Amino acid dipepetide frequency for Legionella oakridgensis ATCC 33761 = DSM 21215

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.494AlaAla: 7.494 ± 0.13
1.193AlaCys: 1.193 ± 0.041
3.702AlaAsp: 3.702 ± 0.068
4.662AlaGlu: 4.662 ± 0.084
3.502AlaPhe: 3.502 ± 0.071
5.536AlaGly: 5.536 ± 0.103
1.988AlaHis: 1.988 ± 0.053
6.426AlaIle: 6.426 ± 0.092
4.69AlaLys: 4.69 ± 0.082
9.714AlaLeu: 9.714 ± 0.106
2.592AlaMet: 2.592 ± 0.058
3.47AlaAsn: 3.47 ± 0.078
2.576AlaPro: 2.576 ± 0.06
3.537AlaGln: 3.537 ± 0.076
3.975AlaArg: 3.975 ± 0.079
5.107AlaSer: 5.107 ± 0.084
4.204AlaThr: 4.204 ± 0.073
5.299AlaVal: 5.299 ± 0.084
0.894AlaTrp: 0.894 ± 0.033
2.68AlaTyr: 2.68 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.852CysAla: 0.852 ± 0.032
0.228CysCys: 0.228 ± 0.018
0.536CysAsp: 0.536 ± 0.027
0.657CysGlu: 0.657 ± 0.036
0.635CysPhe: 0.635 ± 0.028
0.943CysGly: 0.943 ± 0.039
0.4CysHis: 0.4 ± 0.024
0.819CysIle: 0.819 ± 0.034
0.626CysLys: 0.626 ± 0.033
1.351CysLeu: 1.351 ± 0.044
0.322CysMet: 0.322 ± 0.018
0.444CysAsn: 0.444 ± 0.023
0.532CysPro: 0.532 ± 0.028
0.594CysGln: 0.594 ± 0.027
0.638CysArg: 0.638 ± 0.029
0.819CysSer: 0.819 ± 0.033
0.569CysThr: 0.569 ± 0.029
0.727CysVal: 0.727 ± 0.035
0.173CysTrp: 0.173 ± 0.016
0.499CysTyr: 0.499 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.772AspAla: 3.772 ± 0.069
0.611AspCys: 0.611 ± 0.027
2.419AspAsp: 2.419 ± 0.053
3.583AspGlu: 3.583 ± 0.076
2.297AspPhe: 2.297 ± 0.045
2.763AspGly: 2.763 ± 0.062
1.08AspHis: 1.08 ± 0.039
3.718AspIle: 3.718 ± 0.072
3.046AspLys: 3.046 ± 0.074
4.782AspLeu: 4.782 ± 0.073
1.199AspMet: 1.199 ± 0.035
1.934AspAsn: 1.934 ± 0.051
1.837AspPro: 1.837 ± 0.046
1.294AspGln: 1.294 ± 0.042
1.893AspArg: 1.893 ± 0.045
2.581AspSer: 2.581 ± 0.063
2.085AspThr: 2.085 ± 0.052
3.316AspVal: 3.316 ± 0.076
0.684AspTrp: 0.684 ± 0.033
2.044AspTyr: 2.044 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
4.813GluAla: 4.813 ± 0.1
0.531GluCys: 0.531 ± 0.029
2.528GluAsp: 2.528 ± 0.065
4.111GluGlu: 4.111 ± 0.103
2.247GluPhe: 2.247 ± 0.06
2.919GluGly: 2.919 ± 0.07
2.028GluHis: 2.028 ± 0.043
4.013GluIle: 4.013 ± 0.076
4.182GluLys: 4.182 ± 0.09
6.431GluLeu: 6.431 ± 0.095
1.47GluMet: 1.47 ± 0.04
2.387GluAsn: 2.387 ± 0.064
1.956GluPro: 1.956 ± 0.067
3.597GluGln: 3.597 ± 0.079
3.308GluArg: 3.308 ± 0.079
3.073GluSer: 3.073 ± 0.063
3.196GluThr: 3.196 ± 0.068
3.588GluVal: 3.588 ± 0.077
0.59GluTrp: 0.59 ± 0.028
1.669GluTyr: 1.669 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.551PheAla: 3.551 ± 0.074
0.589PheCys: 0.589 ± 0.029
2.283PheAsp: 2.283 ± 0.054
2.095PheGlu: 2.095 ± 0.053
2.295PhePhe: 2.295 ± 0.07
2.572PheGly: 2.572 ± 0.075
1.091PheHis: 1.091 ± 0.041
3.67PheIle: 3.67 ± 0.076
2.274PheLys: 2.274 ± 0.055
4.658PheLeu: 4.658 ± 0.082
1.127PheMet: 1.127 ± 0.038
2.154PheAsn: 2.154 ± 0.056
1.794PhePro: 1.794 ± 0.046
1.47PheGln: 1.47 ± 0.041
1.587PheArg: 1.587 ± 0.047
3.386PheSer: 3.386 ± 0.073
2.435PheThr: 2.435 ± 0.062
2.446PheVal: 2.446 ± 0.057
0.546PheTrp: 0.546 ± 0.029
1.723PheTyr: 1.723 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.443GlyAla: 4.443 ± 0.084
0.88GlyCys: 0.88 ± 0.034
2.705GlyAsp: 2.705 ± 0.063
3.448GlyGlu: 3.448 ± 0.065
3.379GlyPhe: 3.379 ± 0.075
4.171GlyGly: 4.171 ± 0.085
1.741GlyHis: 1.741 ± 0.049
5.064GlyIle: 5.064 ± 0.1
3.833GlyLys: 3.833 ± 0.065
6.774GlyLeu: 6.774 ± 0.1
1.856GlyMet: 1.856 ± 0.05
2.331GlyAsn: 2.331 ± 0.065
1.686GlyPro: 1.686 ± 0.06
2.58GlyGln: 2.58 ± 0.061
2.85GlyArg: 2.85 ± 0.069
3.516GlySer: 3.516 ± 0.077
3.042GlyThr: 3.042 ± 0.054
4.288GlyVal: 4.288 ± 0.079
0.861GlyTrp: 0.861 ± 0.033
2.331GlyTyr: 2.331 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
2.467HisAla: 2.467 ± 0.056
0.495HisCys: 0.495 ± 0.025
1.362HisAsp: 1.362 ± 0.041
1.688HisGlu: 1.688 ± 0.05
1.439HisPhe: 1.439 ± 0.039
1.878HisGly: 1.878 ± 0.049
1.246HisHis: 1.246 ± 0.044
1.622HisIle: 1.622 ± 0.044
1.183HisLys: 1.183 ± 0.035
3.055HisLeu: 3.055 ± 0.063
0.622HisMet: 0.622 ± 0.029
0.866HisAsn: 0.866 ± 0.037
1.412HisPro: 1.412 ± 0.04
1.54HisGln: 1.54 ± 0.044
1.401HisArg: 1.401 ± 0.047
1.55HisSer: 1.55 ± 0.045
1.302HisThr: 1.302 ± 0.041
1.564HisVal: 1.564 ± 0.043
0.486HisTrp: 0.486 ± 0.023
1.285HisTyr: 1.285 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
6.677IleAla: 6.677 ± 0.093
0.836IleCys: 0.836 ± 0.037
3.933IleAsp: 3.933 ± 0.069
4.371IleGlu: 4.371 ± 0.083
2.656IlePhe: 2.656 ± 0.07
4.698IleGly: 4.698 ± 0.085
2.129IleHis: 2.129 ± 0.049
5.305IleIle: 5.305 ± 0.096
4.453IleLys: 4.453 ± 0.076
6.97IleLeu: 6.97 ± 0.109
1.566IleMet: 1.566 ± 0.044
3.571IleAsn: 3.571 ± 0.068
3.385IlePro: 3.385 ± 0.068
2.912IleGln: 2.912 ± 0.06
3.374IleArg: 3.374 ± 0.06
4.644IleSer: 4.644 ± 0.085
3.906IleThr: 3.906 ± 0.071
4.06IleVal: 4.06 ± 0.075
0.666IleTrp: 0.666 ± 0.03
2.254IleTyr: 2.254 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.493LysAla: 4.493 ± 0.079
0.41LysCys: 0.41 ± 0.027
2.526LysAsp: 2.526 ± 0.069
3.965LysGlu: 3.965 ± 0.088
1.499LysPhe: 1.499 ± 0.046
2.872LysGly: 2.872 ± 0.06
1.594LysHis: 1.594 ± 0.041
4.162LysIle: 4.162 ± 0.078
4.065LysLys: 4.065 ± 0.077
5.455LysLeu: 5.455 ± 0.097
1.404LysMet: 1.404 ± 0.039
2.995LysAsn: 2.995 ± 0.071
2.738LysPro: 2.738 ± 0.059
3.485LysGln: 3.485 ± 0.072
3.089LysArg: 3.089 ± 0.066
3.364LysSer: 3.364 ± 0.069
3.47LysThr: 3.47 ± 0.072
2.742LysVal: 2.742 ± 0.062
0.475LysTrp: 0.475 ± 0.024
1.537LysTyr: 1.537 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
9.977LeuAla: 9.977 ± 0.134
1.403LeuCys: 1.403 ± 0.043
5.012LeuAsp: 5.012 ± 0.083
5.525LeuGlu: 5.525 ± 0.096
5.023LeuPhe: 5.023 ± 0.107
6.534LeuGly: 6.534 ± 0.097
2.837LeuHis: 2.837 ± 0.062
7.896LeuIle: 7.896 ± 0.125
6.066LeuLys: 6.066 ± 0.093
12.475LeuLeu: 12.475 ± 0.173
2.858LeuMet: 2.858 ± 0.061
5.106LeuAsn: 5.106 ± 0.087
5.147LeuPro: 5.147 ± 0.078
5.215LeuGln: 5.215 ± 0.093
5.022LeuArg: 5.022 ± 0.081
7.902LeuSer: 7.902 ± 0.102
6.15LeuThr: 6.15 ± 0.089
6.01LeuVal: 6.01 ± 0.086
1.092LeuTrp: 1.092 ± 0.038
3.259LeuTyr: 3.259 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.523MetAla: 2.523 ± 0.053
0.191MetCys: 0.191 ± 0.014
1.266MetAsp: 1.266 ± 0.04
1.379MetGlu: 1.379 ± 0.045
0.814MetPhe: 0.814 ± 0.031
1.456MetGly: 1.456 ± 0.043
0.744MetHis: 0.744 ± 0.031
1.822MetIle: 1.822 ± 0.05
1.497MetLys: 1.497 ± 0.043
2.682MetLeu: 2.682 ± 0.058
0.92MetMet: 0.92 ± 0.038
1.277MetAsn: 1.277 ± 0.042
1.295MetPro: 1.295 ± 0.041
1.384MetGln: 1.384 ± 0.042
1.304MetArg: 1.304 ± 0.045
1.606MetSer: 1.606 ± 0.048
1.57MetThr: 1.57 ± 0.044
1.704MetVal: 1.704 ± 0.049
0.204MetTrp: 0.204 ± 0.016
0.572MetTyr: 0.572 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.331AsnAla: 3.331 ± 0.073
0.453AsnCys: 0.453 ± 0.023
2.104AsnAsp: 2.104 ± 0.051
2.415AsnGlu: 2.415 ± 0.057
1.633AsnPhe: 1.633 ± 0.05
2.322AsnGly: 2.322 ± 0.059
1.47AsnHis: 1.47 ± 0.04
3.058AsnIle: 3.058 ± 0.073
2.633AsnLys: 2.633 ± 0.062
4.18AsnLeu: 4.18 ± 0.079
0.97AsnMet: 0.97 ± 0.036
2.153AsnAsn: 2.153 ± 0.069
2.301AsnPro: 2.301 ± 0.057
2.445AsnGln: 2.445 ± 0.07
2.02AsnArg: 2.02 ± 0.046
2.389AsnSer: 2.389 ± 0.064
2.215AsnThr: 2.215 ± 0.057
2.363AsnVal: 2.363 ± 0.059
0.521AsnTrp: 0.521 ± 0.029
1.658AsnTyr: 1.658 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.266ProAla: 3.266 ± 0.064
0.496ProCys: 0.496 ± 0.028
2.143ProAsp: 2.143 ± 0.053
3.063ProGlu: 3.063 ± 0.074
1.847ProPhe: 1.847 ± 0.053
2.696ProGly: 2.696 ± 0.062
0.996ProHis: 0.996 ± 0.035
2.764ProIle: 2.764 ± 0.058
2.112ProLys: 2.112 ± 0.046
4.578ProLeu: 4.578 ± 0.076
1.138ProMet: 1.138 ± 0.04
1.59ProAsn: 1.59 ± 0.047
1.592ProPro: 1.592 ± 0.053
1.785ProGln: 1.785 ± 0.061
1.553ProArg: 1.553 ± 0.042
2.585ProSer: 2.585 ± 0.059
2.091ProThr: 2.091 ± 0.054
3.186ProVal: 3.186 ± 0.059
0.565ProTrp: 0.565 ± 0.031
1.451ProTyr: 1.451 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
4.558GlnAla: 4.558 ± 0.092
0.52GlnCys: 0.52 ± 0.029
1.97GlnAsp: 1.97 ± 0.059
2.886GlnGlu: 2.886 ± 0.064
2.071GlnPhe: 2.071 ± 0.048
3.042GlnGly: 3.042 ± 0.09
1.477GlnHis: 1.477 ± 0.044
2.831GlnIle: 2.831 ± 0.057
2.539GlnLys: 2.539 ± 0.054
5.416GlnLeu: 5.416 ± 0.096
1.127GlnMet: 1.127 ± 0.041
1.697GlnAsn: 1.697 ± 0.056
1.759GlnPro: 1.759 ± 0.047
3.272GlnGln: 3.272 ± 0.081
2.458GlnArg: 2.458 ± 0.06
2.693GlnSer: 2.693 ± 0.059
2.389GlnThr: 2.389 ± 0.058
2.765GlnVal: 2.765 ± 0.061
0.704GlnTrp: 0.704 ± 0.03
1.696GlnTyr: 1.696 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
3.474ArgAla: 3.474 ± 0.077
0.565ArgCys: 0.565 ± 0.027
2.284ArgAsp: 2.284 ± 0.066
3.018ArgGlu: 3.018 ± 0.062
2.344ArgPhe: 2.344 ± 0.05
2.559ArgGly: 2.559 ± 0.057
1.559ArgHis: 1.559 ± 0.044
3.373ArgIle: 3.373 ± 0.069
2.483ArgLys: 2.483 ± 0.06
5.817ArgLeu: 5.817 ± 0.092
1.271ArgMet: 1.271 ± 0.035
1.812ArgAsn: 1.812 ± 0.049
1.668ArgPro: 1.668 ± 0.046
2.551ArgGln: 2.551 ± 0.056
2.487ArgArg: 2.487 ± 0.065
2.332ArgSer: 2.332 ± 0.058
2.259ArgThr: 2.259 ± 0.055
2.838ArgVal: 2.838 ± 0.055
0.651ArgTrp: 0.651 ± 0.028
1.921ArgTyr: 1.921 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.753SerAla: 4.753 ± 0.092
0.818SerCys: 0.818 ± 0.035
2.687SerAsp: 2.687 ± 0.061
3.301SerGlu: 3.301 ± 0.069
2.817SerPhe: 2.817 ± 0.068
4.37SerGly: 4.37 ± 0.079
1.744SerHis: 1.744 ± 0.05
4.272SerIle: 4.272 ± 0.073
3.062SerLys: 3.062 ± 0.07
7.395SerLeu: 7.395 ± 0.087
1.772SerMet: 1.772 ± 0.038
2.427SerAsn: 2.427 ± 0.055
2.766SerPro: 2.766 ± 0.062
2.915SerGln: 2.915 ± 0.068
2.784SerArg: 2.784 ± 0.05
4.155SerSer: 4.155 ± 0.09
2.967SerThr: 2.967 ± 0.071
3.65SerVal: 3.65 ± 0.072
0.747SerTrp: 0.747 ± 0.033
2.1SerTyr: 2.1 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.496ThrAla: 4.496 ± 0.072
0.654ThrCys: 0.654 ± 0.031
2.191ThrAsp: 2.191 ± 0.055
2.713ThrGlu: 2.713 ± 0.061
2.035ThrPhe: 2.035 ± 0.052
3.682ThrGly: 3.682 ± 0.077
1.438ThrHis: 1.438 ± 0.038
4.01ThrIle: 4.01 ± 0.071
2.297ThrLys: 2.297 ± 0.057
6.238ThrLeu: 6.238 ± 0.084
1.336ThrMet: 1.336 ± 0.044
2.112ThrAsn: 2.112 ± 0.067
2.596ThrPro: 2.596 ± 0.061
2.22ThrGln: 2.22 ± 0.052
2.372ThrArg: 2.372 ± 0.058
3.088ThrSer: 3.088 ± 0.067
3.008ThrThr: 3.008 ± 0.071
3.343ThrVal: 3.343 ± 0.077
0.567ThrTrp: 0.567 ± 0.033
1.702ThrTyr: 1.702 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
5.013ValAla: 5.013 ± 0.086
0.833ValCys: 0.833 ± 0.03
3.186ValAsp: 3.186 ± 0.066
3.389ValGlu: 3.389 ± 0.08
2.859ValPhe: 2.859 ± 0.062
3.759ValGly: 3.759 ± 0.08
1.42ValHis: 1.42 ± 0.046
4.867ValIle: 4.867 ± 0.091
3.259ValLys: 3.259 ± 0.077
6.667ValLeu: 6.667 ± 0.1
1.645ValMet: 1.645 ± 0.048
2.577ValAsn: 2.577 ± 0.057
2.415ValPro: 2.415 ± 0.058
2.003ValGln: 2.003 ± 0.063
2.676ValArg: 2.676 ± 0.06
4.004ValSer: 4.004 ± 0.067
3.197ValThr: 3.197 ± 0.064
4.151ValVal: 4.151 ± 0.086
0.657ValTrp: 0.657 ± 0.028
2.002ValTyr: 2.002 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.746TrpAla: 0.746 ± 0.029
0.15TrpCys: 0.15 ± 0.013
0.468TrpAsp: 0.468 ± 0.025
0.542TrpGlu: 0.542 ± 0.028
0.573TrpPhe: 0.573 ± 0.028
0.732TrpGly: 0.732 ± 0.035
0.397TrpHis: 0.397 ± 0.023
0.758TrpIle: 0.758 ± 0.034
0.465TrpLys: 0.465 ± 0.021
1.728TrpLeu: 1.728 ± 0.053
0.328TrpMet: 0.328 ± 0.021
0.474TrpAsn: 0.474 ± 0.023
0.492TrpPro: 0.492 ± 0.025
0.862TrpGln: 0.862 ± 0.036
0.625TrpArg: 0.625 ± 0.027
0.674TrpSer: 0.674 ± 0.03
0.452TrpThr: 0.452 ± 0.023
0.742TrpVal: 0.742 ± 0.032
0.158TrpTrp: 0.158 ± 0.014
0.397TrpTyr: 0.397 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.544TyrAla: 2.544 ± 0.055
0.51TyrCys: 0.51 ± 0.026
1.634TyrAsp: 1.634 ± 0.045
1.824TyrGlu: 1.824 ± 0.05
1.778TyrPhe: 1.778 ± 0.054
2.275TyrGly: 2.275 ± 0.05
1.084TyrHis: 1.084 ± 0.04
1.918TyrIle: 1.918 ± 0.049
1.577TyrLys: 1.577 ± 0.048
4.141TyrLeu: 4.141 ± 0.071
0.685TyrMet: 0.685 ± 0.03
1.257TyrAsn: 1.257 ± 0.045
1.549TyrPro: 1.549 ± 0.046
2.211TyrGln: 2.211 ± 0.053
1.85TyrArg: 1.85 ± 0.046
2.033TyrSer: 2.033 ± 0.052
1.592TyrThr: 1.592 ± 0.048
1.796TyrVal: 1.796 ± 0.048
0.522TyrTrp: 0.522 ± 0.026
1.426TyrTyr: 1.426 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2907 proteins (808281 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski