Human papillomavirus 59

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 7

Average proteome isoelectric point is 6.52

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 8 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|Q81969|Q81969_HPV59 Probable protein E5 OS=Human papillomavirus 59 OX=37115 GN=ORF putative E5 PE=3 SV=1
MM1 pKa = 7.6HH2 pKa = 7.3GPKK5 pKa = 9.19ATLCDD10 pKa = 3.14IVLDD14 pKa = 4.66LEE16 pKa = 4.32PQNYY20 pKa = 10.01EE21 pKa = 4.02EE22 pKa = 4.75VDD24 pKa = 4.0LVCYY28 pKa = 9.19EE29 pKa = 4.18QLPDD33 pKa = 3.9SDD35 pKa = 4.76SEE37 pKa = 4.29NEE39 pKa = 3.73KK40 pKa = 11.07DD41 pKa = 3.89EE42 pKa = 4.83PDD44 pKa = 4.12GVNHH48 pKa = 7.07PLLLARR54 pKa = 11.84RR55 pKa = 11.84AEE57 pKa = 4.17PQRR60 pKa = 11.84HH61 pKa = 5.95NIVCVCCKK69 pKa = 10.39CNNQLQLVVEE79 pKa = 4.62TSQDD83 pKa = 3.15GLRR86 pKa = 11.84ALQQLFMDD94 pKa = 4.63TLSFVCPLCAANQQ107 pKa = 3.47

Molecular weight: 12.04 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|B9UPE5|B9UPE5_HPV59 Minor capsid protein L2 OS=Human papillomavirus 59 OX=37115 GN=L2 PE=3 SV=1
MM1 pKa = 7.04MPKK4 pKa = 10.52NMGLQTSGKK13 pKa = 8.37CIIMARR19 pKa = 11.84LLIVMTLCAVPVTSKK34 pKa = 11.33YY35 pKa = 10.39PLLDD39 pKa = 3.7LLSNYY44 pKa = 7.42HH45 pKa = 6.37TPPQRR50 pKa = 11.84PPKK53 pKa = 9.33PRR55 pKa = 11.84TWAPKK60 pKa = 8.96RR61 pKa = 11.84PTVRR65 pKa = 11.84RR66 pKa = 11.84RR67 pKa = 11.84LEE69 pKa = 3.99SDD71 pKa = 2.78QDD73 pKa = 3.98SVDD76 pKa = 3.42THH78 pKa = 6.02STLSLPACQWTTVTTQSSVCIQATTRR104 pKa = 11.84DD105 pKa = 4.01GTSLAVTLRR114 pKa = 11.84LL115 pKa = 3.7

Molecular weight: 12.79 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

8

0

8

2441

73

644

305.1

34.32

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.571 ± 0.545

3.195 ± 0.998

6.022 ± 0.63

4.588 ± 0.717

3.933 ± 0.452

5.162 ± 0.707

2.294 ± 0.42

5.162 ± 0.738

5.162 ± 0.863

8.275 ± 1.231

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.925 ± 0.316

4.506 ± 0.503

6.104 ± 1.033

4.302 ± 0.572

5.244 ± 0.72

7.497 ± 0.948

8.644 ± 1.167

7.128 ± 0.545

1.557 ± 0.339

3.728 ± 0.421
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski