Amino acid dipepetide frequency for Ochrobactrum intermedium 229E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.305AlaAla: 14.305 ± 0.167	0.927AlaCys: 0.927 ± 0.03	6.255AlaAsp: 6.255 ± 0.079	7.077AlaGlu: 7.077 ± 0.096	4.398AlaPhe: 4.398 ± 0.069	9.44AlaGly: 9.44 ± 0.106	2.037AlaHis: 2.037 ± 0.045	6.851AlaIle: 6.851 ± 0.081	4.358AlaLys: 4.358 ± 0.076	11.963AlaLeu: 11.963 ± 0.12	3.245AlaMet: 3.245 ± 0.055	3.058AlaAsn: 3.058 ± 0.049	4.595AlaPro: 4.595 ± 0.075	3.62AlaGln: 3.62 ± 0.057	7.423AlaArg: 7.423 ± 0.089	6.726AlaSer: 6.726 ± 0.087	5.358AlaThr: 5.358 ± 0.075	8.015AlaVal: 8.015 ± 0.099	1.252AlaTrp: 1.252 ± 0.039	2.636AlaTyr: 2.636 ± 0.057	0.021AlaXaa: 0.021 ± 0.005
Cys	0.86CysAla: 0.86 ± 0.029	0.129CysCys: 0.129 ± 0.011	0.513CysAsp: 0.513 ± 0.027	0.401CysGlu: 0.401 ± 0.019	0.369CysPhe: 0.369 ± 0.019	0.856CysGly: 0.856 ± 0.031	0.213CysHis: 0.213 ± 0.014	0.455CysIle: 0.455 ± 0.021	0.253CysLys: 0.253 ± 0.014	0.773CysLeu: 0.773 ± 0.03	0.185CysMet: 0.185 ± 0.013	0.2CysAsn: 0.2 ± 0.016	0.389CysPro: 0.389 ± 0.021	0.227CysGln: 0.227 ± 0.014	0.555CysArg: 0.555 ± 0.024	0.488CysSer: 0.488 ± 0.021	0.403CysThr: 0.403 ± 0.019	0.54CysVal: 0.54 ± 0.023	0.126CysTrp: 0.126 ± 0.01	0.185CysTyr: 0.185 ± 0.014	0.002CysXaa: 0.002 ± 0.001
Asp	6.235AspAla: 6.235 ± 0.09	0.469AspCys: 0.469 ± 0.022	3.053AspAsp: 3.053 ± 0.066	3.578AspGlu: 3.578 ± 0.067	2.318AspPhe: 2.318 ± 0.055	4.788AspGly: 4.788 ± 0.071	1.227AspHis: 1.227 ± 0.038	3.445AspIle: 3.445 ± 0.062	2.21AspLys: 2.21 ± 0.045	5.263AspLeu: 5.263 ± 0.084	1.509AspMet: 1.509 ± 0.035	1.609AspAsn: 1.609 ± 0.04	2.919AspPro: 2.919 ± 0.052	1.717AspGln: 1.717 ± 0.04	4.081AspArg: 4.081 ± 0.069	2.125AspSer: 2.125 ± 0.045	2.532AspThr: 2.532 ± 0.05	4.035AspVal: 4.035 ± 0.065	0.898AspTrp: 0.898 ± 0.03	1.618AspTyr: 1.618 ± 0.039	0.003AspXaa: 0.003 ± 0.002
Glu	7.114GluAla: 7.114 ± 0.096	0.372GluCys: 0.372 ± 0.019	2.83GluAsp: 2.83 ± 0.064	3.565GluGlu: 3.565 ± 0.062	1.895GluPhe: 1.895 ± 0.04	4.222GluGly: 4.222 ± 0.063	1.185GluHis: 1.185 ± 0.038	3.844GluIle: 3.844 ± 0.061	3.359GluLys: 3.359 ± 0.061	5.506GluLeu: 5.506 ± 0.091	1.565GluMet: 1.565 ± 0.04	2.167GluAsn: 2.167 ± 0.05	2.626GluPro: 2.626 ± 0.058	2.234GluGln: 2.234 ± 0.05	4.633GluArg: 4.633 ± 0.073	2.42GluSer: 2.42 ± 0.046	3.679GluThr: 3.679 ± 0.063	3.46GluVal: 3.46 ± 0.056	0.71GluTrp: 0.71 ± 0.024	1.082GluTyr: 1.082 ± 0.037	0.001GluXaa: 0.001 ± 0.001
Phe	4.498PheAla: 4.498 ± 0.062	0.387PheCys: 0.387 ± 0.019	2.77PheAsp: 2.77 ± 0.052	2.238PheGlu: 2.238 ± 0.052	1.622PhePhe: 1.622 ± 0.046	3.693PheGly: 3.693 ± 0.061	0.808PheHis: 0.808 ± 0.028	2.142PheIle: 2.142 ± 0.047	1.282PheLys: 1.282 ± 0.037	3.724PheLeu: 3.724 ± 0.068	0.938PheMet: 0.938 ± 0.032	1.346PheAsn: 1.346 ± 0.036	1.638PhePro: 1.638 ± 0.037	1.133PheGln: 1.133 ± 0.03	2.347PheArg: 2.347 ± 0.047	2.615PheSer: 2.615 ± 0.044	2.007PheThr: 2.007 ± 0.047	2.96PheVal: 2.96 ± 0.052	0.631PheTrp: 0.631 ± 0.024	1.006PheTyr: 1.006 ± 0.033	0.003PheXaa: 0.003 ± 0.002
Gly	7.994GlyAla: 7.994 ± 0.089	0.79GlyCys: 0.79 ± 0.03	4.129GlyAsp: 4.129 ± 0.063	4.669GlyGlu: 4.669 ± 0.074	3.72GlyPhe: 3.72 ± 0.062	9.005GlyGly: 9.005 ± 0.148	1.736GlyHis: 1.736 ± 0.044	5.182GlyIle: 5.182 ± 0.071	3.965GlyLys: 3.965 ± 0.065	8.309GlyLeu: 8.309 ± 0.088	2.252GlyMet: 2.252 ± 0.048	2.598GlyAsn: 2.598 ± 0.054	2.967GlyPro: 2.967 ± 0.047	2.759GlyGln: 2.759 ± 0.045	5.178GlyArg: 5.178 ± 0.077	4.716GlySer: 4.716 ± 0.073	4.364GlyThr: 4.364 ± 0.067	5.736GlyVal: 5.736 ± 0.077	1.302GlyTrp: 1.302 ± 0.036	2.282GlyTyr: 2.282 ± 0.047	0.016GlyXaa: 0.016 ± 0.004
His	2.048HisAla: 2.048 ± 0.042	0.205HisCys: 0.205 ± 0.015	1.238HisAsp: 1.238 ± 0.041	1.106HisGlu: 1.106 ± 0.033	0.851HisPhe: 0.851 ± 0.027	1.783HisGly: 1.783 ± 0.044	0.554HisHis: 0.554 ± 0.039	1.11HisIle: 1.11 ± 0.029	0.637HisLys: 0.637 ± 0.025	1.928HisLeu: 1.928 ± 0.042	0.524HisMet: 0.524 ± 0.022	0.549HisAsn: 0.549 ± 0.021	1.204HisPro: 1.204 ± 0.039	0.631HisGln: 0.631 ± 0.026	1.392HisArg: 1.392 ± 0.04	1.001HisSer: 1.001 ± 0.034	0.809HisThr: 0.809 ± 0.028	1.427HisVal: 1.427 ± 0.035	0.302HisTrp: 0.302 ± 0.018	0.591HisTyr: 0.591 ± 0.026	0.001HisXaa: 0.001 ± 0.001
Ile	7.845IleAla: 7.845 ± 0.095	0.6IleCys: 0.6 ± 0.026	3.851IleAsp: 3.851 ± 0.056	3.901IleGlu: 3.901 ± 0.059	2.092IlePhe: 2.092 ± 0.048	5.384IleGly: 5.384 ± 0.073	1.012IleHis: 1.012 ± 0.031	3.109IleIle: 3.109 ± 0.061	1.846IleLys: 1.846 ± 0.04	5.136IleLeu: 5.136 ± 0.068	1.313IleMet: 1.313 ± 0.034	1.759IleAsn: 1.759 ± 0.046	2.49IlePro: 2.49 ± 0.048	1.419IleGln: 1.419 ± 0.038	3.557IleArg: 3.557 ± 0.054	3.618IleSer: 3.618 ± 0.052	2.843IleThr: 2.843 ± 0.052	4.727IleVal: 4.727 ± 0.077	0.65IleTrp: 0.65 ± 0.024	1.331IleTyr: 1.331 ± 0.028	0.007IleXaa: 0.007 ± 0.003
Lys	4.921LysAla: 4.921 ± 0.078	0.183LysCys: 0.183 ± 0.013	2.195LysAsp: 2.195 ± 0.045	2.109LysGlu: 2.109 ± 0.045	1.165LysPhe: 1.165 ± 0.038	3.095LysGly: 3.095 ± 0.057	0.763LysHis: 0.763 ± 0.029	2.269LysIle: 2.269 ± 0.042	1.836LysLys: 1.836 ± 0.05	4.094LysLeu: 4.094 ± 0.062	1.042LysMet: 1.042 ± 0.035	1.328LysAsn: 1.328 ± 0.037	2.522LysPro: 2.522 ± 0.052	1.374LysGln: 1.374 ± 0.036	2.762LysArg: 2.762 ± 0.047	2.389LysSer: 2.389 ± 0.052	2.315LysThr: 2.315 ± 0.045	2.772LysVal: 2.772 ± 0.062	0.44LysTrp: 0.44 ± 0.019	0.742LysTyr: 0.742 ± 0.028	0.006LysXaa: 0.006 ± 0.003
Leu	11.911LeuAla: 11.911 ± 0.126	0.832LeuCys: 0.832 ± 0.028	5.68LeuAsp: 5.68 ± 0.073	5.388LeuGlu: 5.388 ± 0.077	3.877LeuPhe: 3.877 ± 0.072	7.692LeuGly: 7.692 ± 0.105	1.826LeuHis: 1.826 ± 0.041	5.505LeuIle: 5.505 ± 0.082	4.366LeuLys: 4.366 ± 0.055	9.249LeuLeu: 9.249 ± 0.124	2.469LeuMet: 2.469 ± 0.046	2.953LeuAsn: 2.953 ± 0.061	5.235LeuPro: 5.235 ± 0.062	2.941LeuGln: 2.941 ± 0.05	5.967LeuArg: 5.967 ± 0.08	6.653LeuSer: 6.653 ± 0.086	5.427LeuThr: 5.427 ± 0.086	7.258LeuVal: 7.258 ± 0.084	1.065LeuTrp: 1.065 ± 0.034	2.215LeuTyr: 2.215 ± 0.054	0.005LeuXaa: 0.005 ± 0.002
Met	2.998MetAla: 2.998 ± 0.053	0.16MetCys: 0.16 ± 0.012	1.145MetAsp: 1.145 ± 0.037	1.312MetGlu: 1.312 ± 0.031	0.796MetPhe: 0.796 ± 0.026	1.795MetGly: 1.795 ± 0.036	0.48MetHis: 0.48 ± 0.021	1.552MetIle: 1.552 ± 0.038	1.27MetLys: 1.27 ± 0.037	2.533MetLeu: 2.533 ± 0.049	0.734MetMet: 0.734 ± 0.028	0.952MetAsn: 0.952 ± 0.029	1.55MetPro: 1.55 ± 0.039	0.973MetGln: 0.973 ± 0.032	1.944MetArg: 1.944 ± 0.046	1.782MetSer: 1.782 ± 0.045	1.866MetThr: 1.866 ± 0.041	1.802MetVal: 1.802 ± 0.04	0.225MetTrp: 0.225 ± 0.016	0.31MetTyr: 0.31 ± 0.016	0.004MetXaa: 0.004 ± 0.002
Asn	3.469AsnAla: 3.469 ± 0.056	0.25AsnCys: 0.25 ± 0.016	1.678AsnAsp: 1.678 ± 0.043	1.602AsnGlu: 1.602 ± 0.044	1.208AsnPhe: 1.208 ± 0.038	2.882AsnGly: 2.882 ± 0.058	0.567AsnHis: 0.567 ± 0.024	1.875AsnIle: 1.875 ± 0.042	0.971AsnLys: 0.971 ± 0.029	2.848AsnLeu: 2.848 ± 0.048	0.805AsnMet: 0.805 ± 0.026	0.93AsnAsn: 0.93 ± 0.033	1.993AsnPro: 1.993 ± 0.044	0.954AsnGln: 0.954 ± 0.028	2.079AsnArg: 2.079 ± 0.053	1.589AsnSer: 1.589 ± 0.039	1.412AsnThr: 1.412 ± 0.036	2.242AsnVal: 2.242 ± 0.051	0.538AsnTrp: 0.538 ± 0.023	0.844AsnTyr: 0.844 ± 0.028	0.003AsnXaa: 0.003 ± 0.001
Pro	5.267ProAla: 5.267 ± 0.082	0.306ProCys: 0.306 ± 0.019	3.362ProAsp: 3.362 ± 0.054	3.553ProGlu: 3.553 ± 0.064	2.08ProPhe: 2.08 ± 0.044	3.759ProGly: 3.759 ± 0.064	1.076ProHis: 1.076 ± 0.034	2.348ProIle: 2.348 ± 0.043	1.886ProLys: 1.886 ± 0.045	4.439ProLeu: 4.439 ± 0.064	1.14ProMet: 1.14 ± 0.031	1.405ProAsn: 1.405 ± 0.042	3.633ProPro: 3.633 ± 0.064	1.708ProGln: 1.708 ± 0.038	2.426ProArg: 2.426 ± 0.053	2.753ProSer: 2.753 ± 0.051	2.227ProThr: 2.227 ± 0.043	4.231ProVal: 4.231 ± 0.063	0.576ProTrp: 0.576 ± 0.024	1.239ProTyr: 1.239 ± 0.037	0.014ProXaa: 0.014 ± 0.004
Gln	3.663GlnAla: 3.663 ± 0.069	0.214GlnCys: 0.214 ± 0.013	1.444GlnAsp: 1.444 ± 0.038	1.676GlnGlu: 1.676 ± 0.046	1.209GlnPhe: 1.209 ± 0.037	2.171GlnGly: 2.171 ± 0.038	0.685GlnHis: 0.685 ± 0.027	1.987GlnIle: 1.987 ± 0.043	1.473GlnLys: 1.473 ± 0.04	3.098GlnLeu: 3.098 ± 0.054	0.991GlnMet: 0.991 ± 0.031	1.181GlnAsn: 1.181 ± 0.035	1.738GlnPro: 1.738 ± 0.041	1.315GlnGln: 1.315 ± 0.038	2.365GlnArg: 2.365 ± 0.048	2.067GlnSer: 2.067 ± 0.043	1.763GlnThr: 1.763 ± 0.035	2.046GlnVal: 2.046 ± 0.044	0.418GlnTrp: 0.418 ± 0.02	0.713GlnTyr: 0.713 ± 0.029	0.006GlnXaa: 0.006 ± 0.002
Arg	6.4ArgAla: 6.4 ± 0.083	0.49ArgCys: 0.49 ± 0.025	3.572ArgAsp: 3.572 ± 0.071	4.088ArgGlu: 4.088 ± 0.066	3.051ArgPhe: 3.051 ± 0.054	4.207ArgGly: 4.207 ± 0.077	1.564ArgHis: 1.564 ± 0.04	4.195ArgIle: 4.195 ± 0.069	2.789ArgLys: 2.789 ± 0.051	7.001ArgLeu: 7.001 ± 0.092	1.836ArgMet: 1.836 ± 0.044	2.193ArgAsn: 2.193 ± 0.048	2.995ArgPro: 2.995 ± 0.053	2.636ArgGln: 2.636 ± 0.047	4.908ArgArg: 4.908 ± 0.074	3.865ArgSer: 3.865 ± 0.063	3.142ArgThr: 3.142 ± 0.063	4.222ArgVal: 4.222 ± 0.062	0.866ArgTrp: 0.866 ± 0.03	1.74ArgTyr: 1.74 ± 0.042	0.006ArgXaa: 0.006 ± 0.003
Ser	6.233SerAla: 6.233 ± 0.08	0.453SerCys: 0.453 ± 0.021	3.144SerAsp: 3.144 ± 0.057	3.18SerGlu: 3.18 ± 0.06	2.666SerPhe: 2.666 ± 0.049	5.738SerGly: 5.738 ± 0.073	1.106SerHis: 1.106 ± 0.034	3.383SerIle: 3.383 ± 0.059	2.015SerLys: 2.015 ± 0.042	5.785SerLeu: 5.785 ± 0.074	1.555SerMet: 1.555 ± 0.038	1.669SerAsn: 1.669 ± 0.039	2.728SerPro: 2.728 ± 0.057	1.776SerGln: 1.776 ± 0.038	3.754SerArg: 3.754 ± 0.06	3.36SerSer: 3.36 ± 0.061	2.964SerThr: 2.964 ± 0.055	4.263SerVal: 4.263 ± 0.065	0.784SerTrp: 0.784 ± 0.03	1.475SerTyr: 1.475 ± 0.033	0.01SerXaa: 0.01 ± 0.003
Thr	5.901ThrAla: 5.901 ± 0.071	0.396ThrCys: 0.396 ± 0.017	2.763ThrAsp: 2.763 ± 0.054	2.738ThrGlu: 2.738 ± 0.059	1.958ThrPhe: 1.958 ± 0.041	4.94ThrGly: 4.94 ± 0.067	0.952ThrHis: 0.952 ± 0.027	3.203ThrIle: 3.203 ± 0.057	1.691ThrLys: 1.691 ± 0.038	5.514ThrLeu: 5.514 ± 0.073	1.269ThrMet: 1.269 ± 0.037	1.381ThrAsn: 1.381 ± 0.036	2.96ThrPro: 2.96 ± 0.051	1.388ThrGln: 1.388 ± 0.036	3.083ThrArg: 3.083 ± 0.049	2.896ThrSer: 2.896 ± 0.052	2.858ThrThr: 2.858 ± 0.061	4.515ThrVal: 4.515 ± 0.07	0.546ThrTrp: 0.546 ± 0.025	1.281ThrTyr: 1.281 ± 0.033	0.009ThrXaa: 0.009 ± 0.003
Val	8.287ValAla: 8.287 ± 0.097	0.587ValCys: 0.587 ± 0.025	3.903ValAsp: 3.903 ± 0.06	4.492ValGlu: 4.492 ± 0.073	2.929ValPhe: 2.929 ± 0.05	5.259ValGly: 5.259 ± 0.08	1.327ValHis: 1.327 ± 0.04	4.217ValIle: 4.217 ± 0.07	2.724ValLys: 2.724 ± 0.053	7.323ValLeu: 7.323 ± 0.094	1.906ValMet: 1.906 ± 0.048	2.172ValAsn: 2.172 ± 0.048	3.466ValPro: 3.466 ± 0.06	2.045ValGln: 2.045 ± 0.044	4.53ValArg: 4.53 ± 0.069	4.742ValSer: 4.742 ± 0.072	4.401ValThr: 4.401 ± 0.076	5.516ValVal: 5.516 ± 0.079	0.846ValTrp: 0.846 ± 0.025	1.511ValTyr: 1.511 ± 0.04	0.006ValXaa: 0.006 ± 0.002
Trp	1.09TrpAla: 1.09 ± 0.034	0.121TrpCys: 0.121 ± 0.011	0.619TrpAsp: 0.619 ± 0.024	0.512TrpGlu: 0.512 ± 0.023	0.523TrpPhe: 0.523 ± 0.023	0.788TrpGly: 0.788 ± 0.029	0.297TrpHis: 0.297 ± 0.018	0.71TrpIle: 0.71 ± 0.028	0.577TrpLys: 0.577 ± 0.024	1.662TrpLeu: 1.662 ± 0.043	0.354TrpMet: 0.354 ± 0.018	0.533TrpAsn: 0.533 ± 0.024	0.611TrpPro: 0.611 ± 0.027	0.592TrpGln: 0.592 ± 0.021	0.952TrpArg: 0.952 ± 0.028	0.863TrpSer: 0.863 ± 0.029	0.721TrpThr: 0.721 ± 0.027	0.748TrpVal: 0.748 ± 0.03	0.208TrpTrp: 0.208 ± 0.014	0.291TrpTyr: 0.291 ± 0.019	0.004TrpXaa: 0.004 ± 0.002
Tyr	2.507TyrAla: 2.507 ± 0.05	0.247TyrCys: 0.247 ± 0.015	1.481TyrAsp: 1.481 ± 0.045	1.282TyrGlu: 1.282 ± 0.042	1.06TyrPhe: 1.06 ± 0.033	2.156TyrGly: 2.156 ± 0.041	0.473TyrHis: 0.473 ± 0.021	1.1TyrIle: 1.1 ± 0.032	0.811TyrLys: 0.811 ± 0.028	2.358TyrLeu: 2.358 ± 0.045	0.549TyrMet: 0.549 ± 0.023	0.757TyrAsn: 0.757 ± 0.027	1.154TyrPro: 1.154 ± 0.031	0.779TyrGln: 0.779 ± 0.03	1.807TyrArg: 1.807 ± 0.042	1.363TyrSer: 1.363 ± 0.039	1.146TyrThr: 1.146 ± 0.033	1.671TyrVal: 1.671 ± 0.045	0.394TyrTrp: 0.394 ± 0.021	0.694TyrTyr: 0.694 ± 0.026	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.015XaaAla: 0.015 ± 0.005	0.003XaaCys: 0.003 ± 0.001	0.006XaaAsp: 0.006 ± 0.002	0.005XaaGlu: 0.005 ± 0.002	0.003XaaPhe: 0.003 ± 0.002	0.014XaaGly: 0.014 ± 0.003	0.003XaaHis: 0.003 ± 0.002	0.006XaaIle: 0.006 ± 0.003	0.002XaaLys: 0.002 ± 0.001	0.009XaaLeu: 0.009 ± 0.003	0.001XaaMet: 0.001 ± 0.001	0.002XaaAsn: 0.002 ± 0.001	0.016XaaPro: 0.016 ± 0.005	0.004XaaGln: 0.004 ± 0.002	0.021XaaArg: 0.021 ± 0.005	0.009XaaSer: 0.009 ± 0.003	0.006XaaThr: 0.006 ± 0.002	0.003XaaVal: 0.003 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.044XaaXaa: 0.044 ± 0.008

Statistics based on 4249 proteins (1077194 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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