Amino acid dipepetide frequency for Brevundimonas phage vB_BsubS-Delta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.95AlaAla: 14.95 ± 1.914
0.851AlaCys: 0.851 ± 0.204
7.697AlaAsp: 7.697 ± 0.64
6.772AlaGlu: 6.772 ± 0.545
4.144AlaPhe: 4.144 ± 0.38
8.807AlaGly: 8.807 ± 0.794
1.776AlaHis: 1.776 ± 0.256
4.478AlaIle: 4.478 ± 0.578
5.625AlaLys: 5.625 ± 0.492
8.659AlaLeu: 8.659 ± 0.58
3.885AlaMet: 3.885 ± 0.374
3.737AlaAsn: 3.737 ± 0.539
5.033AlaPro: 5.033 ± 0.574
3.626AlaGln: 3.626 ± 0.686
6.291AlaArg: 6.291 ± 0.548
5.625AlaSer: 5.625 ± 0.511
6.439AlaThr: 6.439 ± 0.978
7.031AlaVal: 7.031 ± 0.55
1.48AlaTrp: 1.48 ± 0.279
3.182AlaTyr: 3.182 ± 0.342
0.0AlaXaa: 0.0 ± 0.0
Cys
0.74CysAla: 0.74 ± 0.194
0.185CysCys: 0.185 ± 0.09
0.333CysAsp: 0.333 ± 0.115
0.444CysGlu: 0.444 ± 0.134
0.296CysPhe: 0.296 ± 0.117
0.962CysGly: 0.962 ± 0.167
0.296CysHis: 0.296 ± 0.151
0.518CysIle: 0.518 ± 0.153
0.296CysLys: 0.296 ± 0.094
0.629CysLeu: 0.629 ± 0.163
0.259CysMet: 0.259 ± 0.084
0.37CysAsn: 0.37 ± 0.119
0.703CysPro: 0.703 ± 0.178
0.333CysGln: 0.333 ± 0.119
0.629CysArg: 0.629 ± 0.143
0.296CysSer: 0.296 ± 0.111
0.185CysThr: 0.185 ± 0.069
0.592CysVal: 0.592 ± 0.157
0.259CysTrp: 0.259 ± 0.109
0.148CysTyr: 0.148 ± 0.069
0.0CysXaa: 0.0 ± 0.0
Asp
7.327AspAla: 7.327 ± 0.674
0.296AspCys: 0.296 ± 0.117
4.774AspAsp: 4.774 ± 0.517
5.255AspGlu: 5.255 ± 0.411
2.442AspPhe: 2.442 ± 0.315
5.329AspGly: 5.329 ± 0.509
1.258AspHis: 1.258 ± 0.241
3.182AspIle: 3.182 ± 0.41
2.516AspLys: 2.516 ± 0.31
5.329AspLeu: 5.329 ± 0.564
1.739AspMet: 1.739 ± 0.258
1.776AspAsn: 1.776 ± 0.246
4.107AspPro: 4.107 ± 0.463
1.628AspGln: 1.628 ± 0.211
4.107AspArg: 4.107 ± 0.442
2.997AspSer: 2.997 ± 0.356
3.33AspThr: 3.33 ± 0.348
3.737AspVal: 3.737 ± 0.369
1.443AspTrp: 1.443 ± 0.246
2.22AspTyr: 2.22 ± 0.271
0.0AspXaa: 0.0 ± 0.0
Glu
8.141GluAla: 8.141 ± 0.618
0.37GluCys: 0.37 ± 0.109
3.959GluAsp: 3.959 ± 0.384
3.811GluGlu: 3.811 ± 0.407
2.627GluPhe: 2.627 ± 0.374
5.033GluGly: 5.033 ± 0.534
1.332GluHis: 1.332 ± 0.251
3.515GluIle: 3.515 ± 0.373
2.627GluLys: 2.627 ± 0.36
5.699GluLeu: 5.699 ± 0.473
1.443GluMet: 1.443 ± 0.222
1.998GluAsn: 1.998 ± 0.212
3.515GluPro: 3.515 ± 0.571
3.034GluGln: 3.034 ± 0.438
4.959GluArg: 4.959 ± 0.52
1.924GluSer: 1.924 ± 0.265
4.033GluThr: 4.033 ± 0.343
3.996GluVal: 3.996 ± 0.369
1.147GluTrp: 1.147 ± 0.219
1.517GluTyr: 1.517 ± 0.237
0.0GluXaa: 0.0 ± 0.0
Phe
4.44PheAla: 4.44 ± 0.459
0.296PheCys: 0.296 ± 0.109
3.182PheAsp: 3.182 ± 0.425
2.664PheGlu: 2.664 ± 0.398
1.591PhePhe: 1.591 ± 0.282
3.7PheGly: 3.7 ± 0.391
0.592PheHis: 0.592 ± 0.125
1.406PheIle: 1.406 ± 0.217
1.665PheLys: 1.665 ± 0.343
2.886PheLeu: 2.886 ± 0.399
1.147PheMet: 1.147 ± 0.216
1.443PheAsn: 1.443 ± 0.22
1.443PhePro: 1.443 ± 0.299
1.258PheGln: 1.258 ± 0.234
1.998PheArg: 1.998 ± 0.345
1.702PheSer: 1.702 ± 0.283
2.479PheThr: 2.479 ± 0.324
2.294PheVal: 2.294 ± 0.285
0.592PheTrp: 0.592 ± 0.167
1.295PheTyr: 1.295 ± 0.207
0.0PheXaa: 0.0 ± 0.0
Gly
6.957GlyAla: 6.957 ± 0.836
0.777GlyCys: 0.777 ± 0.215
5.403GlyAsp: 5.403 ± 0.49
4.959GlyGlu: 4.959 ± 0.384
3.626GlyPhe: 3.626 ± 0.307
8.548GlyGly: 8.548 ± 1.436
1.443GlyHis: 1.443 ± 0.248
3.885GlyIle: 3.885 ± 0.409
3.663GlyLys: 3.663 ± 0.439
6.254GlyLeu: 6.254 ± 0.461
2.035GlyMet: 2.035 ± 0.263
2.997GlyAsn: 2.997 ± 0.332
3.367GlyPro: 3.367 ± 0.329
3.33GlyGln: 3.33 ± 0.307
5.144GlyArg: 5.144 ± 0.462
5.477GlySer: 5.477 ± 0.474
4.552GlyThr: 4.552 ± 0.492
6.254GlyVal: 6.254 ± 0.435
1.628GlyTrp: 1.628 ± 0.293
2.886GlyTyr: 2.886 ± 0.45
0.0GlyXaa: 0.0 ± 0.0
His
2.183HisAla: 2.183 ± 0.297
0.222HisCys: 0.222 ± 0.104
1.147HisAsp: 1.147 ± 0.176
1.184HisGlu: 1.184 ± 0.222
0.777HisPhe: 0.777 ± 0.178
1.739HisGly: 1.739 ± 0.271
0.296HisHis: 0.296 ± 0.115
0.555HisIle: 0.555 ± 0.128
0.777HisLys: 0.777 ± 0.194
1.554HisLeu: 1.554 ± 0.244
0.444HisMet: 0.444 ± 0.136
0.481HisAsn: 0.481 ± 0.126
0.962HisPro: 0.962 ± 0.192
0.666HisGln: 0.666 ± 0.169
1.073HisArg: 1.073 ± 0.208
0.962HisSer: 0.962 ± 0.173
0.888HisThr: 0.888 ± 0.191
1.295HisVal: 1.295 ± 0.23
0.703HisTrp: 0.703 ± 0.176
0.666HisTyr: 0.666 ± 0.16
0.0HisXaa: 0.0 ± 0.0
Ile
4.107IleAla: 4.107 ± 0.491
0.592IleCys: 0.592 ± 0.133
4.366IleAsp: 4.366 ± 0.389
3.737IleGlu: 3.737 ± 0.388
1.332IlePhe: 1.332 ± 0.229
3.7IleGly: 3.7 ± 0.505
1.073IleHis: 1.073 ± 0.196
1.813IleIle: 1.813 ± 0.276
2.405IleLys: 2.405 ± 0.28
2.997IleLeu: 2.997 ± 0.363
1.295IleMet: 1.295 ± 0.268
2.072IleAsn: 2.072 ± 0.256
2.405IlePro: 2.405 ± 0.309
1.48IleGln: 1.48 ± 0.213
3.071IleArg: 3.071 ± 0.359
2.59IleSer: 2.59 ± 0.314
3.663IleThr: 3.663 ± 0.371
2.849IleVal: 2.849 ± 0.259
0.407IleTrp: 0.407 ± 0.132
1.406IleTyr: 1.406 ± 0.218
0.0IleXaa: 0.0 ± 0.0
Lys
5.366LysAla: 5.366 ± 0.467
0.333LysCys: 0.333 ± 0.107
2.775LysAsp: 2.775 ± 0.299
2.664LysGlu: 2.664 ± 0.258
1.073LysPhe: 1.073 ± 0.248
3.848LysGly: 3.848 ± 0.38
1.036LysHis: 1.036 ± 0.202
2.22LysIle: 2.22 ± 0.269
2.553LysLys: 2.553 ± 0.355
4.181LysLeu: 4.181 ± 0.474
1.591LysMet: 1.591 ± 0.244
1.332LysAsn: 1.332 ± 0.238
2.923LysPro: 2.923 ± 0.367
1.591LysGln: 1.591 ± 0.269
2.59LysArg: 2.59 ± 0.337
2.294LysSer: 2.294 ± 0.304
2.96LysThr: 2.96 ± 0.349
3.33LysVal: 3.33 ± 0.311
0.666LysTrp: 0.666 ± 0.148
0.888LysTyr: 0.888 ± 0.19
0.0LysXaa: 0.0 ± 0.0
Leu
7.475LeuAla: 7.475 ± 0.69
0.851LeuCys: 0.851 ± 0.195
4.848LeuAsp: 4.848 ± 0.497
4.329LeuGlu: 4.329 ± 0.446
3.034LeuPhe: 3.034 ± 0.389
5.44LeuGly: 5.44 ± 0.449
1.295LeuHis: 1.295 ± 0.232
4.44LeuIle: 4.44 ± 0.387
3.33LeuLys: 3.33 ± 0.435
5.366LeuLeu: 5.366 ± 0.465
2.183LeuMet: 2.183 ± 0.252
3.219LeuAsn: 3.219 ± 0.335
3.885LeuPro: 3.885 ± 0.477
2.072LeuGln: 2.072 ± 0.237
5.514LeuArg: 5.514 ± 0.481
4.959LeuSer: 4.959 ± 0.414
5.588LeuThr: 5.588 ± 0.396
4.774LeuVal: 4.774 ± 0.423
1.443LeuTrp: 1.443 ± 0.258
1.813LeuTyr: 1.813 ± 0.267
0.0LeuXaa: 0.0 ± 0.0
Met
3.404MetAla: 3.404 ± 0.317
0.185MetCys: 0.185 ± 0.082
1.221MetAsp: 1.221 ± 0.218
1.665MetGlu: 1.665 ± 0.229
0.925MetPhe: 0.925 ± 0.17
1.295MetGly: 1.295 ± 0.212
0.222MetHis: 0.222 ± 0.093
1.665MetIle: 1.665 ± 0.245
1.332MetLys: 1.332 ± 0.215
1.665MetLeu: 1.665 ± 0.254
0.74MetMet: 0.74 ± 0.195
1.036MetAsn: 1.036 ± 0.218
1.591MetPro: 1.591 ± 0.248
0.962MetGln: 0.962 ± 0.2
1.998MetArg: 1.998 ± 0.306
2.257MetSer: 2.257 ± 0.269
2.627MetThr: 2.627 ± 0.319
1.628MetVal: 1.628 ± 0.196
0.333MetTrp: 0.333 ± 0.107
0.333MetTyr: 0.333 ± 0.101
0.0MetXaa: 0.0 ± 0.0
Asn
4.144AsnAla: 4.144 ± 0.413
0.333AsnCys: 0.333 ± 0.096
2.035AsnAsp: 2.035 ± 0.288
1.85AsnGlu: 1.85 ± 0.281
0.925AsnPhe: 0.925 ± 0.16
3.7AsnGly: 3.7 ± 0.4
0.555AsnHis: 0.555 ± 0.148
1.295AsnIle: 1.295 ± 0.193
1.184AsnLys: 1.184 ± 0.217
2.368AsnLeu: 2.368 ± 0.313
1.036AsnMet: 1.036 ± 0.137
1.295AsnAsn: 1.295 ± 0.25
3.293AsnPro: 3.293 ± 0.358
1.073AsnGln: 1.073 ± 0.181
2.368AsnArg: 2.368 ± 0.284
1.776AsnSer: 1.776 ± 0.248
2.294AsnThr: 2.294 ± 0.364
2.183AsnVal: 2.183 ± 0.312
0.592AsnTrp: 0.592 ± 0.146
1.406AsnTyr: 1.406 ± 0.281
0.0AsnXaa: 0.0 ± 0.0
Pro
5.44ProAla: 5.44 ± 0.622
0.407ProCys: 0.407 ± 0.132
3.737ProAsp: 3.737 ± 0.492
4.107ProGlu: 4.107 ± 0.373
2.405ProPhe: 2.405 ± 0.405
4.922ProGly: 4.922 ± 0.575
0.777ProHis: 0.777 ± 0.157
2.479ProIle: 2.479 ± 0.326
2.368ProLys: 2.368 ± 0.381
3.219ProLeu: 3.219 ± 0.3
0.814ProMet: 0.814 ± 0.183
1.406ProAsn: 1.406 ± 0.267
2.183ProPro: 2.183 ± 0.457
1.628ProGln: 1.628 ± 0.264
3.034ProArg: 3.034 ± 0.409
3.108ProSer: 3.108 ± 0.358
3.182ProThr: 3.182 ± 0.347
4.033ProVal: 4.033 ± 0.462
1.11ProTrp: 1.11 ± 0.217
1.591ProTyr: 1.591 ± 0.215
0.0ProXaa: 0.0 ± 0.0
Gln
3.848GlnAla: 3.848 ± 0.41
0.259GlnCys: 0.259 ± 0.101
1.998GlnAsp: 1.998 ± 0.292
2.072GlnGlu: 2.072 ± 0.338
1.554GlnPhe: 1.554 ± 0.278
2.442GlnGly: 2.442 ± 0.364
1.036GlnHis: 1.036 ± 0.186
1.776GlnIle: 1.776 ± 0.237
1.85GlnLys: 1.85 ± 0.302
2.627GlnLeu: 2.627 ± 0.408
0.851GlnMet: 0.851 ± 0.172
1.443GlnAsn: 1.443 ± 0.264
1.776GlnPro: 1.776 ± 0.275
1.591GlnGln: 1.591 ± 0.295
2.96GlnArg: 2.96 ± 0.387
1.887GlnSer: 1.887 ± 0.241
2.368GlnThr: 2.368 ± 0.381
2.146GlnVal: 2.146 ± 0.281
0.592GlnTrp: 0.592 ± 0.137
0.888GlnTyr: 0.888 ± 0.168
0.0GlnXaa: 0.0 ± 0.0
Arg
6.994ArgAla: 6.994 ± 0.82
0.592ArgCys: 0.592 ± 0.169
4.589ArgAsp: 4.589 ± 0.415
4.885ArgGlu: 4.885 ± 0.47
2.812ArgPhe: 2.812 ± 0.338
4.663ArgGly: 4.663 ± 0.389
1.406ArgHis: 1.406 ± 0.306
3.034ArgIle: 3.034 ± 0.349
3.293ArgLys: 3.293 ± 0.372
4.626ArgLeu: 4.626 ± 0.427
1.887ArgMet: 1.887 ± 0.287
1.776ArgAsn: 1.776 ± 0.203
2.849ArgPro: 2.849 ± 0.339
2.627ArgGln: 2.627 ± 0.294
4.403ArgArg: 4.403 ± 0.395
3.404ArgSer: 3.404 ± 0.405
2.812ArgThr: 2.812 ± 0.298
4.626ArgVal: 4.626 ± 0.466
1.258ArgTrp: 1.258 ± 0.198
1.85ArgTyr: 1.85 ± 0.251
0.0ArgXaa: 0.0 ± 0.0
Ser
5.514SerAla: 5.514 ± 0.404
0.407SerCys: 0.407 ± 0.114
2.849SerAsp: 2.849 ± 0.303
3.108SerGlu: 3.108 ± 0.365
1.702SerPhe: 1.702 ± 0.268
5.329SerGly: 5.329 ± 0.488
0.888SerHis: 0.888 ± 0.198
2.553SerIle: 2.553 ± 0.377
2.775SerLys: 2.775 ± 0.325
3.367SerLeu: 3.367 ± 0.308
1.517SerMet: 1.517 ± 0.221
2.664SerAsn: 2.664 ± 0.342
2.516SerPro: 2.516 ± 0.316
1.85SerGln: 1.85 ± 0.411
3.367SerArg: 3.367 ± 0.356
2.701SerSer: 2.701 ± 0.326
2.849SerThr: 2.849 ± 0.365
3.848SerVal: 3.848 ± 0.439
0.777SerTrp: 0.777 ± 0.17
2.109SerTyr: 2.109 ± 0.359
0.0SerXaa: 0.0 ± 0.0
Thr
7.068ThrAla: 7.068 ± 0.944
0.296ThrCys: 0.296 ± 0.109
2.627ThrAsp: 2.627 ± 0.306
3.256ThrGlu: 3.256 ± 0.445
2.997ThrPhe: 2.997 ± 0.425
5.847ThrGly: 5.847 ± 0.508
1.147ThrHis: 1.147 ± 0.25
2.812ThrIle: 2.812 ± 0.287
2.664ThrLys: 2.664 ± 0.308
5.514ThrLeu: 5.514 ± 0.375
1.036ThrMet: 1.036 ± 0.201
2.516ThrAsn: 2.516 ± 0.3
3.663ThrPro: 3.663 ± 0.399
2.331ThrGln: 2.331 ± 0.29
2.997ThrArg: 2.997 ± 0.315
2.664ThrSer: 2.664 ± 0.304
3.663ThrThr: 3.663 ± 0.422
4.403ThrVal: 4.403 ± 0.467
0.74ThrTrp: 0.74 ± 0.173
2.183ThrTyr: 2.183 ± 0.306
0.0ThrXaa: 0.0 ± 0.0
Val
7.068ValAla: 7.068 ± 0.558
0.74ValCys: 0.74 ± 0.22
4.181ValAsp: 4.181 ± 0.346
4.663ValGlu: 4.663 ± 0.383
2.146ValPhe: 2.146 ± 0.258
3.996ValGly: 3.996 ± 0.533
1.295ValHis: 1.295 ± 0.236
3.367ValIle: 3.367 ± 0.371
2.738ValLys: 2.738 ± 0.314
5.292ValLeu: 5.292 ± 0.505
1.998ValMet: 1.998 ± 0.262
2.553ValAsn: 2.553 ± 0.315
3.404ValPro: 3.404 ± 0.361
2.997ValGln: 2.997 ± 0.343
4.589ValArg: 4.589 ± 0.39
3.478ValSer: 3.478 ± 0.364
4.366ValThr: 4.366 ± 0.441
5.107ValVal: 5.107 ± 0.497
1.073ValTrp: 1.073 ± 0.178
2.183ValTyr: 2.183 ± 0.316
0.0ValXaa: 0.0 ± 0.0
Trp
1.702TrpAla: 1.702 ± 0.258
0.259TrpCys: 0.259 ± 0.089
0.962TrpAsp: 0.962 ± 0.189
0.999TrpGlu: 0.999 ± 0.2
0.777TrpPhe: 0.777 ± 0.161
1.258TrpGly: 1.258 ± 0.224
0.333TrpHis: 0.333 ± 0.108
1.184TrpIle: 1.184 ± 0.188
0.999TrpLys: 0.999 ± 0.193
1.739TrpLeu: 1.739 ± 0.265
0.444TrpMet: 0.444 ± 0.108
0.666TrpAsn: 0.666 ± 0.188
0.555TrpPro: 0.555 ± 0.126
0.666TrpGln: 0.666 ± 0.166
1.332TrpArg: 1.332 ± 0.249
0.851TrpSer: 0.851 ± 0.194
0.666TrpThr: 0.666 ± 0.174
1.11TrpVal: 1.11 ± 0.238
0.37TrpTrp: 0.37 ± 0.111
0.407TrpTyr: 0.407 ± 0.114
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.219TyrAla: 3.219 ± 0.307
0.222TyrCys: 0.222 ± 0.087
2.109TyrAsp: 2.109 ± 0.291
2.257TyrGlu: 2.257 ± 0.293
0.888TyrPhe: 0.888 ± 0.188
2.627TyrGly: 2.627 ± 0.331
0.518TyrHis: 0.518 ± 0.126
1.184TyrIle: 1.184 ± 0.197
1.591TyrLys: 1.591 ± 0.27
1.887TyrLeu: 1.887 ± 0.246
0.703TyrMet: 0.703 ± 0.162
0.925TyrAsn: 0.925 ± 0.154
1.776TyrPro: 1.776 ± 0.29
1.221TyrGln: 1.221 ± 0.228
1.961TyrArg: 1.961 ± 0.253
1.739TyrSer: 1.739 ± 0.244
1.48TyrThr: 1.48 ± 0.256
1.998TyrVal: 1.998 ± 0.274
0.666TyrTrp: 0.666 ± 0.158
0.962TyrTyr: 0.962 ± 0.168
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 119 proteins (27025 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski