Amino acid dipepetide frequency for Klebsiella pneumoniae subsp. pneumoniae (strain HS11286)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.915AlaAla: 11.915 ± 0.128	1.208AlaCys: 1.208 ± 0.034	5.389AlaAsp: 5.389 ± 0.062	6.007AlaGlu: 6.007 ± 0.066	3.817AlaPhe: 3.817 ± 0.054	8.307AlaGly: 8.307 ± 0.082	1.96AlaHis: 1.96 ± 0.037	6.15AlaIle: 6.15 ± 0.067	3.739AlaLys: 3.739 ± 0.058	12.849AlaLeu: 12.849 ± 0.118	3.188AlaMet: 3.188 ± 0.048	2.945AlaAsn: 2.945 ± 0.043	4.063AlaPro: 4.063 ± 0.06	4.702AlaGln: 4.702 ± 0.061	6.276AlaArg: 6.276 ± 0.07	5.816AlaSer: 5.816 ± 0.065	4.94AlaThr: 4.94 ± 0.051	7.252AlaVal: 7.252 ± 0.066	1.884AlaTrp: 1.884 ± 0.037	1.963AlaTyr: 1.963 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.081CysAla: 1.081 ± 0.025	0.188CysCys: 0.188 ± 0.011	0.579CysAsp: 0.579 ± 0.023	0.586CysGlu: 0.586 ± 0.019	0.452CysPhe: 0.452 ± 0.016	1.11CysGly: 1.11 ± 0.028	0.316CysHis: 0.316 ± 0.015	0.54CysIle: 0.54 ± 0.017	0.319CysLys: 0.319 ± 0.017	1.051CysLeu: 1.051 ± 0.025	0.251CysMet: 0.251 ± 0.011	0.284CysAsn: 0.284 ± 0.014	0.552CysPro: 0.552 ± 0.02	0.473CysGln: 0.473 ± 0.019	0.714CysArg: 0.714 ± 0.022	0.666CysSer: 0.666 ± 0.021	0.474CysThr: 0.474 ± 0.017	0.733CysVal: 0.733 ± 0.023	0.194CysTrp: 0.194 ± 0.011	0.336CysTyr: 0.336 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.321AspAla: 5.321 ± 0.061	0.494AspCys: 0.494 ± 0.018	2.997AspAsp: 2.997 ± 0.053	3.461AspGlu: 3.461 ± 0.05	2.063AspPhe: 2.063 ± 0.035	3.819AspGly: 3.819 ± 0.053	0.986AspHis: 0.986 ± 0.028	3.253AspIle: 3.253 ± 0.051	2.388AspLys: 2.388 ± 0.041	4.775AspLeu: 4.775 ± 0.062	1.269AspMet: 1.269 ± 0.029	2.08AspAsn: 2.08 ± 0.033	2.382AspPro: 2.382 ± 0.043	1.573AspGln: 1.573 ± 0.032	2.892AspArg: 2.892 ± 0.05	2.767AspSer: 2.767 ± 0.04	2.404AspThr: 2.404 ± 0.039	3.555AspVal: 3.555 ± 0.047	0.822AspTrp: 0.822 ± 0.024	1.838AspTyr: 1.838 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.786GluAla: 5.786 ± 0.074	0.451GluCys: 0.451 ± 0.018	2.219GluAsp: 2.219 ± 0.041	3.332GluGlu: 3.332 ± 0.054	1.747GluPhe: 1.747 ± 0.029	3.614GluGly: 3.614 ± 0.05	1.305GluHis: 1.305 ± 0.031	3.078GluIle: 3.078 ± 0.049	3.065GluLys: 3.065 ± 0.053	5.669GluLeu: 5.669 ± 0.064	1.781GluMet: 1.781 ± 0.034	2.073GluAsn: 2.073 ± 0.036	2.08GluPro: 2.08 ± 0.036	3.25GluGln: 3.25 ± 0.049	3.731GluArg: 3.731 ± 0.047	2.864GluSer: 2.864 ± 0.038	2.858GluThr: 2.858 ± 0.048	3.73GluVal: 3.73 ± 0.055	0.784GluTrp: 0.784 ± 0.023	1.383GluTyr: 1.383 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.956PheAla: 3.956 ± 0.052	0.558PheCys: 0.558 ± 0.019	2.323PheAsp: 2.323 ± 0.04	1.614PheGlu: 1.614 ± 0.032	1.735PhePhe: 1.735 ± 0.041	3.176PheGly: 3.176 ± 0.05	0.833PheHis: 0.833 ± 0.02	2.531PheIle: 2.531 ± 0.045	1.158PheLys: 1.158 ± 0.027	3.375PheLeu: 3.375 ± 0.054	0.98PheMet: 0.98 ± 0.025	1.677PheAsn: 1.677 ± 0.032	1.602PhePro: 1.602 ± 0.03	1.157PheGln: 1.157 ± 0.025	1.904PheArg: 1.904 ± 0.031	3.102PheSer: 3.102 ± 0.043	2.467PheThr: 2.467 ± 0.035	2.545PheVal: 2.545 ± 0.045	0.666PheTrp: 0.666 ± 0.022	1.223PheTyr: 1.223 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	6.693GlyAla: 6.693 ± 0.075	1.022GlyCys: 1.022 ± 0.026	3.735GlyAsp: 3.735 ± 0.051	4.745GlyGlu: 4.745 ± 0.057	3.347GlyPhe: 3.347 ± 0.048	5.689GlyGly: 5.689 ± 0.077	1.611GlyHis: 1.611 ± 0.032	4.946GlyIle: 4.946 ± 0.052	3.828GlyLys: 3.828 ± 0.06	7.873GlyLeu: 7.873 ± 0.084	2.501GlyMet: 2.501 ± 0.043	2.534GlyAsn: 2.534 ± 0.047	2.166GlyPro: 2.166 ± 0.035	3.005GlyGln: 3.005 ± 0.046	4.039GlyArg: 4.039 ± 0.051	4.231GlySer: 4.231 ± 0.051	3.608GlyThr: 3.608 ± 0.046	5.879GlyVal: 5.879 ± 0.064	1.375GlyTrp: 1.375 ± 0.034	2.651GlyTyr: 2.651 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.98HisAla: 1.98 ± 0.034	0.312HisCys: 0.312 ± 0.015	1.229HisAsp: 1.229 ± 0.026	1.042HisGlu: 1.042 ± 0.024	1.065HisPhe: 1.065 ± 0.028	1.811HisGly: 1.811 ± 0.037	0.792HisHis: 0.792 ± 0.023	1.296HisIle: 1.296 ± 0.03	0.72HisLys: 0.72 ± 0.022	2.308HisLeu: 2.308 ± 0.035	0.527HisMet: 0.527 ± 0.019	0.766HisAsn: 0.766 ± 0.022	1.369HisPro: 1.369 ± 0.032	1.192HisGln: 1.192 ± 0.026	1.344HisArg: 1.344 ± 0.03	1.234HisSer: 1.234 ± 0.027	1.058HisThr: 1.058 ± 0.025	1.244HisVal: 1.244 ± 0.027	0.409HisTrp: 0.409 ± 0.016	0.906HisTyr: 0.906 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.737IleAla: 6.737 ± 0.072	0.677IleCys: 0.677 ± 0.021	3.481IleAsp: 3.481 ± 0.046	3.009IleGlu: 3.009 ± 0.049	2.095IlePhe: 2.095 ± 0.043	4.571IleGly: 4.571 ± 0.063	1.177IleHis: 1.177 ± 0.029	3.248IleIle: 3.248 ± 0.048	2.146IleLys: 2.146 ± 0.04	4.85IleLeu: 4.85 ± 0.061	1.198IleMet: 1.198 ± 0.031	2.402IleAsn: 2.402 ± 0.036	2.758IlePro: 2.758 ± 0.043	1.712IleGln: 1.712 ± 0.034	2.981IleArg: 2.981 ± 0.042	3.529IleSer: 3.529 ± 0.055	3.252IleThr: 3.252 ± 0.05	3.964IleVal: 3.964 ± 0.053	0.683IleTrp: 0.683 ± 0.018	1.503IleTyr: 1.503 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.247LysAla: 4.247 ± 0.055	0.26LysCys: 0.26 ± 0.012	1.833LysAsp: 1.833 ± 0.035	2.212LysGlu: 2.212 ± 0.04	1.05LysPhe: 1.05 ± 0.025	2.774LysGly: 2.774 ± 0.042	0.801LysHis: 0.801 ± 0.026	2.176LysIle: 2.176 ± 0.045	2.056LysLys: 2.056 ± 0.044	3.934LysLeu: 3.934 ± 0.054	1.197LysMet: 1.197 ± 0.027	1.56LysAsn: 1.56 ± 0.034	1.97LysPro: 1.97 ± 0.041	1.823LysGln: 1.823 ± 0.04	2.47LysArg: 2.47 ± 0.037	2.169LysSer: 2.169 ± 0.039	2.403LysThr: 2.403 ± 0.036	2.875LysVal: 2.875 ± 0.045	0.439LysTrp: 0.439 ± 0.017	1.084LysTyr: 1.084 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.728LeuAla: 12.728 ± 0.123	1.327LeuCys: 1.327 ± 0.031	5.304LeuAsp: 5.304 ± 0.061	5.325LeuGlu: 5.325 ± 0.07	4.314LeuPhe: 4.314 ± 0.054	7.533LeuGly: 7.533 ± 0.082	2.278LeuHis: 2.278 ± 0.04	5.743LeuIle: 5.743 ± 0.068	4.213LeuLys: 4.213 ± 0.059	12.482LeuLeu: 12.482 ± 0.132	2.962LeuMet: 2.962 ± 0.041	3.993LeuAsn: 3.993 ± 0.053	5.918LeuPro: 5.918 ± 0.062	4.468LeuGln: 4.468 ± 0.055	6.54LeuArg: 6.54 ± 0.072	7.351LeuSer: 7.351 ± 0.071	6.399LeuThr: 6.399 ± 0.068	7.122LeuVal: 7.122 ± 0.073	1.514LeuTrp: 1.514 ± 0.034	2.561LeuTyr: 2.561 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.095MetAla: 3.095 ± 0.049	0.202MetCys: 0.202 ± 0.01	1.106MetAsp: 1.106 ± 0.027	1.201MetGlu: 1.201 ± 0.03	0.875MetPhe: 0.875 ± 0.022	1.889MetGly: 1.889 ± 0.037	0.533MetHis: 0.533 ± 0.018	1.458MetIle: 1.458 ± 0.034	1.356MetLys: 1.356 ± 0.029	3.183MetLeu: 3.183 ± 0.048	0.937MetMet: 0.937 ± 0.026	1.101MetAsn: 1.101 ± 0.029	1.379MetPro: 1.379 ± 0.03	1.17MetGln: 1.17 ± 0.026	1.55MetArg: 1.55 ± 0.028	1.859MetSer: 1.859 ± 0.033	1.851MetThr: 1.851 ± 0.035	1.984MetVal: 1.984 ± 0.038	0.268MetTrp: 0.268 ± 0.013	0.524MetTyr: 0.524 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.32AsnAla: 3.32 ± 0.041	0.307AsnCys: 0.307 ± 0.013	1.916AsnAsp: 1.916 ± 0.038	1.718AsnGlu: 1.718 ± 0.033	1.22AsnPhe: 1.22 ± 0.025	2.872AsnGly: 2.872 ± 0.044	0.82AsnHis: 0.82 ± 0.022	2.136AsnIle: 2.136 ± 0.037	1.446AsnLys: 1.446 ± 0.034	3.283AsnLeu: 3.283 ± 0.041	0.88AsnMet: 0.88 ± 0.027	1.427AsnAsn: 1.427 ± 0.032	2.023AsnPro: 2.023 ± 0.034	1.432AsnGln: 1.432 ± 0.033	1.933AsnArg: 1.933 ± 0.036	1.822AsnSer: 1.822 ± 0.038	1.779AsnThr: 1.779 ± 0.03	2.473AsnVal: 2.473 ± 0.038	0.522AsnTrp: 0.522 ± 0.02	1.089AsnTyr: 1.089 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.125ProAla: 5.125 ± 0.075	0.415ProCys: 0.415 ± 0.014	2.753ProAsp: 2.753 ± 0.041	3.285ProGlu: 3.285 ± 0.039	1.895ProPhe: 1.895 ± 0.037	3.696ProGly: 3.696 ± 0.044	1.116ProHis: 1.116 ± 0.029	1.773ProIle: 1.773 ± 0.034	1.368ProLys: 1.368 ± 0.032	5.483ProLeu: 5.483 ± 0.066	1.104ProMet: 1.104 ± 0.026	1.199ProAsn: 1.199 ± 0.026	1.885ProPro: 1.885 ± 0.04	2.548ProGln: 2.548 ± 0.045	2.265ProArg: 2.265 ± 0.036	2.137ProSer: 2.137 ± 0.046	2.12ProThr: 2.12 ± 0.042	3.906ProVal: 3.906 ± 0.052	0.855ProTrp: 0.855 ± 0.023	1.183ProTyr: 1.183 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	5.13GlnAla: 5.13 ± 0.061	0.379GlnCys: 0.379 ± 0.018	1.742GlnAsp: 1.742 ± 0.037	2.108GlnGlu: 2.108 ± 0.04	1.471GlnPhe: 1.471 ± 0.026	3.173GlnGly: 3.173 ± 0.045	1.25GlnHis: 1.25 ± 0.033	2.152GlnIle: 2.152 ± 0.035	1.707GlnLys: 1.707 ± 0.031	5.042GlnLeu: 5.042 ± 0.068	1.188GlnMet: 1.188 ± 0.026	1.309GlnAsn: 1.309 ± 0.032	2.339GlnPro: 2.339 ± 0.051	3.423GlnGln: 3.423 ± 0.065	3.376GlnArg: 3.376 ± 0.046	2.248GlnSer: 2.248 ± 0.034	2.19GlnThr: 2.19 ± 0.038	3.02GlnVal: 3.02 ± 0.045	0.699GlnTrp: 0.699 ± 0.02	1.149GlnTyr: 1.149 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.061ArgAla: 5.061 ± 0.064	0.66ArgCys: 0.66 ± 0.02	3.193ArgAsp: 3.193 ± 0.047	4.022ArgGlu: 4.022 ± 0.053	2.692ArgPhe: 2.692 ± 0.038	3.657ArgGly: 3.657 ± 0.054	1.787ArgHis: 1.787 ± 0.036	3.274ArgIle: 3.274 ± 0.045	2.271ArgLys: 2.271 ± 0.038	6.967ArgLeu: 6.967 ± 0.075	1.644ArgMet: 1.644 ± 0.031	1.917ArgAsn: 1.917 ± 0.036	2.496ArgPro: 2.496 ± 0.043	3.501ArgGln: 3.501 ± 0.05	4.068ArgArg: 4.068 ± 0.061	2.863ArgSer: 2.863 ± 0.042	2.47ArgThr: 2.47 ± 0.04	3.905ArgVal: 3.905 ± 0.054	1.119ArgTrp: 1.119 ± 0.028	2.277ArgTyr: 2.277 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.957SerAla: 5.957 ± 0.062	0.595SerCys: 0.595 ± 0.022	3.018SerAsp: 3.018 ± 0.044	3.042SerGlu: 3.042 ± 0.047	2.283SerPhe: 2.283 ± 0.041	5.232SerGly: 5.232 ± 0.059	1.432SerHis: 1.432 ± 0.029	2.896SerIle: 2.896 ± 0.045	1.861SerLys: 1.861 ± 0.038	6.743SerLeu: 6.743 ± 0.069	1.483SerMet: 1.483 ± 0.027	1.703SerAsn: 1.703 ± 0.036	2.713SerPro: 2.713 ± 0.041	2.523SerGln: 2.523 ± 0.037	3.573SerArg: 3.573 ± 0.048	3.357SerSer: 3.357 ± 0.052	2.845SerThr: 2.845 ± 0.043	4.073SerVal: 4.073 ± 0.053	1.047SerTrp: 1.047 ± 0.024	1.567SerTyr: 1.567 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.118ThrAla: 5.118 ± 0.055	0.519ThrCys: 0.519 ± 0.016	2.428ThrAsp: 2.428 ± 0.039	2.387ThrGlu: 2.387 ± 0.042	2.033ThrPhe: 2.033 ± 0.037	4.394ThrGly: 4.394 ± 0.047	1.172ThrHis: 1.172 ± 0.027	2.842ThrIle: 2.842 ± 0.045	1.369ThrLys: 1.369 ± 0.032	7.473ThrLeu: 7.473 ± 0.08	1.148ThrMet: 1.148 ± 0.027	1.415ThrAsn: 1.415 ± 0.032	3.264ThrPro: 3.264 ± 0.042	1.895ThrGln: 1.895 ± 0.032	3.16ThrArg: 3.16 ± 0.044	2.837ThrSer: 2.837 ± 0.042	2.877ThrThr: 2.877 ± 0.051	3.829ThrVal: 3.829 ± 0.049	0.868ThrTrp: 0.868 ± 0.021	1.116ThrTyr: 1.116 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	7.504ValAla: 7.504 ± 0.074	0.776ValCys: 0.776 ± 0.022	3.701ValAsp: 3.701 ± 0.051	3.94ValGlu: 3.94 ± 0.061	2.576ValPhe: 2.576 ± 0.042	4.94ValGly: 4.94 ± 0.05	1.235ValHis: 1.235 ± 0.028	4.45ValIle: 4.45 ± 0.06	2.946ValLys: 2.946 ± 0.048	7.182ValLeu: 7.182 ± 0.067	2.223ValMet: 2.223 ± 0.036	2.627ValAsn: 2.627 ± 0.046	3.026ValPro: 3.026 ± 0.041	2.392ValGln: 2.392 ± 0.038	3.764ValArg: 3.764 ± 0.047	4.566ValSer: 4.566 ± 0.058	4.137ValThr: 4.137 ± 0.052	5.597ValVal: 5.597 ± 0.059	1.017ValTrp: 1.017 ± 0.026	1.75ValTyr: 1.75 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.067TrpAla: 1.067 ± 0.03	0.186TrpCys: 0.186 ± 0.01	0.663TrpAsp: 0.663 ± 0.022	0.595TrpGlu: 0.595 ± 0.018	0.716TrpPhe: 0.716 ± 0.022	0.985TrpGly: 0.985 ± 0.024	0.461TrpHis: 0.461 ± 0.018	0.739TrpIle: 0.739 ± 0.024	0.486TrpLys: 0.486 ± 0.016	2.531TrpLeu: 2.531 ± 0.041	0.457TrpMet: 0.457 ± 0.015	0.49TrpAsn: 0.49 ± 0.019	0.743TrpPro: 0.743 ± 0.024	1.263TrpGln: 1.263 ± 0.029	1.292TrpArg: 1.292 ± 0.032	0.871TrpSer: 0.871 ± 0.021	0.614TrpThr: 0.614 ± 0.018	0.991TrpVal: 0.991 ± 0.025	0.243TrpTrp: 0.243 ± 0.012	0.446TrpTyr: 0.446 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.548TyrAla: 2.548 ± 0.04	0.364TyrCys: 0.364 ± 0.013	1.532TyrAsp: 1.532 ± 0.035	1.169TyrGlu: 1.169 ± 0.027	1.137TyrPhe: 1.137 ± 0.028	2.235TyrGly: 2.235 ± 0.038	0.74TyrHis: 0.74 ± 0.02	1.294TyrIle: 1.294 ± 0.029	0.889TyrLys: 0.889 ± 0.026	3.02TyrLeu: 3.02 ± 0.05	0.603TyrMet: 0.603 ± 0.02	0.918TyrAsn: 0.918 ± 0.024	1.383TyrPro: 1.383 ± 0.027	1.593TyrGln: 1.593 ± 0.03	1.972TyrArg: 1.972 ± 0.035	1.654TyrSer: 1.654 ± 0.033	1.396TyrThr: 1.396 ± 0.029	1.671TyrVal: 1.671 ± 0.037	0.431TyrTrp: 0.431 ± 0.017	0.926TyrTyr: 0.926 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5728 proteins (1646261 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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