Amino acid dipepetide frequency for Microthlaspi erraticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.644AlaAla: 5.644 ± 0.026	1.084AlaCys: 1.084 ± 0.009	3.075AlaAsp: 3.075 ± 0.015	4.271AlaGlu: 4.271 ± 0.019	2.641AlaPhe: 2.641 ± 0.013	3.677AlaGly: 3.677 ± 0.018	1.28AlaHis: 1.28 ± 0.01	3.385AlaIle: 3.385 ± 0.015	4.011AlaLys: 4.011 ± 0.016	6.07AlaLeu: 6.07 ± 0.02	1.747AlaMet: 1.747 ± 0.011	2.451AlaAsn: 2.451 ± 0.013	2.863AlaPro: 2.863 ± 0.017	2.086AlaGln: 2.086 ± 0.012	3.624AlaArg: 3.624 ± 0.016	5.713AlaSer: 5.713 ± 0.02	3.627AlaThr: 3.627 ± 0.016	4.449AlaVal: 4.449 ± 0.019	0.793AlaTrp: 0.793 ± 0.007	1.736AlaTyr: 1.736 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	0.874CysAla: 0.874 ± 0.009	0.477CysCys: 0.477 ± 0.005	0.967CysAsp: 0.967 ± 0.009	0.936CysGlu: 0.936 ± 0.008	0.93CysPhe: 0.93 ± 0.008	1.325CysGly: 1.325 ± 0.011	0.465CysHis: 0.465 ± 0.005	0.915CysIle: 0.915 ± 0.008	1.192CysLys: 1.192 ± 0.009	1.892CysLeu: 1.892 ± 0.011	0.443CysMet: 0.443 ± 0.005	0.766CysAsn: 0.766 ± 0.007	0.945CysPro: 0.945 ± 0.008	0.559CysGln: 0.559 ± 0.006	1.065CysArg: 1.065 ± 0.008	1.724CysSer: 1.724 ± 0.011	0.8CysThr: 0.8 ± 0.007	1.234CysVal: 1.234 ± 0.01	0.236CysTrp: 0.236 ± 0.004	0.576CysTyr: 0.576 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	3.333AspAla: 3.333 ± 0.017	0.979AspCys: 0.979 ± 0.008	3.795AspAsp: 3.795 ± 0.023	4.293AspGlu: 4.293 ± 0.018	2.474AspPhe: 2.474 ± 0.012	3.719AspGly: 3.719 ± 0.017	1.363AspHis: 1.363 ± 0.011	2.705AspIle: 2.705 ± 0.015	2.783AspLys: 2.783 ± 0.014	5.236AspLeu: 5.236 ± 0.017	1.277AspMet: 1.277 ± 0.009	1.918AspAsn: 1.918 ± 0.012	2.772AspPro: 2.772 ± 0.013	1.885AspGln: 1.885 ± 0.011	2.794AspArg: 2.794 ± 0.016	4.165AspSer: 4.165 ± 0.018	2.232AspThr: 2.232 ± 0.011	3.72AspVal: 3.72 ± 0.014	0.765AspTrp: 0.765 ± 0.007	1.59AspTyr: 1.59 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.946GluAla: 4.946 ± 0.021	0.971GluCys: 0.971 ± 0.008	4.317GluAsp: 4.317 ± 0.019	7.468GluGlu: 7.468 ± 0.038	2.451GluPhe: 2.451 ± 0.012	3.571GluGly: 3.571 ± 0.016	1.309GluHis: 1.309 ± 0.01	3.96GluIle: 3.96 ± 0.017	5.165GluLys: 5.165 ± 0.027	5.812GluLeu: 5.812 ± 0.021	1.917GluMet: 1.917 ± 0.012	2.962GluAsn: 2.962 ± 0.016	2.446GluPro: 2.446 ± 0.013	2.056GluGln: 2.056 ± 0.012	3.742GluArg: 3.742 ± 0.018	4.872GluSer: 4.872 ± 0.021	3.642GluThr: 3.642 ± 0.018	4.151GluVal: 4.151 ± 0.019	0.777GluTrp: 0.777 ± 0.007	1.671GluTyr: 1.671 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.464PheAla: 2.464 ± 0.013	0.877PheCys: 0.877 ± 0.007	2.393PheAsp: 2.393 ± 0.014	2.366PheGlu: 2.366 ± 0.013	1.912PhePhe: 1.912 ± 0.013	2.9PheGly: 2.9 ± 0.016	1.154PheHis: 1.154 ± 0.008	1.986PheIle: 1.986 ± 0.012	2.302PheLys: 2.302 ± 0.014	4.35PheLeu: 4.35 ± 0.018	1.036PheMet: 1.036 ± 0.008	1.636PheAsn: 1.636 ± 0.01	2.175PhePro: 2.175 ± 0.012	1.533PheGln: 1.533 ± 0.01	2.15PheArg: 2.15 ± 0.012	3.963PheSer: 3.963 ± 0.016	2.232PheThr: 2.232 ± 0.013	2.813PheVal: 2.813 ± 0.014	0.624PheTrp: 0.624 ± 0.007	1.225PheTyr: 1.225 ± 0.009	0.0PheXaa: 0.0 ± 0.0
Gly	3.507GlyAla: 3.507 ± 0.017	1.212GlyCys: 1.212 ± 0.01	3.449GlyAsp: 3.449 ± 0.018	3.979GlyGlu: 3.979 ± 0.017	3.19GlyPhe: 3.19 ± 0.015	5.287GlyGly: 5.287 ± 0.047	1.51GlyHis: 1.51 ± 0.011	3.313GlyIle: 3.313 ± 0.017	4.037GlyLys: 4.037 ± 0.019	5.58GlyLeu: 5.58 ± 0.02	1.468GlyMet: 1.468 ± 0.011	2.921GlyAsn: 2.921 ± 0.014	2.197GlyPro: 2.197 ± 0.013	1.993GlyGln: 1.993 ± 0.011	3.957GlyArg: 3.957 ± 0.021	5.531GlySer: 5.531 ± 0.025	3.043GlyThr: 3.043 ± 0.017	4.125GlyVal: 4.125 ± 0.028	0.869GlyTrp: 0.869 ± 0.007	2.143GlyTyr: 2.143 ± 0.014	0.0GlyXaa: 0.0 ± 0.0
His	1.321HisAla: 1.321 ± 0.009	0.527HisCys: 0.527 ± 0.006	1.142HisAsp: 1.142 ± 0.01	1.256HisGlu: 1.256 ± 0.01	1.043HisPhe: 1.043 ± 0.008	1.772HisGly: 1.772 ± 0.012	1.016HisHis: 1.016 ± 0.013	1.2HisIle: 1.2 ± 0.007	1.262HisLys: 1.262 ± 0.008	2.372HisLeu: 2.372 ± 0.013	0.61HisMet: 0.61 ± 0.007	0.899HisAsn: 0.899 ± 0.007	1.346HisPro: 1.346 ± 0.01	1.145HisGln: 1.145 ± 0.01	1.438HisArg: 1.438 ± 0.011	1.758HisSer: 1.758 ± 0.01	1.012HisThr: 1.012 ± 0.009	1.565HisVal: 1.565 ± 0.009	0.326HisTrp: 0.326 ± 0.005	0.671HisTyr: 0.671 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	3.274IleAla: 3.274 ± 0.014	1.019IleCys: 1.019 ± 0.009	2.947IleAsp: 2.947 ± 0.013	3.307IleGlu: 3.307 ± 0.016	2.08IlePhe: 2.08 ± 0.012	3.229IleGly: 3.229 ± 0.014	1.292IleHis: 1.292 ± 0.01	2.36IleIle: 2.36 ± 0.015	2.91IleLys: 2.91 ± 0.013	4.689IleLeu: 4.689 ± 0.018	1.06IleMet: 1.06 ± 0.008	2.043IleAsn: 2.043 ± 0.012	2.833IlePro: 2.833 ± 0.017	1.813IleGln: 1.813 ± 0.01	2.758IleArg: 2.758 ± 0.014	4.692IleSer: 4.692 ± 0.02	2.655IleThr: 2.655 ± 0.013	3.309IleVal: 3.309 ± 0.015	0.769IleTrp: 0.769 ± 0.008	1.396IleTyr: 1.396 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	4.131LysAla: 4.131 ± 0.02	1.001LysCys: 1.001 ± 0.008	3.317LysAsp: 3.317 ± 0.018	4.864LysGlu: 4.864 ± 0.024	2.195LysPhe: 2.195 ± 0.012	3.498LysGly: 3.498 ± 0.015	1.325LysHis: 1.325 ± 0.01	3.365LysIle: 3.365 ± 0.015	5.235LysLys: 5.235 ± 0.03	6.187LysLeu: 6.187 ± 0.024	1.562LysMet: 1.562 ± 0.011	2.499LysAsn: 2.499 ± 0.013	3.059LysPro: 3.059 ± 0.015	2.301LysGln: 2.301 ± 0.012	3.919LysArg: 3.919 ± 0.017	4.87LysSer: 4.87 ± 0.021	3.427LysThr: 3.427 ± 0.016	3.855LysVal: 3.855 ± 0.015	0.871LysTrp: 0.871 ± 0.007	1.501LysTyr: 1.501 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	6.153LeuAla: 6.153 ± 0.021	1.941LeuCys: 1.941 ± 0.01	5.124LeuAsp: 5.124 ± 0.02	6.171LeuGlu: 6.171 ± 0.021	3.792LeuPhe: 3.792 ± 0.018	5.745LeuGly: 5.745 ± 0.024	2.382LeuHis: 2.382 ± 0.014	4.388LeuIle: 4.388 ± 0.019	6.069LeuLys: 6.069 ± 0.025	9.302LeuLeu: 9.302 ± 0.033	2.155LeuMet: 2.155 ± 0.012	3.588LeuAsn: 3.588 ± 0.016	5.132LeuPro: 5.132 ± 0.02	3.793LeuGln: 3.793 ± 0.017	5.658LeuArg: 5.658 ± 0.02	8.212LeuSer: 8.212 ± 0.029	4.668LeuThr: 4.668 ± 0.019	6.366LeuVal: 6.366 ± 0.024	1.267LeuTrp: 1.267 ± 0.008	2.296LeuTyr: 2.296 ± 0.013	0.0LeuXaa: 0.0 ± 0.0
Met	1.948MetAla: 1.948 ± 0.011	0.361MetCys: 0.361 ± 0.005	1.523MetAsp: 1.523 ± 0.01	2.085MetGlu: 2.085 ± 0.011	0.941MetPhe: 0.941 ± 0.009	1.495MetGly: 1.495 ± 0.01	0.496MetHis: 0.496 ± 0.006	1.277MetIle: 1.277 ± 0.009	1.714MetLys: 1.714 ± 0.011	2.068MetLeu: 2.068 ± 0.012	0.767MetMet: 0.767 ± 0.008	1.004MetAsn: 1.004 ± 0.008	0.997MetPro: 0.997 ± 0.008	0.808MetGln: 0.808 ± 0.007	1.337MetArg: 1.337 ± 0.01	1.992MetSer: 1.992 ± 0.011	1.142MetThr: 1.142 ± 0.008	1.702MetVal: 1.702 ± 0.012	0.286MetTrp: 0.286 ± 0.004	0.604MetTyr: 0.604 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.451AsnAla: 2.451 ± 0.011	0.716AsnCys: 0.716 ± 0.006	1.898AsnAsp: 1.898 ± 0.013	2.391AsnGlu: 2.391 ± 0.014	1.677AsnPhe: 1.677 ± 0.01	3.194AsnGly: 3.194 ± 0.016	1.147AsnHis: 1.147 ± 0.009	2.083AsnIle: 2.083 ± 0.013	2.353AsnLys: 2.353 ± 0.012	4.252AsnLeu: 4.252 ± 0.023	1.016AsnMet: 1.016 ± 0.009	2.055AsnAsn: 2.055 ± 0.014	2.466AsnPro: 2.466 ± 0.015	1.672AsnGln: 1.672 ± 0.011	2.27AsnArg: 2.27 ± 0.011	3.423AsnSer: 3.423 ± 0.016	1.917AsnThr: 1.917 ± 0.012	2.648AsnVal: 2.648 ± 0.015	0.559AsnTrp: 0.559 ± 0.005	1.212AsnTyr: 1.212 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	2.978ProAla: 2.978 ± 0.016	0.825ProCys: 0.825 ± 0.007	2.421ProAsp: 2.421 ± 0.013	3.396ProGlu: 3.396 ± 0.017	2.091ProPhe: 2.091 ± 0.012	2.651ProGly: 2.651 ± 0.014	1.138ProHis: 1.138 ± 0.009	2.325ProIle: 2.325 ± 0.012	2.949ProLys: 2.949 ± 0.018	4.326ProLeu: 4.326 ± 0.017	1.078ProMet: 1.078 ± 0.009	2.262ProAsn: 2.262 ± 0.012	4.36ProPro: 4.36 ± 0.063	1.889ProGln: 1.889 ± 0.012	3.098ProArg: 3.098 ± 0.016	5.054ProSer: 5.054 ± 0.025	2.924ProThr: 2.924 ± 0.019	3.259ProVal: 3.259 ± 0.015	0.633ProTrp: 0.633 ± 0.006	1.441ProTyr: 1.441 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	2.372GlnAla: 2.372 ± 0.013	0.576GlnCys: 0.576 ± 0.006	1.656GlnAsp: 1.656 ± 0.01	2.614GlnGlu: 2.614 ± 0.013	1.272GlnPhe: 1.272 ± 0.01	2.284GlnGly: 2.284 ± 0.014	0.803GlnHis: 0.803 ± 0.008	1.894GlnIle: 1.894 ± 0.011	2.046GlnLys: 2.046 ± 0.013	3.222GlnLeu: 3.222 ± 0.017	0.886GlnMet: 0.886 ± 0.008	1.565GlnAsn: 1.565 ± 0.011	1.785GlnPro: 1.785 ± 0.014	1.907GlnGln: 1.907 ± 0.02	2.418GlnArg: 2.418 ± 0.013	2.78GlnSer: 2.78 ± 0.013	1.906GlnThr: 1.906 ± 0.011	2.268GlnVal: 2.268 ± 0.012	0.471GlnTrp: 0.471 ± 0.006	0.774GlnTyr: 0.774 ± 0.007	0.0GlnXaa: 0.0 ± 0.0
Arg	3.468ArgAla: 3.468 ± 0.017	1.104ArgCys: 1.104 ± 0.009	2.932ArgAsp: 2.932 ± 0.015	3.733ArgGlu: 3.733 ± 0.018	2.626ArgPhe: 2.626 ± 0.012	3.495ArgGly: 3.495 ± 0.019	1.33ArgHis: 1.33 ± 0.01	2.956ArgIle: 2.956 ± 0.015	3.94ArgLys: 3.94 ± 0.017	5.482ArgLeu: 5.482 ± 0.019	1.396ArgMet: 1.396 ± 0.01	2.594ArgAsn: 2.594 ± 0.013	3.07ArgPro: 3.07 ± 0.022	1.913ArgGln: 1.913 ± 0.013	4.619ArgArg: 4.619 ± 0.024	5.359ArgSer: 5.359 ± 0.024	2.744ArgThr: 2.744 ± 0.014	3.723ArgVal: 3.723 ± 0.017	0.844ArgTrp: 0.844 ± 0.008	1.601ArgTyr: 1.601 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	5.014SerAla: 5.014 ± 0.02	1.635SerCys: 1.635 ± 0.012	4.42SerAsp: 4.42 ± 0.019	4.868SerGlu: 4.868 ± 0.024	3.96SerPhe: 3.96 ± 0.017	5.658SerGly: 5.658 ± 0.026	2.041SerHis: 2.041 ± 0.012	4.228SerIle: 4.228 ± 0.017	5.023SerLys: 5.023 ± 0.019	8.699SerLeu: 8.699 ± 0.03	2.062SerMet: 2.062 ± 0.013	3.631SerAsn: 3.631 ± 0.019	4.872SerPro: 4.872 ± 0.035	2.981SerGln: 2.981 ± 0.015	5.092SerArg: 5.092 ± 0.021	11.416SerSer: 11.416 ± 0.044	4.684SerThr: 4.684 ± 0.02	5.305SerVal: 5.305 ± 0.02	1.224SerTrp: 1.224 ± 0.01	2.341SerTyr: 2.341 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	3.319ThrAla: 3.319 ± 0.016	0.989ThrCys: 0.989 ± 0.008	2.394ThrAsp: 2.394 ± 0.013	3.063ThrGlu: 3.063 ± 0.017	2.156ThrPhe: 2.156 ± 0.013	3.281ThrGly: 3.281 ± 0.017	1.143ThrHis: 1.143 ± 0.009	2.65ThrIle: 2.65 ± 0.015	3.183ThrLys: 3.183 ± 0.016	4.686ThrLeu: 4.686 ± 0.019	1.309ThrMet: 1.309 ± 0.008	2.089ThrAsn: 2.089 ± 0.011	2.736ThrPro: 2.736 ± 0.016	1.691ThrGln: 1.691 ± 0.011	3.016ThrArg: 3.016 ± 0.016	4.66ThrSer: 4.66 ± 0.017	3.384ThrThr: 3.384 ± 0.017	3.483ThrVal: 3.483 ± 0.016	0.824ThrTrp: 0.824 ± 0.008	1.328ThrTyr: 1.328 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	4.6ValAla: 4.6 ± 0.017	1.205ValCys: 1.205 ± 0.009	3.719ValAsp: 3.719 ± 0.014	4.664ValGlu: 4.664 ± 0.018	2.829ValPhe: 2.829 ± 0.014	3.713ValGly: 3.713 ± 0.024	1.44ValHis: 1.44 ± 0.011	3.304ValIle: 3.304 ± 0.018	4.158ValLys: 4.158 ± 0.016	6.142ValLeu: 6.142 ± 0.023	1.652ValMet: 1.652 ± 0.01	2.545ValAsn: 2.545 ± 0.013	3.216ValPro: 3.216 ± 0.015	2.114ValGln: 2.114 ± 0.012	3.325ValArg: 3.325 ± 0.014	5.664ValSer: 5.664 ± 0.017	3.347ValThr: 3.347 ± 0.015	4.898ValVal: 4.898 ± 0.021	0.878ValTrp: 0.878 ± 0.008	2.087ValTyr: 2.087 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.742TrpAla: 0.742 ± 0.007	0.251TrpCys: 0.251 ± 0.004	0.783TrpAsp: 0.783 ± 0.007	0.886TrpGlu: 0.886 ± 0.008	0.613TrpPhe: 0.613 ± 0.006	0.731TrpGly: 0.731 ± 0.008	0.279TrpHis: 0.279 ± 0.005	0.806TrpIle: 0.806 ± 0.007	0.985TrpLys: 0.985 ± 0.009	1.195TrpLeu: 1.195 ± 0.01	0.369TrpMet: 0.369 ± 0.004	0.732TrpAsn: 0.732 ± 0.007	0.534TrpPro: 0.534 ± 0.006	0.435TrpGln: 0.435 ± 0.005	1.051TrpArg: 1.051 ± 0.009	1.135TrpSer: 1.135 ± 0.01	0.69TrpThr: 0.69 ± 0.007	0.818TrpVal: 0.818 ± 0.007	0.257TrpTrp: 0.257 ± 0.004	0.376TrpTyr: 0.376 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.69TyrAla: 1.69 ± 0.012	0.572TyrCys: 0.572 ± 0.006	1.524TyrAsp: 1.524 ± 0.01	1.596TyrGlu: 1.596 ± 0.011	1.216TyrPhe: 1.216 ± 0.01	2.084TyrGly: 2.084 ± 0.015	0.767TyrHis: 0.767 ± 0.008	1.337TyrIle: 1.337 ± 0.009	1.666TyrLys: 1.666 ± 0.011	2.643TyrLeu: 2.643 ± 0.016	0.738TyrMet: 0.738 ± 0.006	1.238TyrAsn: 1.238 ± 0.009	1.293TyrPro: 1.293 ± 0.01	0.926TyrGln: 0.926 ± 0.007	1.598TyrArg: 1.598 ± 0.011	2.17TyrSer: 2.17 ± 0.017	1.307TyrThr: 1.307 ± 0.009	1.806TyrVal: 1.806 ± 0.013	0.395TyrTrp: 0.395 ± 0.005	0.987TyrTyr: 0.987 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.007XaaXaa: 0.007 ± 0.004

Statistics based on 45482 proteins (16402413 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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