Amino acid dipepetide frequency for Verrucomicrobiae bacterium DG1235

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.004AlaAla: 9.004 ± 0.102	0.946AlaCys: 0.946 ± 0.023	4.826AlaAsp: 4.826 ± 0.078	5.927AlaGlu: 5.927 ± 0.079	4.201AlaPhe: 4.201 ± 0.062	6.708AlaGly: 6.708 ± 0.098	1.509AlaHis: 1.509 ± 0.035	5.713AlaIle: 5.713 ± 0.067	4.625AlaLys: 4.625 ± 0.069	9.364AlaLeu: 9.364 ± 0.104	2.046AlaMet: 2.046 ± 0.039	3.501AlaAsn: 3.501 ± 0.056	3.39AlaPro: 3.39 ± 0.047	2.956AlaGln: 2.956 ± 0.048	4.78AlaArg: 4.78 ± 0.062	6.447AlaSer: 6.447 ± 0.081	4.989AlaThr: 4.989 ± 0.119	5.535AlaVal: 5.535 ± 0.063	1.186AlaTrp: 1.186 ± 0.033	2.61AlaTyr: 2.61 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.673CysAla: 0.673 ± 0.02	0.145CysCys: 0.145 ± 0.009	0.494CysAsp: 0.494 ± 0.016	0.61CysGlu: 0.61 ± 0.022	0.422CysPhe: 0.422 ± 0.019	0.852CysGly: 0.852 ± 0.025	0.284CysHis: 0.284 ± 0.017	0.533CysIle: 0.533 ± 0.021	0.332CysLys: 0.332 ± 0.014	1.006CysLeu: 1.006 ± 0.026	0.17CysMet: 0.17 ± 0.011	0.241CysAsn: 0.241 ± 0.014	0.454CysPro: 0.454 ± 0.02	0.299CysGln: 0.299 ± 0.015	0.543CysArg: 0.543 ± 0.02	0.701CysSer: 0.701 ± 0.019	0.306CysThr: 0.306 ± 0.015	0.587CysVal: 0.587 ± 0.022	0.131CysTrp: 0.131 ± 0.009	0.257CysTyr: 0.257 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.145AspAla: 5.145 ± 0.108	0.531AspCys: 0.531 ± 0.019	3.099AspAsp: 3.099 ± 0.066	4.203AspGlu: 4.203 ± 0.059	3.01AspPhe: 3.01 ± 0.047	5.137AspGly: 5.137 ± 0.109	1.067AspHis: 1.067 ± 0.024	3.185AspIle: 3.185 ± 0.065	2.088AspLys: 2.088 ± 0.039	6.19AspLeu: 6.19 ± 0.069	1.039AspMet: 1.039 ± 0.024	1.686AspAsn: 1.686 ± 0.039	3.263AspPro: 3.263 ± 0.053	1.941AspGln: 1.941 ± 0.037	3.245AspArg: 3.245 ± 0.045	4.106AspSer: 4.106 ± 0.065	3.206AspThr: 3.206 ± 0.094	3.473AspVal: 3.473 ± 0.071	1.212AspTrp: 1.212 ± 0.026	1.99AspTyr: 1.99 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.58GluAla: 6.58 ± 0.076	0.413GluCys: 0.413 ± 0.019	3.783GluAsp: 3.783 ± 0.056	5.185GluGlu: 5.185 ± 0.085	2.634GluPhe: 2.634 ± 0.047	4.889GluGly: 4.889 ± 0.067	1.244GluHis: 1.244 ± 0.034	4.547GluIle: 4.547 ± 0.062	3.736GluLys: 3.736 ± 0.073	7.496GluLeu: 7.496 ± 0.073	1.646GluMet: 1.646 ± 0.035	3.002GluAsn: 3.002 ± 0.05	2.532GluPro: 2.532 ± 0.047	2.353GluGln: 2.353 ± 0.041	4.39GluArg: 4.39 ± 0.064	4.928GluSer: 4.928 ± 0.066	3.973GluThr: 3.973 ± 0.054	4.48GluVal: 4.48 ± 0.065	0.949GluTrp: 0.949 ± 0.029	1.863GluTyr: 1.863 ± 0.035	0.001GluXaa: 0.001 ± 0.001
Phe	4.09PheAla: 4.09 ± 0.058	0.496PheCys: 0.496 ± 0.019	3.035PheAsp: 3.035 ± 0.043	3.336PheGlu: 3.336 ± 0.056	1.99PhePhe: 1.99 ± 0.045	3.823PheGly: 3.823 ± 0.059	0.837PheHis: 0.837 ± 0.023	2.1PheIle: 2.1 ± 0.044	1.725PheLys: 1.725 ± 0.035	4.163PheLeu: 4.163 ± 0.056	0.821PheMet: 0.821 ± 0.022	1.616PheAsn: 1.616 ± 0.03	1.749PhePro: 1.749 ± 0.035	1.384PheGln: 1.384 ± 0.031	2.297PheArg: 2.297 ± 0.039	3.48PheSer: 3.48 ± 0.056	2.375PheThr: 2.375 ± 0.055	2.966PheVal: 2.966 ± 0.045	0.71PheTrp: 0.71 ± 0.022	1.296PheTyr: 1.296 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.952GlyAla: 5.952 ± 0.079	0.731GlyCys: 0.731 ± 0.024	4.562GlyAsp: 4.562 ± 0.096	5.304GlyGlu: 5.304 ± 0.069	3.675GlyPhe: 3.675 ± 0.055	5.871GlyGly: 5.871 ± 0.092	1.496GlyHis: 1.496 ± 0.033	4.864GlyIle: 4.864 ± 0.059	3.941GlyLys: 3.941 ± 0.054	7.535GlyLeu: 7.535 ± 0.089	1.9GlyMet: 1.9 ± 0.038	2.699GlyAsn: 2.699 ± 0.055	2.42GlyPro: 2.42 ± 0.04	2.471GlyGln: 2.471 ± 0.042	4.032GlyArg: 4.032 ± 0.053	5.438GlySer: 5.438 ± 0.089	4.005GlyThr: 4.005 ± 0.094	5.481GlyVal: 5.481 ± 0.082	1.219GlyTrp: 1.219 ± 0.033	2.661GlyTyr: 2.661 ± 0.048	0.001GlyXaa: 0.001 ± 0.0
His	1.59HisAla: 1.59 ± 0.035	0.239HisCys: 0.239 ± 0.014	1.026HisAsp: 1.026 ± 0.028	1.169HisGlu: 1.169 ± 0.029	1.002HisPhe: 1.002 ± 0.024	1.438HisGly: 1.438 ± 0.037	0.52HisHis: 0.52 ± 0.02	0.992HisIle: 0.992 ± 0.027	0.663HisLys: 0.663 ± 0.02	1.986HisLeu: 1.986 ± 0.04	0.351HisMet: 0.351 ± 0.016	0.618HisAsn: 0.618 ± 0.02	1.246HisPro: 1.246 ± 0.035	0.671HisGln: 0.671 ± 0.019	1.074HisArg: 1.074 ± 0.029	1.365HisSer: 1.365 ± 0.029	0.911HisThr: 0.911 ± 0.024	1.131HisVal: 1.131 ± 0.026	0.359HisTrp: 0.359 ± 0.015	0.694HisTyr: 0.694 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.926IleAla: 5.926 ± 0.07	0.641IleCys: 0.641 ± 0.021	4.163IleAsp: 4.163 ± 0.072	4.745IleGlu: 4.745 ± 0.056	2.112IlePhe: 2.112 ± 0.041	4.823IleGly: 4.823 ± 0.06	1.172IleHis: 1.172 ± 0.029	2.626IleIle: 2.626 ± 0.045	2.267IleLys: 2.267 ± 0.041	5.179IleLeu: 5.179 ± 0.069	0.914IleMet: 0.914 ± 0.023	1.945IleAsn: 1.945 ± 0.046	2.783IlePro: 2.783 ± 0.045	2.006IleGln: 2.006 ± 0.035	3.296IleArg: 3.296 ± 0.054	4.07IleSer: 4.07 ± 0.064	2.906IleThr: 2.906 ± 0.066	4.178IleVal: 4.178 ± 0.05	0.706IleTrp: 0.706 ± 0.022	1.536IleTyr: 1.536 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.362LysAla: 4.362 ± 0.071	0.28LysCys: 0.28 ± 0.014	2.361LysAsp: 2.361 ± 0.042	3.158LysGlu: 3.158 ± 0.062	1.415LysPhe: 1.415 ± 0.031	3.15LysGly: 3.15 ± 0.051	0.899LysHis: 0.899 ± 0.026	2.74LysIle: 2.74 ± 0.045	2.626LysLys: 2.626 ± 0.06	4.616LysLeu: 4.616 ± 0.072	1.019LysMet: 1.019 ± 0.026	1.783LysAsn: 1.783 ± 0.038	2.176LysPro: 2.176 ± 0.042	1.592LysGln: 1.592 ± 0.036	3.05LysArg: 3.05 ± 0.057	3.12LysSer: 3.12 ± 0.052	2.744LysThr: 2.744 ± 0.043	3.036LysVal: 3.036 ± 0.045	0.631LysTrp: 0.631 ± 0.022	1.098LysTyr: 1.098 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	10.253LeuAla: 10.253 ± 0.116	1.01LeuCys: 1.01 ± 0.024	6.173LeuAsp: 6.173 ± 0.065	7.334LeuGlu: 7.334 ± 0.086	4.211LeuPhe: 4.211 ± 0.053	7.532LeuGly: 7.532 ± 0.072	1.844LeuHis: 1.844 ± 0.044	5.243LeuIle: 5.243 ± 0.051	4.956LeuLys: 4.956 ± 0.063	9.741LeuLeu: 9.741 ± 0.12	1.832LeuMet: 1.832 ± 0.037	3.545LeuAsn: 3.545 ± 0.058	4.901LeuPro: 4.901 ± 0.061	3.301LeuGln: 3.301 ± 0.049	5.611LeuArg: 5.611 ± 0.076	7.909LeuSer: 7.909 ± 0.081	4.931LeuThr: 4.931 ± 0.071	6.66LeuVal: 6.66 ± 0.077	1.18LeuTrp: 1.18 ± 0.031	2.641LeuTyr: 2.641 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.871MetAla: 1.871 ± 0.034	0.122MetCys: 0.122 ± 0.009	1.132MetAsp: 1.132 ± 0.027	1.274MetGlu: 1.274 ± 0.029	0.618MetPhe: 0.618 ± 0.02	1.58MetGly: 1.58 ± 0.033	0.372MetHis: 0.372 ± 0.015	1.235MetIle: 1.235 ± 0.029	1.309MetLys: 1.309 ± 0.037	2.037MetLeu: 2.037 ± 0.035	0.482MetMet: 0.482 ± 0.019	0.884MetAsn: 0.884 ± 0.025	1.136MetPro: 1.136 ± 0.031	0.718MetGln: 0.718 ± 0.021	1.29MetArg: 1.29 ± 0.032	1.455MetSer: 1.455 ± 0.032	1.116MetThr: 1.116 ± 0.03	1.295MetVal: 1.295 ± 0.03	0.206MetTrp: 0.206 ± 0.011	0.369MetTyr: 0.369 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.282AsnAla: 3.282 ± 0.045	0.337AsnCys: 0.337 ± 0.016	1.965AsnAsp: 1.965 ± 0.047	2.31AsnGlu: 2.31 ± 0.042	1.583AsnPhe: 1.583 ± 0.038	3.093AsnGly: 3.093 ± 0.068	0.694AsnHis: 0.694 ± 0.019	1.874AsnIle: 1.874 ± 0.037	1.326AsnLys: 1.326 ± 0.033	3.67AsnLeu: 3.67 ± 0.055	0.686AsnMet: 0.686 ± 0.02	1.253AsnAsn: 1.253 ± 0.035	2.335AsnPro: 2.335 ± 0.041	1.339AsnGln: 1.339 ± 0.032	2.218AsnArg: 2.218 ± 0.037	2.541AsnSer: 2.541 ± 0.044	1.992AsnThr: 1.992 ± 0.053	2.154AsnVal: 2.154 ± 0.037	0.745AsnTrp: 0.745 ± 0.024	1.266AsnTyr: 1.266 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.832ProAla: 3.832 ± 0.052	0.304ProCys: 0.304 ± 0.013	3.225ProAsp: 3.225 ± 0.061	3.808ProGlu: 3.808 ± 0.058	1.993ProPhe: 1.993 ± 0.039	3.028ProGly: 3.028 ± 0.042	0.87ProHis: 0.87 ± 0.024	2.644ProIle: 2.644 ± 0.042	2.045ProLys: 2.045 ± 0.045	3.99ProLeu: 3.99 ± 0.053	0.924ProMet: 0.924 ± 0.021	1.949ProAsn: 1.949 ± 0.045	1.771ProPro: 1.771 ± 0.045	1.542ProGln: 1.542 ± 0.036	2.038ProArg: 2.038 ± 0.041	3.175ProSer: 3.175 ± 0.047	2.461ProThr: 2.461 ± 0.048	3.043ProVal: 3.043 ± 0.048	0.681ProTrp: 0.681 ± 0.023	1.283ProTyr: 1.283 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.363GlnAla: 3.363 ± 0.06	0.227GlnCys: 0.227 ± 0.011	1.67GlnAsp: 1.67 ± 0.036	2.065GlnGlu: 2.065 ± 0.04	1.325GlnPhe: 1.325 ± 0.028	2.185GlnGly: 2.185 ± 0.041	0.622GlnHis: 0.622 ± 0.02	2.226GlnIle: 2.226 ± 0.035	1.619GlnLys: 1.619 ± 0.036	3.585GlnLeu: 3.585 ± 0.053	0.73GlnMet: 0.73 ± 0.02	1.383GlnAsn: 1.383 ± 0.034	1.419GlnPro: 1.419 ± 0.029	1.241GlnGln: 1.241 ± 0.037	1.988GlnArg: 1.988 ± 0.038	2.465GlnSer: 2.465 ± 0.039	2.014GlnThr: 2.014 ± 0.038	2.147GlnVal: 2.147 ± 0.043	0.463GlnTrp: 0.463 ± 0.016	0.845GlnTyr: 0.845 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	4.138ArgAla: 4.138 ± 0.06	0.495ArgCys: 0.495 ± 0.018	3.159ArgAsp: 3.159 ± 0.049	4.071ArgGlu: 4.071 ± 0.072	3.066ArgPhe: 3.066 ± 0.042	3.531ArgGly: 3.531 ± 0.049	1.077ArgHis: 1.077 ± 0.027	3.939ArgIle: 3.939 ± 0.046	2.677ArgLys: 2.677 ± 0.047	5.943ArgLeu: 5.943 ± 0.071	1.344ArgMet: 1.344 ± 0.033	2.101ArgAsn: 2.101 ± 0.037	2.263ArgPro: 2.263 ± 0.041	1.953ArgGln: 1.953 ± 0.043	3.307ArgArg: 3.307 ± 0.069	3.963ArgSer: 3.963 ± 0.06	2.379ArgThr: 2.379 ± 0.037	3.844ArgVal: 3.844 ± 0.058	0.824ArgTrp: 0.824 ± 0.026	1.992ArgTyr: 1.992 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.789SerAla: 5.789 ± 0.084	0.618SerCys: 0.618 ± 0.023	4.278SerAsp: 4.278 ± 0.091	5.041SerGlu: 5.041 ± 0.061	3.429SerPhe: 3.429 ± 0.053	6.056SerGly: 6.056 ± 0.096	1.38SerHis: 1.38 ± 0.027	4.472SerIle: 4.472 ± 0.07	3.299SerLys: 3.299 ± 0.055	7.747SerLeu: 7.747 ± 0.071	1.529SerMet: 1.529 ± 0.032	2.619SerAsn: 2.619 ± 0.052	3.234SerPro: 3.234 ± 0.052	2.476SerGln: 2.476 ± 0.045	3.74SerArg: 3.74 ± 0.055	5.504SerSer: 5.504 ± 0.084	3.386SerThr: 3.386 ± 0.068	4.833SerVal: 4.833 ± 0.074	1.038SerTrp: 1.038 ± 0.025	2.202SerTyr: 2.202 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.478ThrAla: 4.478 ± 0.079	0.414ThrCys: 0.414 ± 0.016	2.944ThrAsp: 2.944 ± 0.085	3.225ThrGlu: 3.225 ± 0.065	2.368ThrPhe: 2.368 ± 0.053	4.206ThrGly: 4.206 ± 0.078	1.106ThrHis: 1.106 ± 0.031	3.318ThrIle: 3.318 ± 0.069	2.084ThrLys: 2.084 ± 0.04	5.992ThrLeu: 5.992 ± 0.078	0.884ThrMet: 0.884 ± 0.023	1.888ThrAsn: 1.888 ± 0.05	2.994ThrPro: 2.994 ± 0.048	1.729ThrGln: 1.729 ± 0.036	2.756ThrArg: 2.756 ± 0.044	3.472ThrSer: 3.472 ± 0.071	2.892ThrThr: 2.892 ± 0.073	3.628ThrVal: 3.628 ± 0.086	0.71ThrTrp: 0.71 ± 0.021	1.566ThrTyr: 1.566 ± 0.037	0.001ThrXaa: 0.001 ± 0.001
Val	6.418ValAla: 6.418 ± 0.072	0.677ValCys: 0.677 ± 0.023	4.26ValAsp: 4.26 ± 0.064	4.928ValGlu: 4.928 ± 0.065	3.252ValPhe: 3.252 ± 0.061	4.998ValGly: 4.998 ± 0.082	1.097ValHis: 1.097 ± 0.026	3.466ValIle: 3.466 ± 0.053	2.719ValLys: 2.719 ± 0.045	5.973ValLeu: 5.973 ± 0.075	1.321ValMet: 1.321 ± 0.028	2.295ValAsn: 2.295 ± 0.043	2.584ValPro: 2.584 ± 0.042	1.774ValGln: 1.774 ± 0.031	3.421ValArg: 3.421 ± 0.052	5.419ValSer: 5.419 ± 0.079	3.67ValThr: 3.67 ± 0.076	5.033ValVal: 5.033 ± 0.081	0.922ValTrp: 0.922 ± 0.027	1.926ValTyr: 1.926 ± 0.037	0.001ValXaa: 0.001 ± 0.001
Trp	1.054TrpAla: 1.054 ± 0.029	0.117TrpCys: 0.117 ± 0.009	0.826TrpAsp: 0.826 ± 0.029	0.937TrpGlu: 0.937 ± 0.023	0.52TrpPhe: 0.52 ± 0.021	1.097TrpGly: 1.097 ± 0.027	0.323TrpHis: 0.323 ± 0.015	0.958TrpIle: 0.958 ± 0.028	0.784TrpLys: 0.784 ± 0.023	1.522TrpLeu: 1.522 ± 0.033	0.371TrpMet: 0.371 ± 0.014	0.641TrpAsn: 0.641 ± 0.021	0.557TrpPro: 0.557 ± 0.019	0.598TrpGln: 0.598 ± 0.019	0.927TrpArg: 0.927 ± 0.031	0.978TrpSer: 0.978 ± 0.026	0.874TrpThr: 0.874 ± 0.022	0.88TrpVal: 0.88 ± 0.026	0.254TrpTrp: 0.254 ± 0.013	0.387TrpTyr: 0.387 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.045	0.297TyrCys: 0.297 ± 0.013	1.838TyrAsp: 1.838 ± 0.042	1.994TyrGlu: 1.994 ± 0.04	1.459TyrPhe: 1.459 ± 0.035	2.263TyrGly: 2.263 ± 0.042	0.631TyrHis: 0.631 ± 0.021	1.323TyrIle: 1.323 ± 0.033	1.037TyrLys: 1.037 ± 0.03	3.075TyrLeu: 3.075 ± 0.049	0.491TyrMet: 0.491 ± 0.017	1.011TyrAsn: 1.011 ± 0.029	1.398TyrPro: 1.398 ± 0.037	1.239TyrGln: 1.239 ± 0.031	2.062TyrArg: 2.062 ± 0.044	2.132TyrSer: 2.132 ± 0.039	1.525TyrThr: 1.525 ± 0.03	1.77TyrVal: 1.77 ± 0.035	0.48TyrTrp: 0.48 ± 0.018	0.984TyrTyr: 0.984 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.036XaaXaa: 0.036 ± 0.025

Statistics based on 4883 proteins (1699424 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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