Amino acid dipepetide frequency for Human papillomavirus 59

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.738AlaAla: 5.738 ± 1.413
2.049AlaCys: 2.049 ± 0.843
2.869AlaAsp: 2.869 ± 0.772
2.049AlaGlu: 2.049 ± 0.775
2.869AlaPhe: 2.869 ± 1.175
2.459AlaGly: 2.459 ± 0.958
1.23AlaHis: 1.23 ± 0.608
2.459AlaIle: 2.459 ± 0.513
3.689AlaLys: 3.689 ± 1.172
4.098AlaLeu: 4.098 ± 1.439
1.23AlaMet: 1.23 ± 0.565
2.049AlaAsn: 2.049 ± 0.679
3.279AlaPro: 3.279 ± 1.096
2.049AlaGln: 2.049 ± 0.758
5.328AlaArg: 5.328 ± 1.76
2.049AlaSer: 2.049 ± 1.064
4.918AlaThr: 4.918 ± 1.573
2.459AlaVal: 2.459 ± 0.982
0.82AlaTrp: 0.82 ± 0.375
2.049AlaTyr: 2.049 ± 0.782
0.0AlaXaa: 0.0 ± 0.0
Cys
2.869CysAla: 2.869 ± 1.121
1.23CysCys: 1.23 ± 1.223
1.23CysAsp: 1.23 ± 0.647
0.41CysGlu: 0.41 ± 0.367
1.23CysPhe: 1.23 ± 0.558
1.23CysGly: 1.23 ± 0.608
0.0CysHis: 0.0 ± 0.0
2.049CysIle: 2.049 ± 1.034
2.869CysLys: 2.869 ± 1.085
2.459CysLeu: 2.459 ± 0.905
0.41CysMet: 0.41 ± 0.304
1.23CysAsn: 1.23 ± 0.777
2.049CysPro: 2.049 ± 0.635
2.049CysGln: 2.049 ± 0.714
1.639CysArg: 1.639 ± 0.996
2.869CysSer: 2.869 ± 1.372
0.41CysThr: 0.41 ± 0.458
3.689CysVal: 3.689 ± 1.726
0.82CysTrp: 0.82 ± 0.355
1.23CysTyr: 1.23 ± 0.809
0.0CysXaa: 0.0 ± 0.0
Asp
2.459AspAla: 2.459 ± 1.035
2.869AspCys: 2.869 ± 0.834
2.459AspAsp: 2.459 ± 1.022
2.869AspGlu: 2.869 ± 0.657
2.459AspPhe: 2.459 ± 0.467
3.279AspGly: 3.279 ± 1.201
0.41AspHis: 0.41 ± 0.367
5.738AspIle: 5.738 ± 2.382
3.279AspLys: 3.279 ± 1.034
5.738AspLeu: 5.738 ± 1.41
0.41AspMet: 0.41 ± 0.345
3.279AspAsn: 3.279 ± 1.021
3.689AspPro: 3.689 ± 1.752
1.639AspGln: 1.639 ± 0.814
1.23AspArg: 1.23 ± 0.913
7.377AspSer: 7.377 ± 2.097
6.557AspThr: 6.557 ± 1.778
2.459AspVal: 2.459 ± 0.78
1.23AspTrp: 1.23 ± 0.565
0.82AspTyr: 0.82 ± 0.689
0.0AspXaa: 0.0 ± 0.0
Glu
2.049GluAla: 2.049 ± 0.774
0.41GluCys: 0.41 ± 0.528
2.869GluAsp: 2.869 ± 0.676
4.098GluGlu: 4.098 ± 0.869
2.049GluPhe: 2.049 ± 0.711
2.869GluGly: 2.869 ± 1.311
1.23GluHis: 1.23 ± 0.743
2.049GluIle: 2.049 ± 0.871
1.23GluLys: 1.23 ± 0.7
3.279GluLeu: 3.279 ± 1.365
1.23GluMet: 1.23 ± 0.913
4.508GluAsn: 4.508 ± 1.754
3.279GluPro: 3.279 ± 1.744
2.459GluGln: 2.459 ± 1.549
1.639GluArg: 1.639 ± 0.599
1.639GluSer: 1.639 ± 0.594
3.279GluThr: 3.279 ± 1.249
4.098GluVal: 4.098 ± 0.587
0.41GluTrp: 0.41 ± 0.304
1.23GluTyr: 1.23 ± 0.63
0.0GluXaa: 0.0 ± 0.0
Phe
2.049PheAla: 2.049 ± 0.421
0.82PheCys: 0.82 ± 0.517
2.869PheAsp: 2.869 ± 0.895
2.049PheGlu: 2.049 ± 0.956
2.049PhePhe: 2.049 ± 0.67
2.049PheGly: 2.049 ± 0.893
0.41PheHis: 0.41 ± 0.458
3.279PheIle: 3.279 ± 0.588
4.098PheLys: 4.098 ± 1.284
5.738PheLeu: 5.738 ± 1.039
1.23PheMet: 1.23 ± 0.786
1.23PheAsn: 1.23 ± 0.469
0.82PhePro: 0.82 ± 0.355
1.23PheGln: 1.23 ± 0.33
0.41PheArg: 0.41 ± 0.345
1.23PheSer: 1.23 ± 0.666
2.459PheThr: 2.459 ± 2.026
2.459PheVal: 2.459 ± 1.201
1.639PheTrp: 1.639 ± 0.599
1.23PheTyr: 1.23 ± 0.581
0.0PheXaa: 0.0 ± 0.0
Gly
2.459GlyAla: 2.459 ± 0.987
1.639GlyCys: 1.639 ± 0.599
3.279GlyAsp: 3.279 ± 1.196
1.639GlyGlu: 1.639 ± 0.486
0.82GlyPhe: 0.82 ± 0.375
2.459GlyGly: 2.459 ± 0.958
1.639GlyHis: 1.639 ± 0.599
2.459GlyIle: 2.459 ± 0.915
3.689GlyLys: 3.689 ± 1.151
4.508GlyLeu: 4.508 ± 0.704
0.82GlyMet: 0.82 ± 0.609
2.459GlyAsn: 2.459 ± 0.537
2.869GlyPro: 2.869 ± 0.841
1.639GlyGln: 1.639 ± 0.599
2.049GlyArg: 2.049 ± 1.064
4.098GlySer: 4.098 ± 0.633
6.557GlyThr: 6.557 ± 1.838
3.689GlyVal: 3.689 ± 1.429
0.41GlyTrp: 0.41 ± 0.304
2.459GlyTyr: 2.459 ± 0.467
0.0GlyXaa: 0.0 ± 0.0
His
1.23HisAla: 1.23 ± 0.693
0.41HisCys: 0.41 ± 0.367
1.23HisAsp: 1.23 ± 0.647
0.41HisGlu: 0.41 ± 0.458
1.639HisPhe: 1.639 ± 0.486
1.23HisGly: 1.23 ± 0.587
0.0HisHis: 0.0 ± 0.0
1.639HisIle: 1.639 ± 0.799
0.41HisLys: 0.41 ± 0.345
1.23HisLeu: 1.23 ± 0.555
0.0HisMet: 0.0 ± 0.0
1.639HisAsn: 1.639 ± 0.919
2.869HisPro: 2.869 ± 0.855
0.41HisGln: 0.41 ± 0.367
1.23HisArg: 1.23 ± 0.646
0.82HisSer: 0.82 ± 0.591
1.23HisThr: 1.23 ± 0.915
2.459HisVal: 2.459 ± 0.789
1.23HisTrp: 1.23 ± 0.743
1.639HisTyr: 1.639 ± 1.05
0.0HisXaa: 0.0 ± 0.0
Ile
1.23IleAla: 1.23 ± 0.687
1.639IleCys: 1.639 ± 0.952
1.639IleAsp: 1.639 ± 0.545
3.689IleGlu: 3.689 ± 1.063
1.639IlePhe: 1.639 ± 0.561
2.869IleGly: 2.869 ± 1.205
2.049IleHis: 2.049 ± 1.437
2.049IleIle: 2.049 ± 0.777
1.23IleLys: 1.23 ± 0.565
3.689IleLeu: 3.689 ± 1.21
0.41IleMet: 0.41 ± 0.513
3.279IleAsn: 3.279 ± 0.935
3.689IlePro: 3.689 ± 1.417
3.279IleGln: 3.279 ± 1.535
1.639IleArg: 1.639 ± 0.856
5.328IleSer: 5.328 ± 1.994
4.508IleThr: 4.508 ± 1.15
5.738IleVal: 5.738 ± 1.84
0.0IleTrp: 0.0 ± 0.0
2.049IleTyr: 2.049 ± 1.125
0.0IleXaa: 0.0 ± 0.0
Lys
2.459LysAla: 2.459 ± 0.827
3.689LysCys: 3.689 ± 1.329
2.459LysAsp: 2.459 ± 0.749
2.049LysGlu: 2.049 ± 0.62
2.869LysPhe: 2.869 ± 0.953
2.459LysGly: 2.459 ± 0.877
0.82LysHis: 0.82 ± 0.498
2.049LysIle: 2.049 ± 0.357
2.459LysLys: 2.459 ± 1.198
4.098LysLeu: 4.098 ± 1.2
0.0LysMet: 0.0 ± 0.329
2.869LysAsn: 2.869 ± 1.317
2.869LysPro: 2.869 ± 0.848
2.049LysGln: 2.049 ± 0.768
5.738LysArg: 5.738 ± 0.812
2.869LysSer: 2.869 ± 0.997
2.869LysThr: 2.869 ± 1.048
4.098LysVal: 4.098 ± 1.504
0.82LysTrp: 0.82 ± 0.399
1.639LysTyr: 1.639 ± 0.594
0.0LysXaa: 0.0 ± 0.0
Leu
2.869LeuAla: 2.869 ± 0.831
3.689LeuCys: 3.689 ± 1.367
4.508LeuAsp: 4.508 ± 0.902
4.098LeuGlu: 4.098 ± 0.692
3.279LeuPhe: 3.279 ± 0.979
3.689LeuGly: 3.689 ± 1.625
3.279LeuHis: 3.279 ± 0.89
3.279LeuIle: 3.279 ± 1.034
4.918LeuLys: 4.918 ± 1.501
8.607LeuLeu: 8.607 ± 3.835
1.23LeuMet: 1.23 ± 0.753
2.049LeuAsn: 2.049 ± 0.546
4.098LeuPro: 4.098 ± 1.161
6.557LeuGln: 6.557 ± 1.107
4.098LeuArg: 4.098 ± 1.163
5.738LeuSer: 5.738 ± 1.207
5.328LeuThr: 5.328 ± 0.869
5.738LeuVal: 5.738 ± 1.243
1.23LeuTrp: 1.23 ± 0.441
4.508LeuTyr: 4.508 ± 1.155
0.0LeuXaa: 0.0 ± 0.0
Met
2.459MetAla: 2.459 ± 0.535
1.23MetCys: 1.23 ± 0.558
2.049MetAsp: 2.049 ± 0.515
0.41MetGlu: 0.41 ± 0.367
0.82MetPhe: 0.82 ± 0.409
0.82MetGly: 0.82 ± 0.566
1.23MetHis: 1.23 ± 0.647
0.82MetIle: 0.82 ± 0.567
0.0MetLys: 0.0 ± 0.0
1.639MetLeu: 1.639 ± 1.218
0.41MetMet: 0.41 ± 0.513
0.41MetAsn: 0.41 ± 0.345
0.41MetPro: 0.41 ± 0.513
1.23MetGln: 1.23 ± 0.737
0.41MetArg: 0.41 ± 0.304
2.869MetSer: 2.869 ± 1.016
0.41MetThr: 0.41 ± 0.513
1.23MetVal: 1.23 ± 0.33
0.0MetTrp: 0.0 ± 0.0
0.41MetTyr: 0.41 ± 0.304
0.0MetXaa: 0.0 ± 0.0
Asn
1.639AsnAla: 1.639 ± 0.867
1.23AsnCys: 1.23 ± 0.687
2.049AsnAsp: 2.049 ± 0.852
2.049AsnGlu: 2.049 ± 1.172
0.41AsnPhe: 0.41 ± 0.345
2.869AsnGly: 2.869 ± 0.847
1.23AsnHis: 1.23 ± 0.647
4.508AsnIle: 4.508 ± 1.285
3.689AsnLys: 3.689 ± 1.35
0.41AsnLeu: 0.41 ± 0.345
1.23AsnMet: 1.23 ± 0.567
1.639AsnAsn: 1.639 ± 0.934
4.098AsnPro: 4.098 ± 0.929
2.049AsnGln: 2.049 ± 1.063
2.459AsnArg: 2.459 ± 0.85
3.279AsnSer: 3.279 ± 1.276
5.328AsnThr: 5.328 ± 1.134
2.869AsnVal: 2.869 ± 0.604
0.41AsnTrp: 0.41 ± 0.304
1.639AsnTyr: 1.639 ± 0.837
0.0AsnXaa: 0.0 ± 0.0
Pro
4.098ProAla: 4.098 ± 1.739
0.41ProCys: 0.41 ± 0.367
4.508ProAsp: 4.508 ± 1.251
1.23ProGlu: 1.23 ± 0.375
1.23ProPhe: 1.23 ± 0.594
0.82ProGly: 0.82 ± 0.448
0.41ProHis: 0.41 ± 0.338
3.279ProIle: 3.279 ± 1.04
5.328ProLys: 5.328 ± 1.586
7.377ProLeu: 7.377 ± 2.088
0.82ProMet: 0.82 ± 0.375
2.869ProAsn: 2.869 ± 0.798
4.918ProPro: 4.918 ± 1.739
2.459ProGln: 2.459 ± 1.421
2.459ProArg: 2.459 ± 0.868
4.098ProSer: 4.098 ± 1.758
7.787ProThr: 7.787 ± 1.817
3.689ProVal: 3.689 ± 0.635
0.0ProTrp: 0.0 ± 0.0
3.279ProTyr: 3.279 ± 1.005
0.0ProXaa: 0.0 ± 0.0
Gln
3.279GlnAla: 3.279 ± 1.229
1.23GlnCys: 1.23 ± 0.555
2.869GlnAsp: 2.869 ± 1.068
2.049GlnGlu: 2.049 ± 0.852
1.23GlnPhe: 1.23 ± 0.63
2.049GlnGly: 2.049 ± 0.631
0.82GlnHis: 0.82 ± 0.399
2.459GlnIle: 2.459 ± 0.783
0.82GlnLys: 0.82 ± 0.355
5.328GlnLeu: 5.328 ± 2.754
2.049GlnMet: 2.049 ± 0.716
0.41GlnAsn: 0.41 ± 0.566
1.23GlnPro: 1.23 ± 0.33
1.23GlnGln: 1.23 ± 0.779
4.098GlnArg: 4.098 ± 1.012
2.869GlnSer: 2.869 ± 0.969
3.689GlnThr: 3.689 ± 1.775
2.459GlnVal: 2.459 ± 0.892
2.459GlnTrp: 2.459 ± 0.852
0.41GlnTyr: 0.41 ± 0.345
0.0GlnXaa: 0.0 ± 0.0
Arg
4.098ArgAla: 4.098 ± 1.495
1.23ArgCys: 1.23 ± 0.907
2.049ArgAsp: 2.049 ± 0.929
2.459ArgGlu: 2.459 ± 0.866
2.459ArgPhe: 2.459 ± 1.028
1.23ArgGly: 1.23 ± 0.585
2.869ArgHis: 2.869 ± 0.723
0.82ArgIle: 0.82 ± 0.498
4.098ArgLys: 4.098 ± 1.029
6.148ArgLeu: 6.148 ± 1.465
0.41ArgMet: 0.41 ± 0.367
2.049ArgAsn: 2.049 ± 1.16
2.869ArgPro: 2.869 ± 1.102
2.459ArgGln: 2.459 ± 1.003
4.508ArgArg: 4.508 ± 1.08
3.279ArgSer: 3.279 ± 1.087
4.098ArgThr: 4.098 ± 1.261
3.279ArgVal: 3.279 ± 1.49
0.41ArgTrp: 0.41 ± 0.304
1.639ArgTyr: 1.639 ± 0.681
0.0ArgXaa: 0.0 ± 0.0
Ser
4.098SerAla: 4.098 ± 1.643
0.41SerCys: 0.41 ± 0.304
5.738SerAsp: 5.738 ± 1.92
4.508SerGlu: 4.508 ± 1.086
2.459SerPhe: 2.459 ± 0.767
5.328SerGly: 5.328 ± 1.494
1.639SerHis: 1.639 ± 0.486
2.869SerIle: 2.869 ± 1.081
2.049SerLys: 2.049 ± 1.188
3.689SerLeu: 3.689 ± 1.015
1.639SerMet: 1.639 ± 0.261
6.148SerAsn: 6.148 ± 2.403
2.869SerPro: 2.869 ± 0.853
2.869SerGln: 2.869 ± 0.556
2.459SerArg: 2.459 ± 0.913
8.197SerSer: 8.197 ± 2.713
7.787SerThr: 7.787 ± 2.27
7.787SerVal: 7.787 ± 1.356
0.41SerTrp: 0.41 ± 0.367
2.049SerTyr: 2.049 ± 0.761
0.0SerXaa: 0.0 ± 0.0
Thr
3.689ThrAla: 3.689 ± 0.804
2.459ThrCys: 2.459 ± 0.467
6.557ThrAsp: 6.557 ± 1.708
2.049ThrGlu: 2.049 ± 0.732
3.689ThrPhe: 3.689 ± 1.511
8.197ThrGly: 8.197 ± 2.092
0.41ThrHis: 0.41 ± 0.513
3.279ThrIle: 3.279 ± 0.916
1.639ThrLys: 1.639 ± 0.765
7.787ThrLeu: 7.787 ± 2.063
1.639ThrMet: 1.639 ± 0.701
2.459ThrAsn: 2.459 ± 0.868
6.557ThrPro: 6.557 ± 1.308
2.459ThrGln: 2.459 ± 0.839
3.279ThrArg: 3.279 ± 1.195
10.656ThrSer: 10.656 ± 2.427
8.197ThrThr: 8.197 ± 1.547
6.967ThrVal: 6.967 ± 1.005
1.639ThrTrp: 1.639 ± 0.806
2.869ThrTyr: 2.869 ± 0.569
0.0ThrXaa: 0.0 ± 0.0
Val
2.459ValAla: 2.459 ± 0.763
4.508ValCys: 4.508 ± 3.214
6.148ValAsp: 6.148 ± 1.485
4.918ValGlu: 4.918 ± 0.68
3.279ValPhe: 3.279 ± 1.315
2.459ValGly: 2.459 ± 1.049
1.23ValHis: 1.23 ± 0.737
3.689ValIle: 3.689 ± 1.024
2.459ValLys: 2.459 ± 0.997
2.869ValLeu: 2.869 ± 0.862
2.459ValMet: 2.459 ± 0.826
2.869ValAsn: 2.869 ± 1.071
6.148ValPro: 6.148 ± 1.274
3.689ValGln: 3.689 ± 1.108
4.098ValArg: 4.098 ± 1.49
4.098ValSer: 4.098 ± 1.48
5.738ValThr: 5.738 ± 1.542
4.098ValVal: 4.098 ± 1.309
0.41ValTrp: 0.41 ± 0.345
3.689ValTyr: 3.689 ± 1.424
0.0ValXaa: 0.0 ± 0.0
Trp
1.23TrpAla: 1.23 ± 0.567
0.82TrpCys: 0.82 ± 0.399
0.41TrpAsp: 0.41 ± 0.338
0.41TrpGlu: 0.41 ± 0.367
0.41TrpPhe: 0.41 ± 0.304
0.82TrpGly: 0.82 ± 0.399
0.82TrpHis: 0.82 ± 0.448
0.82TrpIle: 0.82 ± 0.609
1.23TrpLys: 1.23 ± 0.608
1.639TrpLeu: 1.639 ± 0.571
0.0TrpMet: 0.0 ± 0.0
0.82TrpAsn: 0.82 ± 0.689
1.23TrpPro: 1.23 ± 0.33
0.41TrpGln: 0.41 ± 0.367
0.82TrpArg: 0.82 ± 0.355
0.0TrpSer: 0.0 ± 0.0
2.869TrpThr: 2.869 ± 0.987
0.41TrpVal: 0.41 ± 0.304
0.0TrpTrp: 0.0 ± 0.0
0.41TrpTyr: 0.41 ± 0.304
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.279TyrAla: 3.279 ± 1.021
0.0TyrCys: 0.0 ± 0.0
2.459TyrAsp: 2.459 ± 0.987
2.459TyrGlu: 2.459 ± 1.195
2.459TyrPhe: 2.459 ± 0.868
2.459TyrGly: 2.459 ± 0.608
1.23TyrHis: 1.23 ± 0.545
2.049TyrIle: 2.049 ± 1.308
2.459TyrLys: 2.459 ± 0.427
2.459TyrLeu: 2.459 ± 0.877
1.23TyrMet: 1.23 ± 0.558
0.82TyrAsn: 0.82 ± 0.448
1.23TyrPro: 1.23 ± 0.648
0.82TyrGln: 0.82 ± 0.355
2.869TyrArg: 2.869 ± 1.302
1.639TyrSer: 1.639 ± 0.565
2.459TyrThr: 2.459 ± 0.751
1.639TyrVal: 1.639 ± 0.651
1.23TyrTrp: 1.23 ± 0.375
2.049TyrTyr: 2.049 ± 1.173
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2441 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski