Amino acid dipepetide frequency for Kandleria vitulina DSM 20405

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.07AlaAla: 4.07 ± 0.103	0.937AlaCys: 0.937 ± 0.037	3.021AlaAsp: 3.021 ± 0.074	2.835AlaGlu: 2.835 ± 0.072	2.972AlaPhe: 2.972 ± 0.077	4.095AlaGly: 4.095 ± 0.091	1.467AlaHis: 1.467 ± 0.05	5.515AlaIle: 5.515 ± 0.103	5.283AlaLys: 5.283 ± 0.105	7.144AlaLeu: 7.144 ± 0.119	2.204AlaMet: 2.204 ± 0.061	2.856AlaAsn: 2.856 ± 0.073	1.623AlaPro: 1.623 ± 0.061	1.7AlaGln: 1.7 ± 0.05	2.249AlaArg: 2.249 ± 0.064	3.95AlaSer: 3.95 ± 0.083	3.333AlaThr: 3.333 ± 0.088	4.098AlaVal: 4.098 ± 0.102	0.398AlaTrp: 0.398 ± 0.025	2.832AlaTyr: 2.832 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.791CysAla: 0.791 ± 0.034	0.176CysCys: 0.176 ± 0.017	0.783CysAsp: 0.783 ± 0.037	0.77CysGlu: 0.77 ± 0.035	0.639CysPhe: 0.639 ± 0.033	1.011CysGly: 1.011 ± 0.047	0.374CysHis: 0.374 ± 0.023	1.029CysIle: 1.029 ± 0.042	0.792CysLys: 0.792 ± 0.037	1.063CysLeu: 1.063 ± 0.044	0.309CysMet: 0.309 ± 0.023	0.489CysAsn: 0.489 ± 0.027	0.457CysPro: 0.457 ± 0.03	0.383CysGln: 0.383 ± 0.026	0.43CysArg: 0.43 ± 0.025	0.646CysSer: 0.646 ± 0.036	0.556CysThr: 0.556 ± 0.033	0.905CysVal: 0.905 ± 0.038	0.068CysTrp: 0.068 ± 0.01	0.517CysTyr: 0.517 ± 0.032	0.0CysXaa: 0.0 ± 0.0
Asp	3.839AspAla: 3.839 ± 0.082	0.63AspCys: 0.63 ± 0.029	3.74AspAsp: 3.74 ± 0.084	5.491AspGlu: 5.491 ± 0.11	2.93AspPhe: 2.93 ± 0.075	3.692AspGly: 3.692 ± 0.087	1.937AspHis: 1.937 ± 0.057	5.128AspIle: 5.128 ± 0.091	3.885AspLys: 3.885 ± 0.07	5.446AspLeu: 5.446 ± 0.124	1.902AspMet: 1.902 ± 0.047	2.6AspAsn: 2.6 ± 0.064	1.807AspPro: 1.807 ± 0.056	1.916AspGln: 1.916 ± 0.054	2.071AspArg: 2.071 ± 0.061	2.882AspSer: 2.882 ± 0.113	2.832AspThr: 2.832 ± 0.075	4.386AspVal: 4.386 ± 0.092	0.37AspTrp: 0.37 ± 0.022	3.697AspTyr: 3.697 ± 0.09	0.003AspXaa: 0.003 ± 0.002
Glu	4.726GluAla: 4.726 ± 0.11	0.792GluCys: 0.792 ± 0.04	4.93GluAsp: 4.93 ± 0.101	7.115GluGlu: 7.115 ± 0.148	2.18GluPhe: 2.18 ± 0.065	4.375GluGly: 4.375 ± 0.096	1.578GluHis: 1.578 ± 0.052	5.365GluIle: 5.365 ± 0.098	6.687GluLys: 6.687 ± 0.117	5.993GluLeu: 5.993 ± 0.106	2.422GluMet: 2.422 ± 0.072	3.882GluAsn: 3.882 ± 0.086	1.299GluPro: 1.299 ± 0.047	1.995GluGln: 1.995 ± 0.06	2.882GluArg: 2.882 ± 0.073	3.046GluSer: 3.046 ± 0.079	3.335GluThr: 3.335 ± 0.076	4.488GluVal: 4.488 ± 0.103	0.533GluTrp: 0.533 ± 0.036	2.852GluTyr: 2.852 ± 0.076	0.0GluXaa: 0.0 ± 0.0
Phe	2.481PheAla: 2.481 ± 0.071	0.449PheCys: 0.449 ± 0.028	2.987PheAsp: 2.987 ± 0.069	2.808PheGlu: 2.808 ± 0.071	1.974PhePhe: 1.974 ± 0.071	2.687PheGly: 2.687 ± 0.069	0.963PheHis: 0.963 ± 0.044	3.934PheIle: 3.934 ± 0.099	3.222PheLys: 3.222 ± 0.067	3.65PheLeu: 3.65 ± 0.104	1.383PheMet: 1.383 ± 0.044	2.351PheAsn: 2.351 ± 0.06	1.235PhePro: 1.235 ± 0.04	0.868PheGln: 0.868 ± 0.036	1.249PheArg: 1.249 ± 0.05	2.9PheSer: 2.9 ± 0.076	2.52PheThr: 2.52 ± 0.075	3.009PheVal: 3.009 ± 0.077	0.283PheTrp: 0.283 ± 0.023	2.072PheTyr: 2.072 ± 0.062	0.0PheXaa: 0.0 ± 0.0
Gly	4.07GlyAla: 4.07 ± 0.097	0.998GlyCys: 0.998 ± 0.044	3.33GlyAsp: 3.33 ± 0.081	3.9GlyGlu: 3.9 ± 0.111	2.855GlyPhe: 2.855 ± 0.071	4.03GlyGly: 4.03 ± 0.102	1.683GlyHis: 1.683 ± 0.063	5.251GlyIle: 5.251 ± 0.099	5.153GlyLys: 5.153 ± 0.121	5.618GlyLeu: 5.618 ± 0.111	2.042GlyMet: 2.042 ± 0.065	2.604GlyAsn: 2.604 ± 0.068	1.238GlyPro: 1.238 ± 0.048	1.757GlyGln: 1.757 ± 0.057	2.261GlyArg: 2.261 ± 0.077	3.378GlySer: 3.378 ± 0.081	3.612GlyThr: 3.612 ± 0.099	4.431GlyVal: 4.431 ± 0.096	0.531GlyTrp: 0.531 ± 0.03	3.188GlyTyr: 3.188 ± 0.08	0.0GlyXaa: 0.0 ± 0.0
His	1.353HisAla: 1.353 ± 0.043	0.341HisCys: 0.341 ± 0.024	1.441HisAsp: 1.441 ± 0.047	1.402HisGlu: 1.402 ± 0.05	1.357HisPhe: 1.357 ± 0.049	1.32HisGly: 1.32 ± 0.051	0.845HisHis: 0.845 ± 0.049	2.238HisIle: 2.238 ± 0.064	1.514HisLys: 1.514 ± 0.049	2.27HisLeu: 2.27 ± 0.062	0.699HisMet: 0.699 ± 0.033	1.042HisAsn: 1.042 ± 0.044	1.037HisPro: 1.037 ± 0.043	0.815HisGln: 0.815 ± 0.036	0.879HisArg: 0.879 ± 0.039	1.319HisSer: 1.319 ± 0.05	1.146HisThr: 1.146 ± 0.042	1.77HisVal: 1.77 ± 0.057	0.153HisTrp: 0.153 ± 0.019	1.372HisTyr: 1.372 ± 0.054	0.0HisXaa: 0.0 ± 0.0
Ile	5.78IleAla: 5.78 ± 0.113	1.051IleCys: 1.051 ± 0.05	5.373IleAsp: 5.373 ± 0.109	5.65IleGlu: 5.65 ± 0.109	3.182IlePhe: 3.182 ± 0.079	5.0IleGly: 5.0 ± 0.108	1.8IleHis: 1.8 ± 0.052	6.885IleIle: 6.885 ± 0.138	6.465IleLys: 6.465 ± 0.112	6.953IleLeu: 6.953 ± 0.124	2.327IleMet: 2.327 ± 0.07	4.394IleAsn: 4.394 ± 0.108	2.826IlePro: 2.826 ± 0.064	1.99IleGln: 1.99 ± 0.057	2.998IleArg: 2.998 ± 0.075	5.281IleSer: 5.281 ± 0.109	4.264IleThr: 4.264 ± 0.079	5.848IleVal: 5.848 ± 0.114	0.415IleTrp: 0.415 ± 0.028	3.309IleTyr: 3.309 ± 0.085	0.0IleXaa: 0.0 ± 0.0
Lys	5.268LysAla: 5.268 ± 0.107	0.692LysCys: 0.692 ± 0.035	5.726LysAsp: 5.726 ± 0.106	8.18LysGlu: 8.18 ± 0.129	1.985LysPhe: 1.985 ± 0.063	4.845LysGly: 4.845 ± 0.11	1.629LysHis: 1.629 ± 0.048	5.61LysIle: 5.61 ± 0.105	9.183LysLys: 9.183 ± 0.17	5.713LysLeu: 5.713 ± 0.1	2.678LysMet: 2.678 ± 0.067	4.673LysAsn: 4.673 ± 0.093	1.863LysPro: 1.863 ± 0.049	2.61LysGln: 2.61 ± 0.068	3.6LysArg: 3.6 ± 0.087	4.249LysSer: 4.249 ± 0.092	4.542LysThr: 4.542 ± 0.101	5.14LysVal: 5.14 ± 0.112	0.633LysTrp: 0.633 ± 0.037	3.505LysTyr: 3.505 ± 0.085	0.0LysXaa: 0.0 ± 0.0
Leu	5.723LeuAla: 5.723 ± 0.116	1.28LeuCys: 1.28 ± 0.044	5.529LeuAsp: 5.529 ± 0.101	5.702LeuGlu: 5.702 ± 0.11	4.286LeuPhe: 4.286 ± 0.118	5.338LeuGly: 5.338 ± 0.1	2.032LeuHis: 2.032 ± 0.069	7.024LeuIle: 7.024 ± 0.141	7.642LeuLys: 7.642 ± 0.129	8.659LeuLeu: 8.659 ± 0.164	2.823LeuMet: 2.823 ± 0.069	4.47LeuAsn: 4.47 ± 0.086	3.009LeuPro: 3.009 ± 0.068	2.233LeuGln: 2.233 ± 0.065	3.415LeuArg: 3.415 ± 0.077	7.255LeuSer: 7.255 ± 0.135	4.859LeuThr: 4.859 ± 0.094	5.418LeuVal: 5.418 ± 0.092	0.549LeuTrp: 0.549 ± 0.037	3.658LeuTyr: 3.658 ± 0.092	0.0LeuXaa: 0.0 ± 0.0
Met	1.979MetAla: 1.979 ± 0.055	0.337MetCys: 0.337 ± 0.023	1.745MetAsp: 1.745 ± 0.05	1.779MetGlu: 1.779 ± 0.059	1.101MetPhe: 1.101 ± 0.047	1.726MetGly: 1.726 ± 0.051	0.686MetHis: 0.686 ± 0.035	2.91MetIle: 2.91 ± 0.076	3.203MetLys: 3.203 ± 0.079	2.473MetLeu: 2.473 ± 0.071	1.2MetMet: 1.2 ± 0.053	2.024MetAsn: 2.024 ± 0.054	1.063MetPro: 1.063 ± 0.04	0.842MetGln: 0.842 ± 0.038	1.201MetArg: 1.201 ± 0.048	1.955MetSer: 1.955 ± 0.065	1.787MetThr: 1.787 ± 0.053	1.744MetVal: 1.744 ± 0.053	0.196MetTrp: 0.196 ± 0.016	1.006MetTyr: 1.006 ± 0.045	0.0MetXaa: 0.0 ± 0.0
Asn	3.322AsnAla: 3.322 ± 0.086	0.491AsnCys: 0.491 ± 0.027	3.209AsnAsp: 3.209 ± 0.076	3.9AsnGlu: 3.9 ± 0.102	1.555AsnPhe: 1.555 ± 0.06	3.364AsnGly: 3.364 ± 0.087	1.287AsnHis: 1.287 ± 0.051	3.906AsnIle: 3.906 ± 0.091	4.541AsnLys: 4.541 ± 0.097	3.62AsnLeu: 3.62 ± 0.081	1.575AsnMet: 1.575 ± 0.044	2.766AsnAsn: 2.766 ± 0.087	1.752AsnPro: 1.752 ± 0.059	1.581AsnGln: 1.581 ± 0.047	1.844AsnArg: 1.844 ± 0.059	2.283AsnSer: 2.283 ± 0.065	2.522AsnThr: 2.522 ± 0.069	3.568AsnVal: 3.568 ± 0.081	0.391AsnTrp: 0.391 ± 0.026	2.303AsnTyr: 2.303 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.596ProAla: 1.596 ± 0.049	0.287ProCys: 0.287 ± 0.023	1.765ProAsp: 1.765 ± 0.054	2.195ProGlu: 2.195 ± 0.063	1.507ProPhe: 1.507 ± 0.051	1.683ProGly: 1.683 ± 0.059	0.828ProHis: 0.828 ± 0.04	2.272ProIle: 2.272 ± 0.055	1.665ProLys: 1.665 ± 0.056	2.856ProLeu: 2.856 ± 0.087	0.741ProMet: 0.741 ± 0.032	1.187ProAsn: 1.187 ± 0.043	0.469ProPro: 0.469 ± 0.027	0.947ProGln: 0.947 ± 0.035	1.013ProArg: 1.013 ± 0.043	1.857ProSer: 1.857 ± 0.058	1.626ProThr: 1.626 ± 0.049	2.249ProVal: 2.249 ± 0.061	0.237ProTrp: 0.237 ± 0.022	1.525ProTyr: 1.525 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	1.807GlnAla: 1.807 ± 0.054	0.374GlnCys: 0.374 ± 0.027	1.468GlnAsp: 1.468 ± 0.048	2.087GlnGlu: 2.087 ± 0.059	1.407GlnPhe: 1.407 ± 0.054	1.609GlnGly: 1.609 ± 0.053	0.459GlnHis: 0.459 ± 0.028	2.124GlnIle: 2.124 ± 0.052	2.164GlnLys: 2.164 ± 0.057	2.98GlnLeu: 2.98 ± 0.072	0.971GlnMet: 0.971 ± 0.04	1.341GlnAsn: 1.341 ± 0.046	0.675GlnPro: 0.675 ± 0.031	0.71GlnGln: 0.71 ± 0.031	1.164GlnArg: 1.164 ± 0.05	1.914GlnSer: 1.914 ± 0.06	1.277GlnThr: 1.277 ± 0.047	2.04GlnVal: 2.04 ± 0.066	0.216GlnTrp: 0.216 ± 0.019	1.441GlnTyr: 1.441 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	2.001ArgAla: 2.001 ± 0.062	0.452ArgCys: 0.452 ± 0.027	2.074ArgAsp: 2.074 ± 0.069	2.734ArgGlu: 2.734 ± 0.059	1.818ArgPhe: 1.818 ± 0.056	2.124ArgGly: 2.124 ± 0.062	0.971ArgHis: 0.971 ± 0.05	3.372ArgIle: 3.372 ± 0.069	3.243ArgLys: 3.243 ± 0.078	3.41ArgLeu: 3.41 ± 0.083	1.282ArgMet: 1.282 ± 0.052	1.898ArgAsn: 1.898 ± 0.053	0.94ArgPro: 0.94 ± 0.037	1.259ArgGln: 1.259 ± 0.049	1.778ArgArg: 1.778 ± 0.069	1.926ArgSer: 1.926 ± 0.058	1.874ArgThr: 1.874 ± 0.057	2.439ArgVal: 2.439 ± 0.074	0.262ArgTrp: 0.262 ± 0.022	2.082ArgTyr: 2.082 ± 0.066	0.0ArgXaa: 0.0 ± 0.0
Ser	3.402SerAla: 3.402 ± 0.084	0.644SerCys: 0.644 ± 0.03	3.368SerAsp: 3.368 ± 0.139	3.38SerGlu: 3.38 ± 0.075	3.267SerPhe: 3.267 ± 0.077	3.908SerGly: 3.908 ± 0.089	1.594SerHis: 1.594 ± 0.054	4.983SerIle: 4.983 ± 0.101	4.285SerLys: 4.285 ± 0.095	6.454SerLeu: 6.454 ± 0.128	1.691SerMet: 1.691 ± 0.058	2.476SerAsn: 2.476 ± 0.07	1.589SerPro: 1.589 ± 0.048	1.924SerGln: 1.924 ± 0.062	2.462SerArg: 2.462 ± 0.072	4.66SerSer: 4.66 ± 0.132	3.024SerThr: 3.024 ± 0.089	3.831SerVal: 3.831 ± 0.086	0.486SerTrp: 0.486 ± 0.029	3.166SerTyr: 3.166 ± 0.075	0.002SerXaa: 0.002 ± 0.002
Thr	2.842ThrAla: 2.842 ± 0.078	0.668ThrCys: 0.668 ± 0.037	2.747ThrAsp: 2.747 ± 0.07	2.402ThrGlu: 2.402 ± 0.062	2.581ThrPhe: 2.581 ± 0.076	3.682ThrGly: 3.682 ± 0.085	1.316ThrHis: 1.316 ± 0.048	4.884ThrIle: 4.884 ± 0.112	3.769ThrLys: 3.769 ± 0.093	5.502ThrLeu: 5.502 ± 0.1	1.448ThrMet: 1.448 ± 0.056	2.446ThrAsn: 2.446 ± 0.073	1.874ThrPro: 1.874 ± 0.063	1.402ThrGln: 1.402 ± 0.054	1.905ThrArg: 1.905 ± 0.055	3.378ThrSer: 3.378 ± 0.081	2.834ThrThr: 2.834 ± 0.088	3.692ThrVal: 3.692 ± 0.096	0.386ThrTrp: 0.386 ± 0.028	2.462ThrTyr: 2.462 ± 0.075	0.0ThrXaa: 0.0 ± 0.0
Val	4.426ValAla: 4.426 ± 0.108	0.871ValCys: 0.871 ± 0.035	4.248ValAsp: 4.248 ± 0.094	4.557ValGlu: 4.557 ± 0.102	2.972ValPhe: 2.972 ± 0.08	4.204ValGly: 4.204 ± 0.078	1.319ValHis: 1.319 ± 0.053	5.561ValIle: 5.561 ± 0.093	5.438ValLys: 5.438 ± 0.111	6.262ValLeu: 6.262 ± 0.11	1.839ValMet: 1.839 ± 0.055	3.451ValAsn: 3.451 ± 0.084	2.079ValPro: 2.079 ± 0.065	1.517ValGln: 1.517 ± 0.054	2.323ValArg: 2.323 ± 0.058	4.542ValSer: 4.542 ± 0.086	3.629ValThr: 3.629 ± 0.08	4.5ValVal: 4.5 ± 0.099	0.419ValTrp: 0.419 ± 0.027	2.81ValTyr: 2.81 ± 0.066	0.002ValXaa: 0.002 ± 0.002
Trp	0.383TrpAla: 0.383 ± 0.022	0.1TrpCys: 0.1 ± 0.014	0.401TrpAsp: 0.401 ± 0.031	0.386TrpGlu: 0.386 ± 0.027	0.346TrpPhe: 0.346 ± 0.023	0.489TrpGly: 0.489 ± 0.028	0.18TrpHis: 0.18 ± 0.02	0.573TrpIle: 0.573 ± 0.032	0.573TrpLys: 0.573 ± 0.036	0.617TrpLeu: 0.617 ± 0.037	0.229TrpMet: 0.229 ± 0.019	0.449TrpAsn: 0.449 ± 0.026	0.184TrpPro: 0.184 ± 0.018	0.271TrpGln: 0.271 ± 0.022	0.209TrpArg: 0.209 ± 0.02	0.388TrpSer: 0.388 ± 0.024	0.348TrpThr: 0.348 ± 0.023	0.39TrpVal: 0.39 ± 0.022	0.082TrpTrp: 0.082 ± 0.012	0.333TrpTyr: 0.333 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.724TyrAla: 2.724 ± 0.081	0.615TyrCys: 0.615 ± 0.034	3.301TyrAsp: 3.301 ± 0.084	3.203TyrGlu: 3.203 ± 0.068	2.109TyrPhe: 2.109 ± 0.067	2.747TyrGly: 2.747 ± 0.07	1.367TyrHis: 1.367 ± 0.052	3.225TyrIle: 3.225 ± 0.085	3.62TyrLys: 3.62 ± 0.086	4.22TyrLeu: 4.22 ± 0.079	1.195TyrMet: 1.195 ± 0.044	2.378TyrAsn: 2.378 ± 0.063	1.483TyrPro: 1.483 ± 0.051	1.507TyrGln: 1.507 ± 0.057	2.005TyrArg: 2.005 ± 0.064	2.786TyrSer: 2.786 ± 0.073	2.301TyrThr: 2.301 ± 0.073	3.022TyrVal: 3.022 ± 0.071	0.322TyrTrp: 0.322 ± 0.024	2.475TyrTyr: 2.475 ± 0.077	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.003XaaIle: 0.003 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.551XaaXaa: 0.551 ± 0.266

Statistics based on 2043 proteins (621057 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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