Amino acid dipepetide frequency for Pseudoalteromonas sp. NBT06-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.42AlaAla: 5.42 ± 0.079	0.908AlaCys: 0.908 ± 0.025	3.804AlaAsp: 3.804 ± 0.051	4.014AlaGlu: 4.014 ± 0.059	3.139AlaPhe: 3.139 ± 0.049	4.66AlaGly: 4.66 ± 0.066	1.468AlaHis: 1.468 ± 0.031	5.833AlaIle: 5.833 ± 0.06	5.196AlaLys: 5.196 ± 0.064	8.203AlaLeu: 8.203 ± 0.078	1.977AlaMet: 1.977 ± 0.037	3.654AlaAsn: 3.654 ± 0.05	2.232AlaPro: 2.232 ± 0.04	3.519AlaGln: 3.519 ± 0.051	2.59AlaArg: 2.59 ± 0.05	4.868AlaSer: 4.868 ± 0.062	3.859AlaThr: 3.859 ± 0.056	4.643AlaVal: 4.643 ± 0.06	0.767AlaTrp: 0.767 ± 0.022	2.231AlaTyr: 2.231 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.679CysAla: 0.679 ± 0.022	0.156CysCys: 0.156 ± 0.01	0.651CysAsp: 0.651 ± 0.025	0.636CysGlu: 0.636 ± 0.02	0.525CysPhe: 0.525 ± 0.018	0.772CysGly: 0.772 ± 0.023	0.305CysHis: 0.305 ± 0.015	0.793CysIle: 0.793 ± 0.023	0.557CysLys: 0.557 ± 0.019	0.982CysLeu: 0.982 ± 0.024	0.223CysMet: 0.223 ± 0.011	0.496CysAsn: 0.496 ± 0.017	0.397CysPro: 0.397 ± 0.017	0.433CysGln: 0.433 ± 0.014	0.391CysArg: 0.391 ± 0.017	0.75CysSer: 0.75 ± 0.023	0.523CysThr: 0.523 ± 0.021	0.552CysVal: 0.552 ± 0.018	0.112CysTrp: 0.112 ± 0.009	0.366CysTyr: 0.366 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.711AspAla: 3.711 ± 0.056	0.508AspCys: 0.508 ± 0.02	3.099AspAsp: 3.099 ± 0.058	3.788AspGlu: 3.788 ± 0.06	2.916AspPhe: 2.916 ± 0.042	3.405AspGly: 3.405 ± 0.072	1.002AspHis: 1.002 ± 0.028	4.861AspIle: 4.861 ± 0.069	4.106AspLys: 4.106 ± 0.056	5.449AspLeu: 5.449 ± 0.064	1.356AspMet: 1.356 ± 0.029	3.175AspAsn: 3.175 ± 0.054	1.794AspPro: 1.794 ± 0.039	1.708AspGln: 1.708 ± 0.039	1.707AspArg: 1.707 ± 0.036	3.398AspSer: 3.398 ± 0.054	2.767AspThr: 2.767 ± 0.05	3.508AspVal: 3.508 ± 0.046	0.798AspTrp: 0.798 ± 0.021	2.172AspTyr: 2.172 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.049GluAla: 4.049 ± 0.065	0.504GluCys: 0.504 ± 0.02	2.667GluAsp: 2.667 ± 0.052	2.941GluGlu: 2.941 ± 0.054	2.722GluPhe: 2.722 ± 0.043	2.964GluGly: 2.964 ± 0.049	1.537GluHis: 1.537 ± 0.034	4.601GluIle: 4.601 ± 0.058	4.405GluLys: 4.405 ± 0.058	6.895GluLeu: 6.895 ± 0.086	1.395GluMet: 1.395 ± 0.028	3.479GluAsn: 3.479 ± 0.052	1.685GluPro: 1.685 ± 0.03	3.846GluGln: 3.846 ± 0.068	2.409GluArg: 2.409 ± 0.046	3.782GluSer: 3.782 ± 0.048	3.031GluThr: 3.031 ± 0.043	3.921GluVal: 3.921 ± 0.044	0.567GluTrp: 0.567 ± 0.021	1.974GluTyr: 1.974 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.023PheAla: 3.023 ± 0.048	0.537PheCys: 0.537 ± 0.02	3.093PheAsp: 3.093 ± 0.04	2.915PheGlu: 2.915 ± 0.044	1.893PhePhe: 1.893 ± 0.039	2.956PheGly: 2.956 ± 0.049	0.789PheHis: 0.789 ± 0.024	3.762PheIle: 3.762 ± 0.051	3.067PheLys: 3.067 ± 0.049	3.628PheLeu: 3.628 ± 0.059	1.059PheMet: 1.059 ± 0.027	2.946PheAsn: 2.946 ± 0.045	1.297PhePro: 1.297 ± 0.029	1.216PheGln: 1.216 ± 0.029	1.315PheArg: 1.315 ± 0.032	4.075PheSer: 4.075 ± 0.052	2.741PheThr: 2.741 ± 0.041	2.523PheVal: 2.523 ± 0.042	0.54PheTrp: 0.54 ± 0.018	1.68PheTyr: 1.68 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	4.294GlyAla: 4.294 ± 0.063	0.795GlyCys: 0.795 ± 0.023	3.355GlyAsp: 3.355 ± 0.054	3.648GlyGlu: 3.648 ± 0.051	3.304GlyPhe: 3.304 ± 0.054	4.032GlyGly: 4.032 ± 0.065	1.332GlyHis: 1.332 ± 0.031	4.757GlyIle: 4.757 ± 0.062	3.963GlyLys: 3.963 ± 0.057	6.225GlyLeu: 6.225 ± 0.077	1.602GlyMet: 1.602 ± 0.035	2.856GlyAsn: 2.856 ± 0.063	1.424GlyPro: 1.424 ± 0.032	2.387GlyGln: 2.387 ± 0.039	2.417GlyArg: 2.417 ± 0.039	3.995GlySer: 3.995 ± 0.069	3.299GlyThr: 3.299 ± 0.065	4.157GlyVal: 4.157 ± 0.063	0.798GlyTrp: 0.798 ± 0.024	2.373GlyTyr: 2.373 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.373HisAla: 1.373 ± 0.027	0.273HisCys: 0.273 ± 0.015	1.025HisAsp: 1.025 ± 0.03	1.122HisGlu: 1.122 ± 0.028	1.18HisPhe: 1.18 ± 0.027	1.351HisGly: 1.351 ± 0.031	0.615HisHis: 0.615 ± 0.02	1.732HisIle: 1.732 ± 0.033	1.391HisLys: 1.391 ± 0.028	2.168HisLeu: 2.168 ± 0.044	0.442HisMet: 0.442 ± 0.016	1.135HisAsn: 1.135 ± 0.029	0.897HisPro: 0.897 ± 0.023	1.093HisGln: 1.093 ± 0.028	0.767HisArg: 0.767 ± 0.023	1.494HisSer: 1.494 ± 0.03	1.069HisThr: 1.069 ± 0.026	1.084HisVal: 1.084 ± 0.024	0.325HisTrp: 0.325 ± 0.016	0.89HisTyr: 0.89 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.241IleAla: 6.241 ± 0.074	0.836IleCys: 0.836 ± 0.023	4.828IleAsp: 4.828 ± 0.057	5.527IleGlu: 5.527 ± 0.06	3.128IlePhe: 3.128 ± 0.052	4.522IleGly: 4.522 ± 0.059	1.401IleHis: 1.401 ± 0.037	5.05IleIle: 5.05 ± 0.07	5.627IleLys: 5.627 ± 0.07	6.642IleLeu: 6.642 ± 0.078	1.496IleMet: 1.496 ± 0.032	4.902IleAsn: 4.902 ± 0.054	2.711IlePro: 2.711 ± 0.042	2.576IleGln: 2.576 ± 0.037	2.609IleArg: 2.609 ± 0.041	6.208IleSer: 6.208 ± 0.068	4.572IleThr: 4.572 ± 0.061	4.063IleVal: 4.063 ± 0.058	0.715IleTrp: 0.715 ± 0.021	2.223IleTyr: 2.223 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.934LysAla: 4.934 ± 0.056	0.468LysCys: 0.468 ± 0.02	3.354LysAsp: 3.354 ± 0.052	3.865LysGlu: 3.865 ± 0.06	2.35LysPhe: 2.35 ± 0.039	3.638LysGly: 3.638 ± 0.045	1.594LysHis: 1.594 ± 0.035	4.884LysIle: 4.884 ± 0.064	4.966LysLys: 4.966 ± 0.069	7.15LysLeu: 7.15 ± 0.073	1.692LysMet: 1.692 ± 0.031	4.303LysAsn: 4.303 ± 0.076	2.538LysPro: 2.538 ± 0.042	3.744LysGln: 3.744 ± 0.061	2.818LysArg: 2.818 ± 0.043	4.738LysSer: 4.738 ± 0.059	3.923LysThr: 3.923 ± 0.041	4.481LysVal: 4.481 ± 0.059	0.673LysTrp: 0.673 ± 0.022	2.13LysTyr: 2.13 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	8.324LeuAla: 8.324 ± 0.088	1.114LeuCys: 1.114 ± 0.025	5.716LeuAsp: 5.716 ± 0.061	5.91LeuGlu: 5.91 ± 0.079	4.499LeuPhe: 4.499 ± 0.069	6.185LeuGly: 6.185 ± 0.066	1.894LeuHis: 1.894 ± 0.036	7.651LeuIle: 7.651 ± 0.088	7.117LeuLys: 7.117 ± 0.086	10.194LeuLeu: 10.194 ± 0.124	2.437LeuMet: 2.437 ± 0.045	6.268LeuAsn: 6.268 ± 0.069	4.164LeuPro: 4.164 ± 0.048	3.417LeuGln: 3.417 ± 0.058	3.369LeuArg: 3.369 ± 0.051	8.397LeuSer: 8.397 ± 0.075	6.277LeuThr: 6.277 ± 0.066	6.252LeuVal: 6.252 ± 0.07	0.959LeuTrp: 0.959 ± 0.029	2.897LeuTyr: 2.897 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.082MetAla: 2.082 ± 0.034	0.202MetCys: 0.202 ± 0.012	1.021MetAsp: 1.021 ± 0.023	1.004MetGlu: 1.004 ± 0.027	0.932MetPhe: 0.932 ± 0.023	1.448MetGly: 1.448 ± 0.03	0.471MetHis: 0.471 ± 0.016	1.511MetIle: 1.511 ± 0.035	1.602MetLys: 1.602 ± 0.029	2.528MetLeu: 2.528 ± 0.043	0.637MetMet: 0.637 ± 0.023	1.215MetAsn: 1.215 ± 0.024	1.025MetPro: 1.025 ± 0.028	1.094MetGln: 1.094 ± 0.029	0.964MetArg: 0.964 ± 0.027	1.871MetSer: 1.871 ± 0.033	1.415MetThr: 1.415 ± 0.03	1.41MetVal: 1.41 ± 0.031	0.184MetTrp: 0.184 ± 0.013	0.56MetTyr: 0.56 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.697AsnAla: 3.697 ± 0.055	0.537AsnCys: 0.537 ± 0.021	3.044AsnAsp: 3.044 ± 0.052	3.449AsnGlu: 3.449 ± 0.045	2.261AsnPhe: 2.261 ± 0.042	3.264AsnGly: 3.264 ± 0.058	1.201AsnHis: 1.201 ± 0.028	4.541AsnIle: 4.541 ± 0.069	4.378AsnLys: 4.378 ± 0.09	5.413AsnLeu: 5.413 ± 0.067	1.188AsnMet: 1.188 ± 0.028	3.677AsnAsn: 3.677 ± 0.067	2.029AsnPro: 2.029 ± 0.035	2.729AsnGln: 2.729 ± 0.042	1.961AsnArg: 1.961 ± 0.035	3.776AsnSer: 3.776 ± 0.051	3.242AsnThr: 3.242 ± 0.054	2.947AsnVal: 2.947 ± 0.044	0.813AsnTrp: 0.813 ± 0.025	2.0AsnTyr: 2.0 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.205ProAla: 2.205 ± 0.034	0.285ProCys: 0.285 ± 0.013	2.136ProAsp: 2.136 ± 0.041	2.695ProGlu: 2.695 ± 0.043	1.604ProPhe: 1.604 ± 0.031	1.932ProGly: 1.932 ± 0.037	0.76ProHis: 0.76 ± 0.025	2.596ProIle: 2.596 ± 0.046	2.315ProLys: 2.315 ± 0.042	3.512ProLeu: 3.512 ± 0.053	0.773ProMet: 0.773 ± 0.021	1.803ProAsn: 1.803 ± 0.037	0.901ProPro: 0.901 ± 0.036	1.33ProGln: 1.33 ± 0.028	1.039ProArg: 1.039 ± 0.022	2.27ProSer: 2.27 ± 0.037	1.876ProThr: 1.876 ± 0.037	2.386ProVal: 2.386 ± 0.041	0.421ProTrp: 0.421 ± 0.018	1.183ProTyr: 1.183 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.606GlnAla: 3.606 ± 0.057	0.407GlnCys: 0.407 ± 0.018	2.069GlnAsp: 2.069 ± 0.036	2.196GlnGlu: 2.196 ± 0.045	1.911GlnPhe: 1.911 ± 0.039	2.709GlnGly: 2.709 ± 0.042	0.929GlnHis: 0.929 ± 0.026	3.106GlnIle: 3.106 ± 0.045	2.859GlnLys: 2.859 ± 0.047	5.146GlnLeu: 5.146 ± 0.072	0.928GlnMet: 0.928 ± 0.026	2.306GlnAsn: 2.306 ± 0.04	1.339GlnPro: 1.339 ± 0.031	2.662GlnGln: 2.662 ± 0.058	1.705GlnArg: 1.705 ± 0.033	3.095GlnSer: 3.095 ± 0.045	2.378GlnThr: 2.378 ± 0.043	3.042GlnVal: 3.042 ± 0.047	0.593GlnTrp: 0.593 ± 0.02	1.552GlnTyr: 1.552 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.535ArgAla: 2.535 ± 0.039	0.35ArgCys: 0.35 ± 0.017	1.948ArgAsp: 1.948 ± 0.039	2.199ArgGlu: 2.199 ± 0.036	1.891ArgPhe: 1.891 ± 0.037	1.991ArgGly: 1.991 ± 0.037	0.861ArgHis: 0.861 ± 0.024	2.84ArgIle: 2.84 ± 0.047	2.241ArgLys: 2.241 ± 0.043	3.986ArgLeu: 3.986 ± 0.057	0.89ArgMet: 0.89 ± 0.026	1.794ArgAsn: 1.794 ± 0.034	1.175ArgPro: 1.175 ± 0.027	1.512ArgGln: 1.512 ± 0.034	1.506ArgArg: 1.506 ± 0.038	2.16ArgSer: 2.16 ± 0.033	1.866ArgThr: 1.866 ± 0.044	2.378ArgVal: 2.378 ± 0.041	0.441ArgTrp: 0.441 ± 0.017	1.499ArgTyr: 1.499 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.073SerAla: 5.073 ± 0.059	0.73SerCys: 0.73 ± 0.026	4.192SerAsp: 4.192 ± 0.061	4.267SerGlu: 4.267 ± 0.05	3.48SerPhe: 3.48 ± 0.045	5.004SerGly: 5.004 ± 0.069	1.666SerHis: 1.666 ± 0.035	5.443SerIle: 5.443 ± 0.06	4.358SerLys: 4.358 ± 0.061	7.564SerLeu: 7.564 ± 0.068	1.548SerMet: 1.548 ± 0.033	3.785SerAsn: 3.785 ± 0.062	2.293SerPro: 2.293 ± 0.038	3.329SerGln: 3.329 ± 0.046	2.521SerArg: 2.521 ± 0.036	5.054SerSer: 5.054 ± 0.076	3.619SerThr: 3.619 ± 0.057	4.433SerVal: 4.433 ± 0.057	0.892SerTrp: 0.892 ± 0.024	2.471SerTyr: 2.471 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.188ThrAla: 4.188 ± 0.054	0.527ThrCys: 0.527 ± 0.017	3.207ThrAsp: 3.207 ± 0.052	3.177ThrGlu: 3.177 ± 0.049	2.27ThrPhe: 2.27 ± 0.041	3.834ThrGly: 3.834 ± 0.062	1.262ThrHis: 1.262 ± 0.028	3.916ThrIle: 3.916 ± 0.061	3.24ThrLys: 3.24 ± 0.047	6.17ThrLeu: 6.17 ± 0.067	1.066ThrMet: 1.066 ± 0.025	2.713ThrAsn: 2.713 ± 0.052	2.374ThrPro: 2.374 ± 0.042	2.8ThrGln: 2.8 ± 0.041	1.836ThrArg: 1.836 ± 0.035	3.896ThrSer: 3.896 ± 0.061	2.994ThrThr: 2.994 ± 0.056	3.511ThrVal: 3.511 ± 0.045	0.588ThrTrp: 0.588 ± 0.02	1.717ThrTyr: 1.717 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.705ValAla: 4.705 ± 0.065	0.626ValCys: 0.626 ± 0.02	3.599ValAsp: 3.599 ± 0.053	3.889ValGlu: 3.889 ± 0.057	2.74ValPhe: 2.74 ± 0.04	3.667ValGly: 3.667 ± 0.06	1.115ValHis: 1.115 ± 0.029	4.974ValIle: 4.974 ± 0.057	4.237ValLys: 4.237 ± 0.054	5.97ValLeu: 5.97 ± 0.073	1.541ValMet: 1.541 ± 0.03	3.501ValAsn: 3.501 ± 0.05	2.079ValPro: 2.079 ± 0.039	2.025ValGln: 2.025 ± 0.035	2.139ValArg: 2.139 ± 0.031	4.659ValSer: 4.659 ± 0.062	3.691ValThr: 3.691 ± 0.054	4.021ValVal: 4.021 ± 0.061	0.636ValTrp: 0.636 ± 0.02	1.861ValTyr: 1.861 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.676TrpAla: 0.676 ± 0.022	0.129TrpCys: 0.129 ± 0.009	0.568TrpAsp: 0.568 ± 0.021	0.451TrpGlu: 0.451 ± 0.017	0.584TrpPhe: 0.584 ± 0.018	0.653TrpGly: 0.653 ± 0.023	0.4TrpHis: 0.4 ± 0.015	0.676TrpIle: 0.676 ± 0.023	0.461TrpLys: 0.461 ± 0.019	1.571TrpLeu: 1.571 ± 0.036	0.279TrpMet: 0.279 ± 0.013	0.528TrpAsn: 0.528 ± 0.019	0.416TrpPro: 0.416 ± 0.018	1.033TrpGln: 1.033 ± 0.026	0.512TrpArg: 0.512 ± 0.017	0.803TrpSer: 0.803 ± 0.027	0.464TrpThr: 0.464 ± 0.02	0.692TrpVal: 0.692 ± 0.025	0.15TrpTrp: 0.15 ± 0.011	0.394TrpTyr: 0.394 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.169TyrAla: 2.169 ± 0.035	0.406TyrCys: 0.406 ± 0.018	1.85TyrAsp: 1.85 ± 0.041	1.68TyrGlu: 1.68 ± 0.033	1.726TyrPhe: 1.726 ± 0.034	2.026TyrGly: 2.026 ± 0.042	0.825TyrHis: 0.825 ± 0.023	2.35TyrIle: 2.35 ± 0.038	2.158TyrLys: 2.158 ± 0.044	3.646TyrLeu: 3.646 ± 0.054	0.646TyrMet: 0.646 ± 0.019	1.611TyrAsn: 1.611 ± 0.04	1.255TyrPro: 1.255 ± 0.029	2.083TyrGln: 2.083 ± 0.039	1.489TyrArg: 1.489 ± 0.032	2.432TyrSer: 2.432 ± 0.048	1.682TyrThr: 1.682 ± 0.04	1.673TyrVal: 1.673 ± 0.034	0.467TyrTrp: 0.467 ± 0.018	1.218TyrTyr: 1.218 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4921 proteins (1573380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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