Amino acid dipepetide frequency for Bovine leukemia virus (BLV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.843AlaAla: 6.843 ± 1.658
1.19AlaCys: 1.19 ± 0.402
3.868AlaAsp: 3.868 ± 0.729
3.57AlaGlu: 3.57 ± 1.132
1.785AlaPhe: 1.785 ± 0.705
3.868AlaGly: 3.868 ± 0.869
2.38AlaHis: 2.38 ± 0.53
5.951AlaIle: 5.951 ± 0.757
0.893AlaLys: 0.893 ± 0.382
10.414AlaLeu: 10.414 ± 2.344
0.298AlaMet: 0.298 ± 0.293
3.57AlaAsn: 3.57 ± 0.924
10.414AlaPro: 10.414 ± 1.994
3.273AlaGln: 3.273 ± 0.353
3.57AlaArg: 3.57 ± 1.208
7.141AlaSer: 7.141 ± 0.636
2.678AlaThr: 2.678 ± 0.82
2.678AlaVal: 2.678 ± 0.593
3.273AlaTrp: 3.273 ± 0.395
0.893AlaTyr: 0.893 ± 0.582
0.0AlaXaa: 0.0 ± 0.0
Cys
1.19CysAla: 1.19 ± 0.341
0.298CysCys: 0.298 ± 0.293
0.0CysAsp: 0.0 ± 0.0
0.893CysGlu: 0.893 ± 0.364
0.298CysPhe: 0.298 ± 0.293
0.298CysGly: 0.298 ± 0.333
0.298CysHis: 0.298 ± 0.293
0.298CysIle: 0.298 ± 0.333
0.893CysLys: 0.893 ± 0.34
2.975CysLeu: 2.975 ± 0.519
0.298CysMet: 0.298 ± 0.481
0.298CysAsn: 0.298 ± 0.194
6.843CysPro: 6.843 ± 2.124
3.273CysGln: 3.273 ± 0.395
0.298CysArg: 0.298 ± 0.333
0.595CysSer: 0.595 ± 0.58
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.298CysTrp: 0.298 ± 0.293
1.19CysTyr: 1.19 ± 0.33
0.0CysXaa: 0.0 ± 0.0
Asp
1.785AspAla: 1.785 ± 0.331
2.38AspCys: 2.38 ± 1.051
1.19AspAsp: 1.19 ± 0.903
1.19AspGlu: 1.19 ± 0.33
1.785AspPhe: 1.785 ± 0.437
2.678AspGly: 2.678 ± 0.725
0.595AspHis: 0.595 ± 0.28
1.488AspIle: 1.488 ± 0.421
0.893AspLys: 0.893 ± 0.363
5.653AspLeu: 5.653 ± 0.517
0.0AspMet: 0.0 ± 0.0
1.785AspAsn: 1.785 ± 0.295
5.058AspPro: 5.058 ± 0.492
2.38AspGln: 2.38 ± 0.65
0.595AspArg: 0.595 ± 0.328
2.678AspSer: 2.678 ± 1.018
2.678AspThr: 2.678 ± 1.239
0.893AspVal: 0.893 ± 0.379
1.785AspTrp: 1.785 ± 0.796
1.19AspTyr: 1.19 ± 0.522
0.0AspXaa: 0.0 ± 0.0
Glu
2.975GluAla: 2.975 ± 0.519
1.488GluCys: 1.488 ± 0.572
0.893GluAsp: 0.893 ± 0.582
1.785GluGlu: 1.785 ± 0.566
1.19GluPhe: 1.19 ± 0.402
4.463GluGly: 4.463 ± 1.416
0.893GluHis: 0.893 ± 0.453
2.083GluIle: 2.083 ± 1.072
0.298GluLys: 0.298 ± 0.194
3.273GluLeu: 3.273 ± 0.785
0.0GluMet: 0.0 ± 0.0
1.785GluAsn: 1.785 ± 0.559
3.868GluPro: 3.868 ± 0.694
3.57GluGln: 3.57 ± 0.494
2.083GluArg: 2.083 ± 0.803
1.19GluSer: 1.19 ± 0.33
2.38GluThr: 2.38 ± 0.587
2.38GluVal: 2.38 ± 0.849
0.298GluTrp: 0.298 ± 0.333
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.19PheAla: 1.19 ± 0.59
0.893PheCys: 0.893 ± 0.513
1.19PheAsp: 1.19 ± 0.363
1.19PheGlu: 1.19 ± 0.954
0.595PhePhe: 0.595 ± 0.451
1.785PheGly: 1.785 ± 0.231
1.19PheHis: 1.19 ± 0.529
0.893PheIle: 0.893 ± 0.363
0.298PheLys: 0.298 ± 0.194
2.975PheLeu: 2.975 ± 1.359
0.298PheMet: 0.298 ± 0.293
1.488PheAsn: 1.488 ± 0.538
4.165PhePro: 4.165 ± 1.181
2.083PheGln: 2.083 ± 0.831
0.595PheArg: 0.595 ± 0.451
2.083PheSer: 2.083 ± 0.738
2.678PheThr: 2.678 ± 0.509
2.38PheVal: 2.38 ± 0.599
0.298PheTrp: 0.298 ± 0.293
0.298PheTyr: 0.298 ± 0.293
0.0PheXaa: 0.0 ± 0.0
Gly
6.248GlyAla: 6.248 ± 0.787
0.595GlyCys: 0.595 ± 0.328
1.488GlyAsp: 1.488 ± 0.253
0.893GlyGlu: 0.893 ± 0.424
1.785GlyPhe: 1.785 ± 0.295
3.868GlyGly: 3.868 ± 1.023
1.488GlyHis: 1.488 ± 0.337
2.678GlyIle: 2.678 ± 0.592
1.785GlyLys: 1.785 ± 0.583
6.843GlyLeu: 6.843 ± 1.041
0.298GlyMet: 0.298 ± 0.187
2.678GlyAsn: 2.678 ± 0.569
12.496GlyPro: 12.496 ± 2.528
1.488GlyGln: 1.488 ± 0.421
3.57GlyArg: 3.57 ± 0.574
2.678GlySer: 2.678 ± 0.88
2.38GlyThr: 2.38 ± 0.899
2.083GlyVal: 2.083 ± 0.853
0.893GlyTrp: 0.893 ± 0.364
0.893GlyTyr: 0.893 ± 0.539
0.0GlyXaa: 0.0 ± 0.0
His
0.595HisAla: 0.595 ± 0.328
0.595HisCys: 0.595 ± 0.451
0.595HisAsp: 0.595 ± 0.328
0.298HisGlu: 0.298 ± 0.333
0.893HisPhe: 0.893 ± 0.782
0.595HisGly: 0.595 ± 0.425
0.893HisHis: 0.893 ± 0.382
1.19HisIle: 1.19 ± 0.495
1.488HisLys: 1.488 ± 0.253
2.975HisLeu: 2.975 ± 1.041
0.893HisMet: 0.893 ± 0.34
1.785HisAsn: 1.785 ± 0.895
1.19HisPro: 1.19 ± 0.399
0.893HisGln: 0.893 ± 0.539
1.785HisArg: 1.785 ± 0.376
1.19HisSer: 1.19 ± 0.399
0.893HisThr: 0.893 ± 0.34
1.785HisVal: 1.785 ± 0.674
3.273HisTrp: 3.273 ± 1.14
0.595HisTyr: 0.595 ± 0.28
0.0HisXaa: 0.0 ± 0.0
Ile
2.678IleAla: 2.678 ± 0.73
1.785IleCys: 1.785 ± 0.231
2.38IleAsp: 2.38 ± 0.834
1.785IleGlu: 1.785 ± 0.566
0.893IlePhe: 0.893 ± 0.539
0.893IleGly: 0.893 ± 0.379
1.488IleHis: 1.488 ± 0.538
3.57IleIle: 3.57 ± 0.444
1.785IleLys: 1.785 ± 0.496
7.141IleLeu: 7.141 ± 1.078
0.0IleMet: 0.0 ± 0.0
2.083IleAsn: 2.083 ± 1.062
3.868IlePro: 3.868 ± 1.298
2.975IleGln: 2.975 ± 0.449
1.488IleArg: 1.488 ± 1.092
6.546IleSer: 6.546 ± 1.072
2.678IleThr: 2.678 ± 0.485
1.488IleVal: 1.488 ± 0.421
0.893IleTrp: 0.893 ± 0.382
0.595IleTyr: 0.595 ± 0.586
0.0IleXaa: 0.0 ± 0.0
Lys
1.19LysAla: 1.19 ± 0.33
0.595LysCys: 0.595 ± 0.28
0.893LysAsp: 0.893 ± 0.392
4.165LysGlu: 4.165 ± 1.256
1.19LysPhe: 1.19 ± 0.341
1.785LysGly: 1.785 ± 1.003
0.0LysHis: 0.0 ± 0.0
1.19LysIle: 1.19 ± 0.522
2.678LysLys: 2.678 ± 0.86
3.868LysLeu: 3.868 ± 0.699
1.19LysMet: 1.19 ± 0.33
2.38LysAsn: 2.38 ± 0.827
2.975LysPro: 2.975 ± 0.519
1.488LysGln: 1.488 ± 0.253
2.083LysArg: 2.083 ± 0.641
0.595LysSer: 0.595 ± 0.292
3.57LysThr: 3.57 ± 0.804
1.19LysVal: 1.19 ± 0.402
0.595LysTrp: 0.595 ± 0.307
1.19LysTyr: 1.19 ± 0.776
0.0LysXaa: 0.0 ± 0.0
Leu
8.331LeuAla: 8.331 ± 0.941
2.678LeuCys: 2.678 ± 0.506
2.975LeuAsp: 2.975 ± 0.569
4.76LeuGlu: 4.76 ± 0.851
3.868LeuPhe: 3.868 ± 1.682
5.356LeuGly: 5.356 ± 1.194
2.678LeuHis: 2.678 ± 1.251
2.975LeuIle: 2.975 ± 0.978
5.356LeuLys: 5.356 ± 0.722
12.496LeuLeu: 12.496 ± 3.599
0.595LeuMet: 0.595 ± 0.307
5.951LeuAsn: 5.951 ± 0.531
9.521LeuPro: 9.521 ± 1.434
12.794LeuGln: 12.794 ± 2.632
6.843LeuArg: 6.843 ± 0.641
12.199LeuSer: 12.199 ± 1.529
8.033LeuThr: 8.033 ± 1.52
8.331LeuVal: 8.331 ± 1.02
2.083LeuTrp: 2.083 ± 0.494
1.785LeuTyr: 1.785 ± 0.705
0.0LeuXaa: 0.0 ± 0.0
Met
0.595MetAla: 0.595 ± 0.665
0.0MetCys: 0.0 ± 0.0
0.595MetAsp: 0.595 ± 0.451
0.298MetGlu: 0.298 ± 0.481
0.0MetPhe: 0.0 ± 0.0
0.893MetGly: 0.893 ± 0.34
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
0.595MetLeu: 0.595 ± 0.307
0.298MetMet: 0.298 ± 0.481
0.298MetAsn: 0.298 ± 0.481
2.083MetPro: 2.083 ± 1.433
0.0MetGln: 0.0 ± 0.0
0.298MetArg: 0.298 ± 0.194
0.595MetSer: 0.595 ± 0.962
1.785MetThr: 1.785 ± 0.295
1.19MetVal: 1.19 ± 0.3
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.273AsnAla: 3.273 ± 0.511
0.595AsnCys: 0.595 ± 0.64
2.083AsnAsp: 2.083 ± 0.489
1.785AsnGlu: 1.785 ± 0.231
0.298AsnPhe: 0.298 ± 0.333
2.083AsnGly: 2.083 ± 0.189
0.595AsnHis: 0.595 ± 0.28
0.298AsnIle: 0.298 ± 0.194
2.083AsnLys: 2.083 ± 0.615
5.653AsnLeu: 5.653 ± 0.824
0.298AsnMet: 0.298 ± 0.409
1.19AsnAsn: 1.19 ± 0.572
4.76AsnPro: 4.76 ± 1.327
3.273AsnGln: 3.273 ± 1.156
4.165AsnArg: 4.165 ± 1.014
2.083AsnSer: 2.083 ± 0.374
2.38AsnThr: 2.38 ± 0.488
1.19AsnVal: 1.19 ± 0.915
1.785AsnTrp: 1.785 ± 0.538
1.488AsnTyr: 1.488 ± 0.421
0.0AsnXaa: 0.0 ± 0.0
Pro
11.009ProAla: 11.009 ± 2.275
2.678ProCys: 2.678 ± 0.851
3.868ProAsp: 3.868 ± 1.516
5.356ProGlu: 5.356 ± 1.168
3.273ProPhe: 3.273 ± 1.882
9.521ProGly: 9.521 ± 1.889
2.083ProHis: 2.083 ± 0.738
6.843ProIle: 6.843 ± 0.21
6.843ProLys: 6.843 ± 1.003
9.521ProLeu: 9.521 ± 1.943
2.083ProMet: 2.083 ± 1.317
2.083ProAsn: 2.083 ± 0.494
15.174ProPro: 15.174 ± 2.199
6.248ProGln: 6.248 ± 0.789
6.248ProArg: 6.248 ± 1.274
10.414ProSer: 10.414 ± 2.447
7.141ProThr: 7.141 ± 1.157
5.356ProVal: 5.356 ± 0.903
4.76ProTrp: 4.76 ± 0.248
2.083ProTyr: 2.083 ± 0.514
0.0ProXaa: 0.0 ± 0.0
Gln
7.736GlnAla: 7.736 ± 1.28
0.893GlnCys: 0.893 ± 0.364
1.488GlnAsp: 1.488 ± 0.253
1.19GlnGlu: 1.19 ± 0.537
2.083GlnPhe: 2.083 ± 0.764
5.951GlnGly: 5.951 ± 0.694
0.0GlnHis: 0.0 ± 0.0
5.356GlnIle: 5.356 ± 0.945
2.38GlnLys: 2.38 ± 0.659
3.57GlnLeu: 3.57 ± 0.851
0.893GlnMet: 0.893 ± 0.424
3.868GlnAsn: 3.868 ± 0.917
8.033GlnPro: 8.033 ± 1.066
2.678GlnGln: 2.678 ± 0.569
3.273GlnArg: 3.273 ± 0.819
3.57GlnSer: 3.57 ± 0.303
4.463GlnThr: 4.463 ± 0.47
1.785GlnVal: 1.785 ± 0.459
1.19GlnTrp: 1.19 ± 0.559
2.083GlnTyr: 2.083 ± 0.641
0.0GlnXaa: 0.0 ± 0.0
Arg
3.868ArgAla: 3.868 ± 0.957
1.488ArgCys: 1.488 ± 0.538
2.975ArgAsp: 2.975 ± 0.787
1.19ArgGlu: 1.19 ± 0.341
2.38ArgPhe: 2.38 ± 0.847
2.678ArgGly: 2.678 ± 0.475
1.19ArgHis: 1.19 ± 0.33
1.785ArgIle: 1.785 ± 0.545
0.298ArgLys: 0.298 ± 0.194
8.926ArgLeu: 8.926 ± 1.755
0.0ArgMet: 0.0 ± 0.0
1.488ArgAsn: 1.488 ± 0.572
7.438ArgPro: 7.438 ± 2.618
2.975ArgGln: 2.975 ± 0.56
4.165ArgArg: 4.165 ± 2.359
5.951ArgSer: 5.951 ± 0.956
0.893ArgThr: 0.893 ± 0.582
2.083ArgVal: 2.083 ± 0.411
1.488ArgTrp: 1.488 ± 0.586
1.488ArgTyr: 1.488 ± 0.288
0.0ArgXaa: 0.0 ± 0.0
Ser
6.248SerAla: 6.248 ± 0.392
0.893SerCys: 0.893 ± 0.34
3.57SerAsp: 3.57 ± 0.303
3.57SerGlu: 3.57 ± 1.145
1.19SerPhe: 1.19 ± 0.522
3.868SerGly: 3.868 ± 0.687
2.678SerHis: 2.678 ± 0.592
2.678SerIle: 2.678 ± 0.936
1.488SerLys: 1.488 ± 0.621
9.521SerLeu: 9.521 ± 1.601
0.595SerMet: 0.595 ± 0.962
2.083SerAsn: 2.083 ± 0.652
12.199SerPro: 12.199 ± 3.101
4.463SerGln: 4.463 ± 0.826
4.463SerArg: 4.463 ± 0.727
4.463SerSer: 4.463 ± 2.031
2.678SerThr: 2.678 ± 1.018
3.57SerVal: 3.57 ± 1.209
0.595SerTrp: 0.595 ± 0.425
3.868SerTyr: 3.868 ± 1.052
0.0SerXaa: 0.0 ± 0.0
Thr
3.868ThrAla: 3.868 ± 1.099
0.893ThrCys: 0.893 ± 0.631
2.38ThrAsp: 2.38 ± 0.465
0.298ThrGlu: 0.298 ± 0.194
2.083ThrPhe: 2.083 ± 0.44
2.678ThrGly: 2.678 ± 0.323
2.38ThrHis: 2.38 ± 0.896
3.273ThrIle: 3.273 ± 0.493
1.488ThrLys: 1.488 ± 0.253
9.819ThrLeu: 9.819 ± 1.294
0.298ThrMet: 0.298 ± 0.373
1.19ThrAsn: 1.19 ± 0.612
5.058ThrPro: 5.058 ± 1.112
2.975ThrGln: 2.975 ± 0.56
3.868ThrArg: 3.868 ± 0.699
3.868ThrSer: 3.868 ± 0.447
2.678ThrThr: 2.678 ± 0.491
2.083ThrVal: 2.083 ± 0.883
1.488ThrTrp: 1.488 ± 0.767
1.488ThrTyr: 1.488 ± 0.641
0.0ThrXaa: 0.0 ± 0.0
Val
3.57ValAla: 3.57 ± 0.92
0.0ValCys: 0.0 ± 0.0
3.273ValAsp: 3.273 ± 0.857
1.785ValGlu: 1.785 ± 0.566
1.19ValPhe: 1.19 ± 0.572
2.975ValGly: 2.975 ± 0.486
2.38ValHis: 2.38 ± 0.913
0.298ValIle: 0.298 ± 0.194
0.893ValLys: 0.893 ± 0.34
7.141ValLeu: 7.141 ± 1.014
0.0ValMet: 0.0 ± 0.0
2.083ValAsn: 2.083 ± 1.072
5.356ValPro: 5.356 ± 0.911
2.083ValGln: 2.083 ± 0.641
3.273ValArg: 3.273 ± 0.636
3.868ValSer: 3.868 ± 1.245
2.083ValThr: 2.083 ± 0.856
0.595ValVal: 0.595 ± 0.425
1.488ValTrp: 1.488 ± 0.337
0.893ValTyr: 0.893 ± 0.312
0.0ValXaa: 0.0 ± 0.0
Trp
3.57TrpAla: 3.57 ± 0.829
0.298TrpCys: 0.298 ± 0.333
1.19TrpAsp: 1.19 ± 0.559
0.893TrpGlu: 0.893 ± 0.539
1.19TrpPhe: 1.19 ± 0.529
0.893TrpGly: 0.893 ± 0.364
0.595TrpHis: 0.595 ± 0.28
1.488TrpIle: 1.488 ± 0.337
1.785TrpLys: 1.785 ± 0.541
4.76TrpLeu: 4.76 ± 1.126
0.298TrpMet: 0.298 ± 0.293
0.595TrpAsn: 0.595 ± 0.425
1.19TrpPro: 1.19 ± 0.559
1.488TrpGln: 1.488 ± 0.393
1.19TrpArg: 1.19 ± 0.537
1.785TrpSer: 1.785 ± 0.958
1.488TrpThr: 1.488 ± 0.337
2.083TrpVal: 2.083 ± 1.081
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.785TyrAla: 1.785 ± 0.566
0.298TyrCys: 0.298 ± 0.194
1.785TyrAsp: 1.785 ± 0.551
0.0TyrGlu: 0.0 ± 0.0
0.595TyrPhe: 0.595 ± 0.388
0.0TyrGly: 0.0 ± 0.0
0.595TyrHis: 0.595 ± 0.388
2.678TyrIle: 2.678 ± 0.569
1.19TyrLys: 1.19 ± 0.776
1.488TyrLeu: 1.488 ± 0.461
0.595TyrMet: 0.595 ± 0.451
2.975TyrAsn: 2.975 ± 0.622
0.893TyrPro: 0.893 ± 0.312
2.083TyrGln: 2.083 ± 0.189
0.893TyrArg: 0.893 ± 0.34
1.19TyrSer: 1.19 ± 0.537
0.595TyrThr: 0.595 ± 0.28
2.083TyrVal: 2.083 ± 0.411
0.298TyrTrp: 0.298 ± 0.293
0.298TyrTyr: 0.298 ± 0.194
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (3362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski