Amino acid dipepetide frequency for Pseudoalteromonas ulvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.429AlaAla: 7.429 ± 0.103	0.969AlaCys: 0.969 ± 0.028	4.721AlaAsp: 4.721 ± 0.064	5.071AlaGlu: 5.071 ± 0.07	3.532AlaPhe: 3.532 ± 0.053	5.609AlaGly: 5.609 ± 0.076	2.017AlaHis: 2.017 ± 0.042	6.163AlaIle: 6.163 ± 0.084	5.159AlaLys: 5.159 ± 0.068	10.033AlaLeu: 10.033 ± 0.092	2.408AlaMet: 2.408 ± 0.04	3.95AlaAsn: 3.95 ± 0.06	2.876AlaPro: 2.876 ± 0.056	4.957AlaGln: 4.957 ± 0.07	3.269AlaArg: 3.269 ± 0.052	5.363AlaSer: 5.363 ± 0.066	4.485AlaThr: 4.485 ± 0.06	5.584AlaVal: 5.584 ± 0.076	0.907AlaTrp: 0.907 ± 0.026	2.407AlaTyr: 2.407 ± 0.045	0.002AlaXaa: 0.002 ± 0.001
Cys	0.795CysAla: 0.795 ± 0.027	0.155CysCys: 0.155 ± 0.012	0.648CysAsp: 0.648 ± 0.025	0.598CysGlu: 0.598 ± 0.022	0.518CysPhe: 0.518 ± 0.018	0.768CysGly: 0.768 ± 0.029	0.362CysHis: 0.362 ± 0.018	0.627CysIle: 0.627 ± 0.021	0.444CysLys: 0.444 ± 0.019	1.134CysLeu: 1.134 ± 0.03	0.209CysMet: 0.209 ± 0.013	0.377CysAsn: 0.377 ± 0.016	0.425CysPro: 0.425 ± 0.019	0.615CysGln: 0.615 ± 0.023	0.395CysArg: 0.395 ± 0.017	0.689CysSer: 0.689 ± 0.025	0.464CysThr: 0.464 ± 0.017	0.683CysVal: 0.683 ± 0.023	0.12CysTrp: 0.12 ± 0.008	0.331CysTyr: 0.331 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.441AspAla: 4.441 ± 0.062	0.516AspCys: 0.516 ± 0.023	3.206AspAsp: 3.206 ± 0.087	3.744AspGlu: 3.744 ± 0.059	2.729AspPhe: 2.729 ± 0.049	3.468AspGly: 3.468 ± 0.071	1.112AspHis: 1.112 ± 0.029	4.084AspIle: 4.084 ± 0.06	3.273AspLys: 3.273 ± 0.065	5.427AspLeu: 5.427 ± 0.08	1.245AspMet: 1.245 ± 0.03	2.692AspAsn: 2.692 ± 0.048	2.026AspPro: 2.026 ± 0.047	2.131AspGln: 2.131 ± 0.041	1.848AspArg: 1.848 ± 0.044	3.309AspSer: 3.309 ± 0.052	2.873AspThr: 2.873 ± 0.045	3.812AspVal: 3.812 ± 0.056	0.809AspTrp: 0.809 ± 0.024	2.167AspTyr: 2.167 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.591GluAla: 4.591 ± 0.074	0.45GluCys: 0.45 ± 0.019	2.462GluAsp: 2.462 ± 0.051	2.943GluGlu: 2.943 ± 0.062	2.774GluPhe: 2.774 ± 0.046	3.111GluGly: 3.111 ± 0.05	1.724GluHis: 1.724 ± 0.037	3.863GluIle: 3.863 ± 0.057	3.459GluLys: 3.459 ± 0.056	7.043GluLeu: 7.043 ± 0.085	1.416GluMet: 1.416 ± 0.036	2.494GluAsn: 2.494 ± 0.044	1.944GluPro: 1.944 ± 0.046	4.985GluGln: 4.985 ± 0.079	2.975GluArg: 2.975 ± 0.055	3.427GluSer: 3.427 ± 0.06	2.831GluThr: 2.831 ± 0.046	3.95GluVal: 3.95 ± 0.059	0.555GluTrp: 0.555 ± 0.021	1.73GluTyr: 1.73 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.98PheAla: 3.98 ± 0.06	0.548PheCys: 0.548 ± 0.022	2.998PheAsp: 2.998 ± 0.058	2.868PheGlu: 2.868 ± 0.046	1.895PhePhe: 1.895 ± 0.044	2.969PheGly: 2.969 ± 0.05	0.848PheHis: 0.848 ± 0.028	3.249PheIle: 3.249 ± 0.054	2.407PheLys: 2.407 ± 0.047	3.568PheLeu: 3.568 ± 0.056	0.991PheMet: 0.991 ± 0.028	2.605PheAsn: 2.605 ± 0.047	1.315PhePro: 1.315 ± 0.031	1.255PheGln: 1.255 ± 0.029	1.394PheArg: 1.394 ± 0.033	3.792PheSer: 3.792 ± 0.057	2.57PheThr: 2.57 ± 0.046	2.861PheVal: 2.861 ± 0.053	0.509PheTrp: 0.509 ± 0.02	1.632PheTyr: 1.632 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	4.919GlyAla: 4.919 ± 0.074	0.819GlyCys: 0.819 ± 0.026	3.413GlyAsp: 3.413 ± 0.054	3.765GlyGlu: 3.765 ± 0.047	3.419GlyPhe: 3.419 ± 0.052	4.114GlyGly: 4.114 ± 0.074	1.608GlyHis: 1.608 ± 0.036	4.161GlyIle: 4.161 ± 0.063	3.279GlyLys: 3.279 ± 0.05	6.826GlyLeu: 6.826 ± 0.08	1.644GlyMet: 1.644 ± 0.041	2.405GlyAsn: 2.405 ± 0.048	1.567GlyPro: 1.567 ± 0.035	3.267GlyGln: 3.267 ± 0.051	2.692GlyArg: 2.692 ± 0.047	3.769GlySer: 3.769 ± 0.061	3.15GlyThr: 3.15 ± 0.059	4.547GlyVal: 4.547 ± 0.065	0.806GlyTrp: 0.806 ± 0.025	2.391GlyTyr: 2.391 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.876HisAla: 1.876 ± 0.035	0.361HisCys: 0.361 ± 0.018	1.192HisAsp: 1.192 ± 0.03	1.159HisGlu: 1.159 ± 0.032	1.286HisPhe: 1.286 ± 0.038	1.478HisGly: 1.478 ± 0.037	0.835HisHis: 0.835 ± 0.024	1.578HisIle: 1.578 ± 0.041	1.095HisLys: 1.095 ± 0.032	2.524HisLeu: 2.524 ± 0.046	0.446HisMet: 0.446 ± 0.017	1.024HisAsn: 1.024 ± 0.024	1.179HisPro: 1.179 ± 0.032	1.625HisGln: 1.625 ± 0.037	0.927HisArg: 0.927 ± 0.029	1.661HisSer: 1.661 ± 0.035	1.306HisThr: 1.306 ± 0.029	1.383HisVal: 1.383 ± 0.035	0.375HisTrp: 0.375 ± 0.016	0.995HisTyr: 0.995 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.553IleAla: 6.553 ± 0.08	0.755IleCys: 0.755 ± 0.024	4.481IleAsp: 4.481 ± 0.06	4.975IleGlu: 4.975 ± 0.064	2.391IlePhe: 2.391 ± 0.045	4.225IleGly: 4.225 ± 0.061	1.315IleHis: 1.315 ± 0.034	3.865IleIle: 3.865 ± 0.057	3.918IleLys: 3.918 ± 0.056	5.301IleLeu: 5.301 ± 0.076	1.263IleMet: 1.263 ± 0.031	3.762IleAsn: 3.762 ± 0.059	2.405IlePro: 2.405 ± 0.044	2.226IleGln: 2.226 ± 0.04	2.571IleArg: 2.571 ± 0.048	4.927IleSer: 4.927 ± 0.063	3.899IleThr: 3.899 ± 0.052	3.92IleVal: 3.92 ± 0.064	0.646IleTrp: 0.646 ± 0.019	1.823IleTyr: 1.823 ± 0.047	0.001IleXaa: 0.001 ± 0.001
Lys	4.674LysAla: 4.674 ± 0.072	0.32LysCys: 0.32 ± 0.02	2.594LysAsp: 2.594 ± 0.048	3.261LysGlu: 3.261 ± 0.056	1.619LysPhe: 1.619 ± 0.032	3.143LysGly: 3.143 ± 0.051	1.439LysHis: 1.439 ± 0.033	3.223LysIle: 3.223 ± 0.06	3.255LysLys: 3.255 ± 0.059	5.363LysLeu: 5.363 ± 0.07	1.337LysMet: 1.337 ± 0.032	2.494LysAsn: 2.494 ± 0.045	2.19LysPro: 2.19 ± 0.041	3.699LysGln: 3.699 ± 0.059	2.63LysArg: 2.63 ± 0.044	3.18LysSer: 3.18 ± 0.057	3.066LysThr: 3.066 ± 0.051	3.708LysVal: 3.708 ± 0.054	0.561LysTrp: 0.561 ± 0.021	1.39LysTyr: 1.39 ± 0.036	0.001LysXaa: 0.001 ± 0.001
Leu	10.523LeuAla: 10.523 ± 0.099	1.174LeuCys: 1.174 ± 0.032	5.811LeuAsp: 5.811 ± 0.081	5.876LeuGlu: 5.876 ± 0.071	4.59LeuPhe: 4.59 ± 0.063	6.55LeuGly: 6.55 ± 0.08	2.141LeuHis: 2.141 ± 0.043	6.839LeuIle: 6.839 ± 0.081	5.937LeuLys: 5.937 ± 0.077	10.914LeuLeu: 10.914 ± 0.134	2.602LeuMet: 2.602 ± 0.044	5.426LeuAsn: 5.426 ± 0.072	4.597LeuPro: 4.597 ± 0.058	4.19LeuGln: 4.19 ± 0.063	3.877LeuArg: 3.877 ± 0.06	8.536LeuSer: 8.536 ± 0.076	6.644LeuThr: 6.644 ± 0.073	6.758LeuVal: 6.758 ± 0.082	1.0LeuTrp: 1.0 ± 0.029	2.846LeuTyr: 2.846 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.365MetAla: 2.365 ± 0.042	0.196MetCys: 0.196 ± 0.013	1.065MetAsp: 1.065 ± 0.03	0.988MetGlu: 0.988 ± 0.031	0.87MetPhe: 0.87 ± 0.028	1.435MetGly: 1.435 ± 0.033	0.503MetHis: 0.503 ± 0.021	1.38MetIle: 1.38 ± 0.033	1.307MetLys: 1.307 ± 0.028	2.593MetLeu: 2.593 ± 0.046	0.69MetMet: 0.69 ± 0.028	1.057MetAsn: 1.057 ± 0.028	1.078MetPro: 1.078 ± 0.025	1.207MetGln: 1.207 ± 0.031	1.063MetArg: 1.063 ± 0.027	1.866MetSer: 1.866 ± 0.031	1.511MetThr: 1.511 ± 0.029	1.454MetVal: 1.454 ± 0.036	0.213MetTrp: 0.213 ± 0.012	0.505MetTyr: 0.505 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.732AsnAla: 3.732 ± 0.06	0.436AsnCys: 0.436 ± 0.019	2.561AsnAsp: 2.561 ± 0.063	2.797AsnGlu: 2.797 ± 0.049	1.646AsnPhe: 1.646 ± 0.035	2.94AsnGly: 2.94 ± 0.062	1.204AsnHis: 1.204 ± 0.027	2.924AsnIle: 2.924 ± 0.043	2.606AsnLys: 2.606 ± 0.052	4.434AsnLeu: 4.434 ± 0.061	0.991AsnMet: 0.991 ± 0.03	2.39AsnAsn: 2.39 ± 0.049	2.105AsnPro: 2.105 ± 0.039	2.934AsnGln: 2.934 ± 0.046	1.849AsnArg: 1.849 ± 0.036	2.764AsnSer: 2.764 ± 0.054	2.605AsnThr: 2.605 ± 0.043	2.762AsnVal: 2.762 ± 0.048	0.654AsnTrp: 0.654 ± 0.023	1.446AsnTyr: 1.446 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.009ProAla: 3.009 ± 0.054	0.288ProCys: 0.288 ± 0.014	2.359ProAsp: 2.359 ± 0.049	2.774ProGlu: 2.774 ± 0.047	1.791ProPhe: 1.791 ± 0.036	2.08ProGly: 2.08 ± 0.044	0.919ProHis: 0.919 ± 0.027	2.647ProIle: 2.647 ± 0.04	1.87ProLys: 1.87 ± 0.039	4.044ProLeu: 4.044 ± 0.057	0.886ProMet: 0.886 ± 0.026	1.73ProAsn: 1.73 ± 0.041	1.029ProPro: 1.029 ± 0.03	1.759ProGln: 1.759 ± 0.035	1.179ProArg: 1.179 ± 0.033	2.569ProSer: 2.569 ± 0.043	2.078ProThr: 2.078 ± 0.042	2.676ProVal: 2.676 ± 0.046	0.486ProTrp: 0.486 ± 0.017	1.221ProTyr: 1.221 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.378GlnAla: 5.378 ± 0.076	0.509GlnCys: 0.509 ± 0.02	2.257GlnAsp: 2.257 ± 0.042	2.418GlnGlu: 2.418 ± 0.046	2.406GlnPhe: 2.406 ± 0.051	3.368GlnGly: 3.368 ± 0.053	1.646GlnHis: 1.646 ± 0.038	2.915GlnIle: 2.915 ± 0.046	2.351GlnLys: 2.351 ± 0.047	6.688GlnLeu: 6.688 ± 0.087	1.097GlnMet: 1.097 ± 0.028	1.892GlnAsn: 1.892 ± 0.038	1.961GlnPro: 1.961 ± 0.041	4.325GlnGln: 4.325 ± 0.093	2.344GlnArg: 2.344 ± 0.04	3.678GlnSer: 3.678 ± 0.061	3.007GlnThr: 3.007 ± 0.054	3.658GlnVal: 3.658 ± 0.061	0.712GlnTrp: 0.712 ± 0.025	1.752GlnTyr: 1.752 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.236ArgAla: 3.236 ± 0.049	0.395ArgCys: 0.395 ± 0.018	2.235ArgAsp: 2.235 ± 0.054	2.354ArgGlu: 2.354 ± 0.048	2.239ArgPhe: 2.239 ± 0.04	2.251ArgGly: 2.251 ± 0.046	1.018ArgHis: 1.018 ± 0.028	2.867ArgIle: 2.867 ± 0.05	1.998ArgLys: 1.998 ± 0.043	4.542ArgLeu: 4.542 ± 0.059	0.97ArgMet: 0.97 ± 0.024	1.67ArgAsn: 1.67 ± 0.041	1.391ArgPro: 1.391 ± 0.033	1.965ArgGln: 1.965 ± 0.04	1.812ArgArg: 1.812 ± 0.044	2.376ArgSer: 2.376 ± 0.043	2.014ArgThr: 2.014 ± 0.04	2.747ArgVal: 2.747 ± 0.05	0.491ArgTrp: 0.491 ± 0.019	1.697ArgTyr: 1.697 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	5.855SerAla: 5.855 ± 0.073	0.653SerCys: 0.653 ± 0.02	3.859SerAsp: 3.859 ± 0.066	3.995SerGlu: 3.995 ± 0.058	3.165SerPhe: 3.165 ± 0.052	4.701SerGly: 4.701 ± 0.063	1.734SerHis: 1.734 ± 0.038	4.296SerIle: 4.296 ± 0.07	3.097SerLys: 3.097 ± 0.051	7.525SerLeu: 7.525 ± 0.079	1.489SerMet: 1.489 ± 0.037	2.933SerAsn: 2.933 ± 0.055	2.475SerPro: 2.475 ± 0.047	3.824SerGln: 3.824 ± 0.054	2.615SerArg: 2.615 ± 0.043	4.533SerSer: 4.533 ± 0.074	3.405SerThr: 3.405 ± 0.056	4.577SerVal: 4.577 ± 0.065	0.807SerTrp: 0.807 ± 0.026	2.177SerTyr: 2.177 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.636ThrAla: 4.636 ± 0.061	0.489ThrCys: 0.489 ± 0.022	3.102ThrAsp: 3.102 ± 0.06	3.143ThrGlu: 3.143 ± 0.049	2.212ThrPhe: 2.212 ± 0.04	3.779ThrGly: 3.779 ± 0.05	1.388ThrHis: 1.388 ± 0.034	3.479ThrIle: 3.479 ± 0.049	2.326ThrLys: 2.326 ± 0.042	6.716ThrLeu: 6.716 ± 0.077	1.019ThrMet: 1.019 ± 0.03	2.186ThrAsn: 2.186 ± 0.045	2.674ThrPro: 2.674 ± 0.055	3.127ThrGln: 3.127 ± 0.053	2.143ThrArg: 2.143 ± 0.037	3.424ThrSer: 3.424 ± 0.054	2.917ThrThr: 2.917 ± 0.046	3.798ThrVal: 3.798 ± 0.059	0.639ThrTrp: 0.639 ± 0.024	1.519ThrTyr: 1.519 ± 0.038	0.001ThrXaa: 0.001 ± 0.001
Val	5.953ValAla: 5.953 ± 0.086	0.789ValCys: 0.789 ± 0.027	3.762ValAsp: 3.762 ± 0.054	4.099ValGlu: 4.099 ± 0.064	2.982ValPhe: 2.982 ± 0.054	3.907ValGly: 3.907 ± 0.067	1.207ValHis: 1.207 ± 0.033	4.741ValIle: 4.741 ± 0.061	3.606ValLys: 3.606 ± 0.056	6.754ValLeu: 6.754 ± 0.085	1.819ValMet: 1.819 ± 0.037	3.121ValAsn: 3.121 ± 0.054	2.359ValPro: 2.359 ± 0.044	2.306ValGln: 2.306 ± 0.04	2.468ValArg: 2.468 ± 0.047	4.954ValSer: 4.954 ± 0.058	3.947ValThr: 3.947 ± 0.057	4.695ValVal: 4.695 ± 0.075	0.711ValTrp: 0.711 ± 0.02	1.941ValTyr: 1.941 ± 0.039	0.001ValXaa: 0.001 ± 0.0
Trp	0.703TrpAla: 0.703 ± 0.023	0.137TrpCys: 0.137 ± 0.011	0.514TrpAsp: 0.514 ± 0.022	0.398TrpGlu: 0.398 ± 0.022	0.586TrpPhe: 0.586 ± 0.02	0.633TrpGly: 0.633 ± 0.023	0.413TrpHis: 0.413 ± 0.019	0.567TrpIle: 0.567 ± 0.019	0.345TrpLys: 0.345 ± 0.017	1.735TrpLeu: 1.735 ± 0.036	0.278TrpMet: 0.278 ± 0.015	0.35TrpAsn: 0.35 ± 0.019	0.506TrpPro: 0.506 ± 0.022	1.346TrpGln: 1.346 ± 0.039	0.614TrpArg: 0.614 ± 0.022	0.738TrpSer: 0.738 ± 0.023	0.449TrpThr: 0.449 ± 0.02	0.727TrpVal: 0.727 ± 0.02	0.161TrpTrp: 0.161 ± 0.011	0.399TrpTyr: 0.399 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.261TyrAla: 2.261 ± 0.043	0.4TyrCys: 0.4 ± 0.017	1.671TyrAsp: 1.671 ± 0.036	1.502TyrGlu: 1.502 ± 0.036	1.604TyrPhe: 1.604 ± 0.037	2.033TyrGly: 2.033 ± 0.041	0.871TyrHis: 0.871 ± 0.025	1.752TyrIle: 1.752 ± 0.037	1.412TyrLys: 1.412 ± 0.035	3.667TyrLeu: 3.667 ± 0.048	0.544TyrMet: 0.544 ± 0.021	1.221TyrAsn: 1.221 ± 0.032	1.294TyrPro: 1.294 ± 0.032	2.615TyrGln: 2.615 ± 0.052	1.607TyrArg: 1.607 ± 0.038	2.157TyrSer: 2.157 ± 0.039	1.497TyrThr: 1.497 ± 0.037	1.822TyrVal: 1.822 ± 0.036	0.441TyrTrp: 0.441 ± 0.019	1.107TyrTyr: 1.107 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3964 proteins (1332564 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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