Amino acid dipepetide frequency for Thalassiosira oceanica (Marine diatom)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.417AlaAla: 10.417 ± 0.052	1.528AlaCys: 1.528 ± 0.012	4.805AlaAsp: 4.805 ± 0.022	5.701AlaGlu: 5.701 ± 0.029	2.689AlaPhe: 2.689 ± 0.018	6.723AlaGly: 6.723 ± 0.034	1.706AlaHis: 1.706 ± 0.012	3.47AlaIle: 3.47 ± 0.018	4.159AlaLys: 4.159 ± 0.024	7.374AlaLeu: 7.374 ± 0.029	2.069AlaMet: 2.069 ± 0.014	2.812AlaAsn: 2.812 ± 0.016	4.818AlaPro: 4.818 ± 0.026	2.675AlaGln: 2.675 ± 0.015	6.501AlaArg: 6.501 ± 0.036	7.566AlaSer: 7.566 ± 0.025	4.963AlaThr: 4.963 ± 0.021	5.981AlaVal: 5.981 ± 0.029	0.877AlaTrp: 0.877 ± 0.01	1.675AlaTyr: 1.675 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	1.38CysAla: 1.38 ± 0.012	0.606CysCys: 0.606 ± 0.008	1.071CysAsp: 1.071 ± 0.009	0.966CysGlu: 0.966 ± 0.01	0.677CysPhe: 0.677 ± 0.008	1.55CysGly: 1.55 ± 0.014	0.476CysHis: 0.476 ± 0.005	0.736CysIle: 0.736 ± 0.008	0.793CysLys: 0.793 ± 0.009	1.611CysLeu: 1.611 ± 0.013	0.387CysMet: 0.387 ± 0.005	0.703CysAsn: 0.703 ± 0.009	1.231CysPro: 1.231 ± 0.014	0.662CysGln: 0.662 ± 0.008	1.424CysArg: 1.424 ± 0.012	1.496CysSer: 1.496 ± 0.011	0.958CysThr: 0.958 ± 0.01	1.121CysVal: 1.121 ± 0.011	0.252CysTrp: 0.252 ± 0.005	0.456CysTyr: 0.456 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.519AspAla: 5.519 ± 0.024	1.159AspCys: 1.159 ± 0.012	5.875AspAsp: 5.875 ± 0.031	5.729AspGlu: 5.729 ± 0.026	2.05AspPhe: 2.05 ± 0.014	6.264AspGly: 6.264 ± 0.031	1.219AspHis: 1.219 ± 0.011	2.427AspIle: 2.427 ± 0.016	2.3AspLys: 2.3 ± 0.016	4.81AspLeu: 4.81 ± 0.021	1.218AspMet: 1.218 ± 0.011	2.008AspAsn: 2.008 ± 0.014	3.128AspPro: 3.128 ± 0.019	1.711AspGln: 1.711 ± 0.012	3.839AspArg: 3.839 ± 0.02	4.491AspSer: 4.491 ± 0.02	2.676AspThr: 2.676 ± 0.015	4.186AspVal: 4.186 ± 0.02	0.802AspTrp: 0.802 ± 0.008	1.457AspTyr: 1.457 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	5.819GluAla: 5.819 ± 0.025	1.071GluCys: 1.071 ± 0.011	4.665GluAsp: 4.665 ± 0.024	6.277GluGlu: 6.277 ± 0.037	1.839GluPhe: 1.839 ± 0.01	5.198GluGly: 5.198 ± 0.026	1.318GluHis: 1.318 ± 0.011	2.623GluIle: 2.623 ± 0.017	3.158GluLys: 3.158 ± 0.022	5.578GluLeu: 5.578 ± 0.025	1.585GluMet: 1.585 ± 0.012	2.077GluAsn: 2.077 ± 0.014	2.682GluPro: 2.682 ± 0.017	2.252GluGln: 2.252 ± 0.016	4.728GluArg: 4.728 ± 0.024	4.876GluSer: 4.876 ± 0.023	3.266GluThr: 3.266 ± 0.019	3.976GluVal: 3.976 ± 0.021	0.741GluTrp: 0.741 ± 0.007	1.534GluTyr: 1.534 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	2.55PheAla: 2.55 ± 0.015	0.764PheCys: 0.764 ± 0.009	2.362PheAsp: 2.362 ± 0.018	1.995PheGlu: 1.995 ± 0.014	1.207PhePhe: 1.207 ± 0.012	2.714PheGly: 2.714 ± 0.016	0.783PheHis: 0.783 ± 0.008	1.244PheIle: 1.244 ± 0.011	1.226PheLys: 1.226 ± 0.012	2.796PheLeu: 2.796 ± 0.016	0.67PheMet: 0.67 ± 0.007	1.137PheAsn: 1.137 ± 0.01	1.546PhePro: 1.546 ± 0.013	1.053PheGln: 1.053 ± 0.01	1.887PheArg: 1.887 ± 0.013	2.407PheSer: 2.407 ± 0.016	1.484PheThr: 1.484 ± 0.012	2.308PheVal: 2.308 ± 0.015	0.4PheTrp: 0.4 ± 0.005	0.874PheTyr: 0.874 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	6.327GlyAla: 6.327 ± 0.031	1.517GlyCys: 1.517 ± 0.012	5.315GlyAsp: 5.315 ± 0.027	4.899GlyGlu: 4.899 ± 0.024	2.329GlyPhe: 2.329 ± 0.014	9.215GlyGly: 9.215 ± 0.055	2.031GlyHis: 2.031 ± 0.014	2.904GlyIle: 2.904 ± 0.015	3.583GlyLys: 3.583 ± 0.024	6.066GlyLeu: 6.066 ± 0.028	1.681GlyMet: 1.681 ± 0.015	2.764GlyAsn: 2.764 ± 0.017	3.958GlyPro: 3.958 ± 0.027	2.58GlyGln: 2.58 ± 0.017	7.197GlyArg: 7.197 ± 0.041	6.391GlySer: 6.391 ± 0.027	4.096GlyThr: 4.096 ± 0.023	5.046GlyVal: 5.046 ± 0.022	1.047GlyTrp: 1.047 ± 0.011	1.859GlyTyr: 1.859 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	1.918HisAla: 1.918 ± 0.015	0.491HisCys: 0.491 ± 0.007	1.426HisAsp: 1.426 ± 0.013	1.427HisGlu: 1.427 ± 0.01	0.862HisPhe: 0.862 ± 0.009	2.044HisGly: 2.044 ± 0.015	0.802HisHis: 0.802 ± 0.01	0.852HisIle: 0.852 ± 0.009	0.831HisLys: 0.831 ± 0.009	2.038HisLeu: 2.038 ± 0.014	0.381HisMet: 0.381 ± 0.006	0.751HisAsn: 0.751 ± 0.008	1.482HisPro: 1.482 ± 0.011	0.909HisGln: 0.909 ± 0.009	1.834HisArg: 1.834 ± 0.013	1.757HisSer: 1.757 ± 0.014	0.993HisThr: 0.993 ± 0.01	1.512HisVal: 1.512 ± 0.013	0.369HisTrp: 0.369 ± 0.007	0.652HisTyr: 0.652 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.288IleAla: 3.288 ± 0.017	0.862IleCys: 0.862 ± 0.008	2.773IleAsp: 2.773 ± 0.017	2.784IleGlu: 2.784 ± 0.017	1.31IlePhe: 1.31 ± 0.012	2.81IleGly: 2.81 ± 0.016	0.92IleHis: 0.92 ± 0.009	1.596IleIle: 1.596 ± 0.012	1.832IleLys: 1.832 ± 0.015	3.339IleLeu: 3.339 ± 0.018	0.824IleMet: 0.824 ± 0.008	1.423IleAsn: 1.423 ± 0.012	2.148IlePro: 2.148 ± 0.016	1.433IleGln: 1.433 ± 0.012	2.5IleArg: 2.5 ± 0.015	3.264IleSer: 3.264 ± 0.021	1.92IleThr: 1.92 ± 0.014	2.566IleVal: 2.566 ± 0.015	0.413IleTrp: 0.413 ± 0.006	0.954IleTyr: 0.954 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.779LysAla: 3.779 ± 0.024	0.771LysCys: 0.771 ± 0.009	2.619LysAsp: 2.619 ± 0.017	3.101LysGlu: 3.101 ± 0.021	1.347LysPhe: 1.347 ± 0.011	3.017LysGly: 3.017 ± 0.019	1.002LysHis: 1.002 ± 0.008	1.937LysIle: 1.937 ± 0.014	3.766LysLys: 3.766 ± 0.035	3.779LysLeu: 3.779 ± 0.021	1.158LysMet: 1.158 ± 0.01	1.704LysAsn: 1.704 ± 0.014	2.168LysPro: 2.168 ± 0.017	1.735LysGln: 1.735 ± 0.014	3.812LysArg: 3.812 ± 0.023	3.933LysSer: 3.933 ± 0.025	2.505LysThr: 2.505 ± 0.016	2.571LysVal: 2.571 ± 0.018	0.536LysTrp: 0.536 ± 0.007	1.165LysTyr: 1.165 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	7.69LeuAla: 7.69 ± 0.031	1.508LeuCys: 1.508 ± 0.014	5.06LeuAsp: 5.06 ± 0.022	5.173LeuGlu: 5.173 ± 0.024	2.729LeuPhe: 2.729 ± 0.016	6.417LeuGly: 6.417 ± 0.031	2.041LeuHis: 2.041 ± 0.015	3.013LeuIle: 3.013 ± 0.015	3.748LeuLys: 3.748 ± 0.021	7.876LeuLeu: 7.876 ± 0.034	1.616LeuMet: 1.616 ± 0.012	2.813LeuAsn: 2.813 ± 0.017	5.192LeuPro: 5.192 ± 0.025	3.115LeuGln: 3.115 ± 0.017	6.231LeuArg: 6.231 ± 0.029	7.194LeuSer: 7.194 ± 0.028	4.108LeuThr: 4.108 ± 0.017	5.238LeuVal: 5.238 ± 0.023	0.948LeuTrp: 0.948 ± 0.008	1.826LeuTyr: 1.826 ± 0.014	0.0LeuXaa: 0.0 ± 0.0
Met	1.871MetAla: 1.871 ± 0.015	0.354MetCys: 0.354 ± 0.005	1.194MetAsp: 1.194 ± 0.009	1.316MetGlu: 1.316 ± 0.011	0.694MetPhe: 0.694 ± 0.008	1.399MetGly: 1.399 ± 0.011	0.467MetHis: 0.467 ± 0.006	0.97MetIle: 0.97 ± 0.009	1.355MetLys: 1.355 ± 0.013	1.676MetLeu: 1.676 ± 0.013	0.629MetMet: 0.629 ± 0.008	0.868MetAsn: 0.868 ± 0.008	1.134MetPro: 1.134 ± 0.01	0.731MetGln: 0.731 ± 0.008	1.407MetArg: 1.407 ± 0.012	1.935MetSer: 1.935 ± 0.013	1.26MetThr: 1.26 ± 0.011	1.147MetVal: 1.147 ± 0.01	0.212MetTrp: 0.212 ± 0.004	0.462MetTyr: 0.462 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.81AsnAla: 2.81 ± 0.018	0.681AsnCys: 0.681 ± 0.009	2.328AsnAsp: 2.328 ± 0.016	2.416AsnGlu: 2.416 ± 0.015	1.161AsnPhe: 1.161 ± 0.01	2.909AsnGly: 2.909 ± 0.017	0.84AsnHis: 0.84 ± 0.009	1.499AsnIle: 1.499 ± 0.012	1.656AsnLys: 1.656 ± 0.013	2.958AsnLeu: 2.958 ± 0.015	0.721AsnMet: 0.721 ± 0.009	1.532AsnAsn: 1.532 ± 0.016	1.888AsnPro: 1.888 ± 0.016	1.189AsnGln: 1.189 ± 0.012	2.085AsnArg: 2.085 ± 0.014	2.716AsnSer: 2.716 ± 0.02	1.639AsnThr: 1.639 ± 0.012	2.11AsnVal: 2.11 ± 0.015	0.448AsnTrp: 0.448 ± 0.007	0.873AsnTyr: 0.873 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	5.13ProAla: 5.13 ± 0.026	0.856ProCys: 0.856 ± 0.011	3.122ProAsp: 3.122 ± 0.019	3.1ProGlu: 3.1 ± 0.016	1.657ProPhe: 1.657 ± 0.014	4.23ProGly: 4.23 ± 0.028	1.245ProHis: 1.245 ± 0.01	1.948ProIle: 1.948 ± 0.014	2.095ProLys: 2.095 ± 0.015	4.302ProLeu: 4.302 ± 0.023	1.003ProMet: 1.003 ± 0.008	1.737ProAsn: 1.737 ± 0.014	5.419ProPro: 5.419 ± 0.038	1.904ProGln: 1.904 ± 0.015	4.56ProArg: 4.56 ± 0.032	6.162ProSer: 6.162 ± 0.049	3.929ProThr: 3.929 ± 0.033	3.462ProVal: 3.462 ± 0.019	0.605ProTrp: 0.605 ± 0.009	1.081ProTyr: 1.081 ± 0.01	0.0ProXaa: 0.0 ± 0.0
Gln	2.923GlnAla: 2.923 ± 0.019	0.564GlnCys: 0.564 ± 0.007	1.755GlnAsp: 1.755 ± 0.012	2.031GlnGlu: 2.031 ± 0.015	1.046GlnPhe: 1.046 ± 0.01	2.374GlnGly: 2.374 ± 0.016	1.014GlnHis: 1.014 ± 0.01	1.404GlnIle: 1.404 ± 0.012	1.564GlnLys: 1.564 ± 0.011	3.042GlnLeu: 3.042 ± 0.021	0.764GlnMet: 0.764 ± 0.009	1.179GlnAsn: 1.179 ± 0.01	1.973GlnPro: 1.973 ± 0.018	2.03GlnGln: 2.03 ± 0.024	2.923GlnArg: 2.923 ± 0.018	2.876GlnSer: 2.876 ± 0.02	1.815GlnThr: 1.815 ± 0.012	2.067GlnVal: 2.067 ± 0.014	0.425GlnTrp: 0.425 ± 0.005	0.922GlnTyr: 0.922 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	6.444ArgAla: 6.444 ± 0.035	1.275ArgCys: 1.275 ± 0.009	4.057ArgAsp: 4.057 ± 0.02	4.355ArgGlu: 4.355 ± 0.023	1.974ArgPhe: 1.974 ± 0.014	6.482ArgGly: 6.482 ± 0.044	2.143ArgHis: 2.143 ± 0.015	2.606ArgIle: 2.606 ± 0.015	3.552ArgLys: 3.552 ± 0.022	6.275ArgLeu: 6.275 ± 0.029	1.421ArgMet: 1.421 ± 0.011	2.376ArgAsn: 2.376 ± 0.016	4.899ArgPro: 4.899 ± 0.035	2.989ArgGln: 2.989 ± 0.018	9.32ArgArg: 9.32 ± 0.062	5.932ArgSer: 5.932 ± 0.027	3.671ArgThr: 3.671 ± 0.02	4.336ArgVal: 4.336 ± 0.022	0.879ArgTrp: 0.879 ± 0.009	1.502ArgTyr: 1.502 ± 0.011	0.0ArgXaa: 0.0 ± 0.0
Ser	7.275SerAla: 7.275 ± 0.025	1.506SerCys: 1.506 ± 0.014	4.898SerAsp: 4.898 ± 0.025	4.458SerGlu: 4.458 ± 0.021	2.886SerPhe: 2.886 ± 0.018	6.322SerGly: 6.322 ± 0.026	1.8SerHis: 1.8 ± 0.014	3.66SerIle: 3.66 ± 0.02	3.856SerLys: 3.856 ± 0.026	7.192SerLeu: 7.192 ± 0.031	1.73SerMet: 1.73 ± 0.012	3.206SerAsn: 3.206 ± 0.02	5.169SerPro: 5.169 ± 0.028	2.755SerGln: 2.755 ± 0.016	5.947SerArg: 5.947 ± 0.028	10.087SerSer: 10.087 ± 0.053	5.25SerThr: 5.25 ± 0.027	4.977SerVal: 4.977 ± 0.019	0.992SerTrp: 0.992 ± 0.009	1.778SerTyr: 1.778 ± 0.015	0.0SerXaa: 0.0 ± 0.0
Thr	5.029ThrAla: 5.029 ± 0.023	1.048ThrCys: 1.048 ± 0.011	2.862ThrAsp: 2.862 ± 0.017	2.895ThrGlu: 2.895 ± 0.018	1.727ThrPhe: 1.727 ± 0.013	3.754ThrGly: 3.754 ± 0.022	1.101ThrHis: 1.101 ± 0.01	2.342ThrIle: 2.342 ± 0.014	2.654ThrLys: 2.654 ± 0.016	4.452ThrLeu: 4.452 ± 0.021	1.208ThrMet: 1.208 ± 0.01	1.986ThrAsn: 1.986 ± 0.015	3.374ThrPro: 3.374 ± 0.02	1.572ThrGln: 1.572 ± 0.012	3.507ThrArg: 3.507 ± 0.019	5.1ThrSer: 5.1 ± 0.026	3.593ThrThr: 3.593 ± 0.023	3.32ThrVal: 3.32 ± 0.019	0.637ThrTrp: 0.637 ± 0.008	1.242ThrTyr: 1.242 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	5.783ValAla: 5.783 ± 0.023	1.18ValCys: 1.18 ± 0.012	4.35ValAsp: 4.35 ± 0.02	4.433ValGlu: 4.433 ± 0.022	1.912ValPhe: 1.912 ± 0.014	4.779ValGly: 4.779 ± 0.024	1.499ValHis: 1.499 ± 0.012	2.271ValIle: 2.271 ± 0.015	2.689ValLys: 2.689 ± 0.017	5.319ValLeu: 5.319 ± 0.025	1.221ValMet: 1.221 ± 0.01	1.985ValAsn: 1.985 ± 0.013	3.718ValPro: 3.718 ± 0.02	2.145ValGln: 2.145 ± 0.014	4.39ValArg: 4.39 ± 0.025	4.872ValSer: 4.872 ± 0.023	3.284ValThr: 3.284 ± 0.019	4.474ValVal: 4.474 ± 0.024	0.659ValTrp: 0.659 ± 0.009	1.421ValTyr: 1.421 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.855TrpAla: 0.855 ± 0.009	0.221TrpCys: 0.221 ± 0.005	0.703TrpAsp: 0.703 ± 0.009	0.715TrpGlu: 0.715 ± 0.009	0.385TrpPhe: 0.385 ± 0.007	0.819TrpGly: 0.819 ± 0.009	0.285TrpHis: 0.285 ± 0.005	0.511TrpIle: 0.511 ± 0.007	0.643TrpLys: 0.643 ± 0.007	0.983TrpLeu: 0.983 ± 0.01	0.339TrpMet: 0.339 ± 0.005	0.476TrpAsn: 0.476 ± 0.006	0.557TrpPro: 0.557 ± 0.007	0.418TrpGln: 0.418 ± 0.006	0.946TrpArg: 0.946 ± 0.01	0.957TrpSer: 0.957 ± 0.011	0.842TrpThr: 0.842 ± 0.01	0.599TrpVal: 0.599 ± 0.007	0.166TrpTrp: 0.166 ± 0.004	0.303TrpTyr: 0.303 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.703TyrAla: 1.703 ± 0.011	0.593TyrCys: 0.593 ± 0.009	1.628TyrAsp: 1.628 ± 0.013	1.492TyrGlu: 1.492 ± 0.014	0.925TyrPhe: 0.925 ± 0.01	1.784TyrGly: 1.784 ± 0.012	0.64TyrHis: 0.64 ± 0.008	0.947TyrIle: 0.947 ± 0.01	0.947TyrLys: 0.947 ± 0.01	2.069TyrLeu: 2.069 ± 0.014	0.452TyrMet: 0.452 ± 0.006	0.924TyrAsn: 0.924 ± 0.011	1.063TyrPro: 1.063 ± 0.01	0.834TyrGln: 0.834 ± 0.009	1.449TyrArg: 1.449 ± 0.011	1.731TyrSer: 1.731 ± 0.012	1.152TyrThr: 1.152 ± 0.01	1.388TyrVal: 1.388 ± 0.012	0.315TyrTrp: 0.315 ± 0.005	0.804TyrTyr: 0.804 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 34431 proteins (12213943 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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