5.824 ± 0.086	0.486SerCys: 0.486 ± 0.028	3.49SerAsp: 3.49 ± 0.066	2.865SerGlu: 2.865 ± 0.06	2.304SerPhe: 2.304 ± 0.053	5.283SerGly: 5.283 ± 0.081	1.117SerHis: 1.117 ± 0.035	2.479SerIle: 2.479 ± 0.055	1.785SerLys: 1.785 ± 0.048	4.96SerLeu: 4.96 ± 0.066	1.451SerMet: 1.451 ± 0.035	1.451SerAsn: 1.451 ± 0.038	2.456SerPro: 2.456 ± 0.044	1.801SerGln: 1.801 ± 0.042	2.948SerArg: 2.948 ± 0.061	2.681SerSer: 2.681 ± 0.062	2.581SerThr: 2.581 ± 0.052	3.847SerVal: 3.847 ± 0.059	0.764SerTrp: 0.764 ± 0.025	1.363SerTyr: 1.363 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.022ThrAla: 6.022 ± 0.095	0.519ThrCys: 0.519 ± 0.024	3.192ThrAsp: 3.192 ± 0.063	2.956ThrGlu: 2.956 ± 0.061	1.958ThrPhe: 1.958 ± 0.044	5.242ThrGly: 5.242 ± 0.083	1.149ThrHis: 1.149 ± 0.037	2.805ThrIle: 2.805 ± 0.06	1.838ThrLys: 1.838 ± 0.052	5.988ThrLeu: 5.988 ± 0.073	1.282ThrMet: 1.282 ± 0.033	1.369ThrAsn: 1.369 ± 0.036	3.483ThrPro: 3.483 ± 0.061	1.891ThrGln: 1.891 ± 0.05	3.318ThrArg: 3.318 ± 0.063	2.629ThrSer: 2.629 ± 0.052	2.879ThrThr: 2.879 ± 0.06	4.072ThrVal: 4.072 ± 0.067	0.654ThrTrp: 0.654 ± 0.029	1.316ThrTyr: 1.316 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.351ValAla: 8.351 ± 0.115	0.607ValCys: 0.607 ± 0.023	4.341ValAsp: 4.341 ± 0.074	4.557ValGlu: 4.557 ± 0.075	2.946ValPhe: 2.946 ± 0.059	5.302ValGly: 5.302 ± 0.078	1.308ValHis: 1.308 ± 0.039	4.202ValIle: 4.202 ± 0.074	2.375ValLys: 2.375 ± 0.058	7.761ValLeu: 7.761 ± 0.105	2.105ValMet: 2.105 ± 0.048	2.046ValAsn: 2.046 ± 0.046	3.438ValPro: 3.438 ± 0.064	2.446ValGln: 2.446 ± 0.053	3.8ValArg: 3.8 ± 0.068	4.262ValSer: 4.262 ± 0.061	4.536ValThr: 4.536 ± 0.079	5.727ValVal: 5.727 ± 0.091	0.972ValTrp: 0.972 ± 0.036	1.505ValTyr: 1.505 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.36TrpAla: 1.36 ± 0.045	0.141TrpCys: 0.141 ± 0.012	0.753TrpAsp: 0.753 ± 0.029	0.654TrpGlu: 0.654 ± 0.028	0.56TrpPhe: 0.56 ± 0.022	1.034TrpGly: 1.034 ± 0.031	0.354TrpHis: 0.354 ± 0.019	0.638TrpIle: 0.638 ± 0.027	0.48TrpLys: 0.48 ± 0.024	1.589TrpLeu: 1.589 ± 0.05	0.419TrpMet: 0.419 ± 0.022	0.449TrpAsn: 0.449 ± 0.022	0.689TrpPro: 0.689 ± 0.027	0.592TrpGln: 0.592 ± 0.023	1.018TrpArg: 1.018 ± 0.031	0.743TrpSer: 0.743 ± 0.031	0.649TrpThr: 0.649 ± 0.026	0.973TrpVal: 0.973 ± 0.033	0.196TrpTrp: 0.196 ± 0.015	0.263TrpTyr: 0.263 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.505TyrAla: 2.505 ± 0.053	0.251TyrCys: 0.251 ± 0.017	1.68TyrAsp: 1.68 ± 0.043	1.347TyrGlu: 1.347 ± 0.037	1.021TyrPhe: 1.021 ± 0.036	2.17TyrGly: 2.17 ± 0.053	0.562TyrHis: 0.562 ± 0.025	1.001TyrIle: 1.001 ± 0.03	0.689TyrLys: 0.689 ± 0.028	2.326TyrLeu: 2.326 ± 0.049	0.481TyrMet: 0.481 ± 0.024	0.624TyrAsn: 0.624 ± 0.029	1.057TyrPro: 1.057 ± 0.033	0.76TyrGln: 0.76 ± 0.027	1.458TyrArg: 1.458 ± 0.038	1.207TyrSer: 1.207 ± 0.034	1.166TyrThr: 1.166 ± 0.038	1.626TyrVal: 1.626 ± 0.04	0.35TyrTrp: 0.35 ± 0.019	0.617TyrTyr: 0.617 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3126 proteins (968251 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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