Amino acid dipepetide frequency for Maritimibacter sp. HL-12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.634AlaAla: 18.634 ± 0.21	1.03AlaCys: 1.03 ± 0.034	7.077AlaAsp: 7.077 ± 0.078	9.245AlaGlu: 9.245 ± 0.131	4.754AlaPhe: 4.754 ± 0.068	11.722AlaGly: 11.722 ± 0.139	2.598AlaHis: 2.598 ± 0.052	5.926AlaIle: 5.926 ± 0.079	3.536AlaLys: 3.536 ± 0.064	15.074AlaLeu: 15.074 ± 0.161	4.006AlaMet: 4.006 ± 0.064	2.725AlaAsn: 2.725 ± 0.055	6.52AlaPro: 6.52 ± 0.102	4.019AlaGln: 4.019 ± 0.072	11.049AlaArg: 11.049 ± 0.142	5.702AlaSer: 5.702 ± 0.098	6.274AlaThr: 6.274 ± 0.085	8.965AlaVal: 8.965 ± 0.109	1.681AlaTrp: 1.681 ± 0.041	2.444AlaTyr: 2.444 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.945CysAla: 0.945 ± 0.03	0.082CysCys: 0.082 ± 0.009	0.552CysAsp: 0.552 ± 0.023	0.441CysGlu: 0.441 ± 0.021	0.25CysPhe: 0.25 ± 0.014	0.856CysGly: 0.856 ± 0.032	0.274CysHis: 0.274 ± 0.019	0.34CysIle: 0.34 ± 0.017	0.159CysLys: 0.159 ± 0.012	0.657CysLeu: 0.657 ± 0.024	0.132CysMet: 0.132 ± 0.01	0.193CysAsn: 0.193 ± 0.011	0.503CysPro: 0.503 ± 0.024	0.178CysGln: 0.178 ± 0.013	0.5CysArg: 0.5 ± 0.021	0.346CysSer: 0.346 ± 0.019	0.41CysThr: 0.41 ± 0.02	0.495CysVal: 0.495 ± 0.024	0.097CysTrp: 0.097 ± 0.01	0.184CysTyr: 0.184 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.634AspAla: 7.634 ± 0.108	0.485AspCys: 0.485 ± 0.025	3.744AspAsp: 3.744 ± 0.08	3.846AspGlu: 3.846 ± 0.068	2.334AspPhe: 2.334 ± 0.053	5.386AspGly: 5.386 ± 0.093	1.491AspHis: 1.491 ± 0.042	2.969AspIle: 2.969 ± 0.051	1.614AspLys: 1.614 ± 0.049	6.27AspLeu: 6.27 ± 0.084	1.596AspMet: 1.596 ± 0.041	1.26AspAsn: 1.26 ± 0.035	3.91AspPro: 3.91 ± 0.054	1.506AspGln: 1.506 ± 0.039	4.37AspArg: 4.37 ± 0.059	1.937AspSer: 1.937 ± 0.043	2.822AspThr: 2.822 ± 0.064	4.02AspVal: 4.02 ± 0.067	1.294AspTrp: 1.294 ± 0.034	1.561AspTyr: 1.561 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	9.637GluAla: 9.637 ± 0.123	0.34GluCys: 0.34 ± 0.019	3.403GluAsp: 3.403 ± 0.073	3.682GluGlu: 3.682 ± 0.083	1.812GluPhe: 1.812 ± 0.039	5.535GluGly: 5.535 ± 0.072	1.206GluHis: 1.206 ± 0.033	4.185GluIle: 4.185 ± 0.059	2.106GluLys: 2.106 ± 0.057	5.011GluLeu: 5.011 ± 0.073	1.839GluMet: 1.839 ± 0.04	1.705GluAsn: 1.705 ± 0.043	2.786GluPro: 2.786 ± 0.064	1.729GluGln: 1.729 ± 0.044	4.517GluArg: 4.517 ± 0.072	2.341GluSer: 2.341 ± 0.048	3.988GluThr: 3.988 ± 0.066	4.864GluVal: 4.864 ± 0.078	0.698GluTrp: 0.698 ± 0.025	0.973GluTyr: 0.973 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.868PheAla: 4.868 ± 0.079	0.349PheCys: 0.349 ± 0.016	2.739PheAsp: 2.739 ± 0.052	2.417PheGlu: 2.417 ± 0.042	1.393PhePhe: 1.393 ± 0.042	3.743PheGly: 3.743 ± 0.064	0.793PheHis: 0.793 ± 0.033	1.625PheIle: 1.625 ± 0.034	0.83PheLys: 0.83 ± 0.032	3.54PheLeu: 3.54 ± 0.062	0.828PheMet: 0.828 ± 0.029	1.028PheAsn: 1.028 ± 0.031	1.58PhePro: 1.58 ± 0.036	0.907PheGln: 0.907 ± 0.032	2.228PheArg: 2.228 ± 0.047	2.139PheSer: 2.139 ± 0.044	2.093PheThr: 2.093 ± 0.049	2.73PheVal: 2.73 ± 0.055	0.592PheTrp: 0.592 ± 0.025	0.889PheTyr: 0.889 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.934GlyAla: 10.934 ± 0.115	0.775GlyCys: 0.775 ± 0.032	5.006GlyAsp: 5.006 ± 0.104	5.406GlyGlu: 5.406 ± 0.075	3.927GlyPhe: 3.927 ± 0.071	7.92GlyGly: 7.92 ± 0.134	2.036GlyHis: 2.036 ± 0.045	4.309GlyIle: 4.309 ± 0.069	3.061GlyLys: 3.061 ± 0.064	9.839GlyLeu: 9.839 ± 0.113	2.539GlyMet: 2.539 ± 0.045	2.1GlyAsn: 2.1 ± 0.057	4.01GlyPro: 4.01 ± 0.067	2.925GlyGln: 2.925 ± 0.056	6.104GlyArg: 6.104 ± 0.089	4.01GlySer: 4.01 ± 0.074	4.637GlyThr: 4.637 ± 0.079	6.643GlyVal: 6.643 ± 0.09	1.682GlyTrp: 1.682 ± 0.047	2.27GlyTyr: 2.27 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.486HisAla: 2.486 ± 0.052	0.194HisCys: 0.194 ± 0.013	1.392HisAsp: 1.392 ± 0.041	1.202HisGlu: 1.202 ± 0.035	0.802HisPhe: 0.802 ± 0.028	2.112HisGly: 2.112 ± 0.055	0.602HisHis: 0.602 ± 0.032	0.957HisIle: 0.957 ± 0.028	0.515HisLys: 0.515 ± 0.021	2.095HisLeu: 2.095 ± 0.05	0.541HisMet: 0.541 ± 0.027	0.466HisAsn: 0.466 ± 0.025	1.443HisPro: 1.443 ± 0.038	0.529HisGln: 0.529 ± 0.024	1.456HisArg: 1.456 ± 0.037	0.809HisSer: 0.809 ± 0.028	0.832HisThr: 0.832 ± 0.031	1.583HisVal: 1.583 ± 0.042	0.395HisTrp: 0.395 ± 0.02	0.556HisTyr: 0.556 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.334IleAla: 7.334 ± 0.106	0.492IleCys: 0.492 ± 0.02	3.584IleAsp: 3.584 ± 0.067	3.887IleGlu: 3.887 ± 0.064	1.642IlePhe: 1.642 ± 0.039	4.897IleGly: 4.897 ± 0.069	0.909IleHis: 0.909 ± 0.034	1.991IleIle: 1.991 ± 0.05	1.225IleLys: 1.225 ± 0.036	4.294IleLeu: 4.294 ± 0.074	0.996IleMet: 0.996 ± 0.032	1.252IleAsn: 1.252 ± 0.041	2.09IlePro: 2.09 ± 0.04	1.037IleGln: 1.037 ± 0.035	3.276IleArg: 3.276 ± 0.054	2.679IleSer: 2.679 ± 0.054	2.841IleThr: 2.841 ± 0.051	3.842IleVal: 3.842 ± 0.067	0.688IleTrp: 0.688 ± 0.024	1.061IleTyr: 1.061 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.903LysAla: 3.903 ± 0.068	0.158LysCys: 0.158 ± 0.011	1.514LysAsp: 1.514 ± 0.041	1.323LysGlu: 1.323 ± 0.039	0.811LysPhe: 0.811 ± 0.025	2.509LysGly: 2.509 ± 0.051	0.543LysHis: 0.543 ± 0.026	1.443LysIle: 1.443 ± 0.035	1.101LysLys: 1.101 ± 0.037	2.811LysLeu: 2.811 ± 0.058	0.745LysMet: 0.745 ± 0.029	0.69LysAsn: 0.69 ± 0.028	1.843LysPro: 1.843 ± 0.049	0.794LysGln: 0.794 ± 0.028	2.113LysArg: 2.113 ± 0.05	1.558LysSer: 1.558 ± 0.036	1.727LysThr: 1.727 ± 0.046	2.295LysVal: 2.295 ± 0.051	0.341LysTrp: 0.341 ± 0.02	0.537LysTyr: 0.537 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	15.011LeuAla: 15.011 ± 0.173	0.694LeuCys: 0.694 ± 0.026	6.448LeuAsp: 6.448 ± 0.078	5.503LeuGlu: 5.503 ± 0.077	3.649LeuPhe: 3.649 ± 0.073	8.923LeuGly: 8.923 ± 0.109	1.904LeuHis: 1.904 ± 0.041	4.956LeuIle: 4.956 ± 0.082	2.961LeuLys: 2.961 ± 0.053	8.564LeuLeu: 8.564 ± 0.117	2.513LeuMet: 2.513 ± 0.049	2.28LeuAsn: 2.28 ± 0.045	5.538LeuPro: 5.538 ± 0.084	2.179LeuGln: 2.179 ± 0.046	7.02LeuArg: 7.02 ± 0.093	5.554LeuSer: 5.554 ± 0.072	5.569LeuThr: 5.569 ± 0.076	7.545LeuVal: 7.545 ± 0.09	1.316LeuTrp: 1.316 ± 0.04	1.815LeuTyr: 1.815 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.487MetAla: 3.487 ± 0.059	0.169MetCys: 0.169 ± 0.012	1.267MetAsp: 1.267 ± 0.035	1.367MetGlu: 1.367 ± 0.037	0.834MetPhe: 0.834 ± 0.027	2.126MetGly: 2.126 ± 0.044	0.478MetHis: 0.478 ± 0.024	1.465MetIle: 1.465 ± 0.04	1.011MetLys: 1.011 ± 0.031	2.535MetLeu: 2.535 ± 0.045	0.698MetMet: 0.698 ± 0.027	0.817MetAsn: 0.817 ± 0.027	1.48MetPro: 1.48 ± 0.038	0.858MetGln: 0.858 ± 0.031	2.015MetArg: 2.015 ± 0.044	1.611MetSer: 1.611 ± 0.036	1.98MetThr: 1.98 ± 0.044	1.896MetVal: 1.896 ± 0.041	0.243MetTrp: 0.243 ± 0.016	0.313MetTyr: 0.313 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.054AsnAla: 3.054 ± 0.049	0.217AsnCys: 0.217 ± 0.015	1.372AsnAsp: 1.372 ± 0.05	1.172AsnGlu: 1.172 ± 0.035	0.865AsnPhe: 0.865 ± 0.029	2.019AsnGly: 2.019 ± 0.05	0.535AsnHis: 0.535 ± 0.024	1.298AsnIle: 1.298 ± 0.037	0.59AsnLys: 0.59 ± 0.023	2.441AsnLeu: 2.441 ± 0.054	0.631AsnMet: 0.631 ± 0.024	0.583AsnAsn: 0.583 ± 0.024	1.845AsnPro: 1.845 ± 0.04	0.588AsnGln: 0.588 ± 0.026	1.715AsnArg: 1.715 ± 0.036	0.964AsnSer: 0.964 ± 0.034	1.23AsnThr: 1.23 ± 0.044	1.673AsnVal: 1.673 ± 0.042	0.399AsnTrp: 0.399 ± 0.022	0.595AsnTyr: 0.595 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.308ProAla: 6.308 ± 0.098	0.338ProCys: 0.338 ± 0.019	4.095ProAsp: 4.095 ± 0.079	4.675ProGlu: 4.675 ± 0.089	1.908ProPhe: 1.908 ± 0.04	5.37ProGly: 5.37 ± 0.078	1.072ProHis: 1.072 ± 0.034	2.133ProIle: 2.133 ± 0.047	1.484ProLys: 1.484 ± 0.044	4.558ProLeu: 4.558 ± 0.074	1.283ProMet: 1.283 ± 0.031	1.222ProAsn: 1.222 ± 0.035	2.593ProPro: 2.593 ± 0.062	1.374ProGln: 1.374 ± 0.037	3.244ProArg: 3.244 ± 0.07	2.291ProSer: 2.291 ± 0.048	2.308ProThr: 2.308 ± 0.046	4.471ProVal: 4.471 ± 0.063	0.733ProTrp: 0.733 ± 0.027	1.125ProTyr: 1.125 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.669GlnAla: 3.669 ± 0.061	0.152GlnCys: 0.152 ± 0.012	1.435GlnAsp: 1.435 ± 0.039	1.346GlnGlu: 1.346 ± 0.037	0.872GlnPhe: 0.872 ± 0.033	2.339GlnGly: 2.339 ± 0.043	0.535GlnHis: 0.535 ± 0.023	1.728GlnIle: 1.728 ± 0.037	0.927GlnLys: 0.927 ± 0.032	2.277GlnLeu: 2.277 ± 0.048	0.895GlnMet: 0.895 ± 0.029	0.739GlnAsn: 0.739 ± 0.027	1.46GlnPro: 1.46 ± 0.037	0.805GlnGln: 0.805 ± 0.029	1.905GlnArg: 1.905 ± 0.038	1.435GlnSer: 1.435 ± 0.038	1.471GlnThr: 1.471 ± 0.036	2.197GlnVal: 2.197 ± 0.044	0.335GlnTrp: 0.335 ± 0.018	0.52GlnTyr: 0.52 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.562ArgAla: 9.562 ± 0.131	0.416ArgCys: 0.416 ± 0.024	4.415ArgAsp: 4.415 ± 0.062	4.339ArgGlu: 4.339 ± 0.071	2.97ArgPhe: 2.97 ± 0.051	5.207ArgGly: 5.207 ± 0.078	1.655ArgHis: 1.655 ± 0.043	3.979ArgIle: 3.979 ± 0.058	2.19ArgLys: 2.19 ± 0.052	7.987ArgLeu: 7.987 ± 0.108	2.047ArgMet: 2.047 ± 0.043	1.636ArgAsn: 1.636 ± 0.035	3.548ArgPro: 3.548 ± 0.066	2.061ArgGln: 2.061 ± 0.042	5.351ArgArg: 5.351 ± 0.089	3.111ArgSer: 3.111 ± 0.051	2.878ArgThr: 2.878 ± 0.058	5.185ArgVal: 5.185 ± 0.082	0.988ArgTrp: 0.988 ± 0.031	1.514ArgTyr: 1.514 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.625SerAla: 5.625 ± 0.087	0.367SerCys: 0.367 ± 0.018	2.786SerAsp: 2.786 ± 0.053	2.705SerGlu: 2.705 ± 0.058	2.047SerPhe: 2.047 ± 0.044	5.191SerGly: 5.191 ± 0.086	1.009SerHis: 1.009 ± 0.032	2.156SerIle: 2.156 ± 0.048	1.232SerLys: 1.232 ± 0.029	4.668SerLeu: 4.668 ± 0.08	1.141SerMet: 1.141 ± 0.037	1.162SerAsn: 1.162 ± 0.037	2.514SerPro: 2.514 ± 0.054	1.356SerGln: 1.356 ± 0.033	3.212SerArg: 3.212 ± 0.057	2.104SerSer: 2.104 ± 0.06	2.328SerThr: 2.328 ± 0.054	3.504SerVal: 3.504 ± 0.052	0.651SerTrp: 0.651 ± 0.025	1.226SerTyr: 1.226 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.253ThrAla: 6.253 ± 0.095	0.423ThrCys: 0.423 ± 0.02	2.962ThrAsp: 2.962 ± 0.053	2.969ThrGlu: 2.969 ± 0.059	1.905ThrPhe: 1.905 ± 0.039	5.64ThrGly: 5.64 ± 0.086	1.048ThrHis: 1.048 ± 0.033	2.637ThrIle: 2.637 ± 0.053	1.224ThrLys: 1.224 ± 0.038	5.699ThrLeu: 5.699 ± 0.074	1.314ThrMet: 1.314 ± 0.032	1.122ThrAsn: 1.122 ± 0.035	3.402ThrPro: 3.402 ± 0.062	1.228ThrGln: 1.228 ± 0.035	3.727ThrArg: 3.727 ± 0.058	2.541ThrSer: 2.541 ± 0.056	2.756ThrThr: 2.756 ± 0.079	3.821ThrVal: 3.821 ± 0.067	0.68ThrTrp: 0.68 ± 0.027	1.113ThrTyr: 1.113 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.647ValAla: 9.647 ± 0.11	0.576ValCys: 0.576 ± 0.022	4.058ValAsp: 4.058 ± 0.062	4.799ValGlu: 4.799 ± 0.064	3.135ValPhe: 3.135 ± 0.059	5.506ValGly: 5.506 ± 0.084	1.4ValHis: 1.4 ± 0.036	4.286ValIle: 4.286 ± 0.074	2.042ValLys: 2.042 ± 0.053	7.781ValLeu: 7.781 ± 0.101	2.06ValMet: 2.06 ± 0.041	1.868ValAsn: 1.868 ± 0.051	3.73ValPro: 3.73 ± 0.062	1.835ValGln: 1.835 ± 0.035	4.495ValArg: 4.495 ± 0.066	4.031ValSer: 4.031 ± 0.068	4.549ValThr: 4.549 ± 0.073	5.977ValVal: 5.977 ± 0.084	0.966ValTrp: 0.966 ± 0.034	1.39ValTyr: 1.39 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.521TrpAla: 1.521 ± 0.037	0.119TrpCys: 0.119 ± 0.012	0.762TrpAsp: 0.762 ± 0.028	0.766TrpGlu: 0.766 ± 0.027	0.582TrpPhe: 0.582 ± 0.024	1.114TrpGly: 1.114 ± 0.037	0.367TrpHis: 0.367 ± 0.018	0.734TrpIle: 0.734 ± 0.024	0.417TrpLys: 0.417 ± 0.02	1.685TrpLeu: 1.685 ± 0.044	0.4TrpMet: 0.4 ± 0.02	0.415TrpAsn: 0.415 ± 0.019	0.745TrpPro: 0.745 ± 0.029	0.571TrpGln: 0.571 ± 0.027	1.192TrpArg: 1.192 ± 0.038	0.772TrpSer: 0.772 ± 0.028	0.732TrpThr: 0.732 ± 0.027	0.962TrpVal: 0.962 ± 0.031	0.236TrpTrp: 0.236 ± 0.015	0.265TrpTyr: 0.265 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.469TyrAla: 2.469 ± 0.045	0.218TyrCys: 0.218 ± 0.013	1.438TyrAsp: 1.438 ± 0.038	1.268TyrGlu: 1.268 ± 0.04	0.819TyrPhe: 0.819 ± 0.032	2.018TyrGly: 2.018 ± 0.039	0.51TyrHis: 0.51 ± 0.023	0.904TyrIle: 0.904 ± 0.031	0.534TyrLys: 0.534 ± 0.022	2.154TyrLeu: 2.154 ± 0.049	0.446TyrMet: 0.446 ± 0.022	0.523TyrAsn: 0.523 ± 0.022	1.046TyrPro: 1.046 ± 0.029	0.561TyrGln: 0.561 ± 0.026	1.548TyrArg: 1.548 ± 0.039	1.048TyrSer: 1.048 ± 0.033	1.039TyrThr: 1.039 ± 0.035	1.465TyrVal: 1.465 ± 0.04	0.342TyrTrp: 0.342 ± 0.017	0.506TyrTyr: 0.506 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3527 proteins (1091098 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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