Amino acid dipepetide frequency for Bisgaardia hudsonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.759AlaAla: 4.759 ± 0.138
0.834AlaCys: 0.834 ± 0.037
3.76AlaAsp: 3.76 ± 0.088
4.891AlaGlu: 4.891 ± 0.109
3.046AlaPhe: 3.046 ± 0.076
4.714AlaGly: 4.714 ± 0.12
1.161AlaHis: 1.161 ± 0.043
6.266AlaIle: 6.266 ± 0.115
5.451AlaLys: 5.451 ± 0.12
8.422AlaLeu: 8.422 ± 0.151
1.991AlaMet: 1.991 ± 0.073
3.497AlaAsn: 3.497 ± 0.082
1.994AlaPro: 1.994 ± 0.06
2.881AlaGln: 2.881 ± 0.074
2.909AlaArg: 2.909 ± 0.07
3.765AlaSer: 3.765 ± 0.083
4.107AlaThr: 4.107 ± 0.096
4.741AlaVal: 4.741 ± 0.107
0.684AlaTrp: 0.684 ± 0.033
2.144AlaTyr: 2.144 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.665CysAla: 0.665 ± 0.031
0.163CysCys: 0.163 ± 0.018
0.608CysAsp: 0.608 ± 0.027
0.61CysGlu: 0.61 ± 0.031
0.465CysPhe: 0.465 ± 0.03
0.91CysGly: 0.91 ± 0.042
0.313CysHis: 0.313 ± 0.024
0.705CysIle: 0.705 ± 0.037
0.515CysLys: 0.515 ± 0.028
0.97CysLeu: 0.97 ± 0.041
0.181CysMet: 0.181 ± 0.017
0.427CysAsn: 0.427 ± 0.026
0.411CysPro: 0.411 ± 0.031
0.418CysGln: 0.418 ± 0.032
0.421CysArg: 0.421 ± 0.024
0.66CysSer: 0.66 ± 0.03
0.416CysThr: 0.416 ± 0.03
0.589CysVal: 0.589 ± 0.032
0.121CysTrp: 0.121 ± 0.014
0.407CysTyr: 0.407 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.002AspAla: 3.002 ± 0.082
0.578AspCys: 0.578 ± 0.031
2.649AspAsp: 2.649 ± 0.083
3.723AspGlu: 3.723 ± 0.084
2.658AspPhe: 2.658 ± 0.061
3.046AspGly: 3.046 ± 0.09
0.939AspHis: 0.939 ± 0.044
4.717AspIle: 4.717 ± 0.099
3.907AspLys: 3.907 ± 0.079
5.299AspLeu: 5.299 ± 0.092
1.071AspMet: 1.071 ± 0.044
2.907AspAsn: 2.907 ± 0.085
2.055AspPro: 2.055 ± 0.062
1.615AspGln: 1.615 ± 0.052
2.134AspArg: 2.134 ± 0.066
2.676AspSer: 2.676 ± 0.071
2.449AspThr: 2.449 ± 0.073
3.357AspVal: 3.357 ± 0.076
0.75AspTrp: 0.75 ± 0.038
2.237AspTyr: 2.237 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.091GluAla: 4.091 ± 0.099
0.495GluCys: 0.495 ± 0.03
2.802GluAsp: 2.802 ± 0.082
4.052GluGlu: 4.052 ± 0.103
2.45GluPhe: 2.45 ± 0.073
3.252GluGly: 3.252 ± 0.086
1.244GluHis: 1.244 ± 0.05
5.361GluIle: 5.361 ± 0.1
5.898GluLys: 5.898 ± 0.112
6.624GluLeu: 6.624 ± 0.128
1.639GluMet: 1.639 ± 0.054
4.549GluAsn: 4.549 ± 0.102
1.602GluPro: 1.602 ± 0.057
3.536GluGln: 3.536 ± 0.093
2.826GluArg: 2.826 ± 0.076
3.013GluSer: 3.013 ± 0.075
3.191GluThr: 3.191 ± 0.077
3.789GluVal: 3.789 ± 0.092
0.698GluTrp: 0.698 ± 0.036
2.081GluTyr: 2.081 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.097PheAla: 3.097 ± 0.069
0.568PheCys: 0.568 ± 0.028
2.778PheAsp: 2.778 ± 0.067
2.518PheGlu: 2.518 ± 0.072
2.134PhePhe: 2.134 ± 0.066
3.234PheGly: 3.234 ± 0.081
0.702PheHis: 0.702 ± 0.032
3.87PheIle: 3.87 ± 0.103
2.528PheLys: 2.528 ± 0.071
4.162PheLeu: 4.162 ± 0.1
0.99PheMet: 0.99 ± 0.035
2.631PheAsn: 2.631 ± 0.068
1.437PhePro: 1.437 ± 0.049
1.42PheGln: 1.42 ± 0.057
1.41PheArg: 1.41 ± 0.048
3.62PheSer: 3.62 ± 0.1
2.505PheThr: 2.505 ± 0.061
2.804PheVal: 2.804 ± 0.065
0.565PheTrp: 0.565 ± 0.031
1.697PheTyr: 1.697 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.549GlyAla: 4.549 ± 0.103
0.749GlyCys: 0.749 ± 0.036
3.046GlyAsp: 3.046 ± 0.082
3.886GlyGlu: 3.886 ± 0.087
3.117GlyPhe: 3.117 ± 0.067
4.293GlyGly: 4.293 ± 0.111
1.249GlyHis: 1.249 ± 0.049
5.946GlyIle: 5.946 ± 0.103
5.046GlyLys: 5.046 ± 0.118
6.588GlyLeu: 6.588 ± 0.113
1.681GlyMet: 1.681 ± 0.057
3.062GlyAsn: 3.062 ± 0.112
1.249GlyPro: 1.249 ± 0.051
2.255GlyGln: 2.255 ± 0.073
2.755GlyArg: 2.755 ± 0.075
3.573GlySer: 3.573 ± 0.083
3.315GlyThr: 3.315 ± 0.103
4.451GlyVal: 4.451 ± 0.1
0.828GlyTrp: 0.828 ± 0.036
2.567GlyTyr: 2.567 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
0.895HisAla: 0.895 ± 0.036
0.332HisCys: 0.332 ± 0.024
0.723HisAsp: 0.723 ± 0.043
0.7HisGlu: 0.7 ± 0.041
1.192HisPhe: 1.192 ± 0.054
1.082HisGly: 1.082 ± 0.042
0.632HisHis: 0.632 ± 0.036
1.766HisIle: 1.766 ± 0.05
1.168HisLys: 1.168 ± 0.044
2.271HisLeu: 2.271 ± 0.071
0.298HisMet: 0.298 ± 0.024
1.213HisAsn: 1.213 ± 0.049
0.92HisPro: 0.92 ± 0.037
1.018HisGln: 1.018 ± 0.039
0.937HisArg: 0.937 ± 0.043
1.399HisSer: 1.399 ± 0.046
0.989HisThr: 0.989 ± 0.045
0.678HisVal: 0.678 ± 0.036
0.286HisTrp: 0.286 ± 0.021
0.868HisTyr: 0.868 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.854IleAla: 6.854 ± 0.121
0.876IleCys: 0.876 ± 0.04
4.854IleAsp: 4.854 ± 0.104
5.211IleGlu: 5.211 ± 0.111
3.539IlePhe: 3.539 ± 0.099
5.517IleGly: 5.517 ± 0.115
1.492IleHis: 1.492 ± 0.054
6.351IleIle: 6.351 ± 0.121
5.077IleLys: 5.077 ± 0.109
7.8IleLeu: 7.8 ± 0.137
1.495IleMet: 1.495 ± 0.054
4.552IleAsn: 4.552 ± 0.121
3.186IlePro: 3.186 ± 0.072
3.123IleGln: 3.123 ± 0.082
3.147IleArg: 3.147 ± 0.071
5.465IleSer: 5.465 ± 0.109
4.375IleThr: 4.375 ± 0.095
4.839IleVal: 4.839 ± 0.091
0.739IleTrp: 0.739 ± 0.037
2.487IleTyr: 2.487 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.927LysAla: 4.927 ± 0.12
0.49LysCys: 0.49 ± 0.033
3.572LysAsp: 3.572 ± 0.096
4.944LysGlu: 4.944 ± 0.109
2.278LysPhe: 2.278 ± 0.066
4.212LysGly: 4.212 ± 0.101
1.228LysHis: 1.228 ± 0.052
5.185LysIle: 5.185 ± 0.1
4.986LysLys: 4.986 ± 0.103
6.945LysLeu: 6.945 ± 0.114
1.95LysMet: 1.95 ± 0.059
4.514LysAsn: 4.514 ± 0.092
2.373LysPro: 2.373 ± 0.063
3.376LysGln: 3.376 ± 0.08
2.863LysArg: 2.863 ± 0.066
3.896LysSer: 3.896 ± 0.085
3.768LysThr: 3.768 ± 0.087
4.501LysVal: 4.501 ± 0.097
0.682LysTrp: 0.682 ± 0.036
2.204LysTyr: 2.204 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
8.243LeuAla: 8.243 ± 0.138
0.994LeuCys: 0.994 ± 0.044
5.64LeuAsp: 5.64 ± 0.108
6.111LeuGlu: 6.111 ± 0.113
4.865LeuPhe: 4.865 ± 0.109
6.979LeuGly: 6.979 ± 0.122
1.791LeuHis: 1.791 ± 0.052
7.511LeuIle: 7.511 ± 0.146
6.54LeuLys: 6.54 ± 0.111
10.966LeuLeu: 10.966 ± 0.215
2.413LeuMet: 2.413 ± 0.068
5.467LeuAsn: 5.467 ± 0.107
4.522LeuPro: 4.522 ± 0.096
4.351LeuGln: 4.351 ± 0.113
4.349LeuArg: 4.349 ± 0.092
7.943LeuSer: 7.943 ± 0.114
5.883LeuThr: 5.883 ± 0.11
6.428LeuVal: 6.428 ± 0.118
1.045LeuTrp: 1.045 ± 0.049
2.975LeuTyr: 2.975 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.05MetAla: 2.05 ± 0.067
0.169MetCys: 0.169 ± 0.014
1.018MetAsp: 1.018 ± 0.036
1.173MetGlu: 1.173 ± 0.042
0.902MetPhe: 0.902 ± 0.038
1.47MetGly: 1.47 ± 0.053
0.339MetHis: 0.339 ± 0.023
1.645MetIle: 1.645 ± 0.052
1.679MetLys: 1.679 ± 0.052
2.517MetLeu: 2.517 ± 0.067
0.64MetMet: 0.64 ± 0.037
1.241MetAsn: 1.241 ± 0.045
0.957MetPro: 0.957 ± 0.036
1.063MetGln: 1.063 ± 0.04
1.015MetArg: 1.015 ± 0.043
1.423MetSer: 1.423 ± 0.045
1.405MetThr: 1.405 ± 0.048
1.418MetVal: 1.418 ± 0.052
0.211MetTrp: 0.211 ± 0.019
0.529MetTyr: 0.529 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.696AsnAla: 3.696 ± 0.088
0.495AsnCys: 0.495 ± 0.029
2.633AsnAsp: 2.633 ± 0.084
3.252AsnGlu: 3.252 ± 0.078
2.136AsnPhe: 2.136 ± 0.059
3.394AsnGly: 3.394 ± 0.093
1.071AsnHis: 1.071 ± 0.046
5.02AsnIle: 5.02 ± 0.115
3.872AsnLys: 3.872 ± 0.089
5.477AsnLeu: 5.477 ± 0.106
1.189AsnMet: 1.189 ± 0.042
3.304AsnAsn: 3.304 ± 0.112
2.346AsnPro: 2.346 ± 0.062
2.647AsnGln: 2.647 ± 0.085
2.134AsnArg: 2.134 ± 0.067
3.052AsnSer: 3.052 ± 0.099
2.881AsnThr: 2.881 ± 0.089
3.013AsnVal: 3.013 ± 0.096
0.7AsnTrp: 0.7 ± 0.036
2.037AsnTyr: 2.037 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.218ProAla: 2.218 ± 0.082
0.298ProCys: 0.298 ± 0.023
1.766ProAsp: 1.766 ± 0.065
2.942ProGlu: 2.942 ± 0.077
1.752ProPhe: 1.752 ± 0.056
1.382ProGly: 1.382 ± 0.053
0.84ProHis: 0.84 ± 0.037
2.918ProIle: 2.918 ± 0.07
2.452ProLys: 2.452 ± 0.066
3.633ProLeu: 3.633 ± 0.081
0.866ProMet: 0.866 ± 0.034
2.162ProAsn: 2.162 ± 0.059
0.923ProPro: 0.923 ± 0.038
1.4ProGln: 1.4 ± 0.044
1.163ProArg: 1.163 ± 0.046
2.073ProSer: 2.073 ± 0.059
2.126ProThr: 2.126 ± 0.061
2.399ProVal: 2.399 ± 0.074
0.345ProTrp: 0.345 ± 0.023
1.432ProTyr: 1.432 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
3.426GlnAla: 3.426 ± 0.091
0.34GlnCys: 0.34 ± 0.024
2.163GlnAsp: 2.163 ± 0.061
2.697GlnGlu: 2.697 ± 0.068
1.858GlnPhe: 1.858 ± 0.059
2.913GlnGly: 2.913 ± 0.104
0.987GlnHis: 0.987 ± 0.042
3.239GlnIle: 3.239 ± 0.081
3.228GlnLys: 3.228 ± 0.082
4.631GlnLeu: 4.631 ± 0.095
0.874GlnMet: 0.874 ± 0.038
2.192GlnAsn: 2.192 ± 0.071
1.42GlnPro: 1.42 ± 0.051
3.134GlnGln: 3.134 ± 0.1
2.008GlnArg: 2.008 ± 0.068
2.46GlnSer: 2.46 ± 0.074
1.926GlnThr: 1.926 ± 0.054
2.644GlnVal: 2.644 ± 0.066
0.557GlnTrp: 0.557 ± 0.033
1.563GlnTyr: 1.563 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.626ArgAla: 2.626 ± 0.075
0.387ArgCys: 0.387 ± 0.022
2.147ArgAsp: 2.147 ± 0.07
2.739ArgGlu: 2.739 ± 0.084
2.087ArgPhe: 2.087 ± 0.06
2.373ArgGly: 2.373 ± 0.063
0.887ArgHis: 0.887 ± 0.038
3.154ArgIle: 3.154 ± 0.059
2.654ArgLys: 2.654 ± 0.066
4.544ArgLeu: 4.544 ± 0.103
0.994ArgMet: 0.994 ± 0.043
2.008ArgAsn: 2.008 ± 0.068
1.355ArgPro: 1.355 ± 0.046
1.971ArgGln: 1.971 ± 0.06
1.883ArgArg: 1.883 ± 0.065
2.228ArgSer: 2.228 ± 0.059
2.008ArgThr: 2.008 ± 0.056
2.689ArgVal: 2.689 ± 0.068
0.502ArgTrp: 0.502 ± 0.031
1.747ArgTyr: 1.747 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.539SerAla: 4.539 ± 0.088
0.54SerCys: 0.54 ± 0.032
3.039SerAsp: 3.039 ± 0.073
3.865SerGlu: 3.865 ± 0.072
2.981SerPhe: 2.981 ± 0.078
4.364SerGly: 4.364 ± 0.107
1.294SerHis: 1.294 ± 0.05
4.957SerIle: 4.957 ± 0.105
3.865SerLys: 3.865 ± 0.092
6.57SerLeu: 6.57 ± 0.122
1.305SerMet: 1.305 ± 0.048
2.888SerAsn: 2.888 ± 0.085
2.134SerPro: 2.134 ± 0.059
2.799SerGln: 2.799 ± 0.075
2.418SerArg: 2.418 ± 0.072
4.028SerSer: 4.028 ± 0.107
3.06SerThr: 3.06 ± 0.077
3.818SerVal: 3.818 ± 0.086
0.774SerTrp: 0.774 ± 0.041
2.133SerTyr: 2.133 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.126ThrAla: 4.126 ± 0.095
0.44ThrCys: 0.44 ± 0.028
2.768ThrAsp: 2.768 ± 0.081
3.43ThrGlu: 3.43 ± 0.079
2.266ThrPhe: 2.266 ± 0.061
3.838ThrGly: 3.838 ± 0.102
1.065ThrHis: 1.065 ± 0.044
4.07ThrIle: 4.07 ± 0.093
3.204ThrLys: 3.204 ± 0.082
6.082ThrLeu: 6.082 ± 0.1
1.063ThrMet: 1.063 ± 0.044
2.518ThrAsn: 2.518 ± 0.069
2.297ThrPro: 2.297 ± 0.065
2.265ThrGln: 2.265 ± 0.072
1.881ThrArg: 1.881 ± 0.057
3.107ThrSer: 3.107 ± 0.069
2.934ThrThr: 2.934 ± 0.086
3.444ThrVal: 3.444 ± 0.088
0.515ThrTrp: 0.515 ± 0.031
1.563ThrTyr: 1.563 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
5.206ValAla: 5.206 ± 0.114
0.648ValCys: 0.648 ± 0.041
3.465ValAsp: 3.465 ± 0.082
4.206ValGlu: 4.206 ± 0.096
2.57ValPhe: 2.57 ± 0.068
4.299ValGly: 4.299 ± 0.093
1.003ValHis: 1.003 ± 0.045
5.165ValIle: 5.165 ± 0.1
4.167ValLys: 4.167 ± 0.106
6.219ValLeu: 6.219 ± 0.115
1.428ValMet: 1.428 ± 0.055
3.189ValAsn: 3.189 ± 0.088
2.162ValPro: 2.162 ± 0.064
2.047ValGln: 2.047 ± 0.06
2.512ValArg: 2.512 ± 0.067
4.136ValSer: 4.136 ± 0.096
3.462ValThr: 3.462 ± 0.076
4.546ValVal: 4.546 ± 0.088
0.569ValTrp: 0.569 ± 0.032
1.721ValTyr: 1.721 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.713TrpAla: 0.713 ± 0.037
0.14TrpCys: 0.14 ± 0.017
0.542TrpAsp: 0.542 ± 0.034
0.581TrpGlu: 0.581 ± 0.033
0.607TrpPhe: 0.607 ± 0.032
0.724TrpGly: 0.724 ± 0.036
0.253TrpHis: 0.253 ± 0.022
0.821TrpIle: 0.821 ± 0.037
0.769TrpLys: 0.769 ± 0.033
1.578TrpLeu: 1.578 ± 0.056
0.173TrpMet: 0.173 ± 0.018
0.526TrpAsn: 0.526 ± 0.032
0.16TrpPro: 0.16 ± 0.015
0.915TrpGln: 0.915 ± 0.042
0.521TrpArg: 0.521 ± 0.029
0.54TrpSer: 0.54 ± 0.031
0.498TrpThr: 0.498 ± 0.026
0.66TrpVal: 0.66 ± 0.035
0.171TrpTrp: 0.171 ± 0.018
0.376TrpTyr: 0.376 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.333TyrAla: 2.333 ± 0.057
0.434TyrCys: 0.434 ± 0.028
1.797TyrAsp: 1.797 ± 0.054
1.663TyrGlu: 1.663 ± 0.061
1.766TyrPhe: 1.766 ± 0.067
2.207TyrGly: 2.207 ± 0.074
0.878TyrHis: 0.878 ± 0.038
2.313TyrIle: 2.313 ± 0.062
1.889TyrLys: 1.889 ± 0.056
3.718TyrLeu: 3.718 ± 0.091
0.619TyrMet: 0.619 ± 0.035
1.502TyrAsn: 1.502 ± 0.054
1.592TyrPro: 1.592 ± 0.043
2.029TyrGln: 2.029 ± 0.066
1.697TyrArg: 1.697 ± 0.046
2.316TyrSer: 2.316 ± 0.072
1.576TyrThr: 1.576 ± 0.053
1.912TyrVal: 1.912 ± 0.053
0.526TyrTrp: 0.526 ± 0.037
1.363TyrTyr: 1.363 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1892 proteins (619903 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski