Amino acid dipepetide frequency for Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.721AlaAla: 9.721 ± 0.107
1.39AlaCys: 1.39 ± 0.029
4.66AlaAsp: 4.66 ± 0.056
5.024AlaGlu: 5.024 ± 0.063
3.113AlaPhe: 3.113 ± 0.05
5.085AlaGly: 5.085 ± 0.059
2.978AlaHis: 2.978 ± 0.042
3.62AlaIle: 3.62 ± 0.05
3.72AlaLys: 3.72 ± 0.055
9.55AlaLeu: 9.55 ± 0.103
2.656AlaMet: 2.656 ± 0.037
2.675AlaAsn: 2.675 ± 0.042
6.095AlaPro: 6.095 ± 0.083
4.409AlaGln: 4.409 ± 0.058
6.476AlaArg: 6.476 ± 0.076
9.447AlaSer: 9.447 ± 0.104
5.471AlaThr: 5.471 ± 0.061
5.225AlaVal: 5.225 ± 0.053
1.531AlaTrp: 1.531 ± 0.035
2.426AlaTyr: 2.426 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
1.271CysAla: 1.271 ± 0.024
0.204CysCys: 0.204 ± 0.011
0.739CysAsp: 0.739 ± 0.018
0.687CysGlu: 0.687 ± 0.019
0.467CysPhe: 0.467 ± 0.016
0.897CysGly: 0.897 ± 0.024
0.366CysHis: 0.366 ± 0.013
0.752CysIle: 0.752 ± 0.022
0.456CysLys: 0.456 ± 0.015
1.264CysLeu: 1.264 ± 0.028
0.435CysMet: 0.435 ± 0.013
0.336CysAsn: 0.336 ± 0.013
0.569CysPro: 0.569 ± 0.016
0.414CysGln: 0.414 ± 0.016
0.749CysArg: 0.749 ± 0.021
0.839CysSer: 0.839 ± 0.021
0.872CysThr: 0.872 ± 0.022
1.111CysVal: 1.111 ± 0.025
0.172CysTrp: 0.172 ± 0.01
0.318CysTyr: 0.318 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.775AspAla: 6.775 ± 0.073
0.501AspCys: 0.501 ± 0.014
4.834AspAsp: 4.834 ± 0.091
4.909AspGlu: 4.909 ± 0.071
1.664AspPhe: 1.664 ± 0.03
3.511AspGly: 3.511 ± 0.042
1.423AspHis: 1.423 ± 0.028
2.501AspIle: 2.501 ± 0.041
2.089AspLys: 2.089 ± 0.035
4.855AspLeu: 4.855 ± 0.057
1.866AspMet: 1.866 ± 0.032
1.513AspAsn: 1.513 ± 0.028
3.186AspPro: 3.186 ± 0.04
1.927AspGln: 1.927 ± 0.035
2.87AspArg: 2.87 ± 0.042
3.813AspSer: 3.813 ± 0.05
3.475AspThr: 3.475 ± 0.049
4.669AspVal: 4.669 ± 0.056
0.774AspTrp: 0.774 ± 0.02
1.277AspTyr: 1.277 ± 0.023
0.0AspXaa: 0.0 ± 0.0
Glu
5.651GluAla: 5.651 ± 0.073
0.714GluCys: 0.714 ± 0.018
3.489GluAsp: 3.489 ± 0.06
4.129GluGlu: 4.129 ± 0.077
1.671GluPhe: 1.671 ± 0.032
2.781GluGly: 2.781 ± 0.044
2.123GluHis: 2.123 ± 0.036
2.115GluIle: 2.115 ± 0.038
2.717GluLys: 2.717 ± 0.055
5.72GluLeu: 5.72 ± 0.056
1.417GluMet: 1.417 ± 0.029
1.967GluAsn: 1.967 ± 0.033
3.175GluPro: 3.175 ± 0.051
3.109GluGln: 3.109 ± 0.049
4.92GluArg: 4.92 ± 0.06
4.628GluSer: 4.628 ± 0.063
3.081GluThr: 3.081 ± 0.039
2.904GluVal: 2.904 ± 0.041
0.81GluTrp: 0.81 ± 0.023
1.534GluTyr: 1.534 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
2.797PheAla: 2.797 ± 0.035
0.501PheCys: 0.501 ± 0.013
2.157PheAsp: 2.157 ± 0.034
1.892PheGlu: 1.892 ± 0.034
1.365PhePhe: 1.365 ± 0.031
2.366PheGly: 2.366 ± 0.052
0.986PheHis: 0.986 ± 0.022
1.197PheIle: 1.197 ± 0.029
1.062PheLys: 1.062 ± 0.025
3.301PheLeu: 3.301 ± 0.045
0.792PheMet: 0.792 ± 0.02
0.91PheAsn: 0.91 ± 0.025
1.609PhePro: 1.609 ± 0.03
1.262PheGln: 1.262 ± 0.025
1.961PheArg: 1.961 ± 0.033
2.695PheSer: 2.695 ± 0.042
1.604PheThr: 1.604 ± 0.028
2.6PheVal: 2.6 ± 0.038
0.459PheTrp: 0.459 ± 0.014
0.93PheTyr: 0.93 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
5.374GlyAla: 5.374 ± 0.061
0.711GlyCys: 0.711 ± 0.021
3.083GlyAsp: 3.083 ± 0.046
2.879GlyGlu: 2.879 ± 0.04
2.126GlyPhe: 2.126 ± 0.032
4.321GlyGly: 4.321 ± 0.084
1.842GlyHis: 1.842 ± 0.03
2.875GlyIle: 2.875 ± 0.041
2.54GlyLys: 2.54 ± 0.046
5.212GlyLeu: 5.212 ± 0.068
1.789GlyMet: 1.789 ± 0.037
1.739GlyAsn: 1.739 ± 0.037
2.839GlyPro: 2.839 ± 0.044
2.125GlyGln: 2.125 ± 0.035
3.719GlyArg: 3.719 ± 0.049
5.068GlySer: 5.068 ± 0.061
3.893GlyThr: 3.893 ± 0.044
3.854GlyVal: 3.854 ± 0.05
0.841GlyTrp: 0.841 ± 0.022
1.561GlyTyr: 1.561 ± 0.034
0.0GlyXaa: 0.0 ± 0.0
His
3.819HisAla: 3.819 ± 0.056
0.342HisCys: 0.342 ± 0.014
1.864HisAsp: 1.864 ± 0.03
1.964HisGlu: 1.964 ± 0.033
0.919HisPhe: 0.919 ± 0.022
2.226HisGly: 2.226 ± 0.033
1.013HisHis: 1.013 ± 0.027
1.393HisIle: 1.393 ± 0.026
1.014HisLys: 1.014 ± 0.021
2.714HisLeu: 2.714 ± 0.04
0.929HisMet: 0.929 ± 0.023
0.8HisAsn: 0.8 ± 0.019
1.789HisPro: 1.789 ± 0.032
1.054HisGln: 1.054 ± 0.023
1.881HisArg: 1.881 ± 0.031
2.093HisSer: 2.093 ± 0.034
1.965HisThr: 1.965 ± 0.038
2.742HisVal: 2.742 ± 0.041
0.402HisTrp: 0.402 ± 0.016
0.68HisTyr: 0.68 ± 0.021
0.0HisXaa: 0.0 ± 0.001
Ile
3.531IleAla: 3.531 ± 0.049
0.596IleCys: 0.596 ± 0.018
2.632IleAsp: 2.632 ± 0.041
2.475IleGlu: 2.475 ± 0.04
1.346IlePhe: 1.346 ± 0.027
2.436IleGly: 2.436 ± 0.046
1.274IleHis: 1.274 ± 0.024
1.554IleIle: 1.554 ± 0.031
1.611IleLys: 1.611 ± 0.036
3.958IleLeu: 3.958 ± 0.055
1.015IleMet: 1.015 ± 0.023
1.196IleAsn: 1.196 ± 0.026
2.528IlePro: 2.528 ± 0.035
1.889IleGln: 1.889 ± 0.029
2.646IleArg: 2.646 ± 0.036
3.0IleSer: 3.0 ± 0.042
2.073IleThr: 2.073 ± 0.036
3.136IleVal: 3.136 ± 0.041
0.516IleTrp: 0.516 ± 0.017
0.96IleTyr: 0.96 ± 0.026
0.001IleXaa: 0.001 ± 0.001
Lys
3.384LysAla: 3.384 ± 0.05
0.436LysCys: 0.436 ± 0.015
2.216LysAsp: 2.216 ± 0.037
2.51LysGlu: 2.51 ± 0.048
1.043LysPhe: 1.043 ± 0.023
2.03LysGly: 2.03 ± 0.038
1.288LysHis: 1.288 ± 0.027
1.564LysIle: 1.564 ± 0.035
2.227LysLys: 2.227 ± 0.06
3.467LysLeu: 3.467 ± 0.048
0.942LysMet: 0.942 ± 0.02
1.439LysAsn: 1.439 ± 0.028
2.32LysPro: 2.32 ± 0.041
1.848LysGln: 1.848 ± 0.024
3.137LysArg: 3.137 ± 0.042
2.913LysSer: 2.913 ± 0.048
2.209LysThr: 2.209 ± 0.034
2.241LysVal: 2.241 ± 0.038
0.413LysTrp: 0.413 ± 0.013
1.139LysTyr: 1.139 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
8.927LeuAla: 8.927 ± 0.092
1.589LeuCys: 1.589 ± 0.031
5.886LeuAsp: 5.886 ± 0.065
5.591LeuGlu: 5.591 ± 0.066
3.273LeuPhe: 3.273 ± 0.049
5.586LeuGly: 5.586 ± 0.061
3.157LeuHis: 3.157 ± 0.047
3.35LeuIle: 3.35 ± 0.051
3.186LeuLys: 3.186 ± 0.042
9.243LeuLeu: 9.243 ± 0.113
2.136LeuMet: 2.136 ± 0.031
2.71LeuAsn: 2.71 ± 0.039
5.803LeuPro: 5.803 ± 0.069
4.324LeuGln: 4.324 ± 0.049
6.865LeuArg: 6.865 ± 0.073
8.016LeuSer: 8.016 ± 0.072
4.833LeuThr: 4.833 ± 0.051
6.321LeuVal: 6.321 ± 0.08
1.183LeuTrp: 1.183 ± 0.03
2.521LeuTyr: 2.521 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.417MetAla: 2.417 ± 0.04
0.327MetCys: 0.327 ± 0.013
1.68MetAsp: 1.68 ± 0.029
1.506MetGlu: 1.506 ± 0.032
0.78MetPhe: 0.78 ± 0.018
1.53MetGly: 1.53 ± 0.03
0.982MetHis: 0.982 ± 0.02
0.96MetIle: 0.96 ± 0.026
0.866MetLys: 0.866 ± 0.023
2.637MetLeu: 2.637 ± 0.039
0.722MetMet: 0.722 ± 0.018
0.994MetAsn: 0.994 ± 0.02
2.103MetPro: 2.103 ± 0.041
1.333MetGln: 1.333 ± 0.023
1.919MetArg: 1.919 ± 0.031
2.529MetSer: 2.529 ± 0.034
1.462MetThr: 1.462 ± 0.027
1.344MetVal: 1.344 ± 0.027
0.325MetTrp: 0.325 ± 0.012
0.856MetTyr: 0.856 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.228AsnAla: 3.228 ± 0.037
0.27AsnCys: 0.27 ± 0.014
1.958AsnAsp: 1.958 ± 0.034
2.292AsnGlu: 2.292 ± 0.036
0.899AsnPhe: 0.899 ± 0.024
2.016AsnGly: 2.016 ± 0.04
0.723AsnHis: 0.723 ± 0.018
1.338AsnIle: 1.338 ± 0.027
1.314AsnLys: 1.314 ± 0.031
2.551AsnLeu: 2.551 ± 0.037
0.941AsnMet: 0.941 ± 0.022
1.008AsnAsn: 1.008 ± 0.027
1.747AsnPro: 1.747 ± 0.034
1.103AsnGln: 1.103 ± 0.024
1.574AsnArg: 1.574 ± 0.03
2.007AsnSer: 2.007 ± 0.034
1.86AsnThr: 1.86 ± 0.037
2.423AsnVal: 2.423 ± 0.039
0.377AsnTrp: 0.377 ± 0.013
0.744AsnTyr: 0.744 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
5.628ProAla: 5.628 ± 0.082
0.594ProCys: 0.594 ± 0.017
3.174ProAsp: 3.174 ± 0.045
3.422ProGlu: 3.422 ± 0.045
1.952ProPhe: 1.952 ± 0.034
3.355ProGly: 3.355 ± 0.053
1.815ProHis: 1.815 ± 0.033
2.354ProIle: 2.354 ± 0.035
2.251ProLys: 2.251 ± 0.042
5.172ProLeu: 5.172 ± 0.066
1.63ProMet: 1.63 ± 0.033
1.939ProAsn: 1.939 ± 0.035
5.059ProPro: 5.059 ± 0.103
2.222ProGln: 2.222 ± 0.042
3.573ProArg: 3.573 ± 0.047
6.744ProSer: 6.744 ± 0.104
4.127ProThr: 4.127 ± 0.065
3.934ProVal: 3.934 ± 0.062
0.775ProTrp: 0.775 ± 0.018
1.506ProTyr: 1.506 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.195GlnAla: 4.195 ± 0.056
0.575GlnCys: 0.575 ± 0.017
2.338GlnAsp: 2.338 ± 0.035
2.381GlnGlu: 2.381 ± 0.039
1.196GlnPhe: 1.196 ± 0.022
2.312GlnGly: 2.312 ± 0.033
1.512GlnHis: 1.512 ± 0.024
1.621GlnIle: 1.621 ± 0.028
1.614GlnLys: 1.614 ± 0.031
4.175GlnLeu: 4.175 ± 0.053
1.077GlnMet: 1.077 ± 0.026
1.354GlnAsn: 1.354 ± 0.03
2.482GlnPro: 2.482 ± 0.05
2.625GlnGln: 2.625 ± 0.074
3.451GlnArg: 3.451 ± 0.041
3.136GlnSer: 3.136 ± 0.04
2.287GlnThr: 2.287 ± 0.038
2.749GlnVal: 2.749 ± 0.036
0.554GlnTrp: 0.554 ± 0.018
1.065GlnTyr: 1.065 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
6.597ArgAla: 6.597 ± 0.075
0.833ArgCys: 0.833 ± 0.025
3.586ArgAsp: 3.586 ± 0.045
4.1ArgGlu: 4.1 ± 0.053
2.163ArgPhe: 2.163 ± 0.033
3.619ArgGly: 3.619 ± 0.049
2.148ArgHis: 2.148 ± 0.032
3.174ArgIle: 3.174 ± 0.047
2.77ArgLys: 2.77 ± 0.045
6.357ArgLeu: 6.357 ± 0.073
1.928ArgMet: 1.928 ± 0.031
1.859ArgAsn: 1.859 ± 0.033
3.633ArgPro: 3.633 ± 0.05
2.751ArgGln: 2.751 ± 0.043
5.689ArgArg: 5.689 ± 0.07
5.267ArgSer: 5.267 ± 0.066
4.033ArgThr: 4.033 ± 0.045
4.446ArgVal: 4.446 ± 0.052
0.908ArgTrp: 0.908 ± 0.019
1.569ArgTyr: 1.569 ± 0.026
0.0ArgXaa: 0.0 ± 0.0
Ser
7.916SerAla: 7.916 ± 0.097
0.902SerCys: 0.902 ± 0.026
4.73SerAsp: 4.73 ± 0.055
4.368SerGlu: 4.368 ± 0.053
2.852SerPhe: 2.852 ± 0.044
4.917SerGly: 4.917 ± 0.06
2.532SerHis: 2.532 ± 0.043
3.38SerIle: 3.38 ± 0.05
3.332SerLys: 3.332 ± 0.05
8.056SerLeu: 8.056 ± 0.069
2.733SerMet: 2.733 ± 0.038
2.666SerAsn: 2.666 ± 0.043
5.203SerPro: 5.203 ± 0.105
3.445SerGln: 3.445 ± 0.046
5.094SerArg: 5.094 ± 0.067
10.395SerSer: 10.395 ± 0.152
6.022SerThr: 6.022 ± 0.079
5.329SerVal: 5.329 ± 0.05
1.013SerTrp: 1.013 ± 0.024
1.857SerTyr: 1.857 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
4.901ThrAla: 4.901 ± 0.056
0.831ThrCys: 0.831 ± 0.02
2.969ThrAsp: 2.969 ± 0.04
2.859ThrGlu: 2.859 ± 0.041
1.901ThrPhe: 1.901 ± 0.036
3.448ThrGly: 3.448 ± 0.052
1.894ThrHis: 1.894 ± 0.034
2.318ThrIle: 2.318 ± 0.033
2.228ThrLys: 2.228 ± 0.038
5.66ThrLeu: 5.66 ± 0.062
1.576ThrMet: 1.576 ± 0.028
2.0ThrAsn: 2.0 ± 0.035
4.433ThrPro: 4.433 ± 0.07
2.403ThrGln: 2.403 ± 0.034
3.595ThrArg: 3.595 ± 0.044
6.103ThrSer: 6.103 ± 0.072
3.815ThrThr: 3.815 ± 0.054
3.305ThrVal: 3.305 ± 0.041
0.839ThrTrp: 0.839 ± 0.021
1.632ThrTyr: 1.632 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
5.592ValAla: 5.592 ± 0.062
1.041ValCys: 1.041 ± 0.025
3.865ValAsp: 3.865 ± 0.044
3.293ValGlu: 3.293 ± 0.042
2.288ValPhe: 2.288 ± 0.036
3.505ValGly: 3.505 ± 0.048
2.331ValHis: 2.331 ± 0.035
2.535ValIle: 2.535 ± 0.043
2.278ValLys: 2.278 ± 0.037
6.836ValLeu: 6.836 ± 0.076
1.59ValMet: 1.59 ± 0.024
1.875ValAsn: 1.875 ± 0.033
4.846ValPro: 4.846 ± 0.051
3.007ValGln: 3.007 ± 0.042
4.781ValArg: 4.781 ± 0.059
5.382ValSer: 5.382 ± 0.06
3.253ValThr: 3.253 ± 0.052
4.151ValVal: 4.151 ± 0.054
0.967ValTrp: 0.967 ± 0.02
1.84ValTyr: 1.84 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
0.972TrpAla: 0.972 ± 0.023
0.226TrpCys: 0.226 ± 0.011
0.951TrpAsp: 0.951 ± 0.025
0.661TrpGlu: 0.661 ± 0.02
0.443TrpPhe: 0.443 ± 0.014
0.664TrpGly: 0.664 ± 0.019
0.524TrpHis: 0.524 ± 0.017
0.714TrpIle: 0.714 ± 0.021
0.552TrpLys: 0.552 ± 0.015
1.385TrpLeu: 1.385 ± 0.031
0.339TrpMet: 0.339 ± 0.012
0.589TrpAsn: 0.589 ± 0.02
0.634TrpPro: 0.634 ± 0.016
0.567TrpGln: 0.567 ± 0.017
1.007TrpArg: 1.007 ± 0.022
1.023TrpSer: 1.023 ± 0.024
0.854TrpThr: 0.854 ± 0.022
0.714TrpVal: 0.714 ± 0.02
0.208TrpTrp: 0.208 ± 0.01
0.363TrpTyr: 0.363 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.578TyrAla: 2.578 ± 0.042
0.335TyrCys: 0.335 ± 0.013
1.621TyrAsp: 1.621 ± 0.03
1.713TyrGlu: 1.713 ± 0.03
0.987TyrPhe: 0.987 ± 0.023
1.785TyrGly: 1.785 ± 0.037
0.692TyrHis: 0.692 ± 0.017
1.056TyrIle: 1.056 ± 0.024
0.941TyrLys: 0.941 ± 0.023
2.385TyrLeu: 2.385 ± 0.032
0.76TyrMet: 0.76 ± 0.021
0.806TyrAsn: 0.806 ± 0.019
1.174TyrPro: 1.174 ± 0.022
0.882TyrGln: 0.882 ± 0.02
1.522TyrArg: 1.522 ± 0.029
1.645TyrSer: 1.645 ± 0.033
1.519TyrThr: 1.519 ± 0.027
2.056TyrVal: 2.056 ± 0.035
0.322TyrTrp: 0.322 ± 0.013
0.752TyrTyr: 0.752 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.001
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4274 proteins (2064385 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski