Amino acid dipepetide frequency for Candidatus Halobonum tyrrellensis G22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.591AlaAla: 17.591 ± 0.231	0.816AlaCys: 0.816 ± 0.03	12.935AlaAsp: 12.935 ± 0.166	9.169AlaGlu: 9.169 ± 0.108	4.397AlaPhe: 4.397 ± 0.077	12.316AlaGly: 12.316 ± 0.151	1.88AlaHis: 1.88 ± 0.045	3.024AlaIle: 3.024 ± 0.06	1.458AlaLys: 1.458 ± 0.039	11.206AlaLeu: 11.206 ± 0.153	2.048AlaMet: 2.048 ± 0.043	2.434AlaAsn: 2.434 ± 0.051	4.736AlaPro: 4.736 ± 0.074	1.749AlaGln: 1.749 ± 0.044	7.46AlaArg: 7.46 ± 0.113	5.931AlaSer: 5.931 ± 0.082	7.289AlaThr: 7.289 ± 0.095	12.894AlaVal: 12.894 ± 0.159	1.271AlaTrp: 1.271 ± 0.035	3.091AlaTyr: 3.091 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.635CysAla: 0.635 ± 0.026	0.079CysCys: 0.079 ± 0.009	0.579CysAsp: 0.579 ± 0.025	0.592CysGlu: 0.592 ± 0.022	0.179CysPhe: 0.179 ± 0.013	0.834CysGly: 0.834 ± 0.035	0.191CysHis: 0.191 ± 0.014	0.214CysIle: 0.214 ± 0.016	0.068CysLys: 0.068 ± 0.009	0.538CysLeu: 0.538 ± 0.021	0.082CysMet: 0.082 ± 0.009	0.146CysAsn: 0.146 ± 0.011	0.496CysPro: 0.496 ± 0.023	0.114CysGln: 0.114 ± 0.011	0.47CysArg: 0.47 ± 0.024	0.422CysSer: 0.422 ± 0.023	0.346CysThr: 0.346 ± 0.018	0.527CysVal: 0.527 ± 0.022	0.094CysTrp: 0.094 ± 0.01	0.181CysTyr: 0.181 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	13.167AspAla: 13.167 ± 0.163	0.737AspCys: 0.737 ± 0.032	9.436AspAsp: 9.436 ± 0.131	7.572AspGlu: 7.572 ± 0.104	1.696AspPhe: 1.696 ± 0.045	9.711AspGly: 9.711 ± 0.12	1.875AspHis: 1.875 ± 0.044	2.277AspIle: 2.277 ± 0.058	0.662AspLys: 0.662 ± 0.029	7.301AspLeu: 7.301 ± 0.111	1.05AspMet: 1.05 ± 0.034	1.111AspAsn: 1.111 ± 0.041	5.891AspPro: 5.891 ± 0.083	1.343AspGln: 1.343 ± 0.045	7.731AspArg: 7.731 ± 0.102	3.412AspSer: 3.412 ± 0.069	3.963AspThr: 3.963 ± 0.065	7.437AspVal: 7.437 ± 0.085	0.95AspTrp: 0.95 ± 0.031	1.882AspTyr: 1.882 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	9.158GluAla: 9.158 ± 0.127	0.4GluCys: 0.4 ± 0.022	3.807GluAsp: 3.807 ± 0.08	6.277GluGlu: 6.277 ± 0.113	3.122GluPhe: 3.122 ± 0.058	6.105GluGly: 6.105 ± 0.086	1.666GluHis: 1.666 ± 0.046	2.377GluIle: 2.377 ± 0.061	1.3GluLys: 1.3 ± 0.039	6.68GluLeu: 6.68 ± 0.093	1.812GluMet: 1.812 ± 0.042	1.778GluAsn: 1.778 ± 0.044	3.544GluPro: 3.544 ± 0.07	1.882GluGln: 1.882 ± 0.048	8.361GluArg: 8.361 ± 0.115	4.914GluSer: 4.914 ± 0.078	6.356GluThr: 6.356 ± 0.085	5.874GluVal: 5.874 ± 0.084	1.186GluTrp: 1.186 ± 0.034	2.593GluTyr: 2.593 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	4.099PheAla: 4.099 ± 0.07	0.245PheCys: 0.245 ± 0.016	3.628PheAsp: 3.628 ± 0.074	2.886PheGlu: 2.886 ± 0.064	0.963PhePhe: 0.963 ± 0.038	3.439PheGly: 3.439 ± 0.061	0.612PheHis: 0.612 ± 0.022	0.723PheIle: 0.723 ± 0.029	0.363PheLys: 0.363 ± 0.018	2.798PheLeu: 2.798 ± 0.067	0.43PheMet: 0.43 ± 0.021	0.592PheAsn: 0.592 ± 0.028	1.416PhePro: 1.416 ± 0.04	0.629PheGln: 0.629 ± 0.027	1.902PheArg: 1.902 ± 0.044	1.64PheSer: 1.64 ± 0.043	1.795PheThr: 1.795 ± 0.047	3.392PheVal: 3.392 ± 0.07	0.369PheTrp: 0.369 ± 0.019	0.819PheTyr: 0.819 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.443GlyAla: 10.443 ± 0.139	0.72GlyCys: 0.72 ± 0.032	7.919GlyAsp: 7.919 ± 0.112	7.68GlyGlu: 7.68 ± 0.113	3.385GlyPhe: 3.385 ± 0.053	9.49GlyGly: 9.49 ± 0.151	1.664GlyHis: 1.664 ± 0.047	2.864GlyIle: 2.864 ± 0.066	1.496GlyLys: 1.496 ± 0.041	7.658GlyLeu: 7.658 ± 0.117	1.727GlyMet: 1.727 ± 0.041	1.803GlyAsn: 1.803 ± 0.056	3.79GlyPro: 3.79 ± 0.073	1.616GlyGln: 1.616 ± 0.04	6.207GlyArg: 6.207 ± 0.083	5.748GlySer: 5.748 ± 0.096	6.368GlyThr: 6.368 ± 0.094	9.529GlyVal: 9.529 ± 0.107	1.313GlyTrp: 1.313 ± 0.037	2.802GlyTyr: 2.802 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.088HisAla: 2.088 ± 0.043	0.169HisCys: 0.169 ± 0.012	1.837HisAsp: 1.837 ± 0.044	1.486HisGlu: 1.486 ± 0.04	0.519HisPhe: 0.519 ± 0.022	1.842HisGly: 1.842 ± 0.043	0.508HisHis: 0.508 ± 0.027	0.406HisIle: 0.406 ± 0.02	0.189HisLys: 0.189 ± 0.014	1.706HisLeu: 1.706 ± 0.046	0.256HisMet: 0.256 ± 0.015	0.364HisAsn: 0.364 ± 0.018	1.278HisPro: 1.278 ± 0.038	0.368HisGln: 0.368 ± 0.02	1.305HisArg: 1.305 ± 0.038	0.748HisSer: 0.748 ± 0.029	0.938HisThr: 0.938 ± 0.031	1.875HisVal: 1.875 ± 0.046	0.208HisTrp: 0.208 ± 0.014	0.484HisTyr: 0.484 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	3.214IleAla: 3.214 ± 0.071	0.156IleCys: 0.156 ± 0.011	2.684IleAsp: 2.684 ± 0.063	2.621IleGlu: 2.621 ± 0.065	0.575IlePhe: 0.575 ± 0.028	2.545IleGly: 2.545 ± 0.06	0.525IleHis: 0.525 ± 0.025	0.748IleIle: 0.748 ± 0.036	0.445IleLys: 0.445 ± 0.024	1.935IleLeu: 1.935 ± 0.055	0.342IleMet: 0.342 ± 0.019	0.657IleAsn: 0.657 ± 0.026	1.493IlePro: 1.493 ± 0.04	0.668IleGln: 0.668 ± 0.028	1.839IleArg: 1.839 ± 0.046	1.381IleSer: 1.381 ± 0.042	1.557IleThr: 1.557 ± 0.044	2.442IleVal: 2.442 ± 0.062	0.201IleTrp: 0.201 ± 0.013	0.611IleTyr: 0.611 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	1.365LysAla: 1.365 ± 0.041	0.087LysCys: 0.087 ± 0.008	0.678LysAsp: 0.678 ± 0.027	0.998LysGlu: 0.998 ± 0.036	0.431LysPhe: 0.431 ± 0.022	1.063LysGly: 1.063 ± 0.039	0.327LysHis: 0.327 ± 0.019	0.42LysIle: 0.42 ± 0.021	0.313LysLys: 0.313 ± 0.021	1.373LysLeu: 1.373 ± 0.043	0.259LysMet: 0.259 ± 0.018	0.369LysAsn: 0.369 ± 0.021	0.752LysPro: 0.752 ± 0.029	0.559LysGln: 0.559 ± 0.028	1.335LysArg: 1.335 ± 0.038	0.848LysSer: 0.848 ± 0.035	0.946LysThr: 0.946 ± 0.028	0.936LysVal: 0.936 ± 0.034	0.177LysTrp: 0.177 ± 0.015	0.427LysTyr: 0.427 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	11.814LeuAla: 11.814 ± 0.16	0.592LeuCys: 0.592 ± 0.023	8.111LeuAsp: 8.111 ± 0.112	5.08LeuGlu: 5.08 ± 0.081	3.178LeuPhe: 3.178 ± 0.07	7.673LeuGly: 7.673 ± 0.103	1.422LeuHis: 1.422 ± 0.039	2.041LeuIle: 2.041 ± 0.048	1.227LeuLys: 1.227 ± 0.038	8.365LeuLeu: 8.365 ± 0.13	1.233LeuMet: 1.233 ± 0.04	1.625LeuAsn: 1.625 ± 0.048	4.493LeuPro: 4.493 ± 0.065	1.494LeuGln: 1.494 ± 0.039	6.232LeuArg: 6.232 ± 0.086	5.524LeuSer: 5.524 ± 0.07	5.076LeuThr: 5.076 ± 0.077	9.011LeuVal: 9.011 ± 0.127	0.862LeuTrp: 0.862 ± 0.03	2.236LeuTyr: 2.236 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.708MetAla: 1.708 ± 0.042	0.104MetCys: 0.104 ± 0.009	1.248MetAsp: 1.248 ± 0.035	1.037MetGlu: 1.037 ± 0.035	0.461MetPhe: 0.461 ± 0.022	1.435MetGly: 1.435 ± 0.042	0.279MetHis: 0.279 ± 0.017	0.437MetIle: 0.437 ± 0.023	0.34MetLys: 0.34 ± 0.016	1.414MetLeu: 1.414 ± 0.037	0.261MetMet: 0.261 ± 0.017	0.533MetAsn: 0.533 ± 0.023	0.787MetPro: 0.787 ± 0.028	0.355MetGln: 0.355 ± 0.019	1.187MetArg: 1.187 ± 0.037	1.495MetSer: 1.495 ± 0.033	1.302MetThr: 1.302 ± 0.033	1.28MetVal: 1.28 ± 0.039	0.147MetTrp: 0.147 ± 0.013	0.428MetTyr: 0.428 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.574AsnAla: 2.574 ± 0.054	0.184AsnCys: 0.184 ± 0.016	1.462AsnAsp: 1.462 ± 0.041	1.423AsnGlu: 1.423 ± 0.041	0.597AsnPhe: 0.597 ± 0.028	1.868AsnGly: 1.868 ± 0.056	0.419AsnHis: 0.419 ± 0.022	0.589AsnIle: 0.589 ± 0.025	0.308AsnLys: 0.308 ± 0.017	1.771AsnLeu: 1.771 ± 0.047	0.345AsnMet: 0.345 ± 0.02	0.456AsnAsn: 0.456 ± 0.024	1.387AsnPro: 1.387 ± 0.035	0.487AsnGln: 0.487 ± 0.021	1.421AsnArg: 1.421 ± 0.04	0.862AsnSer: 0.862 ± 0.033	1.136AsnThr: 1.136 ± 0.035	2.237AsnVal: 2.237 ± 0.052	0.288AsnTrp: 0.288 ± 0.02	0.642AsnTyr: 0.642 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.934ProAla: 5.934 ± 0.084	0.215ProCys: 0.215 ± 0.014	5.626ProAsp: 5.626 ± 0.083	4.373ProGlu: 4.373 ± 0.072	1.68ProPhe: 1.68 ± 0.042	4.402ProGly: 4.402 ± 0.068	0.894ProHis: 0.894 ± 0.033	1.231ProIle: 1.231 ± 0.036	0.615ProLys: 0.615 ± 0.025	4.047ProLeu: 4.047 ± 0.063	0.788ProMet: 0.788 ± 0.028	1.061ProAsn: 1.061 ± 0.035	2.453ProPro: 2.453 ± 0.054	0.788ProGln: 0.788 ± 0.031	2.503ProArg: 2.503 ± 0.053	2.598ProSer: 2.598 ± 0.055	3.419ProThr: 3.419 ± 0.063	4.683ProVal: 4.683 ± 0.069	0.527ProTrp: 0.527 ± 0.027	1.165ProTyr: 1.165 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.881GlnAla: 1.881 ± 0.047	0.112GlnCys: 0.112 ± 0.011	0.891GlnAsp: 0.891 ± 0.038	1.288GlnGlu: 1.288 ± 0.045	0.855GlnPhe: 0.855 ± 0.032	1.336GlnGly: 1.336 ± 0.041	0.369GlnHis: 0.369 ± 0.018	0.701GlnIle: 0.701 ± 0.032	0.379GlnLys: 0.379 ± 0.02	1.805GlnLeu: 1.805 ± 0.044	0.413GlnMet: 0.413 ± 0.022	0.545GlnAsn: 0.545 ± 0.022	0.925GlnPro: 0.925 ± 0.029	0.731GlnGln: 0.731 ± 0.033	1.626GlnArg: 1.626 ± 0.047	1.175GlnSer: 1.175 ± 0.041	1.15GlnThr: 1.15 ± 0.035	1.682GlnVal: 1.682 ± 0.041	0.312GlnTrp: 0.312 ± 0.018	0.677GlnTyr: 0.677 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.238ArgAla: 8.238 ± 0.123	0.487ArgCys: 0.487 ± 0.024	5.543ArgAsp: 5.543 ± 0.082	7.145ArgGlu: 7.145 ± 0.108	2.567ArgPhe: 2.567 ± 0.054	5.445ArgGly: 5.445 ± 0.081	1.248ArgHis: 1.248 ± 0.037	2.225ArgIle: 2.225 ± 0.049	1.085ArgLys: 1.085 ± 0.035	6.738ArgLeu: 6.738 ± 0.094	1.421ArgMet: 1.421 ± 0.037	1.495ArgAsn: 1.495 ± 0.043	3.141ArgPro: 3.141 ± 0.055	1.491ArgGln: 1.491 ± 0.036	5.896ArgArg: 5.896 ± 0.107	3.772ArgSer: 3.772 ± 0.071	4.436ArgThr: 4.436 ± 0.058	7.031ArgVal: 7.031 ± 0.09	0.832ArgTrp: 0.832 ± 0.032	2.076ArgTyr: 2.076 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.859SerAla: 5.859 ± 0.077	0.287SerCys: 0.287 ± 0.022	4.403SerAsp: 4.403 ± 0.074	3.987SerGlu: 3.987 ± 0.074	1.832SerPhe: 1.832 ± 0.039	5.587SerGly: 5.587 ± 0.086	0.914SerHis: 0.914 ± 0.031	1.648SerIle: 1.648 ± 0.047	0.899SerLys: 0.899 ± 0.03	4.756SerLeu: 4.756 ± 0.072	0.965SerMet: 0.965 ± 0.032	1.258SerAsn: 1.258 ± 0.043	2.532SerPro: 2.532 ± 0.051	1.015SerGln: 1.015 ± 0.037	3.16SerArg: 3.16 ± 0.052	2.621SerSer: 2.621 ± 0.062	3.385SerThr: 3.385 ± 0.06	5.457SerVal: 5.457 ± 0.091	0.603SerTrp: 0.603 ± 0.028	1.451SerTyr: 1.451 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.635ThrAla: 7.635 ± 0.106	0.345ThrCys: 0.345 ± 0.019	5.944ThrAsp: 5.944 ± 0.083	4.128ThrGlu: 4.128 ± 0.073	2.063ThrPhe: 2.063 ± 0.048	6.019ThrGly: 6.019 ± 0.086	1.15ThrHis: 1.15 ± 0.03	1.646ThrIle: 1.646 ± 0.046	0.769ThrLys: 0.769 ± 0.029	5.962ThrLeu: 5.962 ± 0.082	0.952ThrMet: 0.952 ± 0.033	1.367ThrAsn: 1.367 ± 0.042	3.522ThrPro: 3.522 ± 0.066	1.048ThrGln: 1.048 ± 0.034	3.719ThrArg: 3.719 ± 0.063	2.459ThrSer: 2.459 ± 0.051	4.099ThrThr: 4.099 ± 0.074	7.216ThrVal: 7.216 ± 0.116	0.659ThrTrp: 0.659 ± 0.026	1.669ThrTyr: 1.669 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	12.16ValAla: 12.16 ± 0.144	0.737ValCys: 0.737 ± 0.026	8.947ValAsp: 8.947 ± 0.096	8.296ValGlu: 8.296 ± 0.104	2.992ValPhe: 2.992 ± 0.062	9.611ValGly: 9.611 ± 0.139	1.792ValHis: 1.792 ± 0.047	2.222ValIle: 2.222 ± 0.057	1.175ValLys: 1.175 ± 0.036	7.532ValLeu: 7.532 ± 0.109	1.288ValMet: 1.288 ± 0.036	1.973ValAsn: 1.973 ± 0.048	4.623ValPro: 4.623 ± 0.067	1.579ValGln: 1.579 ± 0.04	6.91ValArg: 6.91 ± 0.091	5.381ValSer: 5.381 ± 0.083	6.528ValThr: 6.528 ± 0.091	10.927ValVal: 10.927 ± 0.149	0.929ValTrp: 0.929 ± 0.033	2.286ValTyr: 2.286 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.047TrpAla: 1.047 ± 0.034	0.089TrpCys: 0.089 ± 0.009	0.787TrpAsp: 0.787 ± 0.028	0.853TrpGlu: 0.853 ± 0.034	0.444TrpPhe: 0.444 ± 0.024	0.947TrpGly: 0.947 ± 0.031	0.244TrpHis: 0.244 ± 0.018	0.297TrpIle: 0.297 ± 0.018	0.227TrpLys: 0.227 ± 0.014	1.164TrpLeu: 1.164 ± 0.035	0.229TrpMet: 0.229 ± 0.015	0.37TrpAsn: 0.37 ± 0.018	0.488TrpPro: 0.488 ± 0.021	0.31TrpGln: 0.31 ± 0.019	0.929TrpArg: 0.929 ± 0.034	0.609TrpSer: 0.609 ± 0.023	0.856TrpThr: 0.856 ± 0.028	0.995TrpVal: 0.995 ± 0.029	0.217TrpTrp: 0.217 ± 0.014	0.385TrpTyr: 0.385 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.087TyrAla: 3.087 ± 0.048	0.225TyrCys: 0.225 ± 0.015	2.741TyrAsp: 2.741 ± 0.054	2.302TyrGlu: 2.302 ± 0.049	0.801TyrPhe: 0.801 ± 0.033	2.554TyrGly: 2.554 ± 0.055	0.593TyrHis: 0.593 ± 0.025	0.548TyrIle: 0.548 ± 0.023	0.344TyrLys: 0.344 ± 0.018	2.541TyrLeu: 2.541 ± 0.047	0.331TyrMet: 0.331 ± 0.019	0.521TyrAsn: 0.521 ± 0.023	1.257TyrPro: 1.257 ± 0.038	0.629TyrGln: 0.629 ± 0.022	2.122TyrArg: 2.122 ± 0.042	1.081TyrSer: 1.081 ± 0.031	1.423TyrThr: 1.423 ± 0.04	2.463TyrVal: 2.463 ± 0.048	0.342TyrTrp: 0.342 ± 0.021	0.852TyrTyr: 0.852 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3445 proteins (1030664 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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