Amino acid dipepetide frequency for Gemmataceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.535AlaAla: 21.535 ± 0.157	1.335AlaCys: 1.335 ± 0.03	8.096AlaAsp: 8.096 ± 0.075	7.753AlaGlu: 7.753 ± 0.071	4.309AlaPhe: 4.309 ± 0.049	11.591AlaGly: 11.591 ± 0.092	2.171AlaHis: 2.171 ± 0.034	3.786AlaIle: 3.786 ± 0.045	5.268AlaLys: 5.268 ± 0.081	12.076AlaLeu: 12.076 ± 0.111	2.074AlaMet: 2.074 ± 0.034	2.892AlaAsn: 2.892 ± 0.044	7.11AlaPro: 7.11 ± 0.089	2.978AlaGln: 2.978 ± 0.044	8.648AlaArg: 8.648 ± 0.076	4.969AlaSer: 4.969 ± 0.045	6.827AlaThr: 6.827 ± 0.063	11.32AlaVal: 11.32 ± 0.087	1.786AlaTrp: 1.786 ± 0.036	2.347AlaTyr: 2.347 ± 0.033	0.0AlaXaa: 0.0 ± 0.001
Cys	1.014CysAla: 1.014 ± 0.023	0.206CysCys: 0.206 ± 0.013	0.647CysAsp: 0.647 ± 0.02	0.609CysGlu: 0.609 ± 0.018	0.338CysPhe: 0.338 ± 0.012	1.17CysGly: 1.17 ± 0.028	0.369CysHis: 0.369 ± 0.018	0.244CysIle: 0.244 ± 0.011	0.321CysLys: 0.321 ± 0.013	0.955CysLeu: 0.955 ± 0.023	0.144CysMet: 0.144 ± 0.009	0.225CysAsn: 0.225 ± 0.01	0.749CysPro: 0.749 ± 0.022	0.286CysGln: 0.286 ± 0.012	0.888CysArg: 0.888 ± 0.023	0.474CysSer: 0.474 ± 0.016	0.44CysThr: 0.44 ± 0.017	0.945CysVal: 0.945 ± 0.024	0.187CysTrp: 0.187 ± 0.009	0.253CysTyr: 0.253 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.979AspAla: 7.979 ± 0.072	0.483AspCys: 0.483 ± 0.015	3.372AspAsp: 3.372 ± 0.062	3.435AspGlu: 3.435 ± 0.041	1.889AspPhe: 1.889 ± 0.031	5.707AspGly: 5.707 ± 0.07	1.297AspHis: 1.297 ± 0.025	1.531AspIle: 1.531 ± 0.029	2.225AspLys: 2.225 ± 0.036	5.963AspLeu: 5.963 ± 0.063	0.792AspMet: 0.792 ± 0.018	1.122AspAsn: 1.122 ± 0.025	4.818AspPro: 4.818 ± 0.049	1.542AspGln: 1.542 ± 0.027	4.883AspArg: 4.883 ± 0.055	1.99AspSer: 1.99 ± 0.029	2.733AspThr: 2.733 ± 0.033	4.503AspVal: 4.503 ± 0.05	1.027AspTrp: 1.027 ± 0.026	1.312AspTyr: 1.312 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.699GluAla: 6.699 ± 0.074	0.514GluCys: 0.514 ± 0.016	2.226GluAsp: 2.226 ± 0.035	2.654GluGlu: 2.654 ± 0.043	2.324GluPhe: 2.324 ± 0.031	3.556GluGly: 3.556 ± 0.037	1.151GluHis: 1.151 ± 0.022	1.893GluIle: 1.893 ± 0.033	2.826GluLys: 2.826 ± 0.051	6.237GluLeu: 6.237 ± 0.058	1.162GluMet: 1.162 ± 0.023	1.187GluAsn: 1.187 ± 0.021	3.502GluPro: 3.502 ± 0.042	2.102GluGln: 2.102 ± 0.035	4.451GluArg: 4.451 ± 0.049	2.379GluSer: 2.379 ± 0.028	2.607GluThr: 2.607 ± 0.033	4.837GluVal: 4.837 ± 0.057	0.959GluTrp: 0.959 ± 0.024	1.385GluTyr: 1.385 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.489PheAla: 4.489 ± 0.048	0.384PheCys: 0.384 ± 0.014	2.632PheAsp: 2.632 ± 0.039	2.0PheGlu: 2.0 ± 0.032	1.184PhePhe: 1.184 ± 0.026	3.365PheGly: 3.365 ± 0.046	0.749PheHis: 0.749 ± 0.019	0.919PheIle: 0.919 ± 0.022	1.188PheLys: 1.188 ± 0.026	3.388PheLeu: 3.388 ± 0.039	0.449PheMet: 0.449 ± 0.013	0.951PheAsn: 0.951 ± 0.021	1.951PhePro: 1.951 ± 0.028	0.951PheGln: 0.951 ± 0.021	2.61PheArg: 2.61 ± 0.036	1.649PheSer: 1.649 ± 0.029	2.224PheThr: 2.224 ± 0.034	3.034PheVal: 3.034 ± 0.044	0.525PheTrp: 0.525 ± 0.016	0.77PheTyr: 0.77 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	8.575GlyAla: 8.575 ± 0.072	1.126GlyCys: 1.126 ± 0.025	4.932GlyAsp: 4.932 ± 0.053	4.668GlyGlu: 4.668 ± 0.045	3.268GlyPhe: 3.268 ± 0.042	8.618GlyGly: 8.618 ± 0.137	1.818GlyHis: 1.818 ± 0.032	2.776GlyIle: 2.776 ± 0.054	4.294GlyLys: 4.294 ± 0.055	8.008GlyLeu: 8.008 ± 0.077	1.833GlyMet: 1.833 ± 0.039	2.202GlyAsn: 2.202 ± 0.041	4.86GlyPro: 4.86 ± 0.055	2.481GlyGln: 2.481 ± 0.033	6.568GlyArg: 6.568 ± 0.062	4.396GlySer: 4.396 ± 0.051	5.913GlyThr: 5.913 ± 0.089	7.243GlyVal: 7.243 ± 0.059	1.532GlyTrp: 1.532 ± 0.026	2.334GlyTyr: 2.334 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.384HisAla: 2.384 ± 0.033	0.299HisCys: 0.299 ± 0.012	1.183HisAsp: 1.183 ± 0.023	1.035HisGlu: 1.035 ± 0.024	0.794HisPhe: 0.794 ± 0.021	1.838HisGly: 1.838 ± 0.033	0.622HisHis: 0.622 ± 0.017	0.588HisIle: 0.588 ± 0.017	0.607HisLys: 0.607 ± 0.016	2.216HisLeu: 2.216 ± 0.034	0.298HisMet: 0.298 ± 0.012	0.49HisAsn: 0.49 ± 0.014	1.654HisPro: 1.654 ± 0.025	0.554HisGln: 0.554 ± 0.017	1.541HisArg: 1.541 ± 0.028	0.895HisSer: 0.895 ± 0.021	1.093HisThr: 1.093 ± 0.024	1.559HisVal: 1.559 ± 0.031	0.333HisTrp: 0.333 ± 0.013	0.542HisTyr: 0.542 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.026IleAla: 4.026 ± 0.047	0.302IleCys: 0.302 ± 0.013	2.598IleAsp: 2.598 ± 0.038	2.211IleGlu: 2.211 ± 0.034	0.805IlePhe: 0.805 ± 0.019	3.123IleGly: 3.123 ± 0.05	0.598IleHis: 0.598 ± 0.018	0.922IleIle: 0.922 ± 0.025	1.192IleLys: 1.192 ± 0.023	2.591IleLeu: 2.591 ± 0.043	0.415IleMet: 0.415 ± 0.014	0.827IleAsn: 0.827 ± 0.021	1.791IlePro: 1.791 ± 0.034	0.782IleGln: 0.782 ± 0.019	2.261IleArg: 2.261 ± 0.032	1.364IleSer: 1.364 ± 0.027	1.785IleThr: 1.785 ± 0.033	2.544IleVal: 2.544 ± 0.034	0.326IleTrp: 0.326 ± 0.012	0.659IleTyr: 0.659 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.671LysAla: 4.671 ± 0.064	0.364LysCys: 0.364 ± 0.014	2.371LysAsp: 2.371 ± 0.047	2.232LysGlu: 2.232 ± 0.042	1.31LysPhe: 1.31 ± 0.028	3.022LysGly: 3.022 ± 0.046	0.81LysHis: 0.81 ± 0.022	1.289LysIle: 1.289 ± 0.027	2.404LysLys: 2.404 ± 0.051	4.415LysLeu: 4.415 ± 0.053	1.025LysMet: 1.025 ± 0.021	1.086LysAsn: 1.086 ± 0.031	3.161LysPro: 3.161 ± 0.049	1.344LysGln: 1.344 ± 0.027	2.407LysArg: 2.407 ± 0.038	1.755LysSer: 1.755 ± 0.032	2.155LysThr: 2.155 ± 0.037	3.456LysVal: 3.456 ± 0.055	0.628LysTrp: 0.628 ± 0.017	0.985LysTyr: 0.985 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.21LeuAla: 14.21 ± 0.103	1.019LeuCys: 1.019 ± 0.021	6.008LeuAsp: 6.008 ± 0.051	4.662LeuGlu: 4.662 ± 0.056	3.361LeuPhe: 3.361 ± 0.042	8.19LeuGly: 8.19 ± 0.075	1.791LeuHis: 1.791 ± 0.032	3.199LeuIle: 3.199 ± 0.042	4.047LeuLys: 4.047 ± 0.058	9.64LeuLeu: 9.64 ± 0.091	1.477LeuMet: 1.477 ± 0.027	2.416LeuAsn: 2.416 ± 0.032	6.28LeuPro: 6.28 ± 0.054	2.237LeuGln: 2.237 ± 0.033	7.049LeuArg: 7.049 ± 0.072	4.639LeuSer: 4.639 ± 0.047	6.096LeuThr: 6.096 ± 0.051	8.21LeuVal: 8.21 ± 0.071	1.254LeuTrp: 1.254 ± 0.027	2.0LeuTyr: 2.0 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	1.941MetAla: 1.941 ± 0.035	0.19MetCys: 0.19 ± 0.009	0.737MetAsp: 0.737 ± 0.021	0.681MetGlu: 0.681 ± 0.019	0.572MetPhe: 0.572 ± 0.017	1.246MetGly: 1.246 ± 0.03	0.343MetHis: 0.343 ± 0.013	0.678MetIle: 0.678 ± 0.018	0.762MetLys: 0.762 ± 0.02	1.616MetLeu: 1.616 ± 0.027	0.333MetMet: 0.333 ± 0.013	0.576MetAsn: 0.576 ± 0.016	1.331MetPro: 1.331 ± 0.024	0.456MetGln: 0.456 ± 0.014	1.281MetArg: 1.281 ± 0.026	1.115MetSer: 1.115 ± 0.02	1.365MetThr: 1.365 ± 0.024	1.213MetVal: 1.213 ± 0.021	0.218MetTrp: 0.218 ± 0.01	0.33MetTyr: 0.33 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.652AsnAla: 2.652 ± 0.038	0.277AsnCys: 0.277 ± 0.012	1.341AsnAsp: 1.341 ± 0.027	1.146AsnGlu: 1.146 ± 0.023	0.861AsnPhe: 0.861 ± 0.02	2.365AsnGly: 2.365 ± 0.04	0.534AsnHis: 0.534 ± 0.016	0.803AsnIle: 0.803 ± 0.021	0.847AsnLys: 0.847 ± 0.021	2.518AsnLeu: 2.518 ± 0.03	0.397AsnMet: 0.397 ± 0.012	0.754AsnAsn: 0.754 ± 0.022	2.276AsnPro: 2.276 ± 0.035	0.77AsnGln: 0.77 ± 0.02	1.78AsnArg: 1.78 ± 0.028	1.024AsnSer: 1.024 ± 0.023	1.347AsnThr: 1.347 ± 0.03	1.934AsnVal: 1.934 ± 0.032	0.452AsnTrp: 0.452 ± 0.016	0.649AsnTyr: 0.649 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	9.632ProAla: 9.632 ± 0.098	0.434ProCys: 0.434 ± 0.016	4.795ProAsp: 4.795 ± 0.05	4.246ProGlu: 4.246 ± 0.044	2.158ProPhe: 2.158 ± 0.033	6.241ProGly: 6.241 ± 0.06	1.439ProHis: 1.439 ± 0.024	1.761ProIle: 1.761 ± 0.027	2.925ProLys: 2.925 ± 0.056	5.227ProLeu: 5.227 ± 0.053	0.979ProMet: 0.979 ± 0.022	1.819ProAsn: 1.819 ± 0.029	5.415ProPro: 5.415 ± 0.081	1.669ProGln: 1.669 ± 0.033	3.919ProArg: 3.919 ± 0.054	2.724ProSer: 2.724 ± 0.038	3.803ProThr: 3.803 ± 0.044	5.853ProVal: 5.853 ± 0.07	0.811ProTrp: 0.811 ± 0.021	1.146ProTyr: 1.146 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.129GlnAla: 3.129 ± 0.038	0.274GlnCys: 0.274 ± 0.01	1.132GlnAsp: 1.132 ± 0.023	1.224GlnGlu: 1.224 ± 0.025	1.219GlnPhe: 1.219 ± 0.021	1.803GlnGly: 1.803 ± 0.033	0.582GlnHis: 0.582 ± 0.016	1.169GlnIle: 1.169 ± 0.02	1.31GlnLys: 1.31 ± 0.031	3.009GlnLeu: 3.009 ± 0.035	0.579GlnMet: 0.579 ± 0.017	0.729GlnAsn: 0.729 ± 0.023	1.913GlnPro: 1.913 ± 0.046	1.039GlnGln: 1.039 ± 0.025	1.95GlnArg: 1.95 ± 0.028	1.24GlnSer: 1.24 ± 0.026	1.51GlnThr: 1.51 ± 0.028	2.42GlnVal: 2.42 ± 0.035	0.441GlnTrp: 0.441 ± 0.016	0.66GlnTyr: 0.66 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.28ArgAla: 8.28 ± 0.077	0.779ArgCys: 0.779 ± 0.02	4.504ArgAsp: 4.504 ± 0.046	4.407ArgGlu: 4.407 ± 0.054	2.962ArgPhe: 2.962 ± 0.039	5.477ArgGly: 5.477 ± 0.052	1.622ArgHis: 1.622 ± 0.029	2.443ArgIle: 2.443 ± 0.035	2.606ArgLys: 2.606 ± 0.036	7.485ArgLeu: 7.485 ± 0.077	1.418ArgMet: 1.418 ± 0.028	1.703ArgAsn: 1.703 ± 0.025	4.64ArgPro: 4.64 ± 0.055	2.077ArgGln: 2.077 ± 0.035	5.583ArgArg: 5.583 ± 0.066	3.371ArgSer: 3.371 ± 0.043	4.252ArgThr: 4.252 ± 0.048	6.582ArgVal: 6.582 ± 0.062	1.19ArgTrp: 1.19 ± 0.024	1.815ArgTyr: 1.815 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	5.075SerAla: 5.075 ± 0.044	0.449SerCys: 0.449 ± 0.017	2.566SerAsp: 2.566 ± 0.035	2.183SerGlu: 2.183 ± 0.032	1.561SerPhe: 1.561 ± 0.025	4.75SerGly: 4.75 ± 0.054	0.976SerHis: 0.976 ± 0.021	1.384SerIle: 1.384 ± 0.025	1.57SerLys: 1.57 ± 0.032	4.251SerLeu: 4.251 ± 0.04	0.777SerMet: 0.777 ± 0.018	1.195SerAsn: 1.195 ± 0.023	3.385SerPro: 3.385 ± 0.044	1.179SerGln: 1.179 ± 0.022	3.179SerArg: 3.179 ± 0.036	2.059SerSer: 2.059 ± 0.035	2.35SerThr: 2.35 ± 0.041	3.871SerVal: 3.871 ± 0.04	0.662SerTrp: 0.662 ± 0.017	1.008SerTyr: 1.008 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	7.104ThrAla: 7.104 ± 0.07	0.526ThrCys: 0.526 ± 0.019	3.584ThrAsp: 3.584 ± 0.044	2.854ThrGlu: 2.854 ± 0.036	2.116ThrPhe: 2.116 ± 0.033	5.961ThrGly: 5.961 ± 0.072	1.213ThrHis: 1.213 ± 0.026	1.886ThrIle: 1.886 ± 0.032	1.894ThrLys: 1.894 ± 0.037	5.456ThrLeu: 5.456 ± 0.051	0.807ThrMet: 0.807 ± 0.018	1.429ThrAsn: 1.429 ± 0.03	4.325ThrPro: 4.325 ± 0.051	1.4ThrGln: 1.4 ± 0.027	3.911ThrArg: 3.911 ± 0.05	2.444ThrSer: 2.444 ± 0.039	3.1ThrThr: 3.1 ± 0.055	5.27ThrVal: 5.27 ± 0.069	0.784ThrTrp: 0.784 ± 0.025	1.184ThrTyr: 1.184 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.235ValAla: 11.235 ± 0.09	1.036ValCys: 1.036 ± 0.021	3.575ValAsp: 3.575 ± 0.045	4.704ValGlu: 4.704 ± 0.049	2.913ValPhe: 2.913 ± 0.037	6.483ValGly: 6.483 ± 0.066	1.5ValHis: 1.5 ± 0.027	2.91ValIle: 2.91 ± 0.041	3.195ValLys: 3.195 ± 0.043	8.58ValLeu: 8.58 ± 0.067	1.39ValMet: 1.39 ± 0.027	2.091ValAsn: 2.091 ± 0.033	5.795ValPro: 5.795 ± 0.062	2.208ValGln: 2.208 ± 0.029	7.245ValArg: 7.245 ± 0.068	4.093ValSer: 4.093 ± 0.038	5.587ValThr: 5.587 ± 0.068	7.947ValVal: 7.947 ± 0.073	1.368ValTrp: 1.368 ± 0.029	1.974ValTyr: 1.974 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.658TrpAla: 1.658 ± 0.032	0.198TrpCys: 0.198 ± 0.011	0.96TrpAsp: 0.96 ± 0.022	0.749TrpGlu: 0.749 ± 0.02	0.603TrpPhe: 0.603 ± 0.019	1.029TrpGly: 1.029 ± 0.023	0.378TrpHis: 0.378 ± 0.014	0.387TrpIle: 0.387 ± 0.013	0.63TrpLys: 0.63 ± 0.018	1.721TrpLeu: 1.721 ± 0.034	0.301TrpMet: 0.301 ± 0.012	0.456TrpAsn: 0.456 ± 0.011	0.749TrpPro: 0.749 ± 0.02	0.517TrpGln: 0.517 ± 0.015	1.076TrpArg: 1.076 ± 0.021	0.793TrpSer: 0.793 ± 0.02	0.807TrpThr: 0.807 ± 0.023	1.452TrpVal: 1.452 ± 0.023	0.282TrpTrp: 0.282 ± 0.012	0.372TrpTyr: 0.372 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.586TyrAla: 2.586 ± 0.036	0.268TyrCys: 0.268 ± 0.012	1.345TyrAsp: 1.345 ± 0.03	1.197TyrGlu: 1.197 ± 0.025	0.864TyrPhe: 0.864 ± 0.02	1.906TyrGly: 1.906 ± 0.029	0.562TyrHis: 0.562 ± 0.016	0.554TyrIle: 0.554 ± 0.016	0.777TyrLys: 0.777 ± 0.02	2.431TyrLeu: 2.431 ± 0.035	0.332TyrMet: 0.332 ± 0.012	0.577TyrAsn: 0.577 ± 0.019	1.293TyrPro: 1.293 ± 0.026	0.758TyrGln: 0.758 ± 0.018	1.967TyrArg: 1.967 ± 0.03	1.059TyrSer: 1.059 ± 0.023	1.255TyrThr: 1.255 ± 0.027	1.637TyrVal: 1.637 ± 0.029	0.353TyrTrp: 0.353 ± 0.014	0.627TyrTyr: 0.627 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.022XaaXaa: 0.022 ± 0.025

Statistics based on 6468 proteins (2271994 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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