Amino acid dipepetide frequency for Acholeplasma axanthum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.927AlaAla: 2.927 ± 0.103	0.33AlaCys: 0.33 ± 0.027	2.378AlaAsp: 2.378 ± 0.071	2.557AlaGlu: 2.557 ± 0.077	2.559AlaPhe: 2.559 ± 0.08	2.882AlaGly: 2.882 ± 0.114	0.812AlaHis: 0.812 ± 0.038	5.226AlaIle: 5.226 ± 0.113	4.323AlaLys: 4.323 ± 0.118	5.285AlaLeu: 5.285 ± 0.134	1.173AlaMet: 1.173 ± 0.047	2.884AlaAsn: 2.884 ± 0.076	1.155AlaPro: 1.155 ± 0.048	1.143AlaGln: 1.143 ± 0.06	1.812AlaArg: 1.812 ± 0.064	3.207AlaSer: 3.207 ± 0.094	2.93AlaThr: 2.93 ± 0.094	3.314AlaVal: 3.314 ± 0.104	0.373AlaTrp: 0.373 ± 0.028	2.227AlaTyr: 2.227 ± 0.076	0.0AlaXaa: 0.0 ± 0.0
Cys	0.187CysAla: 0.187 ± 0.017	0.025CysCys: 0.025 ± 0.008	0.245CysAsp: 0.245 ± 0.023	0.22CysGlu: 0.22 ± 0.021	0.245CysPhe: 0.245 ± 0.023	0.395CysGly: 0.395 ± 0.028	0.107CysHis: 0.107 ± 0.013	0.337CysIle: 0.337 ± 0.024	0.279CysLys: 0.279 ± 0.024	0.398CysLeu: 0.398 ± 0.027	0.125CysMet: 0.125 ± 0.016	0.271CysAsn: 0.271 ± 0.025	0.209CysPro: 0.209 ± 0.019	0.082CysGln: 0.082 ± 0.013	0.145CysArg: 0.145 ± 0.015	0.295CysSer: 0.295 ± 0.025	0.162CysThr: 0.162 ± 0.018	0.22CysVal: 0.22 ± 0.021	0.034CysTrp: 0.034 ± 0.008	0.177CysTyr: 0.177 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.791AspAla: 2.791 ± 0.084	0.212AspCys: 0.212 ± 0.02	3.23AspAsp: 3.23 ± 0.084	4.8AspGlu: 4.8 ± 0.097	3.205AspPhe: 3.205 ± 0.079	3.357AspGly: 3.357 ± 0.105	0.755AspHis: 0.755 ± 0.035	5.303AspIle: 5.303 ± 0.114	5.059AspLys: 5.059 ± 0.104	5.875AspLeu: 5.875 ± 0.111	1.061AspMet: 1.061 ± 0.047	3.619AspAsn: 3.619 ± 0.081	1.289AspPro: 1.289 ± 0.049	1.434AspGln: 1.434 ± 0.053	1.664AspArg: 1.664 ± 0.052	3.446AspSer: 3.446 ± 0.081	2.525AspThr: 2.525 ± 0.07	3.85AspVal: 3.85 ± 0.08	0.407AspTrp: 0.407 ± 0.026	3.316AspTyr: 3.316 ± 0.081	0.0AspXaa: 0.0 ± 0.0
Glu	3.53GluAla: 3.53 ± 0.094	0.198GluCys: 0.198 ± 0.021	3.352GluAsp: 3.352 ± 0.094	5.425GluGlu: 5.425 ± 0.124	3.202GluPhe: 3.202 ± 0.076	3.257GluGly: 3.257 ± 0.097	1.043GluHis: 1.043 ± 0.041	7.492GluIle: 7.492 ± 0.142	7.139GluLys: 7.139 ± 0.146	7.516GluLeu: 7.516 ± 0.141	1.853GluMet: 1.853 ± 0.065	4.964GluAsn: 4.964 ± 0.096	1.298GluPro: 1.298 ± 0.051	1.898GluGln: 1.898 ± 0.065	2.539GluArg: 2.539 ± 0.076	3.559GluSer: 3.559 ± 0.084	3.725GluThr: 3.725 ± 0.091	4.925GluVal: 4.925 ± 0.117	0.537GluTrp: 0.537 ± 0.035	3.668GluTyr: 3.668 ± 0.081	0.0GluXaa: 0.0 ± 0.0
Phe	2.236PheAla: 2.236 ± 0.064	0.229PheCys: 0.229 ± 0.022	3.43PheAsp: 3.43 ± 0.073	3.45PheGlu: 3.45 ± 0.087	2.484PhePhe: 2.484 ± 0.096	2.962PheGly: 2.962 ± 0.08	0.664PheHis: 0.664 ± 0.035	4.78PheIle: 4.78 ± 0.105	4.41PheLys: 4.41 ± 0.099	4.55PheLeu: 4.55 ± 0.105	1.175PheMet: 1.175 ± 0.048	3.594PheAsn: 3.594 ± 0.084	1.162PhePro: 1.162 ± 0.048	1.075PheGln: 1.075 ± 0.043	1.332PheArg: 1.332 ± 0.052	3.4PheSer: 3.4 ± 0.083	2.586PheThr: 2.586 ± 0.075	3.05PheVal: 3.05 ± 0.079	0.362PheTrp: 0.362 ± 0.026	2.321PheTyr: 2.321 ± 0.078	0.0PheXaa: 0.0 ± 0.0
Gly	2.957GlyAla: 2.957 ± 0.087	0.255GlyCys: 0.255 ± 0.023	2.753GlyAsp: 2.753 ± 0.08	3.285GlyGlu: 3.285 ± 0.089	3.141GlyPhe: 3.141 ± 0.085	3.33GlyGly: 3.33 ± 0.136	0.998GlyHis: 0.998 ± 0.043	5.841GlyIle: 5.841 ± 0.118	4.794GlyLys: 4.794 ± 0.106	5.255GlyLeu: 5.255 ± 0.118	1.291GlyMet: 1.291 ± 0.058	3.289GlyAsn: 3.289 ± 0.104	1.039GlyPro: 1.039 ± 0.051	1.273GlyGln: 1.273 ± 0.06	1.912GlyArg: 1.912 ± 0.065	3.437GlySer: 3.437 ± 0.101	3.405GlyThr: 3.405 ± 0.15	3.969GlyVal: 3.969 ± 0.104	0.555GlyTrp: 0.555 ± 0.057	3.093GlyTyr: 3.093 ± 0.11	0.0GlyXaa: 0.0 ± 0.0
His	0.8HisAla: 0.8 ± 0.036	0.054HisCys: 0.054 ± 0.009	0.927HisAsp: 0.927 ± 0.044	1.143HisGlu: 1.143 ± 0.046	0.755HisPhe: 0.755 ± 0.037	0.921HisGly: 0.921 ± 0.047	0.377HisHis: 0.377 ± 0.03	1.323HisIle: 1.323 ± 0.053	1.087HisLys: 1.087 ± 0.045	1.432HisLeu: 1.432 ± 0.054	0.321HisMet: 0.321 ± 0.025	0.848HisAsn: 0.848 ± 0.049	0.562HisPro: 0.562 ± 0.036	0.498HisGln: 0.498 ± 0.033	0.584HisArg: 0.584 ± 0.033	0.829HisSer: 0.829 ± 0.038	0.734HisThr: 0.734 ± 0.043	0.921HisVal: 0.921 ± 0.041	0.114HisTrp: 0.114 ± 0.015	0.755HisTyr: 0.755 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.198IleAla: 5.198 ± 0.112	0.402IleCys: 0.402 ± 0.028	6.457IleAsp: 6.457 ± 0.124	7.028IleGlu: 7.028 ± 0.121	4.469IlePhe: 4.469 ± 0.119	5.609IleGly: 5.609 ± 0.111	1.227IleHis: 1.227 ± 0.049	10.119IleIle: 10.119 ± 0.198	9.344IleLys: 9.344 ± 0.159	8.887IleLeu: 8.887 ± 0.179	1.966IleMet: 1.966 ± 0.074	6.803IleAsn: 6.803 ± 0.134	3.037IlePro: 3.037 ± 0.082	2.021IleGln: 2.021 ± 0.067	2.825IleArg: 2.825 ± 0.071	6.714IleSer: 6.714 ± 0.131	5.709IleThr: 5.709 ± 0.139	6.733IleVal: 6.733 ± 0.116	0.637IleTrp: 0.637 ± 0.035	3.994IleTyr: 3.994 ± 0.093	0.0IleXaa: 0.0 ± 0.0
Lys	3.893LysAla: 3.893 ± 0.099	0.28LysCys: 0.28 ± 0.022	5.671LysAsp: 5.671 ± 0.111	8.285LysGlu: 8.285 ± 0.143	3.405LysPhe: 3.405 ± 0.086	4.151LysGly: 4.151 ± 0.085	1.43LysHis: 1.43 ± 0.056	8.482LysIle: 8.482 ± 0.137	9.126LysLys: 9.126 ± 0.187	7.73LysLeu: 7.73 ± 0.144	2.411LysMet: 2.411 ± 0.069	7.035LysAsn: 7.035 ± 0.138	2.187LysPro: 2.187 ± 0.066	2.494LysGln: 2.494 ± 0.055	3.334LysArg: 3.334 ± 0.095	4.75LysSer: 4.75 ± 0.086	5.517LysThr: 5.517 ± 0.1	5.682LysVal: 5.682 ± 0.108	0.814LysTrp: 0.814 ± 0.038	5.05LysTyr: 5.05 ± 0.103	0.0LysXaa: 0.0 ± 0.0
Leu	5.01LeuAla: 5.01 ± 0.117	0.405LeuCys: 0.405 ± 0.03	5.653LeuAsp: 5.653 ± 0.102	6.817LeuGlu: 6.817 ± 0.124	4.619LeuPhe: 4.619 ± 0.116	5.35LeuGly: 5.35 ± 0.124	1.068LeuHis: 1.068 ± 0.044	9.524LeuIle: 9.524 ± 0.214	8.898LeuLys: 8.898 ± 0.175	8.931LeuLeu: 8.931 ± 0.189	1.937LeuMet: 1.937 ± 0.067	6.366LeuAsn: 6.366 ± 0.107	2.75LeuPro: 2.75 ± 0.073	1.864LeuGln: 1.864 ± 0.062	2.98LeuArg: 2.98 ± 0.076	6.691LeuSer: 6.691 ± 0.118	5.544LeuThr: 5.544 ± 0.101	6.517LeuVal: 6.517 ± 0.113	0.632LeuTrp: 0.632 ± 0.041	3.832LeuTyr: 3.832 ± 0.094	0.0LeuXaa: 0.0 ± 0.0
Met	1.143MetAla: 1.143 ± 0.052	0.087MetCys: 0.087 ± 0.013	1.07MetAsp: 1.07 ± 0.047	1.264MetGlu: 1.264 ± 0.048	1.191MetPhe: 1.191 ± 0.047	1.162MetGly: 1.162 ± 0.044	0.354MetHis: 0.354 ± 0.026	2.407MetIle: 2.407 ± 0.061	2.337MetLys: 2.337 ± 0.08	1.971MetLeu: 1.971 ± 0.066	0.548MetMet: 0.548 ± 0.03	1.375MetAsn: 1.375 ± 0.046	0.748MetPro: 0.748 ± 0.034	0.646MetGln: 0.646 ± 0.036	0.791MetArg: 0.791 ± 0.033	1.382MetSer: 1.382 ± 0.05	1.145MetThr: 1.145 ± 0.046	1.223MetVal: 1.223 ± 0.051	0.173MetTrp: 0.173 ± 0.017	0.866MetTyr: 0.866 ± 0.043	0.0MetXaa: 0.0 ± 0.0
Asn	2.978AsnAla: 2.978 ± 0.075	0.236AsnCys: 0.236 ± 0.025	4.401AsnAsp: 4.401 ± 0.097	5.764AsnGlu: 5.764 ± 0.116	2.866AsnPhe: 2.866 ± 0.075	3.853AsnGly: 3.853 ± 0.111	1.189AsnHis: 1.189 ± 0.051	6.482AsnIle: 6.482 ± 0.116	6.66AsnLys: 6.66 ± 0.134	5.978AsnLeu: 5.978 ± 0.119	1.323AsnMet: 1.323 ± 0.047	5.198AsnAsn: 5.198 ± 0.124	2.103AsnPro: 2.103 ± 0.068	2.216AsnGln: 2.216 ± 0.065	2.025AsnArg: 2.025 ± 0.066	3.862AsnSer: 3.862 ± 0.108	3.048AsnThr: 3.048 ± 0.078	4.246AsnVal: 4.246 ± 0.107	0.479AsnTrp: 0.479 ± 0.029	3.389AsnTyr: 3.389 ± 0.086	0.0AsnXaa: 0.0 ± 0.0
Pro	1.193ProAla: 1.193 ± 0.052	0.109ProCys: 0.109 ± 0.014	1.166ProAsp: 1.166 ± 0.054	1.8ProGlu: 1.8 ± 0.06	1.555ProPhe: 1.555 ± 0.053	1.312ProGly: 1.312 ± 0.047	0.5ProHis: 0.5 ± 0.032	2.494ProIle: 2.494 ± 0.066	2.182ProLys: 2.182 ± 0.07	2.371ProLeu: 2.371 ± 0.077	0.48ProMet: 0.48 ± 0.034	1.907ProAsn: 1.907 ± 0.059	0.407ProPro: 0.407 ± 0.027	0.602ProGln: 0.602 ± 0.042	0.759ProArg: 0.759 ± 0.038	1.716ProSer: 1.716 ± 0.061	1.595ProThr: 1.595 ± 0.059	1.755ProVal: 1.755 ± 0.067	0.241ProTrp: 0.241 ± 0.023	1.252ProTyr: 1.252 ± 0.051	0.0ProXaa: 0.0 ± 0.0
Gln	1.355GlnAla: 1.355 ± 0.052	0.062GlnCys: 0.062 ± 0.013	1.152GlnAsp: 1.152 ± 0.039	1.755GlnGlu: 1.755 ± 0.061	0.993GlnPhe: 0.993 ± 0.044	1.496GlnGly: 1.496 ± 0.068	0.286GlnHis: 0.286 ± 0.024	2.428GlnIle: 2.428 ± 0.072	2.446GlnLys: 2.446 ± 0.075	2.366GlnLeu: 2.366 ± 0.062	0.695GlnMet: 0.695 ± 0.035	1.621GlnAsn: 1.621 ± 0.052	0.487GlnPro: 0.487 ± 0.027	0.627GlnGln: 0.627 ± 0.04	1.043GlnArg: 1.043 ± 0.047	1.477GlnSer: 1.477 ± 0.056	1.52GlnThr: 1.52 ± 0.057	1.612GlnVal: 1.612 ± 0.053	0.207GlnTrp: 0.207 ± 0.02	1.107GlnTyr: 1.107 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	1.587ArgAla: 1.587 ± 0.052	0.121ArgCys: 0.121 ± 0.013	1.725ArgAsp: 1.725 ± 0.063	2.352ArgGlu: 2.352 ± 0.075	1.716ArgPhe: 1.716 ± 0.048	1.698ArgGly: 1.698 ± 0.067	0.487ArgHis: 0.487 ± 0.034	3.432ArgIle: 3.432 ± 0.084	3.157ArgLys: 3.157 ± 0.1	3.171ArgLeu: 3.171 ± 0.082	0.83ArgMet: 0.83 ± 0.04	2.127ArgAsn: 2.127 ± 0.071	0.77ArgPro: 0.77 ± 0.038	0.936ArgGln: 0.936 ± 0.042	1.253ArgArg: 1.253 ± 0.052	1.657ArgSer: 1.657 ± 0.056	1.695ArgThr: 1.695 ± 0.069	2.219ArgVal: 2.219 ± 0.066	0.273ArgTrp: 0.273 ± 0.022	1.662ArgTyr: 1.662 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	2.727SerAla: 2.727 ± 0.086	0.307SerCys: 0.307 ± 0.022	3.466SerAsp: 3.466 ± 0.081	3.702SerGlu: 3.702 ± 0.089	3.694SerPhe: 3.694 ± 0.096	3.905SerGly: 3.905 ± 0.109	0.92SerHis: 0.92 ± 0.043	6.232SerIle: 6.232 ± 0.134	5.887SerLys: 5.887 ± 0.108	5.994SerLeu: 5.994 ± 0.103	1.296SerMet: 1.296 ± 0.049	4.571SerAsn: 4.571 ± 0.11	1.375SerPro: 1.375 ± 0.048	1.332SerGln: 1.332 ± 0.054	2.157SerArg: 2.157 ± 0.064	3.996SerSer: 3.996 ± 0.086	3.057SerThr: 3.057 ± 0.082	3.832SerVal: 3.832 ± 0.083	0.511SerTrp: 0.511 ± 0.032	3.0SerTyr: 3.0 ± 0.087	0.0SerXaa: 0.0 ± 0.0
Thr	2.836ThrAla: 2.836 ± 0.101	0.212ThrCys: 0.212 ± 0.021	2.796ThrAsp: 2.796 ± 0.078	3.137ThrGlu: 3.137 ± 0.105	2.828ThrPhe: 2.828 ± 0.079	3.335ThrGly: 3.335 ± 0.114	0.925ThrHis: 0.925 ± 0.039	5.812ThrIle: 5.812 ± 0.11	4.969ThrLys: 4.969 ± 0.092	5.194ThrLeu: 5.194 ± 0.102	1.002ThrMet: 1.002 ± 0.044	3.789ThrAsn: 3.789 ± 0.084	1.646ThrPro: 1.646 ± 0.069	1.168ThrGln: 1.168 ± 0.058	1.753ThrArg: 1.753 ± 0.06	3.516ThrSer: 3.516 ± 0.086	3.044ThrThr: 3.044 ± 0.081	3.694ThrVal: 3.694 ± 0.138	0.393ThrTrp: 0.393 ± 0.031	2.594ThrTyr: 2.594 ± 0.076	0.0ThrXaa: 0.0 ± 0.0
Val	3.525ValAla: 3.525 ± 0.104	0.337ValCys: 0.337 ± 0.023	3.719ValAsp: 3.719 ± 0.087	4.128ValGlu: 4.128 ± 0.117	3.446ValPhe: 3.446 ± 0.08	3.764ValGly: 3.764 ± 0.115	0.832ValHis: 0.832 ± 0.037	6.73ValIle: 6.73 ± 0.123	5.137ValLys: 5.137 ± 0.103	6.935ValLeu: 6.935 ± 0.146	1.266ValMet: 1.266 ± 0.05	4.246ValAsn: 4.246 ± 0.109	1.712ValPro: 1.712 ± 0.055	1.252ValGln: 1.252 ± 0.052	1.984ValArg: 1.984 ± 0.067	4.646ValSer: 4.646 ± 0.088	3.926ValThr: 3.926 ± 0.132	4.718ValVal: 4.718 ± 0.111	0.523ValTrp: 0.523 ± 0.032	2.932ValTyr: 2.932 ± 0.081	0.0ValXaa: 0.0 ± 0.0
Trp	0.332TrpAla: 0.332 ± 0.024	0.061TrpCys: 0.061 ± 0.01	0.404TrpAsp: 0.404 ± 0.036	0.462TrpGlu: 0.462 ± 0.027	0.459TrpPhe: 0.459 ± 0.029	0.432TrpGly: 0.432 ± 0.032	0.152TrpHis: 0.152 ± 0.018	0.729TrpIle: 0.729 ± 0.038	0.643TrpLys: 0.643 ± 0.038	0.709TrpLeu: 0.709 ± 0.037	0.22TrpMet: 0.22 ± 0.02	0.562TrpAsn: 0.562 ± 0.038	0.164TrpPro: 0.164 ± 0.022	0.275TrpGln: 0.275 ± 0.022	0.286TrpArg: 0.286 ± 0.025	0.436TrpSer: 0.436 ± 0.026	0.35TrpThr: 0.35 ± 0.028	0.437TrpVal: 0.437 ± 0.033	0.109TrpTrp: 0.109 ± 0.012	0.493TrpTyr: 0.493 ± 0.047	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.294TyrAla: 2.294 ± 0.074	0.232TyrCys: 0.232 ± 0.02	3.205TyrAsp: 3.205 ± 0.089	3.744TyrGlu: 3.744 ± 0.091	2.419TyrPhe: 2.419 ± 0.079	2.702TyrGly: 2.702 ± 0.075	0.861TyrHis: 0.861 ± 0.043	4.005TyrIle: 4.005 ± 0.092	3.85TyrLys: 3.85 ± 0.094	4.841TyrLeu: 4.841 ± 0.11	0.909TyrMet: 0.909 ± 0.038	3.227TyrAsn: 3.227 ± 0.109	1.293TyrPro: 1.293 ± 0.054	1.9TyrGln: 1.9 ± 0.061	1.691TyrArg: 1.691 ± 0.06	2.946TyrSer: 2.946 ± 0.082	2.43TyrThr: 2.43 ± 0.074	2.841TyrVal: 2.841 ± 0.071	0.337TyrTrp: 0.337 ± 0.027	2.636TyrTyr: 2.636 ± 0.095	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1645 proteins (560043 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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