Amino acid dipepetide frequency for Avian paramyxovirus UPO216

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.137AlaAla: 7.137 ± 1.539
1.946AlaCys: 1.946 ± 0.619
3.244AlaAsp: 3.244 ± 0.729
3.893AlaGlu: 3.893 ± 0.857
1.514AlaPhe: 1.514 ± 0.411
4.109AlaGly: 4.109 ± 1.476
2.163AlaHis: 2.163 ± 0.837
4.758AlaIle: 4.758 ± 0.563
2.379AlaLys: 2.379 ± 0.469
8.218AlaLeu: 8.218 ± 2.393
1.514AlaMet: 1.514 ± 0.478
3.028AlaAsn: 3.028 ± 1.177
2.811AlaPro: 2.811 ± 0.625
3.244AlaGln: 3.244 ± 0.882
4.758AlaArg: 4.758 ± 0.436
6.92AlaSer: 6.92 ± 1.216
4.542AlaThr: 4.542 ± 1.045
4.758AlaVal: 4.758 ± 1.08
0.649AlaTrp: 0.649 ± 0.246
1.73AlaTyr: 1.73 ± 0.649
0.0AlaXaa: 0.0 ± 0.0
Cys
1.73CysAla: 1.73 ± 0.305
0.433CysCys: 0.433 ± 0.259
1.081CysAsp: 1.081 ± 0.431
0.433CysGlu: 0.433 ± 0.259
0.649CysPhe: 0.649 ± 0.244
0.433CysGly: 0.433 ± 0.362
0.0CysHis: 0.0 ± 0.0
1.73CysIle: 1.73 ± 0.471
0.865CysLys: 0.865 ± 0.457
1.73CysLeu: 1.73 ± 0.46
1.081CysMet: 1.081 ± 0.48
0.433CysAsn: 0.433 ± 0.259
0.649CysPro: 0.649 ± 0.461
0.865CysGln: 0.865 ± 0.433
1.514CysArg: 1.514 ± 0.553
1.514CysSer: 1.514 ± 0.437
1.081CysThr: 1.081 ± 0.638
0.433CysVal: 0.433 ± 0.216
0.0CysTrp: 0.0 ± 0.0
1.298CysTyr: 1.298 ± 0.24
0.0CysXaa: 0.0 ± 0.0
Asp
3.244AspAla: 3.244 ± 0.831
0.433AspCys: 0.433 ± 0.262
2.811AspAsp: 2.811 ± 0.679
2.379AspGlu: 2.379 ± 0.73
2.163AspPhe: 2.163 ± 0.312
2.811AspGly: 2.811 ± 0.62
0.649AspHis: 0.649 ± 0.567
3.244AspIle: 3.244 ± 0.616
3.893AspLys: 3.893 ± 0.817
3.46AspLeu: 3.46 ± 0.515
0.865AspMet: 0.865 ± 0.519
1.946AspAsn: 1.946 ± 0.476
4.758AspPro: 4.758 ± 0.907
2.811AspGln: 2.811 ± 0.935
1.73AspArg: 1.73 ± 0.495
3.46AspSer: 3.46 ± 1.01
4.325AspThr: 4.325 ± 1.059
2.379AspVal: 2.379 ± 1.175
0.433AspTrp: 0.433 ± 0.216
0.865AspTyr: 0.865 ± 0.557
0.0AspXaa: 0.0 ± 0.0
Glu
3.244GluAla: 3.244 ± 0.936
0.865GluCys: 0.865 ± 0.275
3.244GluAsp: 3.244 ± 0.808
3.676GluGlu: 3.676 ± 0.166
1.298GluPhe: 1.298 ± 0.547
3.46GluGly: 3.46 ± 1.209
0.433GluHis: 0.433 ± 0.216
2.811GluIle: 2.811 ± 0.795
2.595GluLys: 2.595 ± 0.557
5.407GluLeu: 5.407 ± 0.731
1.514GluMet: 1.514 ± 0.724
1.73GluAsn: 1.73 ± 0.477
1.081GluPro: 1.081 ± 0.429
1.298GluGln: 1.298 ± 0.389
1.946GluArg: 1.946 ± 0.53
3.46GluSer: 3.46 ± 0.644
4.542GluThr: 4.542 ± 1.064
4.542GluVal: 4.542 ± 1.141
0.433GluTrp: 0.433 ± 0.213
2.379GluTyr: 2.379 ± 0.666
0.0GluXaa: 0.0 ± 0.0
Phe
2.379PheAla: 2.379 ± 0.731
1.081PheCys: 1.081 ± 0.339
3.46PheAsp: 3.46 ± 0.813
1.73PheGlu: 1.73 ± 0.599
1.946PhePhe: 1.946 ± 0.553
1.298PheGly: 1.298 ± 0.39
0.649PheHis: 0.649 ± 0.389
1.946PheIle: 1.946 ± 0.451
1.73PheLys: 1.73 ± 0.522
2.595PheLeu: 2.595 ± 0.766
0.865PheMet: 0.865 ± 0.425
2.163PheAsn: 2.163 ± 0.705
1.946PhePro: 1.946 ± 0.776
0.216PheGln: 0.216 ± 0.13
1.73PheArg: 1.73 ± 0.522
2.595PheSer: 2.595 ± 0.657
2.163PheThr: 2.163 ± 0.292
2.595PheVal: 2.595 ± 0.918
0.433PheTrp: 0.433 ± 0.213
0.433PheTyr: 0.433 ± 0.216
0.0PheXaa: 0.0 ± 0.0
Gly
3.893GlyAla: 3.893 ± 0.968
1.298GlyCys: 1.298 ± 1.053
3.46GlyAsp: 3.46 ± 1.125
1.73GlyGlu: 1.73 ± 0.954
0.865GlyPhe: 0.865 ± 0.457
5.407GlyGly: 5.407 ± 1.842
0.433GlyHis: 0.433 ± 0.259
3.893GlyIle: 3.893 ± 0.997
1.514GlyLys: 1.514 ± 0.488
5.839GlyLeu: 5.839 ± 1.184
1.514GlyMet: 1.514 ± 0.817
4.974GlyAsn: 4.974 ± 0.888
1.946GlyPro: 1.946 ± 0.913
1.081GlyGln: 1.081 ± 0.482
3.676GlyArg: 3.676 ± 0.417
6.272GlySer: 6.272 ± 1.958
5.407GlyThr: 5.407 ± 1.498
4.109GlyVal: 4.109 ± 0.923
0.216GlyTrp: 0.216 ± 0.26
1.946GlyTyr: 1.946 ± 0.722
0.0GlyXaa: 0.0 ± 0.0
His
1.081HisAla: 1.081 ± 0.458
0.433HisCys: 0.433 ± 0.259
0.433HisAsp: 0.433 ± 0.216
1.73HisGlu: 1.73 ± 0.609
1.081HisPhe: 1.081 ± 0.372
0.649HisGly: 0.649 ± 0.244
0.216HisHis: 0.216 ± 0.28
1.298HisIle: 1.298 ± 0.336
0.216HisLys: 0.216 ± 0.13
1.946HisLeu: 1.946 ± 0.918
0.216HisMet: 0.216 ± 0.13
1.514HisAsn: 1.514 ± 0.668
1.73HisPro: 1.73 ± 0.521
0.865HisGln: 0.865 ± 0.326
0.649HisArg: 0.649 ± 0.389
2.379HisSer: 2.379 ± 0.724
1.081HisThr: 1.081 ± 0.499
1.081HisVal: 1.081 ± 0.3
0.0HisTrp: 0.0 ± 0.0
0.216HisTyr: 0.216 ± 0.26
0.0HisXaa: 0.0 ± 0.0
Ile
5.19IleAla: 5.19 ± 0.987
0.649IleCys: 0.649 ± 0.532
3.676IleAsp: 3.676 ± 1.006
3.244IleGlu: 3.244 ± 0.776
3.46IlePhe: 3.46 ± 0.787
3.244IleGly: 3.244 ± 1.042
1.73IleHis: 1.73 ± 0.393
3.893IleIle: 3.893 ± 0.748
2.811IleLys: 2.811 ± 0.628
6.055IleLeu: 6.055 ± 0.527
2.379IleMet: 2.379 ± 0.342
3.676IleAsn: 3.676 ± 0.677
2.811IlePro: 2.811 ± 0.585
3.676IleGln: 3.676 ± 0.837
4.109IleArg: 4.109 ± 0.441
6.272IleSer: 6.272 ± 0.557
4.974IleThr: 4.974 ± 1.185
4.109IleVal: 4.109 ± 1.081
0.433IleTrp: 0.433 ± 0.213
1.081IleTyr: 1.081 ± 0.416
0.0IleXaa: 0.0 ± 0.0
Lys
3.028LysAla: 3.028 ± 0.691
0.433LysCys: 0.433 ± 0.259
2.811LysAsp: 2.811 ± 1.031
3.676LysGlu: 3.676 ± 1.265
1.514LysPhe: 1.514 ± 0.509
3.244LysGly: 3.244 ± 1.017
0.865LysHis: 0.865 ± 0.387
3.893LysIle: 3.893 ± 0.832
2.811LysLys: 2.811 ± 1.204
5.19LysLeu: 5.19 ± 0.937
1.73LysMet: 1.73 ± 1.033
2.811LysAsn: 2.811 ± 0.831
0.865LysPro: 0.865 ± 0.44
2.595LysGln: 2.595 ± 0.309
2.811LysArg: 2.811 ± 0.563
2.595LysSer: 2.595 ± 0.902
1.946LysThr: 1.946 ± 0.853
2.379LysVal: 2.379 ± 0.678
0.0LysTrp: 0.0 ± 0.0
2.163LysTyr: 2.163 ± 0.432
0.0LysXaa: 0.0 ± 0.0
Leu
7.785LeuAla: 7.785 ± 1.133
2.379LeuCys: 2.379 ± 0.788
5.839LeuAsp: 5.839 ± 1.344
5.19LeuGlu: 5.19 ± 0.615
4.974LeuPhe: 4.974 ± 1.331
5.839LeuGly: 5.839 ± 1.316
2.595LeuHis: 2.595 ± 1.373
7.569LeuIle: 7.569 ± 1.555
4.542LeuLys: 4.542 ± 1.182
11.029LeuLeu: 11.029 ± 2.005
3.244LeuMet: 3.244 ± 0.704
4.542LeuAsn: 4.542 ± 0.943
3.893LeuPro: 3.893 ± 0.952
2.595LeuGln: 2.595 ± 1.236
4.758LeuArg: 4.758 ± 0.901
12.111LeuSer: 12.111 ± 1.238
8.651LeuThr: 8.651 ± 1.214
3.676LeuVal: 3.676 ± 0.435
0.865LeuTrp: 0.865 ± 0.387
3.46LeuTyr: 3.46 ± 0.752
0.0LeuXaa: 0.0 ± 0.0
Met
1.73MetAla: 1.73 ± 0.633
0.433MetCys: 0.433 ± 0.259
0.649MetAsp: 0.649 ± 0.29
1.946MetGlu: 1.946 ± 0.571
0.649MetPhe: 0.649 ± 0.389
2.163MetGly: 2.163 ± 0.668
1.298MetHis: 1.298 ± 0.28
1.73MetIle: 1.73 ± 0.529
0.865MetLys: 0.865 ± 0.279
2.811MetLeu: 2.811 ± 0.976
1.514MetMet: 1.514 ± 0.881
1.298MetAsn: 1.298 ± 0.684
0.433MetPro: 0.433 ± 0.213
1.081MetGln: 1.081 ± 0.462
2.163MetArg: 2.163 ± 1.285
3.46MetSer: 3.46 ± 0.545
1.298MetThr: 1.298 ± 0.444
1.514MetVal: 1.514 ± 0.443
0.216MetTrp: 0.216 ± 0.285
1.081MetTyr: 1.081 ± 0.822
0.0MetXaa: 0.0 ± 0.0
Asn
3.676AsnAla: 3.676 ± 0.613
0.649AsnCys: 0.649 ± 0.299
1.514AsnAsp: 1.514 ± 0.653
1.298AsnGlu: 1.298 ± 0.594
1.298AsnPhe: 1.298 ± 0.43
3.028AsnGly: 3.028 ± 0.371
1.081AsnHis: 1.081 ± 0.499
3.46AsnIle: 3.46 ± 0.645
2.811AsnLys: 2.811 ± 0.287
6.272AsnLeu: 6.272 ± 1.427
1.081AsnMet: 1.081 ± 0.244
2.379AsnAsn: 2.379 ± 1.708
2.811AsnPro: 2.811 ± 0.923
1.946AsnGln: 1.946 ± 0.636
1.73AsnArg: 1.73 ± 0.89
2.595AsnSer: 2.595 ± 0.516
4.542AsnThr: 4.542 ± 1.286
2.811AsnVal: 2.811 ± 0.847
0.865AsnTrp: 0.865 ± 0.519
0.865AsnTyr: 0.865 ± 0.252
0.0AsnXaa: 0.0 ± 0.0
Pro
4.109ProAla: 4.109 ± 0.79
0.649ProCys: 0.649 ± 0.244
1.946ProAsp: 1.946 ± 0.663
2.595ProGlu: 2.595 ± 0.531
1.514ProPhe: 1.514 ± 0.554
3.244ProGly: 3.244 ± 1.203
1.081ProHis: 1.081 ± 0.421
1.73ProIle: 1.73 ± 0.46
2.163ProLys: 2.163 ± 0.406
6.055ProLeu: 6.055 ± 1.039
1.73ProMet: 1.73 ± 0.348
1.298ProAsn: 1.298 ± 0.72
2.379ProPro: 2.379 ± 0.868
2.379ProGln: 2.379 ± 0.924
1.514ProArg: 1.514 ± 0.475
4.109ProSer: 4.109 ± 1.411
3.46ProThr: 3.46 ± 0.884
3.893ProVal: 3.893 ± 2.241
0.0ProTrp: 0.0 ± 0.0
2.163ProTyr: 2.163 ± 0.411
0.0ProXaa: 0.0 ± 0.0
Gln
2.379GlnAla: 2.379 ± 0.86
0.433GlnCys: 0.433 ± 0.259
1.514GlnAsp: 1.514 ± 0.789
1.946GlnGlu: 1.946 ± 0.521
1.73GlnPhe: 1.73 ± 0.634
2.595GlnGly: 2.595 ± 1.028
0.433GlnHis: 0.433 ± 0.229
4.325GlnIle: 4.325 ± 0.382
3.676GlnLys: 3.676 ± 0.792
4.758GlnLeu: 4.758 ± 1.374
1.514GlnMet: 1.514 ± 0.407
1.514GlnAsn: 1.514 ± 0.536
1.514GlnPro: 1.514 ± 0.798
1.946GlnGln: 1.946 ± 0.672
1.946GlnArg: 1.946 ± 0.577
3.244GlnSer: 3.244 ± 0.487
1.946GlnThr: 1.946 ± 0.773
3.46GlnVal: 3.46 ± 0.185
0.216GlnTrp: 0.216 ± 0.13
0.649GlnTyr: 0.649 ± 0.284
0.0GlnXaa: 0.0 ± 0.0
Arg
3.028ArgAla: 3.028 ± 0.809
0.649ArgCys: 0.649 ± 0.284
3.028ArgAsp: 3.028 ± 0.445
2.595ArgGlu: 2.595 ± 0.872
0.433ArgPhe: 0.433 ± 0.213
2.811ArgGly: 2.811 ± 0.659
1.298ArgHis: 1.298 ± 0.778
4.542ArgIle: 4.542 ± 0.418
2.163ArgLys: 2.163 ± 0.625
6.704ArgLeu: 6.704 ± 1.306
1.298ArgMet: 1.298 ± 0.618
1.514ArgAsn: 1.514 ± 0.635
1.514ArgPro: 1.514 ± 0.443
1.946ArgGln: 1.946 ± 0.579
3.028ArgArg: 3.028 ± 0.738
4.758ArgSer: 4.758 ± 0.631
3.244ArgThr: 3.244 ± 0.942
4.109ArgVal: 4.109 ± 0.681
0.216ArgTrp: 0.216 ± 0.224
1.73ArgTyr: 1.73 ± 0.679
0.0ArgXaa: 0.0 ± 0.0
Ser
6.704SerAla: 6.704 ± 0.827
1.514SerCys: 1.514 ± 0.358
4.109SerAsp: 4.109 ± 0.957
4.109SerGlu: 4.109 ± 0.813
3.244SerPhe: 3.244 ± 0.547
5.19SerGly: 5.19 ± 1.105
1.298SerHis: 1.298 ± 0.488
5.623SerIle: 5.623 ± 1.392
3.028SerLys: 3.028 ± 0.598
9.516SerLeu: 9.516 ± 1.135
1.514SerMet: 1.514 ± 0.307
5.839SerAsn: 5.839 ± 1.07
5.839SerPro: 5.839 ± 1.035
4.542SerGln: 4.542 ± 2.107
3.893SerArg: 3.893 ± 1.544
7.785SerSer: 7.785 ± 0.889
6.488SerThr: 6.488 ± 0.872
5.839SerVal: 5.839 ± 1.06
0.865SerTrp: 0.865 ± 0.274
3.244SerTyr: 3.244 ± 0.965
0.0SerXaa: 0.0 ± 0.0
Thr
5.839ThrAla: 5.839 ± 1.7
1.946ThrCys: 1.946 ± 0.387
3.028ThrAsp: 3.028 ± 0.582
4.109ThrGlu: 4.109 ± 1.035
1.73ThrPhe: 1.73 ± 0.396
4.758ThrGly: 4.758 ± 1.425
1.081ThrHis: 1.081 ± 0.582
4.325ThrIle: 4.325 ± 1.099
3.46ThrLys: 3.46 ± 0.544
6.704ThrLeu: 6.704 ± 1.669
1.514ThrMet: 1.514 ± 0.316
2.379ThrAsn: 2.379 ± 0.55
4.758ThrPro: 4.758 ± 1.807
4.325ThrGln: 4.325 ± 0.924
3.676ThrArg: 3.676 ± 1.153
5.839ThrSer: 5.839 ± 1.886
4.974ThrThr: 4.974 ± 0.805
5.19ThrVal: 5.19 ± 0.847
0.433ThrTrp: 0.433 ± 0.216
1.73ThrTyr: 1.73 ± 0.631
0.0ThrXaa: 0.0 ± 0.0
Val
4.325ValAla: 4.325 ± 0.966
0.865ValCys: 0.865 ± 0.298
1.73ValAsp: 1.73 ± 0.497
2.379ValGlu: 2.379 ± 0.429
2.811ValPhe: 2.811 ± 0.59
3.028ValGly: 3.028 ± 0.879
1.081ValHis: 1.081 ± 0.283
4.109ValIle: 4.109 ± 0.648
3.46ValLys: 3.46 ± 0.645
6.92ValLeu: 6.92 ± 1.265
1.514ValMet: 1.514 ± 0.328
1.73ValAsn: 1.73 ± 0.415
4.325ValPro: 4.325 ± 1.215
2.595ValGln: 2.595 ± 0.277
2.811ValArg: 2.811 ± 0.999
6.704ValSer: 6.704 ± 0.685
4.758ValThr: 4.758 ± 2.075
3.028ValVal: 3.028 ± 0.554
0.433ValTrp: 0.433 ± 0.216
2.595ValTyr: 2.595 ± 0.747
0.0ValXaa: 0.0 ± 0.0
Trp
0.433TrpAla: 0.433 ± 0.259
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.216TrpGlu: 0.216 ± 0.28
0.433TrpPhe: 0.433 ± 0.259
0.433TrpGly: 0.433 ± 0.213
0.216TrpHis: 0.216 ± 0.224
0.433TrpIle: 0.433 ± 0.259
0.216TrpLys: 0.216 ± 0.13
0.649TrpLeu: 0.649 ± 0.299
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.433TrpPro: 0.433 ± 0.216
0.0TrpGln: 0.0 ± 0.0
1.081TrpArg: 1.081 ± 0.293
1.081TrpSer: 1.081 ± 0.321
0.649TrpThr: 0.649 ± 0.284
0.216TrpVal: 0.216 ± 0.224
0.0TrpTrp: 0.0 ± 0.0
0.433TrpTyr: 0.433 ± 0.216
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.379TyrAla: 2.379 ± 0.663
0.865TyrCys: 0.865 ± 0.477
1.081TyrAsp: 1.081 ± 0.481
1.081TyrGlu: 1.081 ± 0.471
0.649TyrPhe: 0.649 ± 0.244
1.73TyrGly: 1.73 ± 0.315
0.216TyrHis: 0.216 ± 0.285
2.163TyrIle: 2.163 ± 0.836
2.379TyrLys: 2.379 ± 1.016
3.676TyrLeu: 3.676 ± 1.703
1.514TyrMet: 1.514 ± 0.572
1.946TyrAsn: 1.946 ± 0.438
1.514TyrPro: 1.514 ± 1.08
1.73TyrGln: 1.73 ± 0.37
1.081TyrArg: 1.081 ± 0.472
3.028TyrSer: 3.028 ± 0.757
1.73TyrThr: 1.73 ± 1.146
1.081TyrVal: 1.081 ± 0.431
0.216TyrTrp: 0.216 ± 0.13
1.946TyrTyr: 1.946 ± 0.722
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (4625 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski