Amino acid dipepetide frequency for Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.816AlaAla: 9.816 ± 0.113	1.051AlaCys: 1.051 ± 0.034	4.322AlaAsp: 4.322 ± 0.07	6.252AlaGlu: 6.252 ± 0.085	3.499AlaPhe: 3.499 ± 0.058	7.289AlaGly: 7.289 ± 0.099	2.16AlaHis: 2.16 ± 0.045	5.742AlaIle: 5.742 ± 0.092	3.813AlaLys: 3.813 ± 0.065	11.503AlaLeu: 11.503 ± 0.141	2.307AlaMet: 2.307 ± 0.049	2.657AlaAsn: 2.657 ± 0.052	3.818AlaPro: 3.818 ± 0.063	4.272AlaGln: 4.272 ± 0.072	6.167AlaArg: 6.167 ± 0.095	5.061AlaSer: 5.061 ± 0.074	4.496AlaThr: 4.496 ± 0.064	6.521AlaVal: 6.521 ± 0.101	1.473AlaTrp: 1.473 ± 0.043	2.609AlaTyr: 2.609 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.838CysAla: 0.838 ± 0.031	0.146CysCys: 0.146 ± 0.015	0.454CysAsp: 0.454 ± 0.02	0.531CysGlu: 0.531 ± 0.023	0.43CysPhe: 0.43 ± 0.023	0.895CysGly: 0.895 ± 0.033	0.393CysHis: 0.393 ± 0.023	0.486CysIle: 0.486 ± 0.025	0.294CysLys: 0.294 ± 0.019	1.111CysLeu: 1.111 ± 0.033	0.178CysMet: 0.178 ± 0.012	0.285CysAsn: 0.285 ± 0.02	0.584CysPro: 0.584 ± 0.031	0.516CysGln: 0.516 ± 0.027	0.696CysArg: 0.696 ± 0.026	0.607CysSer: 0.607 ± 0.028	0.433CysThr: 0.433 ± 0.02	0.577CysVal: 0.577 ± 0.023	0.145CysTrp: 0.145 ± 0.01	0.356CysTyr: 0.356 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.527AspAla: 3.527 ± 0.07	0.512AspCys: 0.512 ± 0.025	2.094AspAsp: 2.094 ± 0.06	3.092AspGlu: 3.092 ± 0.063	2.347AspPhe: 2.347 ± 0.051	3.34AspGly: 3.34 ± 0.076	1.088AspHis: 1.088 ± 0.038	3.068AspIle: 3.068 ± 0.059	2.133AspLys: 2.133 ± 0.043	5.315AspLeu: 5.315 ± 0.079	1.003AspMet: 1.003 ± 0.033	1.554AspAsn: 1.554 ± 0.047	2.804AspPro: 2.804 ± 0.056	1.83AspGln: 1.83 ± 0.047	3.016AspArg: 3.016 ± 0.059	2.721AspSer: 2.721 ± 0.057	2.3AspThr: 2.3 ± 0.05	2.784AspVal: 2.784 ± 0.061	0.801AspTrp: 0.801 ± 0.028	1.742AspTyr: 1.742 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.991GluAla: 6.991 ± 0.114	0.461GluCys: 0.461 ± 0.022	2.902GluAsp: 2.902 ± 0.053	4.926GluGlu: 4.926 ± 0.097	2.228GluPhe: 2.228 ± 0.05	4.683GluGly: 4.683 ± 0.076	1.498GluHis: 1.498 ± 0.046	4.288GluIle: 4.288 ± 0.072	3.425GluLys: 3.425 ± 0.067	6.383GluLeu: 6.383 ± 0.089	1.604GluMet: 1.604 ± 0.041	2.219GluAsn: 2.219 ± 0.042	2.423GluPro: 2.423 ± 0.05	3.544GluGln: 3.544 ± 0.067	4.947GluArg: 4.947 ± 0.075	3.316GluSer: 3.316 ± 0.066	3.52GluThr: 3.52 ± 0.069	4.297GluVal: 4.297 ± 0.072	0.823GluTrp: 0.823 ± 0.029	1.564GluTyr: 1.564 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.284PheAla: 3.284 ± 0.058	0.472PheCys: 0.472 ± 0.022	2.142PheAsp: 2.142 ± 0.046	2.258PheGlu: 2.258 ± 0.049	1.889PhePhe: 1.889 ± 0.046	2.966PheGly: 2.966 ± 0.068	1.003PheHis: 1.003 ± 0.039	2.444PheIle: 2.444 ± 0.06	1.538PheLys: 1.538 ± 0.05	4.256PheLeu: 4.256 ± 0.079	0.879PheMet: 0.879 ± 0.029	1.512PheAsn: 1.512 ± 0.039	1.941PhePro: 1.941 ± 0.045	1.538PheGln: 1.538 ± 0.04	2.209PheArg: 2.209 ± 0.048	2.773PheSer: 2.773 ± 0.052	2.13PheThr: 2.13 ± 0.045	2.249PheVal: 2.249 ± 0.054	0.652PheTrp: 0.652 ± 0.026	1.314PheTyr: 1.314 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.38GlyAla: 6.38 ± 0.1	0.9GlyCys: 0.9 ± 0.032	3.525GlyAsp: 3.525 ± 0.073	4.967GlyGlu: 4.967 ± 0.089	3.324GlyPhe: 3.324 ± 0.076	6.051GlyGly: 6.051 ± 0.116	1.852GlyHis: 1.852 ± 0.043	5.066GlyIle: 5.066 ± 0.077	3.774GlyLys: 3.774 ± 0.067	8.223GlyLeu: 8.223 ± 0.092	1.955GlyMet: 1.955 ± 0.048	2.4GlyAsn: 2.4 ± 0.051	2.654GlyPro: 2.654 ± 0.049	3.111GlyGln: 3.111 ± 0.054	4.747GlyArg: 4.747 ± 0.071	4.112GlySer: 4.112 ± 0.064	3.865GlyThr: 3.865 ± 0.071	5.335GlyVal: 5.335 ± 0.079	1.332GlyTrp: 1.332 ± 0.041	2.526GlyTyr: 2.526 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.867HisAla: 1.867 ± 0.041	0.348HisCys: 0.348 ± 0.02	1.066HisAsp: 1.066 ± 0.032	1.216HisGlu: 1.216 ± 0.03	1.103HisPhe: 1.103 ± 0.037	1.894HisGly: 1.894 ± 0.045	0.81HisHis: 0.81 ± 0.033	1.337HisIle: 1.337 ± 0.036	0.833HisLys: 0.833 ± 0.03	2.789HisLeu: 2.789 ± 0.055	0.463HisMet: 0.463 ± 0.023	0.72HisAsn: 0.72 ± 0.025	1.668HisPro: 1.668 ± 0.041	1.125HisGln: 1.125 ± 0.032	1.678HisArg: 1.678 ± 0.047	1.381HisSer: 1.381 ± 0.039	1.21HisThr: 1.21 ± 0.037	1.227HisVal: 1.227 ± 0.034	0.49HisTrp: 0.49 ± 0.023	0.969HisTyr: 0.969 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.944IleAla: 5.944 ± 0.089	0.56IleCys: 0.56 ± 0.026	3.137IleAsp: 3.137 ± 0.059	3.922IleGlu: 3.922 ± 0.067	2.232IlePhe: 2.232 ± 0.052	4.488IleGly: 4.488 ± 0.081	1.467IleHis: 1.467 ± 0.041	3.433IleIle: 3.433 ± 0.067	2.547IleLys: 2.547 ± 0.053	6.012IleLeu: 6.012 ± 0.078	1.041IleMet: 1.041 ± 0.031	2.099IleAsn: 2.099 ± 0.045	3.228IlePro: 3.228 ± 0.059	2.381IleGln: 2.381 ± 0.049	3.508IleArg: 3.508 ± 0.061	3.484IleSer: 3.484 ± 0.064	3.151IleThr: 3.151 ± 0.058	3.656IleVal: 3.656 ± 0.077	0.66IleTrp: 0.66 ± 0.028	1.644IleTyr: 1.644 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.221LysAla: 4.221 ± 0.071	0.261LysCys: 0.261 ± 0.017	1.955LysAsp: 1.955 ± 0.042	3.092LysGlu: 3.092 ± 0.061	1.173LysPhe: 1.173 ± 0.036	2.991LysGly: 2.991 ± 0.055	0.927LysHis: 0.927 ± 0.033	2.479LysIle: 2.479 ± 0.05	2.387LysLys: 2.387 ± 0.055	4.059LysLeu: 4.059 ± 0.081	0.911LysMet: 0.911 ± 0.031	1.605LysAsn: 1.605 ± 0.05	2.034LysPro: 2.034 ± 0.046	1.904LysGln: 1.904 ± 0.047	3.022LysArg: 3.022 ± 0.058	2.228LysSer: 2.228 ± 0.048	2.338LysThr: 2.338 ± 0.048	2.805LysVal: 2.805 ± 0.053	0.471LysTrp: 0.471 ± 0.021	0.957LysTyr: 0.957 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	12.184LeuAla: 12.184 ± 0.123	1.039LeuCys: 1.039 ± 0.032	5.424LeuAsp: 5.424 ± 0.089	7.64LeuGlu: 7.64 ± 0.098	4.218LeuPhe: 4.218 ± 0.072	8.531LeuGly: 8.531 ± 0.113	2.417LeuHis: 2.417 ± 0.049	6.137LeuIle: 6.137 ± 0.106	4.693LeuLys: 4.693 ± 0.076	12.9LeuLeu: 12.9 ± 0.162	2.308LeuMet: 2.308 ± 0.052	3.514LeuAsn: 3.514 ± 0.058	6.116LeuPro: 6.116 ± 0.098	4.545LeuGln: 4.545 ± 0.082	7.172LeuArg: 7.172 ± 0.1	7.108LeuSer: 7.108 ± 0.087	5.616LeuThr: 5.616 ± 0.071	7.001LeuVal: 7.001 ± 0.098	1.527LeuTrp: 1.527 ± 0.049	2.772LeuTyr: 2.772 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.567MetAla: 2.567 ± 0.052	0.155MetCys: 0.155 ± 0.012	1.078MetAsp: 1.078 ± 0.036	1.567MetGlu: 1.567 ± 0.036	0.594MetPhe: 0.594 ± 0.028	1.846MetGly: 1.846 ± 0.046	0.411MetHis: 0.411 ± 0.021	1.188MetIle: 1.188 ± 0.034	1.032MetLys: 1.032 ± 0.038	2.203MetLeu: 2.203 ± 0.043	0.515MetMet: 0.515 ± 0.024	0.794MetAsn: 0.794 ± 0.027	1.185MetPro: 1.185 ± 0.035	0.726MetGln: 0.726 ± 0.028	1.326MetArg: 1.326 ± 0.04	1.187MetSer: 1.187 ± 0.031	1.223MetThr: 1.223 ± 0.038	1.55MetVal: 1.55 ± 0.046	0.159MetTrp: 0.159 ± 0.012	0.34MetTyr: 0.34 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.737AsnAla: 2.737 ± 0.058	0.312AsnCys: 0.312 ± 0.019	1.392AsnAsp: 1.392 ± 0.043	1.769AsnGlu: 1.769 ± 0.046	1.356AsnPhe: 1.356 ± 0.043	2.338AsnGly: 2.338 ± 0.079	0.804AsnHis: 0.804 ± 0.025	2.047AsnIle: 2.047 ± 0.045	1.3AsnLys: 1.3 ± 0.038	3.563AsnLeu: 3.563 ± 0.064	0.626AsnMet: 0.626 ± 0.027	1.192AsnAsn: 1.192 ± 0.038	2.16AsnPro: 2.16 ± 0.049	1.425AsnGln: 1.425 ± 0.035	2.218AsnArg: 2.218 ± 0.046	1.717AsnSer: 1.717 ± 0.051	1.681AsnThr: 1.681 ± 0.046	1.721AsnVal: 1.721 ± 0.049	0.472AsnTrp: 0.472 ± 0.022	1.0AsnTyr: 1.0 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	4.334ProAla: 4.334 ± 0.079	0.432ProCys: 0.432 ± 0.023	2.68ProAsp: 2.68 ± 0.058	4.187ProGlu: 4.187 ± 0.07	1.919ProPhe: 1.919 ± 0.047	3.841ProGly: 3.841 ± 0.067	1.118ProHis: 1.118 ± 0.033	2.508ProIle: 2.508 ± 0.053	1.9ProLys: 1.9 ± 0.052	5.597ProLeu: 5.597 ± 0.088	1.041ProMet: 1.041 ± 0.03	1.542ProAsn: 1.542 ± 0.042	2.828ProPro: 2.828 ± 0.06	2.125ProGln: 2.125 ± 0.049	2.733ProArg: 2.733 ± 0.062	2.918ProSer: 2.918 ± 0.052	2.204ProThr: 2.204 ± 0.048	3.577ProVal: 3.577 ± 0.057	0.769ProTrp: 0.769 ± 0.03	1.362ProTyr: 1.362 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.034GlnAla: 5.034 ± 0.086	0.376GlnCys: 0.376 ± 0.022	1.89GlnAsp: 1.89 ± 0.043	3.102GlnGlu: 3.102 ± 0.066	1.497GlnPhe: 1.497 ± 0.039	3.531GlnGly: 3.531 ± 0.063	1.029GlnHis: 1.029 ± 0.033	2.452GlnIle: 2.452 ± 0.051	1.735GlnLys: 1.735 ± 0.051	4.598GlnLeu: 4.598 ± 0.076	0.854GlnMet: 0.854 ± 0.032	1.224GlnAsn: 1.224 ± 0.036	2.035GlnPro: 2.035 ± 0.049	2.633GlnGln: 2.633 ± 0.061	3.44GlnArg: 3.44 ± 0.074	2.172GlnSer: 2.172 ± 0.051	2.013GlnThr: 2.013 ± 0.051	3.362GlnVal: 3.362 ± 0.062	0.711GlnTrp: 0.711 ± 0.029	1.035GlnTyr: 1.035 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.401ArgAla: 5.401 ± 0.082	0.686ArgCys: 0.686 ± 0.026	2.865ArgAsp: 2.865 ± 0.058	4.693ArgGlu: 4.693 ± 0.077	2.866ArgPhe: 2.866 ± 0.058	4.222ArgGly: 4.222 ± 0.067	1.808ArgHis: 1.808 ± 0.044	3.965ArgIle: 3.965 ± 0.066	2.639ArgLys: 2.639 ± 0.059	8.094ArgLeu: 8.094 ± 0.108	1.5ArgMet: 1.5 ± 0.042	2.035ArgAsn: 2.035 ± 0.043	2.699ArgPro: 2.699 ± 0.057	3.524ArgGln: 3.524 ± 0.082	4.882ArgArg: 4.882 ± 0.091	3.246ArgSer: 3.246 ± 0.067	2.818ArgThr: 2.818 ± 0.061	4.301ArgVal: 4.301 ± 0.06	1.156ArgTrp: 1.156 ± 0.035	2.433ArgTyr: 2.433 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.887SerAla: 4.887 ± 0.062	0.586SerCys: 0.586 ± 0.025	2.471SerAsp: 2.471 ± 0.058	3.281SerGlu: 3.281 ± 0.062	2.355SerPhe: 2.355 ± 0.046	4.771SerGly: 4.771 ± 0.088	1.475SerHis: 1.475 ± 0.039	3.095SerIle: 3.095 ± 0.068	2.272SerLys: 2.272 ± 0.046	6.812SerLeu: 6.812 ± 0.082	1.222SerMet: 1.222 ± 0.036	1.767SerAsn: 1.767 ± 0.043	3.066SerPro: 3.066 ± 0.067	2.576SerGln: 2.576 ± 0.051	3.646SerArg: 3.646 ± 0.058	3.627SerSer: 3.627 ± 0.065	2.694SerThr: 2.694 ± 0.054	3.34SerVal: 3.34 ± 0.057	0.877SerTrp: 0.877 ± 0.028	1.667SerTyr: 1.667 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.802ThrAla: 4.802 ± 0.079	0.49ThrCys: 0.49 ± 0.024	2.226ThrAsp: 2.226 ± 0.047	2.86ThrGlu: 2.86 ± 0.052	1.804ThrPhe: 1.804 ± 0.043	4.36ThrGly: 4.36 ± 0.067	1.301ThrHis: 1.301 ± 0.039	2.656ThrIle: 2.656 ± 0.055	1.538ThrLys: 1.538 ± 0.038	6.545ThrLeu: 6.545 ± 0.09	0.952ThrMet: 0.952 ± 0.033	1.302ThrAsn: 1.302 ± 0.042	3.015ThrPro: 3.015 ± 0.059	2.163ThrGln: 2.163 ± 0.05	2.817ThrArg: 2.817 ± 0.058	2.616ThrSer: 2.616 ± 0.053	2.529ThrThr: 2.529 ± 0.056	3.78ThrVal: 3.78 ± 0.059	0.619ThrTrp: 0.619 ± 0.029	1.321ThrTyr: 1.321 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.597ValAla: 6.597 ± 0.096	0.651ValCys: 0.651 ± 0.026	3.456ValAsp: 3.456 ± 0.062	4.289ValGlu: 4.289 ± 0.074	2.695ValPhe: 2.695 ± 0.06	4.742ValGly: 4.742 ± 0.076	1.336ValHis: 1.336 ± 0.039	4.098ValIle: 4.098 ± 0.081	2.51ValLys: 2.51 ± 0.061	7.199ValLeu: 7.199 ± 0.087	1.488ValMet: 1.488 ± 0.038	2.117ValAsn: 2.117 ± 0.046	3.143ValPro: 3.143 ± 0.055	2.276ValGln: 2.276 ± 0.05	4.07ValArg: 4.07 ± 0.077	3.9ValSer: 3.9 ± 0.067	3.601ValThr: 3.601 ± 0.057	4.981ValVal: 4.981 ± 0.087	0.905ValTrp: 0.905 ± 0.031	1.671ValTyr: 1.671 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.127TrpAla: 1.127 ± 0.034	0.155TrpCys: 0.155 ± 0.013	0.64TrpAsp: 0.64 ± 0.023	0.864TrpGlu: 0.864 ± 0.031	0.592TrpPhe: 0.592 ± 0.027	0.991TrpGly: 0.991 ± 0.032	0.417TrpHis: 0.417 ± 0.018	0.789TrpIle: 0.789 ± 0.031	0.549TrpLys: 0.549 ± 0.025	2.153TrpLeu: 2.153 ± 0.055	0.333TrpMet: 0.333 ± 0.019	0.487TrpAsn: 0.487 ± 0.025	0.691TrpPro: 0.691 ± 0.029	0.815TrpGln: 0.815 ± 0.028	1.2TrpArg: 1.2 ± 0.045	0.737TrpSer: 0.737 ± 0.029	0.58TrpThr: 0.58 ± 0.025	1.025TrpVal: 1.025 ± 0.034	0.309TrpTrp: 0.309 ± 0.019	0.388TrpTyr: 0.388 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.291TyrAla: 2.291 ± 0.048	0.365TyrCys: 0.365 ± 0.018	1.353TyrAsp: 1.353 ± 0.037	1.536TyrGlu: 1.536 ± 0.043	1.323TyrPhe: 1.323 ± 0.04	2.329TyrGly: 2.329 ± 0.051	0.878TyrHis: 0.878 ± 0.033	1.316TyrIle: 1.316 ± 0.036	0.911TyrLys: 0.911 ± 0.033	3.546TyrLeu: 3.546 ± 0.065	0.467TyrMet: 0.467 ± 0.023	0.806TyrAsn: 0.806 ± 0.03	1.52TyrPro: 1.52 ± 0.046	1.694TyrGln: 1.694 ± 0.045	2.339TyrArg: 2.339 ± 0.056	1.572TyrSer: 1.572 ± 0.039	1.293TyrThr: 1.293 ± 0.032	1.636TyrVal: 1.636 ± 0.041	0.493TyrTrp: 0.493 ± 0.025	1.028TyrTyr: 1.028 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2995 proteins (987868 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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