Amino acid dipepetide frequency for Macaca mulatta papillomavirus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.013AlaAla: 7.013 ± 2.033
0.413AlaCys: 0.413 ± 0.333
3.713AlaAsp: 3.713 ± 0.678
2.888AlaGlu: 2.888 ± 1.136
4.538AlaPhe: 4.538 ± 1.485
1.65AlaGly: 1.65 ± 0.785
0.825AlaHis: 0.825 ± 0.408
1.238AlaIle: 1.238 ± 0.45
4.95AlaLys: 4.95 ± 1.559
5.363AlaLeu: 5.363 ± 1.381
0.825AlaMet: 0.825 ± 0.402
0.825AlaAsn: 0.825 ± 0.426
3.713AlaPro: 3.713 ± 1.769
2.475AlaGln: 2.475 ± 0.931
3.3AlaArg: 3.3 ± 1.193
2.888AlaSer: 2.888 ± 0.552
2.888AlaThr: 2.888 ± 0.867
2.888AlaVal: 2.888 ± 1.13
0.825AlaTrp: 0.825 ± 0.666
2.888AlaTyr: 2.888 ± 0.764
0.0AlaXaa: 0.0 ± 0.0
Cys
2.475CysAla: 2.475 ± 1.3
1.65CysCys: 1.65 ± 1.019
2.063CysAsp: 2.063 ± 1.004
2.063CysGlu: 2.063 ± 0.769
0.413CysPhe: 0.413 ± 0.37
0.0CysGly: 0.0 ± 0.0
0.413CysHis: 0.413 ± 0.467
1.238CysIle: 1.238 ± 0.999
1.65CysLys: 1.65 ± 0.7
0.413CysLeu: 0.413 ± 0.467
0.413CysMet: 0.413 ± 0.467
1.65CysAsn: 1.65 ± 1.039
1.65CysPro: 1.65 ± 0.802
0.825CysGln: 0.825 ± 0.393
1.65CysArg: 1.65 ± 1.442
0.413CysSer: 0.413 ± 0.467
0.0CysThr: 0.0 ± 0.0
0.825CysVal: 0.825 ± 0.934
0.825CysTrp: 0.825 ± 0.501
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.713AspAla: 3.713 ± 0.833
1.65AspCys: 1.65 ± 0.656
4.538AspAsp: 4.538 ± 1.675
3.3AspGlu: 3.3 ± 1.469
2.063AspPhe: 2.063 ± 1.019
3.713AspGly: 3.713 ± 1.471
1.65AspHis: 1.65 ± 0.616
5.363AspIle: 5.363 ± 1.393
3.713AspLys: 3.713 ± 1.02
5.363AspLeu: 5.363 ± 1.065
1.238AspMet: 1.238 ± 0.343
2.888AspAsn: 2.888 ± 1.17
5.776AspPro: 5.776 ± 1.334
2.475AspGln: 2.475 ± 0.447
2.063AspArg: 2.063 ± 1.144
4.125AspSer: 4.125 ± 0.713
4.95AspThr: 4.95 ± 1.27
3.713AspVal: 3.713 ± 1.221
1.65AspTrp: 1.65 ± 0.946
1.65AspTyr: 1.65 ± 0.678
0.0AspXaa: 0.0 ± 0.0
Glu
2.475GluAla: 2.475 ± 0.512
0.413GluCys: 0.413 ± 0.333
4.95GluAsp: 4.95 ± 1.126
10.726GluGlu: 10.726 ± 4.988
3.3GluPhe: 3.3 ± 0.651
6.601GluGly: 6.601 ± 2.388
1.238GluHis: 1.238 ± 0.626
2.475GluIle: 2.475 ± 1.177
2.475GluLys: 2.475 ± 0.681
5.363GluLeu: 5.363 ± 1.3
0.413GluMet: 0.413 ± 0.333
3.3GluAsn: 3.3 ± 0.724
4.95GluPro: 4.95 ± 1.195
1.65GluGln: 1.65 ± 0.678
2.063GluArg: 2.063 ± 0.575
6.188GluSer: 6.188 ± 2.299
4.125GluThr: 4.125 ± 1.025
2.888GluVal: 2.888 ± 0.552
0.0GluTrp: 0.0 ± 0.0
0.825GluTyr: 0.825 ± 0.527
0.0GluXaa: 0.0 ± 0.0
Phe
2.475PheAla: 2.475 ± 0.844
0.413PheCys: 0.413 ± 0.467
4.125PheAsp: 4.125 ± 0.931
1.65PheGlu: 1.65 ± 1.135
2.475PhePhe: 2.475 ± 0.931
4.538PheGly: 4.538 ± 1.555
0.413PheHis: 0.413 ± 0.561
2.888PheIle: 2.888 ± 0.855
3.3PheLys: 3.3 ± 1.882
4.125PheLeu: 4.125 ± 0.87
0.825PheMet: 0.825 ± 0.402
2.063PheAsn: 2.063 ± 1.013
2.063PhePro: 2.063 ± 0.5
1.238PheGln: 1.238 ± 0.655
1.238PheArg: 1.238 ± 0.639
3.713PheSer: 3.713 ± 1.085
2.063PheThr: 2.063 ± 0.5
2.063PheVal: 2.063 ± 0.854
1.238PheTrp: 1.238 ± 0.429
2.063PheTyr: 2.063 ± 0.996
0.0PheXaa: 0.0 ± 0.0
Gly
4.125GlyAla: 4.125 ± 1.136
0.825GlyCys: 0.825 ± 0.527
3.713GlyAsp: 3.713 ± 0.86
6.188GlyGlu: 6.188 ± 1.802
1.65GlyPhe: 1.65 ± 0.962
6.601GlyGly: 6.601 ± 2.914
2.063GlyHis: 2.063 ± 0.772
5.363GlyIle: 5.363 ± 1.089
2.063GlyLys: 2.063 ± 1.015
4.125GlyLeu: 4.125 ± 0.498
0.0GlyMet: 0.0 ± 0.0
3.713GlyAsn: 3.713 ± 0.761
1.65GlyPro: 1.65 ± 0.622
1.238GlyGln: 1.238 ± 0.383
3.3GlyArg: 3.3 ± 1.194
7.426GlySer: 7.426 ± 2.009
4.125GlyThr: 4.125 ± 2.626
4.538GlyVal: 4.538 ± 0.803
0.413GlyTrp: 0.413 ± 0.333
0.825GlyTyr: 0.825 ± 0.683
0.0GlyXaa: 0.0 ± 0.0
His
0.413HisAla: 0.413 ± 0.333
1.65HisCys: 1.65 ± 0.755
1.238HisAsp: 1.238 ± 0.95
0.825HisGlu: 0.825 ± 0.402
1.238HisPhe: 1.238 ± 0.598
1.238HisGly: 1.238 ± 0.846
0.825HisHis: 0.825 ± 0.605
0.413HisIle: 0.413 ± 0.342
2.063HisLys: 2.063 ± 1.221
2.475HisLeu: 2.475 ± 1.103
0.0HisMet: 0.0 ± 0.0
0.825HisAsn: 0.825 ± 0.501
1.65HisPro: 1.65 ± 0.815
0.825HisGln: 0.825 ± 0.63
1.238HisArg: 1.238 ± 0.65
0.413HisSer: 0.413 ± 0.342
0.413HisThr: 0.413 ± 0.404
0.413HisVal: 0.413 ± 0.37
0.0HisTrp: 0.0 ± 0.0
0.825HisTyr: 0.825 ± 0.402
0.0HisXaa: 0.0 ± 0.0
Ile
3.3IleAla: 3.3 ± 1.916
1.238IleCys: 1.238 ± 0.429
3.713IleAsp: 3.713 ± 1.827
4.125IleGlu: 4.125 ± 0.939
1.65IlePhe: 1.65 ± 0.788
4.95IleGly: 4.95 ± 0.962
0.413IleHis: 0.413 ± 0.561
3.713IleIle: 3.713 ± 0.891
1.65IleLys: 1.65 ± 0.554
4.125IleLeu: 4.125 ± 1.521
0.413IleMet: 0.413 ± 0.404
0.413IleAsn: 0.413 ± 0.333
4.538IlePro: 4.538 ± 1.584
0.825IleGln: 0.825 ± 0.666
1.65IleArg: 1.65 ± 1.004
3.3IleSer: 3.3 ± 0.615
2.888IleThr: 2.888 ± 0.919
4.95IleVal: 4.95 ± 1.791
0.825IleTrp: 0.825 ± 0.605
2.475IleTyr: 2.475 ± 0.858
0.0IleXaa: 0.0 ± 0.0
Lys
0.825LysAla: 0.825 ± 0.426
1.65LysCys: 1.65 ± 0.951
3.3LysAsp: 3.3 ± 1.183
3.713LysGlu: 3.713 ± 1.341
3.713LysPhe: 3.713 ± 1.639
2.475LysGly: 2.475 ± 0.797
1.65LysHis: 1.65 ± 0.941
1.65LysIle: 1.65 ± 0.582
2.888LysLys: 2.888 ± 1.71
3.713LysLeu: 3.713 ± 1.405
1.65LysMet: 1.65 ± 0.734
3.3LysAsn: 3.3 ± 1.181
1.238LysPro: 1.238 ± 0.626
3.3LysGln: 3.3 ± 1.164
6.601LysArg: 6.601 ± 1.815
2.475LysSer: 2.475 ± 1.292
2.063LysThr: 2.063 ± 0.701
4.125LysVal: 4.125 ± 0.671
0.413LysTrp: 0.413 ± 0.37
2.063LysTyr: 2.063 ± 0.868
0.0LysXaa: 0.0 ± 0.0
Leu
4.95LeuAla: 4.95 ± 1.023
2.475LeuCys: 2.475 ± 1.412
4.538LeuAsp: 4.538 ± 1.442
7.426LeuGlu: 7.426 ± 2.168
4.538LeuPhe: 4.538 ± 0.834
5.363LeuGly: 5.363 ± 1.378
2.063LeuHis: 2.063 ± 0.996
3.3LeuIle: 3.3 ± 0.695
4.538LeuLys: 4.538 ± 1.784
8.251LeuLeu: 8.251 ± 2.892
1.238LeuMet: 1.238 ± 0.726
5.776LeuAsn: 5.776 ± 1.659
3.3LeuPro: 3.3 ± 1.009
6.601LeuGln: 6.601 ± 1.765
4.538LeuArg: 4.538 ± 1.064
12.376LeuSer: 12.376 ± 1.933
3.713LeuThr: 3.713 ± 0.93
2.063LeuVal: 2.063 ± 1.06
0.0LeuTrp: 0.0 ± 0.0
4.125LeuTyr: 4.125 ± 1.151
0.0LeuXaa: 0.0 ± 0.0
Met
0.825MetAla: 0.825 ± 0.501
0.413MetCys: 0.413 ± 0.37
1.238MetAsp: 1.238 ± 0.697
0.825MetGlu: 0.825 ± 0.605
0.825MetPhe: 0.825 ± 0.393
0.413MetGly: 0.413 ± 0.333
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.413MetLys: 0.413 ± 0.467
2.063MetLeu: 2.063 ± 1.098
0.413MetMet: 0.413 ± 0.404
0.413MetAsn: 0.413 ± 0.333
1.65MetPro: 1.65 ± 0.595
0.825MetGln: 0.825 ± 0.598
0.825MetArg: 0.825 ± 0.666
2.063MetSer: 2.063 ± 1.264
1.65MetThr: 1.65 ± 0.595
0.413MetVal: 0.413 ± 0.333
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.888AsnAla: 2.888 ± 0.862
0.825AsnCys: 0.825 ± 0.393
2.063AsnAsp: 2.063 ± 0.675
2.063AsnGlu: 2.063 ± 1.31
1.65AsnPhe: 1.65 ± 1.042
1.238AsnGly: 1.238 ± 0.697
0.0AsnHis: 0.0 ± 0.0
2.475AsnIle: 2.475 ± 0.902
3.3AsnLys: 3.3 ± 0.597
4.125AsnLeu: 4.125 ± 1.796
1.238AsnMet: 1.238 ± 0.65
2.063AsnAsn: 2.063 ± 1.077
2.888AsnPro: 2.888 ± 0.716
2.063AsnGln: 2.063 ± 0.93
2.475AsnArg: 2.475 ± 1.167
4.125AsnSer: 4.125 ± 1.64
4.538AsnThr: 4.538 ± 1.669
2.475AsnVal: 2.475 ± 0.667
0.413AsnTrp: 0.413 ± 0.37
1.238AsnTyr: 1.238 ± 0.429
0.0AsnXaa: 0.0 ± 0.0
Pro
3.3ProAla: 3.3 ± 1.268
1.65ProCys: 1.65 ± 1.065
4.95ProAsp: 4.95 ± 1.521
3.713ProGlu: 3.713 ± 0.789
0.413ProPhe: 0.413 ± 0.342
2.888ProGly: 2.888 ± 1.276
1.238ProHis: 1.238 ± 0.699
1.238ProIle: 1.238 ± 0.343
3.3ProLys: 3.3 ± 0.702
5.363ProLeu: 5.363 ± 1.923
0.0ProMet: 0.0 ± 0.0
2.888ProAsn: 2.888 ± 0.948
6.188ProPro: 6.188 ± 2.86
1.65ProGln: 1.65 ± 0.903
3.713ProArg: 3.713 ± 2.138
6.188ProSer: 6.188 ± 1.488
4.125ProThr: 4.125 ± 1.271
5.363ProVal: 5.363 ± 1.094
0.825ProTrp: 0.825 ± 0.668
2.063ProTyr: 2.063 ± 1.153
0.0ProXaa: 0.0 ± 0.0
Gln
2.888GlnAla: 2.888 ± 1.009
1.238GlnCys: 1.238 ± 0.598
0.825GlnAsp: 0.825 ± 0.449
3.3GlnGlu: 3.3 ± 1.191
2.063GlnPhe: 2.063 ± 0.415
2.063GlnGly: 2.063 ± 0.752
0.825GlnHis: 0.825 ± 0.807
2.475GlnIle: 2.475 ± 1.127
0.825GlnLys: 0.825 ± 0.426
6.188GlnLeu: 6.188 ± 1.551
0.825GlnMet: 0.825 ± 0.402
0.825GlnAsn: 0.825 ± 0.501
0.825GlnPro: 0.825 ± 0.683
0.825GlnGln: 0.825 ± 0.408
2.475GlnArg: 2.475 ± 0.951
2.063GlnSer: 2.063 ± 1.048
2.475GlnThr: 2.475 ± 1.354
2.888GlnVal: 2.888 ± 0.68
0.413GlnTrp: 0.413 ± 0.333
1.65GlnTyr: 1.65 ± 0.5
0.0GlnXaa: 0.0 ± 0.0
Arg
2.888ArgAla: 2.888 ± 0.999
2.063ArgCys: 2.063 ± 0.788
2.888ArgAsp: 2.888 ± 1.236
1.65ArgGlu: 1.65 ± 0.554
0.825ArgPhe: 0.825 ± 0.501
4.95ArgGly: 4.95 ± 2.117
2.475ArgHis: 2.475 ± 0.914
2.475ArgIle: 2.475 ± 1.12
4.95ArgLys: 4.95 ± 1.499
6.601ArgLeu: 6.601 ± 1.595
1.238ArgMet: 1.238 ± 0.633
2.063ArgAsn: 2.063 ± 0.723
3.3ArgPro: 3.3 ± 1.455
2.475ArgGln: 2.475 ± 0.962
7.426ArgArg: 7.426 ± 3.394
3.713ArgSer: 3.713 ± 1.781
2.475ArgThr: 2.475 ± 1.207
2.888ArgVal: 2.888 ± 1.03
0.0ArgTrp: 0.0 ± 0.0
2.063ArgTyr: 2.063 ± 0.377
0.0ArgXaa: 0.0 ± 0.0
Ser
4.538SerAla: 4.538 ± 1.067
0.413SerCys: 0.413 ± 0.333
3.713SerAsp: 3.713 ± 0.92
4.538SerGlu: 4.538 ± 1.285
2.888SerPhe: 2.888 ± 1.351
5.363SerGly: 5.363 ± 0.991
0.825SerHis: 0.825 ± 0.393
6.188SerIle: 6.188 ± 2.043
3.713SerLys: 3.713 ± 1.272
8.663SerLeu: 8.663 ± 2.565
1.65SerMet: 1.65 ± 0.937
2.475SerAsn: 2.475 ± 0.836
5.776SerPro: 5.776 ± 1.485
2.888SerGln: 2.888 ± 1.509
4.125SerArg: 4.125 ± 0.706
9.488SerSer: 9.488 ± 2.613
7.426SerThr: 7.426 ± 2.86
4.95SerVal: 4.95 ± 0.92
0.825SerTrp: 0.825 ± 0.426
2.888SerTyr: 2.888 ± 1.181
0.0SerXaa: 0.0 ± 0.0
Thr
2.888ThrAla: 2.888 ± 0.805
0.413ThrCys: 0.413 ± 0.467
6.601ThrAsp: 6.601 ± 2.24
2.475ThrGlu: 2.475 ± 1.04
3.713ThrPhe: 3.713 ± 1.148
4.125ThrGly: 4.125 ± 1.301
1.238ThrHis: 1.238 ± 0.594
3.3ThrIle: 3.3 ± 1.184
2.475ThrLys: 2.475 ± 0.586
4.95ThrLeu: 4.95 ± 1.719
0.825ThrMet: 0.825 ± 0.623
3.3ThrAsn: 3.3 ± 1.1
4.538ThrPro: 4.538 ± 1.842
1.238ThrGln: 1.238 ± 0.45
5.776ThrArg: 5.776 ± 1.587
2.888ThrSer: 2.888 ± 0.963
3.3ThrThr: 3.3 ± 1.47
6.601ThrVal: 6.601 ± 1.357
0.413ThrTrp: 0.413 ± 0.333
0.413ThrTyr: 0.413 ± 0.37
0.0ThrXaa: 0.0 ± 0.0
Val
1.65ValAla: 1.65 ± 0.97
0.413ValCys: 0.413 ± 0.37
4.95ValAsp: 4.95 ± 0.848
3.3ValGlu: 3.3 ± 0.937
3.713ValPhe: 3.713 ± 0.966
4.125ValGly: 4.125 ± 1.54
0.413ValHis: 0.413 ± 0.342
2.063ValIle: 2.063 ± 0.699
2.063ValLys: 2.063 ± 0.377
5.776ValLeu: 5.776 ± 1.806
0.413ValMet: 0.413 ± 0.401
1.65ValAsn: 1.65 ± 0.642
4.538ValPro: 4.538 ± 0.663
2.888ValGln: 2.888 ± 0.84
2.063ValArg: 2.063 ± 1.014
7.013ValSer: 7.013 ± 1.754
5.363ValThr: 5.363 ± 1.883
3.713ValVal: 3.713 ± 1.295
1.238ValTrp: 1.238 ± 0.783
2.475ValTyr: 2.475 ± 1.359
0.0ValXaa: 0.0 ± 0.0
Trp
0.825TrpAla: 0.825 ± 0.666
0.413TrpCys: 0.413 ± 0.333
0.825TrpAsp: 0.825 ± 0.627
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.413TrpHis: 0.413 ± 0.404
0.413TrpIle: 0.413 ± 0.333
1.238TrpLys: 1.238 ± 0.429
2.063TrpLeu: 2.063 ± 0.828
0.413TrpMet: 0.413 ± 0.37
1.238TrpAsn: 1.238 ± 0.783
0.413TrpPro: 0.413 ± 0.37
0.0TrpGln: 0.0 ± 0.0
0.825TrpArg: 0.825 ± 0.605
0.0TrpSer: 0.0 ± 0.0
1.65TrpThr: 1.65 ± 0.729
0.413TrpVal: 0.413 ± 0.404
0.0TrpTrp: 0.0 ± 0.0
0.413TrpTyr: 0.413 ± 0.333
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.65TyrAla: 1.65 ± 0.678
0.413TyrCys: 0.413 ± 0.333
1.65TyrAsp: 1.65 ± 0.615
1.65TyrGlu: 1.65 ± 0.922
3.3TyrPhe: 3.3 ± 1.593
1.65TyrGly: 1.65 ± 0.814
0.0TyrHis: 0.0 ± 0.0
2.888TyrIle: 2.888 ± 0.475
1.238TyrLys: 1.238 ± 0.697
2.475TyrLeu: 2.475 ± 0.98
0.825TyrMet: 0.825 ± 0.666
2.475TyrAsn: 2.475 ± 0.424
0.413TyrPro: 0.413 ± 0.404
1.65TyrGln: 1.65 ± 0.5
2.063TyrArg: 2.063 ± 0.5
2.475TyrSer: 2.475 ± 0.775
1.238TyrThr: 1.238 ± 0.429
1.65TyrVal: 1.65 ± 0.691
1.238TyrTrp: 1.238 ± 0.783
3.3TyrTyr: 3.3 ± 2.385
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2425 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski